International Journal of Clinical Oncology and Cancer Research最新文献

{"title":"An Audit and Analysis of Causes of Treatment Default in Head and Neck Cancer: A Single Tertiary Cancer Centre Experience","authors":"S. Baral, S. Silwal, Deep Lamichhane","doi":"10.11648/j.ijcocr.20240902.11","DOIUrl":"https://doi.org/10.11648/j.ijcocr.20240902.11","url":null,"abstract":"Background: Treatment default is widespread among cancer patients and usually compromise patients’ clinical outcome. This not only compromises the management plan but also makes it harder to measure our treatment outcomes. Method: We reviewed Outpatient department (OPD) clinical record files of head and neck cancer patients who were registered at our hospital in a year. Patients were chosen on the basis of availability of record files at the time of sampling. All patients' OPD files were evaluated for treatment completion and causes of treatment default were recorded from the OPD record file. If information was not available in the OPD record file, patients or patients' relatives (if a contact number was available) were called for further information and cause of default. The Google spreadsheet was prepared to record demographics and causes of treatment default. Results: 72.19% were male among 205 patients analysed for the study. Most common site was oral cavity (30.24%), followed by oropharynx (21.9%), larynx (20%) and others. Intent was curative in 175 patients (85.36%) and palliative in 22patients (10.73%). 112 curative intent patients (64%) and 11 palliative intent (50%) completed planned treatment, 27 curative intent patients (15.42%) and 7 palliative patients (31.81%) defaulted during treatment and 36 curative patients (20.57%) and 4 palliative patients (18.18%) defaulted before starting Primary treatment (Surgery or Radiotherapy). Treatment related toxicities in 20 patients (26.31%) waiting time for radiotherapy in 14 patients (18.42%) were major causes of default in this study. In curative intent cases, 44 patients (39.28%) had complete response, 41 patients (36.3%) had partial response, 10 patients (8.92%) had progressive disease and 6 patients (5.35%) had metastatic disease, 3-month post treatment. Conclusion: Among various reasons for noncompliance, few can be addressed immediately like arranging multidisciplinary team discussions at an institutional level to prioritize management. Further large-scale studies are needed to estimate the exact dimensions of the issues in our setup.","PeriodicalId":158614,"journal":{"name":"International Journal of Clinical Oncology and Cancer Research","volume":"15 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140715302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Study of Whole Brain Radiotherapy vs Whole Brain Radiotherapy with Concurrent Temozolomide in Brain Metastases","authors":"Md. Ruhul Amin Bhuiyan, Farhana Hussain Sadia, Ahammad Al Mamun Sweet, Md Ershadul Haque, Khandaker Md. Rezwan Bayzid, Azm Sumsuzoha, A. Chowdhury, Md. Abdul Mannan","doi":"10.11648/j.ijcocr.20240901.11","DOIUrl":"https://doi.org/10.11648/j.ijcocr.20240901.11","url":null,"abstract":"","PeriodicalId":158614,"journal":{"name":"International Journal of Clinical Oncology and Cancer Research","volume":"180 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139629025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological, Diagnostic, Therapeutic and Evolutionary Profile of Inflammatory Breast Cancer (IBC) in the Oncology-Hematology Service, Burkina Faso","authors":"Bambara Hierrhum Aboubacar, Zoure Abdou Azaque, Zerbo Nina Assanatou Jumelle, Yameogo Prisca Emmanuelle Aida, Adico Marc Donald Wilfried, Odero-Marah Valérie","doi":"10.11648/j.ijcocr.20230804.12","DOIUrl":"https://doi.org/10.11648/j.ijcocr.20230804.12","url":null,"abstract":"","PeriodicalId":158614,"journal":{"name":"International Journal of Clinical Oncology and Cancer Research","volume":"10 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138984588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Factors for Prostate Cancer at the Brazzaville University Hospital Center","authors":"Bambara Hierrhum Aboubacar, Zerbo Nina Assanatou Jumelle, Odero-Marah Valérie, Nkoua Epala Brice Aymard, Nsonde Malanda Judith, Nkoua-Mbon Jean-Bernard","doi":"10.11648/j.ijcocr.20230804.13","DOIUrl":"https://doi.org/10.11648/j.ijcocr.20230804.13","url":null,"abstract":"","PeriodicalId":158614,"journal":{"name":"International Journal of Clinical Oncology and Cancer Research","volume":"29 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138984056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precancerous Lesions of the Cervix: Screening and Management at the Matam Maternity Hospital and the Donka Gynaecological Cancer Prevention Centre (Guinea)","authors":"Conté Ibrahima, Kouyaté Sekouba, Leno Daniel William Atanase, Diallo Thierno Ibrahima, Sow Alhassane Mohamed, Diallo Yaya, S. Telly, Hyjazi Yolande, K. Namory","doi":"10.11648/j.ijcocr.20230804.11","DOIUrl":"https://doi.org/10.11648/j.ijcocr.20230804.11","url":null,"abstract":"","PeriodicalId":158614,"journal":{"name":"International Journal of Clinical Oncology and Cancer Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139251386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Nutrition Education on Nutritional Status, Tolerance and Response to Chemotherapy: Experience at Douala General Hospital, Cameroon, Central Africa","authors":"Dina Bell Esther Hortense Murielle, Esson Mapoko Berthe, Sango Anne, A. Etienne, Maïson Mayeh, Mekah Mapenya, Ndangue Ntone Nancy, Anaba Dominique, Ntama Ambroise, Aminatou Ada, Mbemmo Murielle Laure, Ngo Bikond Grace, Yondo Edimo Suzanne, Mouelle Mbassi W, Mouelle Michel, Tchakounté Boris, Ananga Noa, Mananga Jean Charles, H.D.G. Mbiatat, Njock Louis Richard","doi":"10.11648/j.ijcocr.20230803.12","DOIUrl":"https://doi.org/10.11648/j.ijcocr.20230803.12","url":null,"abstract":"","PeriodicalId":158614,"journal":{"name":"International Journal of Clinical Oncology and Cancer Research","volume":"26 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116506860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social Representation of Cancer among Nurses in Burkina Faso and Influence on Early Diagnosis of Cancer","authors":"Augustin Tozoula Bambara, Michel Ilboudo, Dagnagnewende Dieudonne Kabore, Pingwende Fidele Kabore, Alice Cynthia Sama","doi":"10.11648/j.ijcocr.20230803.11","DOIUrl":"https://doi.org/10.11648/j.ijcocr.20230803.11","url":null,"abstract":": Objective : We conducted this study with the aim of determining the association between the social representation of cancer of nurses in Ouagadougou and the decision they make when faced with a sign suggestive of cancer. Methods : We conducted a survey over a period from December 27, 2022 to March 26, 2023 in the city of Ouagadougou. A total of 341 nurses working in the Health and Social Promotion Centers participated in the survey by completing a questionnaire. They were asked to produce a series of five words that came to mind spontaneously from the word “cancer” inducer then to rank these words in descending order of importance according to their judgment. The subjects surveyed were finally asked about their practices in front of signs suggestive of cancer. These practices have been categorized into “I refer” and “I do not refer” to a higher level of care. We compared these two groups through a prototypical analysis using the Iramuteq software. Results : In group 1, the central core was composed of 8 words which are: Pain, Incurable, Suffering, Breast, Nodule, Chemotherapy, Expensive, Tumor. The second periphery was composed of: Death, Fear, Metastasis, Chronic, Expenditure, Compassion, Serious. In group 2, the core was composed of 15 words which are Death, Pain, Tumor, Suffering, Expensive, Metastasis, Nodule. The first periphery was composed of the following words: Fear, Incurable, Chemotherapy, Chronic. The maximum tree of representation indicates that the words cited in both groups are organized around the words “death”, “pain”, “incurable” and “fear”. Conclusion : This difference in perception of the disease has a probable influence on their readiness to refer patients to health centers better equipped for patient management. It seems necessary to reflect on ways to train nurses, to inform them about cancer and on the benefits of adequate and early management.","PeriodicalId":158614,"journal":{"name":"International Journal of Clinical Oncology and Cancer Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130012091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Peptide Immunotherapy in the Treatment of Cervical Dysplasia: Clinical Cases","authors":"О.V. Bulavenko, Тetiana Lunko, Оleksii Таtskyy, Тetiana Fomina, Мaria Pikul, Оleksandr Zdanevych, Mykhailo Каzarnovskyy, Victor Zadorozhnyy, Svitlana Тurbanist, Svitlana Pysmenna, Olena Yamkova-Bodnaruk, Liudmyla Lytvynchuk","doi":"10.11648/j.ijcocr.20230802.13","DOIUrl":"https://doi.org/10.11648/j.ijcocr.20230802.13","url":null,"abstract":": Introduction . Since one of the main factors determining the pathogenic effect of HPV infection is local immunodeficiency, a number of authors suggest using various cytokines and immunomodulators. Recently, peptide-based agents have been increasingly used in routine clinical practice. Objective . To study the effect of peptide immunocorrection on molecular and cellular factors affecting the course of grade II cervical dysplasia (CIN2) as a precancerous process and to evaluate the effectiveness of the proposed regimen. Materials and methods . The study included 2 groups of patients aged 28 to 44 years who were colposcopically and cytologically diagnosed with grade 2 cervical dysplasia. Clinical monitoring, determination of HPV by PCR, immunohistochemical studies of biomarkers of inflammation and proliferation, as well as counting of T-lymphocytes in cervical mucus preparations were performed before treatment, after treatment, after 6 weeks and after 3 months. Results . During the study of the expression level of pro-oncogenic interleukin IL-8 and anti-oncogenic IL-12, it was established that in both observation groups after the immunotherapy, a tendency to decrease the pro-oncogenic potential of cervical mucus was noted. Analysis of the level of expression of the cell proliferation marker Ki-67 in the clinical monitoring groups showed that the proposed therapy schemes reduced the proliferative potential of the cervical epithelium. The number of active cytotoxic lymphocytes in the cervical mucus in both observation groups predictably increased after the use of local immunotherapy. The study showed that immunotherapy of cervical dysplasia with the use of peptides demonstrated significantly better clinical results compared to the reference group. Conclusion . Taking into account the obtained research results and the given clinical cases, peptide immunocorrection can be reasonably recommended as an immunological component in the treatment of cervical dysplasia (ASCUS and LSIL).","PeriodicalId":158614,"journal":{"name":"International Journal of Clinical Oncology and Cancer Research","volume":"2016 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122920931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological and Therapeutic Aspects of the Single Visit Approach in the Management of Precancerous Lesions of the Cervix in Guinea Conakry in 2022","authors":"Soumah Aboubacar Fode Momo, Conté Ibrahima, Leno Daniel Williams Atanasse, S. Ibrahima","doi":"10.11648/j.ijcocr.20230802.12","DOIUrl":"https://doi.org/10.11648/j.ijcocr.20230802.12","url":null,"abstract":": Objective: to evaluate the epidemiological and therapeutic aspects of the single visit approach in the management of precancerous lesions of the cervix in the CECAP sites of Conakry in 2022. Methodology : This was a multicenter cross-sectional descriptive study, using retrospective data at the six CECAP sites from July 1 to Conakry. Three data collection tools: the individual form, a screening register, and a monthly summary sheet or reporting template, were used to track key single-visit service variables: the number of women screened using VIA, proportion of women screened positive for VIA and proportion of women screened VIA positive who received cryotherapy on the same day, KoBo Collect served the collections and the analysis was carried out by the software EPI info version 7.2 6. Results : during our three-month study, in the six pilot sites of Conakry, 786 women were screened, of whom 3.18% (25/786), had IVA+, 62.5% benefited from cryotherapy the same day, it was postponed in 37.5% of cases, the program did not train providers in the management of large lesions, which is one of the limitations of our study. Conclusion : Visual inspection with acetic acid is a simple test, requiring minimal infrastructure and expense, little provider training. The integration of VIA with cryotherapy at the primary care level in the communal medical centers of the city of Conakry, could constitute a feasible program for the prevention of cervical cancer in Guinea.","PeriodicalId":158614,"journal":{"name":"International Journal of Clinical Oncology and Cancer Research","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126524096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Study of Hypofractionated Palliative Radiotherapy 17 Gy in 2 Fractions vs. 30 Gy in 10 Fractions in Lethal Locally Advanced Non-small Cell Lung Cancer","authors":"Kamrun Nahar Tania, Jannatun Nisa, Moarraf Hossen, Muhammad Masudul Hassan Arup, Muhammad Abdullah-Al-Noman, Mohammad Shaiful Hassan Shameem, Sonya Begum, M. Arifur Rahman","doi":"10.11648/j.ijcocr.20230802.11","DOIUrl":"https://doi.org/10.11648/j.ijcocr.20230802.11","url":null,"abstract":"Comparative Study of Hypofractionated","PeriodicalId":158614,"journal":{"name":"International Journal of Clinical Oncology and Cancer Research","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116975624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}