{"title":"Development of framework to support software requirement elicitation using a domain ontology","authors":"Abdalmoneim Mohamed Mohamed Khair, Farid Meziane","doi":"10.51527/v2i2.11","DOIUrl":"https://doi.org/10.51527/v2i2.11","url":null,"abstract":"One of the main goals of Software Requirements Engineering is to understand customers' needs and to put their customer needs in requirement. The requirement engineering has several processes one of them are requirement elicitation the requirement elicitation considered as one process of requirement engineering and also considered as important process so the process of elicit the requirement has difficult, due to the incompleteness problem, ontology has player important rule to helps the requirement elicitation by adding more information about the words. in this paper implementing framework by using domain ontology, the framework implements using java and ontology using protégé, the framework evaluated using requirement in in banking domain, and show the results helps the software developer to choose the requirement.","PeriodicalId":158972,"journal":{"name":"Sudanese Online Research Journal","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124160507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ayman Sabah Elkhair Yousif Abdelgadir, A. Albkrye, Hind, A. Elnasri, M. A. Khaier
{"title":"Insilco Analysis of Non-Synonymous Single Nucleotide Polymorphisms of GATA 2 binding factor Human Gene","authors":"Ayman Sabah Elkhair Yousif Abdelgadir, A. Albkrye, Hind, A. Elnasri, M. A. Khaier","doi":"10.51527/v2i2.12","DOIUrl":"https://doi.org/10.51527/v2i2.12","url":null,"abstract":"GATA2 or GATA-binding factor 2 is a transcription factor, which regulates the expression of genes that are critical for the embryonic development, self-renewal, maintenance, and functionality of blood-forming lymphatic system-forming, and other tissue-forming stem cells. GATA2 protein is encoded by the GATA2 gene which often suffers germ line and somatic mutations which lead to a wide range of familial and sporadic diseases. Association of data including protein and genetic interactions, pathways, co-expression, co-localization and protein domain similarity were predicted using Gene MANIA software. This gene was investigated in NCBI database and the Non-Synonymous Single Nucleotide Polymorphisms (nsSNPs) were analyzed by computational software, (SIFT, PROVEAN, Polyphen-2, SNPs&GO, PHD-SNPs, I-Mutant and MUpro). The Protein structural analysis was done by modelling of amino acid substitutions using Project Hope for all predicted pathological polymorphisms. GeneMANIA results showed that GATA 2 gene was associated with 20 other genes. It interacts mainly with ZFPM1 gene (Zinc Finger Protein), FOG family member 1and HDAC5 histone deacetylase5. A total of 246 nsSNPs were obtained from the SNPs database in NCBI consisting of 47 Deleterious predicted by SIFT software. Using PROVEAN 41 SNPs were predicted to have deleterious effect, 17 SNPs were predicted to be damaging by (Polyphen- 2), while 4 SNPs were benign, 14 SNPs were found to be disease related using SNPs&GO and 30 SNPS were found to be disease related using PHD- SNP. By using I-MUTANT and MUPRO software the stability of the protein was predicted. From the results of SIFT, PROVEAN and PolyPhen-2 with respect to PHD-SNPs and SNPs&GO software programs, 6 nsSNPs (rs148942346 (R344I), rs371096438 (P385N), rs387906629 (R398W), rs387906629 (R384W), rs387906633 (C359R) and rs387906633 (C373R)) were predicted to be deleterious, damaging, affecting the protein stability and related to the formation of a disease variants. These results might be beneficial for a precise diagnosis of GATA2 deficiency and related myeloid neoplasm.","PeriodicalId":158972,"journal":{"name":"Sudanese Online Research Journal","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125046196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Esterification of Guar Gum using Dodecanoyl and \u0000Myristoyl Acid Chlorides in N, N – dimethylacetamide\u0000/ lithium chloride Solvent System","authors":"","doi":"10.51527/v2i1.2me","DOIUrl":"https://doi.org/10.51527/v2i1.2me","url":null,"abstract":"Guar gum, the naturally occurring polysaccharide which contains about 80% of galactomannan sugar consisting of mannose and galactose (2:1). This study aims to transform hydroxyl groups in the sugar structure into ester groups by reacting them with organic acid chlorides and producing biodegradable plasticized materials to overcome environmental pollution. Guar was purified using a modified procedure. Solublization of purified guar gum is carried out in N, N- dimethyl Acetamide (DMAc)/Lithium Chloride (LiCl) system. Treatment of solubilized guar gum with Dodecanoyl and Myristoyl acid chlorides in the presence of pyridine converts the hydroxyl groups of galactomannan sugar into ester groups through neucliophilic substitution reaction mechanism, and The maximum degree of esterification which can take place is three hydroxyl groups for every galactose and mannose unit, hence for lauriated guar gum the yield was 0.5g and Recuperation Yield (RY (%)) was 38.09% and for myristylated guar gum the yield was 0.652g and RY (%) was 38.56% Degree of Substitution (DS) value assumed to be 3 in both products. Occurrence of the reaction was confirmed using Fourier transform infrared spectroscopy (FT-IR). The structural modification of guar gum attained, did not result in a significant change in the solubility properties of guar gum., Further research is needed to evaluate the gum esters synthesized during the work for developing better internally plasticized material and making biodegradable plastics and polymers.","PeriodicalId":158972,"journal":{"name":"Sudanese Online Research Journal","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115142736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}