Journal of Fuel Cell Science and Technology最新文献

{"title":"Real-life omalizumab exposure and discontinuation in a large nationwide population-based study of paediatric and adult asthma patients.","authors":"Marc Humbert, Arnaud Bourdin, Camille Taillé, Driss Kamar, Céline Thonnelier, Audrey Lajoinie, Alexandre Rigault, Antoine Deschildre, Mathieu Molimard","doi":"10.1183/13993003.03130-2021","DOIUrl":"10.1183/13993003.03130-2021","url":null,"abstract":"<p><strong>Background: </strong>This real-life study aimed to assess omalizumab treatment patterns in adult and paediatric asthma patients, and to describe asthma control and healthcare resource use (HCRU) at omalizumab initiation and discontinuation.</p><p><strong>Methods: </strong>The French healthcare database system (Système National des Données de Santé (SNDS)) was used to identify asthma patients aged ≥6 years who initiated omalizumab for at least 16 weeks from 2009 to 2019. We examined omalizumab treatment patterns using dispensation records.</p><p><strong>Results: </strong>We identified 16 750 adults and 2453 children initiating omalizumab. Median treatment persistence before discontinuation (T_STOP) was 51.2 (95% CI 49.3-53.4) months in adults and 53.7 (95% CI 50.6-56.4) months in children. At 2 years of omalizumab exposure, rate of hospitalisation for asthma decreased by 75% and use of oral corticosteroids (OCS) by 30%, in adults and children. Among adults who discontinued omalizumab while asthma was controlled, 70%, 39% and 24% remained controlled and did not resume omalizumab at 1, 2 and 3 years after discontinuation, respectively. These proportions were higher in children (76%, 44% and 33%, respectively). Over 2 years of follow-up after discontinuation, HCRU remained stable in adults and children, notably rate of hospitalisations for asthma (none before T_STOP, 1.3% and 0.6% at 2 years) and use of OCS (in adults and children, respectively: 20.0% and 20.2% before T_STOP, 33.3% and 24.6% at 2 years).</p><p><strong>Conclusion: </strong>This is the first large-scale study describing omalizumab real-life exposure patterns in adult and paediatric asthma patients in France with >10 years of follow-up. We showed the long-term maintenance of low HCRU in adults and children who discontinued omalizumab while asthma was controlled, notably for OCS use and hospitalisations for asthma.</p>","PeriodicalId":15829,"journal":{"name":"Journal of Fuel Cell Science and Technology","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9647070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85530472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Letter to the Editor.","authors":"Kelli Baldwin, Sara Karjoo, Melissa Crenshaw","doi":"10.1177/00099228221094544","DOIUrl":"10.1177/00099228221094544","url":null,"abstract":"","PeriodicalId":15829,"journal":{"name":"Journal of Fuel Cell Science and Technology","volume":"8 1","pages":"587"},"PeriodicalIF":1.6,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85507318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What Is Monkeypox?","authors":"Kristin Walter, Preeti N Malani","doi":"10.1001/jama.2022.10259","DOIUrl":"10.1001/jama.2022.10259","url":null,"abstract":"","PeriodicalId":15829,"journal":{"name":"Journal of Fuel Cell Science and Technology","volume":"5 1","pages":"222"},"PeriodicalIF":29.0,"publicationDate":"2022-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85601564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Primary Angle-Closure Glaucoma.","authors":"Jimmy Lai, Bonnie N K Choy, Jennifer W H Shum","doi":"10.1097/APO.0000000000000180","DOIUrl":"10.1097/APO.0000000000000180","url":null,"abstract":"<p><p>Primary angle-closure glaucoma (PACG) is a progressive optic nerve degeneration and is defined as a glaucomatous optic neuropathy with associated characteristic enlargement of optic disc cupping and visual field loss that is secondary to ocular hypertension caused by closure of the drainage angle. Angle closure is caused by appositional approximation or adhesion between the iris and the trabecular meshwork. The main treatment strategy for PACG lies in the reduction of intraocular pressure, reopening of the closed angle, and possible prevention of further angle closure. There is no universally agreed best surgical treatment for PACG. Trabeculectomy, goniosynechialysis (GSL), glaucoma implant, and cyclodestructive procedures are effective surgical options. Each of them plays an important role in the management of PACG with its own pros and cons. Accumulating evidence is available to show the effectiveness of visually significant and visually nonsignificant cataract extraction in the treatment of PACG. Trabeculectomy and GSL are often combined with cataract extraction, which may offer additional pressure control benefits to patients with PACG. This review article will discuss laser peripheral iridotomy, argon laser peripheral iridoplasty, and surgeries such as GSL, phacoemulsification, and phaco plus glaucoma surgeries that lower intraocular pressure and also alter the anterior segment and/or drainage angle anatomy. Currently, glaucoma implants and cyclodestruction are mainly reserved for PACG patients who have failed previous filtering operations. Their role as initial surgical treatment for PACG will not be discussed.</p>","PeriodicalId":15829,"journal":{"name":"Journal of Fuel Cell Science and Technology","volume":"4 1","pages":"59-62"},"PeriodicalIF":4.4,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85601420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interface Reactions Between Sealing Glass and Metal Interconnect Under Static and Dynamic Heat Treatment Conditions","authors":"Lianwei Peng, Qingshan Zhu, Z. Xie, Ping Wang","doi":"10.1115/1.4032337","DOIUrl":"https://doi.org/10.1115/1.4032337","url":null,"abstract":"Chemical compatibility of sealing glass with metal interconnects is a critical issue for planar solid oxide fuel cell (SOFC). In this paper, interface reactions between a sealing glass and a ferritic metal interconnect (SS410) are tested under three different heat treatment conditions: sealing (static), aging (static), and thermal cycling (dynamic). The results show that the BaCrO4 crystals with two different morphology (round-shaped and needle-shaped) form both at the three-phase boundary (where air, glass, and SS410 meet) and on the surface of the sealing glass under the three conditions. Round-shaped BaCrO4 crystals form with low O-2 concentration and short reaction time. Needle-shaped BaCrO4 crystals form with high O-2 concentration and long reaction time. For the thermal cycling condition, the BaCrO4 formed at early stages causes the delamination of the sealing interface. Then, O-2 diffuses into the interior interface along the delamination path, which results in the formation of BaCrO4 at the interior interface. The delaminationenhanced BaCrO4 formation during thermal cycling will lead to crack along the sealing interface, causing the striking increase of leak rates.","PeriodicalId":15829,"journal":{"name":"Journal of Fuel Cell Science and Technology","volume":"31 1","pages":"061009"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1115/1.4032337","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63494237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanistic Three-Dimensional Analytical Solutions for a Direct Liquid Fuel Cell Stack","authors":"C. Ling, Ming Han, Yunzhong Chen, E. Birgersson","doi":"10.1115/1.4031958","DOIUrl":"https://doi.org/10.1115/1.4031958","url":null,"abstract":"","PeriodicalId":15829,"journal":{"name":"Journal of Fuel Cell Science and Technology","volume":"82 1","pages":"061003"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1115/1.4031958","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63492991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depositing Catalyst Layers in Polymer Electrolyte Membrane Fuel Cells: A Review","authors":"A. Strong, Courtney Thornberry, S. Beattie, Rongrong Chen, S. Coles","doi":"10.1115/1.4031961","DOIUrl":"https://doi.org/10.1115/1.4031961","url":null,"abstract":"Fuel cell technology continues to advance and offers to be a potentially promising solution to many energy needs. Of particular interest are manufacturing techniques to improve performance and decrease overall cost. For catalyst deposition on the membrane electrode assembly (MEA), there are a number of techniques that have been used in the past decades. This paper aims to review many of these main techniques that have been published to show the wide variety of catalyst deposition methods.","PeriodicalId":15829,"journal":{"name":"Journal of Fuel Cell Science and Technology","volume":"12 1","pages":"064001"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1115/1.4031961","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63493038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hybrid Direct Carbon Fuel Cell Performance With Anode Current Collector Material","authors":"L. Deleebeeck, K. Hansen","doi":"10.1115/1.4032260","DOIUrl":"https://doi.org/10.1115/1.4032260","url":null,"abstract":"","PeriodicalId":15829,"journal":{"name":"Journal of Fuel Cell Science and Technology","volume":"12 1","pages":"064501"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1115/1.4032260","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63494428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modeling and Temperature Analysis of the Nexa 1.2 kW Fuel Cell System","authors":"Reem Salim, H. Noura, Mahmoud Nabag, A. Fardoun","doi":"10.1115/1.4032061","DOIUrl":"https://doi.org/10.1115/1.4032061","url":null,"abstract":"","PeriodicalId":15829,"journal":{"name":"Journal of Fuel Cell Science and Technology","volume":"36 1","pages":"061006"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1115/1.4032061","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63493667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Validation of a Uniaxial Nonlinear Viscoelastic Viscoplastic Stress Model for a Fuel Cell Membrane","authors":"J. A. May, M. Ellis, D. Dillard, S. Case, R. Moore, Yonqiang Li, Y. Lai, Craig A. Gittleman","doi":"10.1115/1.4032491","DOIUrl":"https://doi.org/10.1115/1.4032491","url":null,"abstract":"Proton exchange membranes (PEMs) in operating fuel cells are subjected to varying thermal and hygral loads while under mechanical constraint imposed within the compressed stack. Swelling during hygrothermal cycles can result in residual in-plane tensile stresses in the membrane and lead to mechanical degradation or failure through thinning or pinhole development. Numerical models can predict the stresses resulting from applied loads based on material characteristics, thus aiding in the development of more durable membrane materials. In this work, a nonlinear viscoelastic stress model based on the Schapery constitutive formulation is used with a viscoplastic term to describe the response of a novel membrane material comprised of a blend of perfluorocyclobutane (PFCB) ionomer and poly(vinylidene fluoride) (PVDF). Uniaxial creep and recovery experiments characterize the time-dependent linear viscoelastic compliance and the fitting parameters for the nonlinear viscoelastic viscoplastic model. The stress model is implemented in a commercial finite element code, abaqus®, to predict the response of a membrane subjected to mechanical loads. The stress model is validated by comparing model predictions to the experimental responses of membranes subjected to multiple-step creep, stress relaxation, and force ramp loads in uniaxial tension.","PeriodicalId":15829,"journal":{"name":"Journal of Fuel Cell Science and Technology","volume":"12 1","pages":"061011"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1115/1.4032491","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63494694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}