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Expression of TSP-1 in the endometrial adenocarcinoma and its correlation with VEGF and CD105 子宫内膜腺癌组织中TSP-1的表达及其与VEGF、CD105的相关性

Journal of Fujian Medical University Pub Date : 2009-10-10 DOI: 10.3760/CMA.J.ISSN.1008-1372.2009.10.002

Yu-xiu Huang, Xiu Zheng, Lin-fang Liu, Zhong-qing Jiang, Guizhu Wu

{"title":"Expression of TSP-1 in the endometrial adenocarcinoma and its correlation with VEGF and CD105","authors":"Yu-xiu Huang, Xiu Zheng, Lin-fang Liu, Zhong-qing Jiang, Guizhu Wu","doi":"10.3760/CMA.J.ISSN.1008-1372.2009.10.002","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2009.10.002","url":null,"abstract":"Objective To study the expression of inhibitors of DNA binding-1(Id-1)in endometrial adenocarcinoma and its correlation with VEGF,TSP-1.Methods By using immunohistochemistry and image analysis,the expressions of Id-1,VEGF and TSP-1 proteins were studied in a group of 56 patients with endometrial adenocarcinoma,18 patients with atypia hyperplasia and 20 patients with normal endometria.Results The expression of Id-1 in endometrial adenocarcinoma tissues was significantly higher than that in normal endometria and atypia hyperplasia tissues(P0.05)and was significantly correlated with the histological grades,depth of myometrial invasion and clinica1 stage(all P0.05).Id-1 expression in endometrial adenocarcinoma tissues was positively correlated with VEGF expression(r=0.318,P=0.017)and negatively correlated with TSP-1 expression(r=-0.453,P=0.000).No significant association was found between Id-1 expression and patients' survival time.Conclusions Overexpression of Id-1 is common in endometrial adenocarcinoma.Id-1 might be related to the carcinogenesis and progression of endometrial adenocarcinoma by decreasing TSP-1 expression and increasing VEGF expression.","PeriodicalId":15818,"journal":{"name":"Journal of Fujian Medical University","volume":"11 1","pages":"1301-1303"},"PeriodicalIF":0.0,"publicationDate":"2009-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69916349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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