Journal of Food Science and Nutrition Research最新文献

{"title":"Improvement on BAF53B Mutation Caused Developmental and Epileptic Encephalopathy with a Ketogenic Diet","authors":"Danli Wang, Linlin Fan, Haoying Yang, Mingming Pan, Junping Shi, Ang Li, Nini Wang, Xue Xia, Yang Liu","doi":"10.26502/jfsnr.2642-110000118","DOIUrl":"https://doi.org/10.26502/jfsnr.2642-110000118","url":null,"abstract":"Purpose: Genetic mutation is the leading cause of Developmental and Epileptic Encephalopathy (DEE, OMIM 308350), a spectrum of disorders characterized by severe epilepsy and usually begins in infancy, accompanied with psychomotor development arrest and hypsarrhythmiaon electroencephalogram (EEG).Up till now, mutations of 101 genes were confirmed as the cause of DEE, and were categorized accordingly into 101 different sub-types (DEE1-101). Here, we report a case of DEE76 with a tortuous path to genetic diagnosis and an illuminating treatment of ketogenic diet (KD). Methods: Through high throughput sequencing, we identified a DEE76 case caused by biallelic BAF53B mutation inherited in an autosomal recessive manner, and report the pathogenic variants NM_016188.4:c.892C>T (p.Arg298*) and NM_016188.4:c.991_996delinsAA (p.Gly331Asnfs*44) for the first time. Results: The proband commenced seizures on day five after birth and rapidly deteriorated during development. After a series of therapeutic exploration, ketogenic diet turned out to be the most hopeful treatment available. Conclusion: ultra-rare gene therapy KD, seizures","PeriodicalId":15858,"journal":{"name":"Journal of Food Science and Nutrition Research","volume":"205 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75864566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronasomnia: A Hidden Problem of the COVID era. Is Melatonin a Potential Solution?","authors":"R. Supriya, Kumar Purnendu Singh, F. Dutheil, Yaodong Gu, Julien S Baker","doi":"10.26502/jfsnr.2642-11000084","DOIUrl":"https://doi.org/10.26502/jfsnr.2642-11000084","url":null,"abstract":"Globally, changes in work cultures have impacted on all life, and individuals have reported increased insomnia “Coronasomnia” as a result of COVID-19. Correct nutrition, in relation to micronutrient concentration, may have beneficial effects in controlling our biological sleep clocks. Specifically, melatonin supplementaions are being recommended for the COVID generation. However, there have been J Food Sci Nutr Res 2022; 5 (1): 325-340 DOI: 10.26502/jfsnr.2642-11000084 Journal of Food Science and Nutrition Research Vol. 5 No. 1 March 2022. [ISSN 2642-1100] 326 mixed reports regarding melatonin supplementation using high dosages for certain population groups, and there may be disadvantages in using melatonin as an exogenous supplement (oral tablet or injectable drug) in the long term. As a result, melatonin may not be suitable for all post COVID generations without further clinical trials. However, melatonin as a dietary supplement could have significant health benefits without causing any adverse effects. Therefore, the main aim of this opinion article is to highlight the challenges of “Coronasomnia” related to COVID 19, which has been overlooked. In addition, we highlight the research need for clinical trials on melatonin supplementation for inclusion in the diets of the COVID generation. Supplementation regimes using naturally occurring melatonin obtained from dietary sources will regulate central biological cycle naturally. Consequently, future research is needed to investigate whether melatonin containing foods are clinically beneficial to the COVID generation by increasing the bioavailability of melatonin using dietary supplementation.","PeriodicalId":15858,"journal":{"name":"Journal of Food Science and Nutrition Research","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84039013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional Status Pre-Gestational and Gestational Among Women Living With HIV Positive in Luanda, Angola","authors":"Maura Eunice João Filipe, M. Santana","doi":"10.26502/jfsnr.2642-110000116","DOIUrl":"https://doi.org/10.26502/jfsnr.2642-110000116","url":null,"abstract":"","PeriodicalId":15858,"journal":{"name":"Journal of Food Science and Nutrition Research","volume":"97 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88960428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Randomized Controlled Clinical Trial to Study the Impact of Multigrain Instant Health Drink Mix in Clinical Management of Anemia in Women","authors":"V. Vaidya, G. Ganu, N. Naik, Murugan Narayanaswamy","doi":"10.26502/jfsnr.2642-11000091","DOIUrl":"https://doi.org/10.26502/jfsnr.2642-11000091","url":null,"abstract":"A controlled clinical trial to study the impact of Multigrain Instant Health Mix in clinical management of anemia in women. Abstract Background WHO considers Iron Deficiency Anemia (IDA) as one of the most expensive diseases in the world due to lost productivity and the sheer numbers of the affected population. In 2019, global anemia prevalence was 29.9% (95% uncertainty interval (UI) 27.0%, 32.8%) in women of reproductive age, equivalent to over half a billion women aged 15-49 years. Prevalence was 29.6% (95% UI 26.6%, 32.5%) in non-pregnant women of reproductive age, and 36.5% (95% UI 34.0%, 39.1%) in pregnant women. consume warm milk twice a day and provided counselling for nutrition and anemia over 90 days. There was significant increase in hemoglobin levels (20.6%) in Health Drink Mix treated group compared to 2.76% in control group. The levels of serum iron were significantly increased in Health Drink Mix Group than control group (35.38%). Health Drink Mix led to reduction in symptoms such as weakness, pale and yellow skin, dysmenorrhea, lightheadedness. There was significant reduction in fatigue severity score in Health Drink Mix treated group than control. It can be concluded from the present study that Multigrain Instant Health Drink Mix is safe and efficacious in treatment of anemia in women. It can offer 360 degree improvement in anemia. It ensures improvement in Hb, Ferritin, Iron levels along with reduction in TIBC. The present research ensures consumers of this product to get the effectiveness to treat and manage the anemia and related complaints with no side effects related to iron supplementation.","PeriodicalId":15858,"journal":{"name":"Journal of Food Science and Nutrition Research","volume":"123 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83465320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Nutritional Status and Associated Factors in Children Aged 6 to 59 Months in Ayos Locality, Cameroon","authors":"Angèle Eveline Tchapda, Serge Berlin Dzeukou, Christine Fernande Biyegue Nyangono, Nicolas Policarpe Nolla, I. Gouado, E. Tetanye","doi":"10.26502/jfsnr.2642-110000110","DOIUrl":"https://doi.org/10.26502/jfsnr.2642-110000110","url":null,"abstract":"Childhood malnutrition is a serious public health problem around the world, particularly in Cameroon. This study was conducted to assess nutritional status and associated factors for children aged 6 to 59 months in the locality of Ayos. This is a cross-sectional and descriptive study that took place from August to October 2019 on a random sample of 309 children and his mothers. Anthropometric parameters of children were measured, socio-demographic data of mothers and children's eating habits were collected using a questionnaire, association between socio-demographic factors, dietary practices and malnutrition were identified. The results showed that 9.06% of children were wasted with 3.56% in the severe form, 26.54% were underweight with 10.03% in the severe form and 53.07% were stunted with 34.96% in the severe form. Overall, 86.1% of mothers have a poor understanding of the concept of dietary diversity. The first complementary food introduced is the poorly enriched local porridge used by 40.52% of the mothers, followed by the family meal, used by 38.52% of them. Marital status (p=0.009), level of education (p=0.001), occupation (p=0.046) were associated with chronic malnutrition. Type of breastfeeding (p=0.005), age of introduction of complementary foods (p=0.004), reason for introduction (p=0.002) had a significant association on the prevalence of stunting. There is a significant influence between the type of breastfeeding (p=0.017) and the first food introduced (p=0.022) on the prevalence of wasting. The prevalence of malnutrition in Ayos locality was accentuated in children who received inadequate breastfeeding and feeding. Nutrition education for mothers could improve this situation.","PeriodicalId":15858,"journal":{"name":"Journal of Food Science and Nutrition Research","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80479210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microwave Treatment Prevents Cytomegalovirus Transmission to Preterm Infants through Human Milk","authors":"Mizuno K, Kohda C, D. H.","doi":"10.26502/jfsnr.2642-110000103","DOIUrl":"https://doi.org/10.26502/jfsnr.2642-110000103","url":null,"abstract":"Background: Mother’s own milk (MOM) is the best nutrition for preterm infants; however, milk from cytomegalovirus (CMV)-seropositive mothers may cause the transmission of the virus to the infants. As extremely preterm infants are at a risk of developing serious conditions due to CMV infection, even MOM is sometimes pasteurized. Previously, we demonstrated that microwave heating of 50 mL formula milk containing CMV at 500 W for 40s prevented CMV infection in living cells. However, we do not know if this is the case with reactivated CMV in human milk (HM). Therefore, we investigated if microwave heating of HM would be effective in preventing CMV infection in living cells. Methods: Twenty-three CMV-IgG-positive and four CMV-IgG-negative mothers who donated HM to the human milk bank during 6 to 16 weeks postpartum were enrolled. The HM was treated with microwave at 500 W. HFL-III cells were seeded in culture dishes. Aliquots of HM samples subjected to microwave was inoculated onto susceptible cell monolayers. Infectious vial titer was measured by the 50% median tissue culture infectious Dose (TCID50) assay. Results: The TCID50 assay was decreased in five out of eight 100-mL samples after microwave at 200W for 60 s. The CMV infectivity assay was negative in three, decreased in eight, and no change in six 100-mL samples, and negative in four and decreased in eight 50-mL samples. Conclusions: Microwave heating of HM at low settings could decrease CMV transmission through HM, however, to obtain entire prevention is difficult when loss of bioactive properties is considered.","PeriodicalId":15858,"journal":{"name":"Journal of Food Science and Nutrition Research","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81001458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of COVID-19 Restrictions on Dietary and Lifestyle Habits of Hamad Medical Corporation staff (Public healthcare workers in Qatar) - A Crosssectional Survey","authors":"Sibusiso Reuben Kutama, Noora Mohammed S Aljaffali, Reem Khalid A Al-Saadi, Anwar Mohd Faleh Qudaisat, E. Hany, Lindon Mark, M. Reynald, Miled Mohamed","doi":"10.26502/jfsnr.2642-110000100","DOIUrl":"https://doi.org/10.26502/jfsnr.2642-110000100","url":null,"abstract":"Health care workers are on the frontline in the fight against the COVID-19 pandemic which has resulted in many containment measures associated with dietary and lifestyle changes and probable constrained public health delivery. Objectives: This study aims to determine whether COVID-19 induced restrictions have changed the dietary and lifestyle habits of Hamad Medical Corporation staff during the pandemic. Methods: A descriptive cross-sectional online survey was conducted, collecting pre COVID-19 pandemic details and current information of dietary and lifestyle habits of HMC staff without any interventions. The data was collected using validated modified self-administered online questionnaire, to collect data on demographics, and to explore the impact of COVID-19 induced restrictions on diet and physical activity patterns, and lifestyle habits. The study received ethical clearance from MRC Qatar. Results: The participants (n=248) were mostly female (57.3%) between the ages of 31-40 years (48.1%) all employed by Hamad Medical Corporation the principal healthcare provider in the State of Qatar. When BMI categories were grouped by gender 69.7% of females and 70.9% of males were found to be overweight. The data shows that vegetables consumption increased with 50% reporting an increase in fresh vegetables consumption but a decrease in fruits consumption and 31.5% reporting skipping 1 meal or more per day. Food items which were placed under the Sugar, Sweets and Others food group had a number of varied responses, with items like Jam 40.3%, soft/sugary drinks 22.2%, sugar 22.6%, ice cream 26.6% and pickles 25.0% being reported to have a higher percentage of being consumed more. Our results also show that 55.2% of participants in this survey do not engage in any specific physical activities, with 45.6% spending more than 4 hours per day doing sedentary activities. About 37.9% of participants decreased their sleeping time by 1-2 hours per day. Conclusion: This study suggests that the COVID-19 pandemic and the containment restrictions triggered weight gain, inadequate intake of a balanced diet and physical inactivity among healthcare workers in Qatar.","PeriodicalId":15858,"journal":{"name":"Journal of Food Science and Nutrition Research","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80663336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Vacuum Packaging on Instrumental Surface Color Characteristics of Frozen Beef Steaks","authors":"Madison P. Wagoner, Tristan M Reyes, Virgina E Zorn, Madison M Coursen, Katie E. Corbitt, Barney S Wilborn, T. Brandebourg, Aeriel D Belk, Tom Bonner, Jason T Sawyer","doi":"10.26502/jfsnr.2642-110000111","DOIUrl":"https://doi.org/10.26502/jfsnr.2642-110000111","url":null,"abstract":"Consumers often consider beef color as a sole indicator of product freshness at the time of purchase. However, disruptions in meat manufacturing may cause manufacturers to create frozen retail meat products, but changes to surface color during frozen storage may be deleterious. Therefore, the objective for the current study was to determine the effect of vacuum packaging on instrumental surface color values of boneless ribeye steaks during frozen storage. Steaks were cut 2.54-cm-thick, assigned to one of three packaging films, allowed to bloom for 30 min and immediately frozen. Throughout the 25 days of frozen storage, instrumental surface color values were collected. Steaks packaged using MDF were lighter (p < 0.05) but became darker as storage time increased. However, redness (a*) values were greater (p < 0.05) for steaks packaged using MDF from day 10 to 25, as well as more yellow (b*) from day 7 to 25 (p < 0.05). Furthermore, steaks packaged in MDF were more (p < 0.05) vivid (C*) and possessed redder values for red-to-brown (RTB), oxymyoglobin (OMb), and hue angle from day 7 to 25 of the simulated storage period. These data indicate that choice of vacuum packaging film impacted instrumental surface color of frozen retail cuts with MDF packaging more effectively maintaining optimal color throughout the duration of this study.","PeriodicalId":15858,"journal":{"name":"Journal of Food Science and Nutrition Research","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86007609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Growth of Fusarium oxysporum (Schlencht) and Phoma exigua (Desm) isolated from Cowpea (Vigna unguiculata) in various concentrations of six different sugars","authors":"Isalar Oluwatoyin F, Okom Cynthia, Omo-Udoyo Ejiroghene, Ataga Anthony E","doi":"10.26502/jfsnr.2642-11000083","DOIUrl":"https://doi.org/10.26502/jfsnr.2642-11000083","url":null,"abstract":"A study was carried out on the growth of Fusarium oxysporum (Schlencht) and Phoma exigua (Desm) using six different sugars (sucrose, glucose, maltose, lactose, xylose and fructose) at various concentrations. The results showed that all the sugars supported growth of Fusarium oxysporum and Phoma exigua. The growth of Fusarium oxysporum and Phoma exigua in potato sucrose agar (PSA) attained optimum growth than glucose, maltose, lactose, xylose and fructose when used. Potato fructose agar supported the least growth of the fungi. Generally the concentration of sugars did not affect the growth of the organism.","PeriodicalId":15858,"journal":{"name":"Journal of Food Science and Nutrition Research","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85858302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological Activity and Therapeutic Potential of Quercetin for Inflammatory Bowel Disease","authors":"Alyssa Waslyk, M. Bakovic","doi":"10.26502/jfsnr.2642-11000065","DOIUrl":"https://doi.org/10.26502/jfsnr.2642-11000065","url":null,"abstract":"Rates of inflammatory bowel disease (IBD) are increasing globally. IBD is an idiopathic chronic inflammatory disorder of the gastrointestinal tract characterized by acute disease flares and remission. IBD has a multifactorial pathogenesis whereby environmental and genetic factors contribute to disease onset. IBD is a serious clinical disorder that significantly impairs the patient’s quality of life, and is associated with increased morbidity, mortality, and cancer risk. IBD is characterized by the loss of tolerance to luminal antigens resulting in a persistent and excessive immune response. There is currently an unmet need for novel treatment options for patients with IBD. In recent years, flavonoids, a class of polyphenols widely distributed in fruits and vegetables gained significant interest as potential therapeutic agents for inflammatory disorders including IBD. Many flavonoids regulate cellular transcription factors critical in antioxidant and antiinflammatory pathways within the innate and adaptive immune response. Among these flavonoids, quercetin and its related glycosides have demonstrated remarkable effects capable of attenuating inflammation in experimental models of IBD. To date, many mechanisms underlying quercetin’s biological activity have been elucidated; wherein quercetin is reported to downregulate NFκB, MAPK, STAT and AP-1, and upregulate Nrf2. Thus, the aim of the review is to present the evidence surrounding quercetins biological activity, and its potential as a novel dietary intervention for IBD.","PeriodicalId":15858,"journal":{"name":"Journal of Food Science and Nutrition Research","volume":"104 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80680994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}