Expression of TSP-1 in the endometrial adenocarcinoma and its correlation with VEGF and CD105

福建医科大学学报 Pub Date : 2009-10-10 DOI:10.3760/CMA.J.ISSN.1008-1372.2009.10.002

Yu-xiu Huang, Xiu Zheng, Lin-fang Liu, Zhong-qing Jiang, Guizhu Wu

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Abstract

Objective To study the expression of inhibitors of DNA binding-1(Id-1)in endometrial adenocarcinoma and its correlation with VEGF,TSP-1.Methods By using immunohistochemistry and image analysis,the expressions of Id-1,VEGF and TSP-1 proteins were studied in a group of 56 patients with endometrial adenocarcinoma,18 patients with atypia hyperplasia and 20 patients with normal endometria.Results The expression of Id-1 in endometrial adenocarcinoma tissues was significantly higher than that in normal endometria and atypia hyperplasia tissues(P0.05)and was significantly correlated with the histological grades,depth of myometrial invasion and clinica1 stage(all P0.05).Id-1 expression in endometrial adenocarcinoma tissues was positively correlated with VEGF expression(r=0.318,P=0.017)and negatively correlated with TSP-1 expression(r=-0.453,P=0.000).No significant association was found between Id-1 expression and patients' survival time.Conclusions Overexpression of Id-1 is common in endometrial adenocarcinoma.Id-1 might be related to the carcinogenesis and progression of endometrial adenocarcinoma by decreasing TSP-1 expression and increasing VEGF expression.

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子宫内膜腺癌组织中TSP-1的表达及其与VEGF、CD105的相关性

目的研究DNA结合-1抑制剂(Id-1)在子宫内膜腺癌组织中的表达及其与VEGF、TSP-1的相关性。方法采用免疫组化和图像分析的方法，对56例子宫内膜腺癌患者、18例异型增生患者和20例正常子宫内膜患者中Id-1、VEGF和TSP-1蛋白的表达进行了研究。结果Id-1在子宫内膜腺癌组织中的表达明显高于正常子宫内膜和异型增生组织(P0.05)，且与组织学分级、子宫内膜浸润深度及临床分期有显著相关性(均P0.05)。子宫内膜腺癌组织中Id-1表达与VEGF表达呈正相关(r=0.318,P=0.017)，与TSP-1表达负相关(r=-0.453,P=0.000)。Id-1表达与患者生存时间无显著相关性。结论Id-1在子宫内膜腺癌中普遍过表达。Id-1可能通过降低TSP-1表达和增加VEGF表达与子宫内膜腺癌的发生发展有关。

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来源期刊

福建医科大学学报

自引率

0.00%

发文量

7403

期刊介绍： Journal of Fujian Medical University (bimonthly), founded in 1959, is a comprehensive academic journal of medicine and health, openly circulated both at home and abroad, included in China Academic Journals (CD-ROM Version), China Academic Journals Comprehensive Evaluation Database, Wanfang Data-Digital Journals Cluster, China Medical Abstracts, Chinese Biological Abstracts and other important databases and abstract journals. The Journal of Fujian Medical University is included in important databases and abstract journals. Journal of Fujian Medical University strives to timely and accurately reflect the new theories, new achievements, new experiences, new technologies and new methods in scientific research, teaching and medical treatment, to provide the society with the latest information on scientific research and academic activities, to promote the development of the cause of medical sciences, and to endeavour to serve the majority of health care personnel, scientific researchers, and teachers and students of medical colleges and universities. The main columns of Journal of Fujian Medical University include theses, reviews, lectures, clinical studies, short reports, case reports, techniques and methods, introduction of new instruments and drugs, research briefs and so on.