Digestive Endoscopy最新文献

{"title":"New milestone for clinical research about biliary drainage","authors":"Atsushi Kanno, Hironori Yamamoto","doi":"10.1111/den.14934","DOIUrl":"10.1111/den.14934","url":null,"abstract":"<p>Endoscopic bile duct stenting has been the first-line treatment for bile duct obstruction, regardless of resectability or benign/malignant status,<span><sup>1-3</sup></span> although the criteria for evaluating the outcome of bile duct stents have not been adequately explored. For example, since the definition of stent occlusion varied across different articles, a meta-analysis of bile duct stent outcomes was summarized as stent dysfunction in terms of results. Furthermore, while stent occlusion due to tumor invasion was the main stent dysfunction in the case of inserted plastic stents or uncovered self-expandable metallic stents (SEMS), the advent of covered SEMS has made it necessary to consider stent migration or dislocation as a stent dysfunction.<span><sup>4, 5</sup></span> In this context, a need existed for common definitions regarding procedure-related early outcomes for stents, outcomes of stents during follow-up, and adverse events. Previous TOKYO criteria defined terms associated with the technical and clinical success of biliary stenting, recurrent biliary obstruction (RBO) and related factors, and adverse events.<span><sup>6</sup></span> Technical success was defined as the ability of the stent to adequately bypass the planned bile duct stenosis site, and clinical success was defined as a normal or 50% reduction in total bilirubin levels within 14 days of stent placement. In addition, RBO was defined as an outcome measure, including occlusion or deviation, used to assess the duration of stent function from the date of stent placement. An important aspect of RBO was that it focused on symptoms rather than stent patency alone. The time of symptom recurrence due to stent occlusion or deviation was specified as the time of onset of RBO, and this time point was to be used for assessment. The causes of obstruction of the RBO, such as internal growths associated with tumor growth, tumor growths on the edge of the stent, biliary debris or food residues, the direction of stent dislocation or migration (intrahepatic bile duct or duodenal papillary side), and whether pancreatitis or cholecystitis was present, were to be described separately. In addition, items on survival and contingencies other than RBOs have been created and described uniformly to provide an overall clinical picture from the results of clinical studies.</p><p>The progress of biliary drainage over the past decade has been so rapid that it has become increasingly difficult to cover it in the previous TOKYO criteria. For example, balloon endoscopy-assisted endoscopic retrograde cholangiopancreatography (ERCP) for cases with altered anatomy has become widely used.<span><sup>7</sup></span> In ERCP for patients with altered anatomy, the rate of reach to the bile duct orifice should be included in the assessment of technical success.<span><sup>8</sup></span> Endoscopic ultrasound-biliary drainage (EUS-BD) is also widely recognized as a common procedure. It does not bypass the bil","PeriodicalId":159,"journal":{"name":"Digestive Endoscopy","volume":"36 11","pages":"1211-1212"},"PeriodicalIF":5.0,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/den.14934","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WEO Newsletter: Tips and Tricks for Endoscopic Ultrasound guided Celiac Plexus interventions","authors":"","doi":"10.1111/den.14935","DOIUrl":"10.1111/den.14935","url":null,"abstract":"<p>WEO Newsletter Editor: Nalini M Guda MD, MASGE, AGAF, FACG, FJGES</p><p><b>Dr. Sridhar Sundaram</b></p><p><b>MD, DM, FISG</b></p><p>Present Designation:</p><p>Professor (Gastroenterology), Department of Digestive Diseases and Clinical Nutrition, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai</p><p>Consultant- GI Disease Management Group, Tata Memorial Hospital, Mumbai</p><p>Governing Council Member – Indian Society of Gastroenterology</p><p>Member – ESGE Diversity and Equity Working Group</p><p>Managing Editor – Indian Journal of Gastroenterology</p><p>Member – India EUS Club</p><p>Primary areas of interest: Therapeutic Endoscopic Ultrasound, Endoscopic Resection techniques for early GI cancer</p><p>Abdominal pain due to perineural invasion is one of the most debilitating symptoms associated with pancreaticobiliary cancers. In addition, pain remains one of the most complex symptoms associated with chronic pancreatitis needing intervention (<span>1</span>). Pain from upper abdominal viscera is transmitted via the afferent pathway to the celiac plexus leading into the spinal cord at the T12-L2 level. The efferents from the celiac plexus consists mainly of sympathetic fibres of a network of interconnected para-aortic ganglia, including those at the level of the celiac axis, superior mesenteric artery origin and also renal artery. In addition, parasympathetic efferents of the celiac plexus come from the vagus nerve (<span>2</span>). Traditionally celiac plexus block was performed as an intraoperative ablative procedure. Subsequently fluoroscopy guided celiac plexus interventions were performed. Endoscopic Ultrasound guided celiac plexus block (CPB) was first described in 1996 and has now become the standard of care (<span>3</span>).</p><p>Chronic pancreatitis patients with pain not responding to conventional measures like pancreatic enzyme replacement, antioxidants, non-narcotic and narcotic medications may be candidates who may benefit in short term from CPB. However, the caveat remains that block provides temporary relief and may be an adjunct to other modalities. Celiac plexus neurolysis (CPN) is recommended only in the setting of inoperable pancreatic cancer. In cases of operable pancreatic cancer, neurolysis may lead to scarring the operative field, thereby making surgery technically more challenging. Most patients who do not respond to conventional opioids or require significantly higher doses with adverse events are candidates to consider CPN (<span>4</span>).</p><p>CPB is typically for patients with pain not responding to analgesics and can be repeated at 3–6 months intervals. As pain becomes chronic, response to CPB is likely to be lesser, considering formation of neural feedback loops with cerebral pain conditioning. In patients with pancreatic cancer, pain responds better earlier in the course of disease to CPN. As disease progresses and pain persists, the neural pathways become less responsive and efficacy of CPN reduce","PeriodicalId":159,"journal":{"name":"Digestive Endoscopy","volume":"36 10","pages":"1185-1189"},"PeriodicalIF":5.0,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/den.14935","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142402208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic ability and adverse events of mucosal incision-assisted biopsy for gastric subepithelial tumors: Systematic review and meta-analysis","authors":"Eriko Koizumi,&nbsp;Osamu Goto,&nbsp;Akihisa Matsuda,&nbsp;Toshiaki Otsuka,&nbsp;Yumiko Ishikawa,&nbsp;Shun Nakagome,&nbsp;Masahiro Niikawa,&nbsp;Tsugumi Habu,&nbsp;Keiichiro Yoshikata,&nbsp;Kumiko Kirita,&nbsp;Hiroto Noda,&nbsp;Kazutoshi Higuchi,&nbsp;Takeshi Onda,&nbsp;Jun Omori,&nbsp;Naohiko Akimoto,&nbsp;Hiroshi Yoshida,&nbsp;Katsuhiko Iwakiri","doi":"10.1111/den.14933","DOIUrl":"10.1111/den.14933","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This systematic review and meta-analysis aimed to evaluate the diagnostic ability and examine the efficacy of countermeasures to adverse events of mucosal incision-assisted biopsy (MIAB) for gastric subepithelial tumors (SETs).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We performed a literature search and identified 533 relevant articles. Eleven articles, including 339 lesions, were ultimately used in the meta-analysis. The primary end-point was the pathological diagnostic rate of MIAB for gastric SETs, and the secondary end-point was the incidence of adverse events. The efficacy of acid secretion inhibitors in preventing postoperative bleeding and that of local injection before incision to prevent perforation were also examined.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Nine studies were conducted in Japan and two in South Korea, of which only two were prospective studies. The pooled pathological diagnostic rate of MIAB for gastric SETs was 87.8% (95% confidence interval [CI] 80.2–94.0; <i>I</i>² = 68.7%). The adverse event rate of the pooled population was 0.2% (95% CI 0–1.4; <i>I</i>² = 0%). The acid secretion inhibitors significantly reduced postoperative bleeding (odds ratio 0.06, 95% CI 0.01–0.66, <i>P</i> = 0.02). Perforation occurred in 0% and 2.6% of the local and nonlocal injection cohorts, respectively, and the pathological diagnostic rates were 50% and 66.7%, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>MIAB is a reliable technique with a favorable diagnostic rate and few adverse events. Acid secretion inhibitors may effectively prevent postoperative bleeding; however, the efficacy of local injection remains unclear. This technique could be an option for tissue sampling in gastric SETs.</p>\u0000 </section>\u0000 </div>","PeriodicalId":159,"journal":{"name":"Digestive Endoscopy","volume":"37 3","pages":"236-246"},"PeriodicalIF":5.0,"publicationDate":"2024-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142382614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is endoscopic ultrasound-guided gastroenterostomy better than surgical gastrojejunostomy or duodenal stenting?","authors":"Anthony Yuen Bun Teoh,&nbsp;Shannon Melissa Chan,&nbsp;Hon Chi Yip","doi":"10.1111/den.14929","DOIUrl":"10.1111/den.14929","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Gastrojejunostomy is a critical procedure for managing gastric outlet obstruction. While surgical gastrojejunostomy has traditionally been the standard approach, endoscopic ultrasound (EUS)-guided gastroenterostomy has emerged as a promising endoscopic alternative. This comprehensive review aims to explore the development, techniques, outcomes, and comparative effectiveness of EUS-guided gastroenterostomy in comparison to duodenal stenting and surgical gastrojejunostomy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A comprehensive literature search was conducted using electronic databases to identify relevant studies published up to April 2024. The search included keywords related to EUS-guided gastrojejunostomy, surgical gastrojejunostomy, and duodenal stenting. Studies reporting on technical success, clinical success, complications, recurrence rates, quality of life, and long-term outcomes were included for analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The development of EUS-guided gastroenterostomy has evolved significantly over the years, driven by device advancements and improved endoscopic techniques. Comparative studies have shown that the technique offers several advantages, including the ability to create an anastomosis without the need for surgery, reduced invasiveness, shorter hospital stays, and potentially improved patient outcomes as compared to duodenal stenting and surgical gastrojejunostomy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Endoscopic ultrasound-guided gastroenterostomy represents a promising alternative to surgical gastrojejunostomy and duodenal stenting for the management of gastric outlet obstruction. The technique has evolved significantly, offering a less invasive and more effective treatment option.</p>\u0000 </section>\u0000 </div>","PeriodicalId":159,"journal":{"name":"Digestive Endoscopy","volume":"37 1","pages":"77-84"},"PeriodicalIF":5.0,"publicationDate":"2024-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11718137/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142382615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proposal of classification and terminology of interventional endoscopic ultrasonography/endosonography","authors":"Hiroyuki Isayama,&nbsp;Yousuke Nakai,&nbsp;Koji Matsuda,&nbsp;Yoshihide Kanno,&nbsp;Kazuo Hara,&nbsp;Takeshi Ogura,&nbsp;Nobutsugu Abe,&nbsp;Akio Katanuma,&nbsp;Masayuki Kitano,&nbsp;Ichiro Yasuda,&nbsp;Naoki Okano,&nbsp;Takayoshi Tsuchiya,&nbsp;Naotaka Fujita,&nbsp;Kazuo Inui,&nbsp;Toshiharu Ueki,&nbsp;Atsushi Irisawa,&nbsp;Hiro-o Yamano,&nbsp;The Subcommittee for Terminology of Interventional EUS of Japan Gastroenterological Endoscopy Society","doi":"10.1111/den.14927","DOIUrl":"10.1111/den.14927","url":null,"abstract":"<p>Interventional endoscopic ultrasonography/endosongraphy (I-EUS) procedures have rapidly evolved since their introduction three decades ago; however, the classification and terminology for these procedures remain unstandardized. To address this, the Subcommittee for Terminology of I-EUS in the Japan Gastroenterological Endoscopy Society was established to define classifications and a glossary of I-EUS terms. They categorized I-EUS procedures into five types based on purpose and method: (i) EUS-guided sampling; (ii) EUS-guided through-the-needle examination; (iii) EUS-guided drainage/anastomosis (EUS-D/A); (iv) trans-endosonographically/EUS-guided created route (ESCR) procedures; and (v) EUS-guided delivery. EUS-guided sampling includes tissue acquisition and fluid sampling, classified by needle type into fine needle aspiration and fine needle biopsy. Through-the-needle examinations include imaging, measurements, and biopsies. EUS-D/A includes organ drainage/anastomosis, fluid collection drainage, and digestive tract anastomosis. In the EUS-D/A route, “anastomosis” is used for organ-to-organ procedures, whereas “tract” is for fluid drainage. ESCR is a newly proposed term for procedures via anastomosis or tract, such as endoscopic necrosectomy and EUS-guided antegrade stenting. The term “trans-luminal drainage/anastomosis stent” is used for stents that maintain the ESCR rather than treating strictures. EUS-guided delivery involves the delivery of substances, such as fluids, drugs, medical devices, and energy. This proposed categorization and terminology aimed to clarify I-EUS procedures and will require updates as new techniques and concepts emerge.</p>","PeriodicalId":159,"journal":{"name":"Digestive Endoscopy","volume":"37 1","pages":"5-17"},"PeriodicalIF":5.0,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/den.14927","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142373690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current status and future perspectives for endoscopic treatment of local complications in chronic pancreatitis","authors":"Ken Ito,&nbsp;Kensuke Takuma,&nbsp;Naoki Okano,&nbsp;Yuto Yamada,&nbsp;Michihiro Saito,&nbsp;Manabu Watanabe,&nbsp;Yoshinori Igarashi,&nbsp;Takahisa Matsuda","doi":"10.1111/den.14926","DOIUrl":"10.1111/den.14926","url":null,"abstract":"<p>Chronic pancreatitis is a progressive disease characterized by irregular fibrosis, cellular infiltration, and parenchymal loss within the pancreas. Chronic pancreatitis treatment includes lifestyle modifications based on disease etiology, dietary adjustments appropriate for each stage and condition, drug therapy, endoscopic treatments, and surgical treatments. Although surgical treatments of symptomatic chronic pancreatitis provide good pain relief, endoscopic therapies are recommended as the first-line treatment because they are minimally invasive. In recent years, endoscopic therapy has emerged as an alternative treatment method to surgery for managing local complications in patients with chronic pancreatitis. For pancreatic stone removal, a combination of extracorporeal shock wave lithotripsy and endoscopic extraction is used. For refractory pancreatic duct stones, intracorporeal fragmentation techniques, such as pancreatoscopy-guided electrohydraulic lithotripsy and laser lithotripsy, offer additional options. Interventional endoscopic ultrasound has become the primary treatment modality for pancreatic pseudocysts, except in the absence of disconnected pancreatic duct syndrome. This review focuses on the current status of endoscopic therapies for common local complications of chronic pancreatitis, including updated information in the past few years.</p>","PeriodicalId":159,"journal":{"name":"Digestive Endoscopy","volume":"37 3","pages":"219-235"},"PeriodicalIF":5.0,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/den.14926","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142373679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Snare-assisted clipping method for closure of mucosal incision of gastric peroral endoscopic myotomy","authors":"Niroshan Muwanwella","doi":"10.1111/den.14930","DOIUrl":"10.1111/den.14930","url":null,"abstract":"<p>Gastric peroral endoscopic myotomy (G-POEM) is an emerging treatment modality for gastroparesis. This technique involves mucosal incision, submucosal tunneling, and pyloric myotomy followed by closure of the mucosal incision.</p><p>There are multiple closure methods described in the literature, including through-the-scope (TTS) clips,<span>¹</span> over-the-scope clips, and endoscopic suturing.<span>²</span> TTS clips are the easiest and most economical of the above methods. However, mucosal closure after G-POEM with TTS clips can by difficult due to the thicker gastric mucosa and widening of the mucosal entry site, resulting in difficulty of apposition of mucosal edges.</p><p>Clip and snare traction is well described in the literature to assist endoscopic submucosal dissection.<span>³</span> An internal traction method has been previously described for full-thickness mucosal defect closure.<span>⁴</span></p><p>I describe an adaptation of the above methods to assist clip deployment for mucosal closure.</p><p>Once the myotomy is complete, the scope is withdrawn and a snare is attached to the end of the scope by closing the snare over the distal attachment cap. Then the scope is reinserted and a TTS clip is closed just distal to the distal edge of the mucosal incision. Prior to full deployment of the clip, the snare is opened to disengage from the scope and closed over the stem of the clip.</p><p>The snare is then used to apply gentle traction to pull the mucosa upwards, creating a mucosal “tent.” The next clip is then deployed, closing the mucosal edges together. Another clip is then introduced through the channel and is used to transfer the snare to the stem of the last deployed clip. This process is repeated until the mucosal incision is completely closed. In this case, the final clip is deployed without the assistance of the snare.</p><p>This case illustrates a novel method of gastric mucosal incision closure using inexpensive, widely available devices.</p><p>Author declares no conflict of interest for this article.</p><p>Approval of the research protocol by an Institutional Review Board: N/A.</p><p>Informed consent: Informed consent was obtained from the patient to publish deidentified endoscopic images and videos.</p><p>Registry and the registration no. of the study/trial: N/A.</p><p>Animal studies: N/A.</p>","PeriodicalId":159,"journal":{"name":"Digestive Endoscopy","volume":"36 12","pages":"1388"},"PeriodicalIF":5.0,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/den.14930","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142333703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comorbidity burden and outcomes of endoscopic ultrasound-guided treatment of pancreatic fluid collections: Multicenter study with nationwide data-based validation","authors":"Tsuyoshi Hamada,&nbsp;Atsuhiro Masuda,&nbsp;Nobuaki Michihata,&nbsp;Tomotaka Saito,&nbsp;Masahiro Tsujimae,&nbsp;Mamoru Takenaka,&nbsp;Shunsuke Omoto,&nbsp;Takuji Iwashita,&nbsp;Shinya Uemura,&nbsp;Shogo Ota,&nbsp;Hideyuki Shiomi,&nbsp;Toshio Fujisawa,&nbsp;Sho Takahashi,&nbsp;Saburo Matsubara,&nbsp;Kentaro Suda,&nbsp;Hiroki Matsui,&nbsp;Akinori Maruta,&nbsp;Kensaku Yoshida,&nbsp;Keisuke Iwata,&nbsp;Mitsuru Okuno,&nbsp;Nobuhiko Hayashi,&nbsp;Tsuyoshi Mukai,&nbsp;Kiyohide Fushimi,&nbsp;Ichiro Yasuda,&nbsp;Hiroyuki Isayama,&nbsp;Hideo Yasunaga,&nbsp;Yousuke Nakai,&nbsp;the WONDERFUL study group in Japan and collaborators","doi":"10.1111/den.14924","DOIUrl":"10.1111/den.14924","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The appropriate holistic management is mandatory for successful endoscopic ultrasound (EUS)-guided treatment of pancreatic fluid collections (PFCs). However, comorbidity status has not been fully examined in relation to clinical outcomes of this treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Using a multi-institutional cohort of 406 patients receiving EUS-guided treatment of PFCs in 2010–2020, we examined the associations of Charlson Comorbidity Index (CCI) with in-hospital mortality and other clinical outcomes. Multivariable logistic regression analysis was conducted with adjustment for potential confounders. The findings were validated using a Japanese nationwide inpatient database including 4053 patients treated at 486 hospitals in 2010–2020.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In the clinical multi-institutional cohort, CCI was positively associated with the risk of in-hospital mortality (<i>P</i>_trend &lt; 0.001). Compared to patients with CCI = 0, patients with CCI of 1–2, 3–5, and ≥6 had adjusted odds ratios (95% confidence intervals) of 0.76 (0.22–2.54), 5.39 (1.74–16.7), and 8.77 (2.36–32.6), respectively. In the nationwide validation cohort, a similar positive association was observed; the corresponding odds ratios (95% confidence interval) were 1.21 (0.90–1.64), 1.52 (0.92–2.49), and 4.84 (2.63–8.88), respectively (<i>P</i>_trend &lt; 0.001). The association of higher CCI with longer length of stay was observed in the nationwide cohort (<i>P</i>_trend &lt; 0.001), but not in the clinical cohort (<i>P</i>_trend = 0.18). CCI was not associated with the risk of procedure-related adverse events.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Higher levels of CCI were associated with a higher risk of in-hospital mortality among patients receiving EUS-guided treatment of PFCs, suggesting the potential of CCI in stratifying the periprocedural mortality risk.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial registration</h3>\u0000 \u0000 <p>The research based on the clinical data from the WONDERFUL cohort was registered with UMIN-CTR (registration number UMIN000044130).</p>\u0000 </section>\u0000 </div>","PeriodicalId":159,"journal":{"name":"Digestive Endoscopy","volume":"37 4","pages":"413-425"},"PeriodicalIF":5.0,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/den.14924","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142333701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic ultrasound-guided vascular interventions","authors":"Atsushi Irisawa,&nbsp;Kazunori Nagashima,&nbsp;Akira Yamamiya,&nbsp;Yoko Abe,&nbsp;Takumi Maki,&nbsp;Ken Kashima,&nbsp;Yasuhito Kunogi,&nbsp;Koh Fukushi,&nbsp;Fumi Sakuma,&nbsp;Yasunori Inaba,&nbsp;Keiichi Tominaga","doi":"10.1111/den.14925","DOIUrl":"10.1111/den.14925","url":null,"abstract":"<p>With the recent development of interventional endoscopic ultrasound (EUS), EUS-guided vascular interventions have seen increased clinical and research focus. This modality can be used to diagnose portal hypertension and treat portal hypertension-related gastrointestinal varices and refractory gastrointestinal hemorrhage, including pseudoaneurysm. The vascular embolic materials used for treatment include tissue adhesives (cyanoacrylates), sclerosants, thrombin, and vascular embolic coils, all of which are associated with favorable results. The feasibility of EUS-guided procedures, including portal vein stenting and portosystemic shunt formation conventionally performed percutaneously and transvenously, has also been demonstrated, albeit in animal studies. As EUS-guided vascular intervention is a technique that may receive significant attention in the future, we provide a thorough review of the current evidence for its use.</p>","PeriodicalId":159,"journal":{"name":"Digestive Endoscopy","volume":"37 1","pages":"85-92"},"PeriodicalIF":5.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/den.14925","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142333702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phase concept: Novel dynamic endoscopic assessment of intramural antireflux mechanisms (with video)","authors":"Haruhiro Inoue,&nbsp;Mayo Tanabe,&nbsp;Yuto Shimamura,&nbsp;Kazuki Yamamoto,&nbsp;Yohei Nishikawa,&nbsp;Kei Ushikubo,&nbsp;Miyuki Iwasaki,&nbsp;Hidenori Tanaka,&nbsp;Ippei Tanaka,&nbsp;Kaori Owada,&nbsp;Satoshi Abiko,&nbsp;Manabu Onimaru,&nbsp;Stefan Seewald","doi":"10.1111/den.14922","DOIUrl":"10.1111/den.14922","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The gastroesophageal junction (GEJ) consists of various anatomical components that together form a barrier to prevent reflux of gastric content. This study introduces a novel phase concept to dynamically evaluate the antireflux barrier (ARB) during endoscopy and analyzes its functionality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We reviewed previously the recorded endoscopic videos of subjects who underwent the endoscopic pressure study integrated system (EPSIS) from February to April 2024 for indications other than gastroesophageal reflux disease symptoms. This device was used as an auxiliary tool to measure intragastric pressure (IGP) during endoscopy with a retroflex view. The ARB dynamic was divided into three phases: Phase I (gastric phase), Phase II (lower esophageal sphincter phase), and Phase III (esophageal clearance phase). We evaluated the morphological changes in the ARB during insufflation using EPSIS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The median age of the 30 subjects was 58 years (interquartile range [IQR] 46.5–68.8), including 20 men and 10 women. Endoscopic findings and IGPs were recorded during the three phases. In Phase I, at low IGP (median 6.75 mmHg), the gastroesophageal flap valve and longitudinal folds were observed in 80% of cases. In Phase II, at moderate IGP (median 11.8 mmHg), the scope holding sign was observed in 86.7%. In Phase III, at high IGP (median 19 mmHg) inducing belching, peristalsis was observed in 80% of cases with median recovery time of 5 s.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The phase concept provides a valuable framework for understanding the antireflux mechanism. Further research is needed to validate these findings in GEJ disorders and explore correlations with other modalities.</p>\u0000 </section>\u0000 </div>","PeriodicalId":159,"journal":{"name":"Digestive Endoscopy","volume":"37 3","pages":"257-265"},"PeriodicalIF":5.0,"publicationDate":"2024-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/den.14922","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142302453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}