Journal of Experimental Nanoscience最新文献_第8页

Oak gum mediated sustainable synthesis of gold nanoparticles (Au NPs): evaluation of its antioxidant and anti-colon cancer effects 橡树胶介导的金纳米粒子（Au-NPs）的可持续合成：其抗氧化和抗克隆癌症作用的评价

IF 2.8 4区材料科学

Journal of Experimental Nanoscience Pub Date : 2022-05-27 DOI: 10.1080/17458080.2022.2050905

Lin Lu, Qing-ye Zhao, Zhihai Wang, Fang Ju

{"title":"Oak gum mediated sustainable synthesis of gold nanoparticles (Au NPs): evaluation of its antioxidant and anti-colon cancer effects","authors":"Lin Lu, Qing-ye Zhao, Zhihai Wang, Fang Ju","doi":"10.1080/17458080.2022.2050905","DOIUrl":"https://doi.org/10.1080/17458080.2022.2050905","url":null,"abstract":"Abstract Herein, we represent the bio-synthesis of gold nanoparticles (Au NPs) employing Oak gum extract as the green template, an efficient natural and non-toxic reductant and stabilizer based on its phytochemicals. The characterization of as-synthesized Au NPs was performed through Fourier transformed infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive X-ray spectroscopy (EDS), elemental mapping, UV-Vis and X-ray diffraction (XRD). TEM analysis explored the average particle size being 10-15 nm. The as-developed material was biologically explored in the inhibition of human colon cancer. Cytotoxicity of assessed over standard colon cancer cell line HT-29 and Caco-2. Cell viability of the two cell lines showed excellent outcomes, as observed by MTT assay. Futhermore, the Au@O. Gum nanocomposite was employed in the determination of the antioxidant properties following DPPH radical scavenging potential in presence of butylated hydroxytoluene (BHT) as the positive control and the result was compared to the raw Oak gum which resulted the scavenging activity as 21.54 and 54.56% respectively. The obtained results evidently validate the Au@O. Gum material as a potent colon cancer protective drug for the treatment of human colon cancer.","PeriodicalId":15673,"journal":{"name":"Journal of Experimental Nanoscience","volume":"17 1","pages":"377 - 388"},"PeriodicalIF":2.8,"publicationDate":"2022-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47836674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Construction of high-performance polymer hydrogel composite materials for artificial bionic organs 人造仿生器官高性能高分子水凝胶复合材料的构建

IF 2.8 4区材料科学

Journal of Experimental Nanoscience Pub Date : 2022-05-19 DOI: 10.1080/17458080.2022.2073999

Ming Yu, Wenhao Liu, Huimin Zhang, Guanjun Liu, Feng Luo, D. Cao

{"title":"Construction of high-performance polymer hydrogel composite materials for artificial bionic organs","authors":"Ming Yu, Wenhao Liu, Huimin Zhang, Guanjun Liu, Feng Luo, D. Cao","doi":"10.1080/17458080.2022.2073999","DOIUrl":"https://doi.org/10.1080/17458080.2022.2073999","url":null,"abstract":"Abstract Hydrogel, with excellent hydrophilicity biocompatibility and stimuli responsive, has been widely used in biomedical and artificial organs fields. However, synthetic hydrogel usually displays poor gel strength, poor toughness and slow speed of absorbing water. Therefore, extensive exploratory research is still required to develop new composite materials for the application of bionic viscera. In this work, we constructed a new kind of composite hydrogel by a facile wet chemistry method to cross-link three kinds of polymer resin, polyvinyl alcohol, carboxymethyl cellulose, and carboxymethyl starch. The conductivity, moisture content and elastic modulus of hydrogel can be controlled by the dosage of potassium salt, sodium salt, water and glycerol. After molding and testing, the electrical conductivity, elastic modulus, and moisture content of the artificial liver and kidney organs were similar to those of the corresponding pig viscera, which is superior to most of the current research on hydrogels. This work provides a facile approach to synthesize highly efficient hydrogel, which accelerates the application of hydrogel in bionic organs.","PeriodicalId":15673,"journal":{"name":"Journal of Experimental Nanoscience","volume":"17 1","pages":"339 - 350"},"PeriodicalIF":2.8,"publicationDate":"2022-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"59980218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

One-pot preparation of nano-scaled magnetic-pectin particles (Fe3O4@pectin NPs): cytotoxicity, antioxidant, and anti-liver cancer properties 一锅法制备纳米磁性果胶颗粒(Fe3O4@pectinNPs）：细胞毒性、抗氧化和抗肝癌癌症特性

IF 2.8 4区材料科学

Journal of Experimental Nanoscience Pub Date : 2022-05-19 DOI: 10.1080/17458080.2022.2063279

Qiaoyun Zhang, Wenyu Cui, Hong-Ye Guo, Baoqing Wang, He Wang, Jimei Zhang, Wenlan Li

{"title":"One-pot preparation of nano-scaled magnetic-pectin particles (Fe3O4@pectin NPs): cytotoxicity, antioxidant, and anti-liver cancer properties","authors":"Qiaoyun Zhang, Wenyu Cui, Hong-Ye Guo, Baoqing Wang, He Wang, Jimei Zhang, Wenlan Li","doi":"10.1080/17458080.2022.2063279","DOIUrl":"https://doi.org/10.1080/17458080.2022.2063279","url":null,"abstract":"Abstract This work described the one-pot synthesis of orange pectin encapsulated Fe3O4 nanoparticles (Fe3O4@Pectin NPs) which is prepared by co-precipitation of Fe(II/(III) ions in alkaline solution mediated by pectin. This process led to formation of magnetic nanoparticles within the network of pectin. Physicochemical characterization of the as-synthesized Fe3O4@Pectin NPs was carried out through Fourier transformed infrared spectroscopy (FT-IR), electron microscopy (SEM and TEM), energy dispersive X-ray spectroscopy (EDX), vibrating sample magnetometer (VSM) and X-ray diffraction (XRD). The in vitro cytotoxic and anti-liver cancer effects of biologically synthesized Fe3O4@Pectin NPs against pleomorphic hepatocellular carcinoma (SNU-387), hepatic ductal carcinoma (LMH/2A), morris hepatoma (McA-RH7777), and novikoff hepatoma (N1-S1 Fudr) cancer cell lines were assessed. The anti-liver cancer properties of the Fe3O4@Pectin NPs could significantly remove pleomorphic hepatocellular carcinoma (SNU-387), hepatic ductal carcinoma (LMH/2A), morris hepatoma (McA-RH7777), and novikoff hepatoma (N1-S1 Fudr) cancer cell lines in a time and concentration-dependent manner by MTT assay. The IC50 of the Fe3O4@Pectin NPs were 8, 13, 10, and 7 µg/mL against pleomorphic hepatocellular carcinoma (SNU-387), hepatic ductal carcinoma (LMH/2A), morris hepatoma (McA-RH7777), and novikoff hepatoma (N1-S1 Fudr) cancer cell lines. The antioxidant activity of Fe3O4@Pectin NPs was determined by DPPH method. The Fe3O4@Pectin NPs showed the high antioxidant activity according to the IC50 value. It seems that the anti-human liver cancer effect of recent nanoparticles is due to their antioxidant effects.","PeriodicalId":15673,"journal":{"name":"Journal of Experimental Nanoscience","volume":"17 1","pages":"326 - 338"},"PeriodicalIF":2.8,"publicationDate":"2022-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48410520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Pectin mediated green synthesis of CuO nanoparticles: evaluation of its cytotoxicity, antioxidant and anti-human cervical cancer properties 果胶介导的CuO纳米颗粒绿色合成:细胞毒性、抗氧化和抗人宫颈癌特性的评价

IF 2.8 4区材料科学

Journal of Experimental Nanoscience Pub Date : 2022-05-04 DOI: 10.1080/17458080.2021.2013470

X. Liang, L. Shi, Run Zhang, Mingying Zhang

{"title":"Pectin mediated green synthesis of CuO nanoparticles: evaluation of its cytotoxicity, antioxidant and anti-human cervical cancer properties","authors":"X. Liang, L. Shi, Run Zhang, Mingying Zhang","doi":"10.1080/17458080.2021.2013470","DOIUrl":"https://doi.org/10.1080/17458080.2021.2013470","url":null,"abstract":"Abstract Regarding applicative, facile, green chemical research, a bio-inspired approach is being reported for the synthesis of CuO nanoparticles by pectin (PEC) as a natural reducing and stabilizing agentin alkaline medium without using any toxic reducing agent. The biosynthesized CuO NPs@Pectin were characterized by advanced physicochemical techniques like ultraviolet–visible (UV–Vis), Fourier Transformed Infrared spectroscopy (FTIR), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Energy Dispersive X-ray spectroscopy (EDX) and X-ray Diffraction (XRD) study. It has been established that pectin-stabilized copper nanoparticles have a spherical shape with a mean diameter from approximately 10 nm. To survey the cytotoxicity and anti-human cervical cancer effects of CuO NPs@Pectin, MTT assay was used on C-33 A [c-33a], SiHa, Ca Ski, DoTc2 4510, HT-3 and LM-MEL-41 cell lines. The resulting IC50 values of the CuO NPs@Pectin against C-33 A [c-33a], SiHa, Ca Ski, DoTc2 4510, HT-3 and LM-MEL-41 cell lines were 231, 214, 243, 376, 315 and 169 µg/mL, respectively. Antioxidant properties of CuO NPs@Pectin were surveyed through the DPPH test in presence of butylated hydroxytoluene as the positive control. The CuO NPs@Pectin inhibited half of the DPPH molecules in the concentration of 98 µg/mL. The cell viability of the treated cell lines was found to reduce dose-dependently over the CuO NPs@Pectin nanocomposite. After approving the above results in the clinical trial studies, the CuO NPs@Pectin can be used as a chemotherapeutic drug for the treatment of several types of cervical cancers.","PeriodicalId":15673,"journal":{"name":"Journal of Experimental Nanoscience","volume":"17 1","pages":"315 - 325"},"PeriodicalIF":2.8,"publicationDate":"2022-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45837271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

New experimental low-cost nanoscience technology for formulation of silver nanoparticles-activated carbon composite as a promising antiviral, biocide, and efficient catalyst 新的实验性低成本纳米科学技术，用于配制银纳米颗粒-活性炭复合材料，作为一种有前途的抗病毒、杀生物剂和高效催化剂

IF 2.8 4区材料科学

Journal of Experimental Nanoscience Pub Date : 2022-04-29 DOI: 10.1080/17458080.2022.2068794

H. Fetouh, H. Abd-Elnaby, M. Alsubaie, E. R. Sallam

{"title":"New experimental low-cost nanoscience technology for formulation of silver nanoparticles-activated carbon composite as a promising antiviral, biocide, and efficient catalyst","authors":"H. Fetouh, H. Abd-Elnaby, M. Alsubaie, E. R. Sallam","doi":"10.1080/17458080.2022.2068794","DOIUrl":"https://doi.org/10.1080/17458080.2022.2068794","url":null,"abstract":"Abstract A simple low-cost one-pot photodeposition synthesis with no hazardous reactants or products is used to make silver nanoparticles-activated carbon composite (SNPs@AC). The SNPs are homogenously and photodeposited and absorbed into the activated carbon matrix. Both SNPs and SNPs@AC composite have particle sizes around 10 nm and 100 nm, respectively. The SNPs@AC composite showed good antiviral activity to VERO (ATCC ccl-81) cells. Zeta potential of SNPs@AC composite is −25 mV, showing that this colloidal system is electrically stable and resistant to coagulation. For many Gram-positive and Gram-negative bacteria, the SNPs@AC composite demonstrated strong antibacterial efficacy. The SNPs@AC composite has 75.72 percent anti-inflammatory effect at concentration 500 µg/mL. This composite has a maximum non-toxic concentration (MNTC) of 78.125 g/mL, which corresponds to antiviral activity of up to 96.7 percent against hepatitis A. virus (HAV). It is suggested as a candidate for pharmaceutical formulations, such as integration into the manufacture of N95 masks for COVID-19 infection protection. Concentration 160 μg/mL SNPs@AC composite has antioxidant activity 42.74% percent. The SNPs@AC composite exhibited selective catalytic activity for the organosynthesis hydrazination reaction of 4-chloro-3, 5-di-nitro-benzo-triflouride, giving 1-hydroxy-4-nitro-6-trifluoro-methyl benzotriazole, a common antiviral drug for severe acute respiratory syndrome (SARS). SNPs@composite's well-defined pores provide suitable active sites for binding reactants: 4-Cl-3, 5-di-NO2-benzotriflouride, and hydrazine, which react to create 1-hydroxy-4-nitro-6-trifluoromethyl benzotriazole, which diffuses into solution away from the catalyst surface, leaving the catalyst surface unaffected.","PeriodicalId":15673,"journal":{"name":"Journal of Experimental Nanoscience","volume":"17 1","pages":"297 - 314"},"PeriodicalIF":2.8,"publicationDate":"2022-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45654839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Design and synthesis of copper nanoparticles for the treatment of human esophageal cancer: introducing a novel chemotherapeutic supplement 设计和合成用于治疗人类食管癌的铜纳米颗粒:介绍一种新的化疗补充剂

IF 2.8 4区材料科学

Journal of Experimental Nanoscience Pub Date : 2022-04-22 DOI: 10.1080/17458080.2022.2065264

Xiaofei Zhuang, Y. Kang, Lingxia Zhao, Shiping Guo

{"title":"Design and synthesis of copper nanoparticles for the treatment of human esophageal cancer: introducing a novel chemotherapeutic supplement","authors":"Xiaofei Zhuang, Y. Kang, Lingxia Zhao, Shiping Guo","doi":"10.1080/17458080.2022.2065264","DOIUrl":"https://doi.org/10.1080/17458080.2022.2065264","url":null,"abstract":"Abstract In this study, copper nanoparticles (Cu NPs) were synthesized in an eco-friendly pathway applying Mentha piperita extract as reducing/stabilizing agent. The morphological and physicochemical features of the prepared nanoparticles were determined using several advanced techniques like FE-SEM, EDX, and UV–Vis studies. The as synthesized Cu NPs was explored in the antioxidant and anti-human esophageal cancer tests. The in vitro cytotoxic and anti-esophageal cancer effects of biologically synthesized Cu NPs against human esophageal squamous cell carcinoma (KYSE-270), human caucasian esophageal carcinoma (OE33), and adenocarcinoma of the gastroesophageal junction (ESO26) cancer cell lines were assessed. The anti-esophageal cancer properties of the Cu NPs could significantly remove KYSE-270, OE33, and ESO26 cancer cell lines in a time and concentration-dependent manner by MTT assay. The IC50 of the Cu NPs were 241, 278, and 240 µg/mL against KYSE-270, OE33, and ESO26 cancer cell lines. The antioxidant activity of Cu NPs was determined by DPPH method. The Cu NPs showed the high antioxidant activity according to the IC50 value. It seems that the anti-human esophageal cancer effect of recent nanoparticles is due to their antioxidant effects.","PeriodicalId":15673,"journal":{"name":"Journal of Experimental Nanoscience","volume":"17 1","pages":"274 - 284"},"PeriodicalIF":2.8,"publicationDate":"2022-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47757917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Anti-human lung adenocarcinoma, cytotoxicity, and antioxidant potentials of copper nanoparticles green-synthesized by Calendula officinalis 金盏菊合成纳米铜绿的抗人肺腺癌、细胞毒性和抗氧化潜能

IF 2.8 4区材料科学

Journal of Experimental Nanoscience Pub Date : 2022-04-22 DOI: 10.1080/17458080.2022.2066082

J. Gu, A. Aidy, S. Goorani

{"title":"Anti-human lung adenocarcinoma, cytotoxicity, and antioxidant potentials of copper nanoparticles green-synthesized by Calendula officinalis","authors":"J. Gu, A. Aidy, S. Goorani","doi":"10.1080/17458080.2022.2066082","DOIUrl":"https://doi.org/10.1080/17458080.2022.2066082","url":null,"abstract":"Abstract Calendula officinalis is known as a popular plant with various uses as pharmaceutical agent or food additive around the world. In this study, cooper nanoparticles were green synthesized using the aqueous extract of Calendula officinalis as the stabilizing, reducing, and capping agents. The formation of CuNPs@C. officinalis was screened using different chemical technique such as FT-IR spectroscopy, XRD, SEM, and Energy EDS. The antioxidant and anti-cancer activity of CuNPs@C. officinalis was studied using common assay including free radical scavenging and MTT assays. The results confirm the green synthesized of CuNPs@C. officinalis with aspherical morphology in the range size of 19.64 to 39.15 nm. In the antioxidant test, the IC50 of CuNPs@C. officinalis and BHT against DPPH free radicals were 193 and 154 µg/mL, respectively. In the cellular and molecular part of the recent study, the treated cells with CuNPs@C. officinalis were assessed by MTT assay for 24, 48, and 72 h about the cytotoxicity and anti-human lung adenocarcinoma properties on normal (HUVEC) and lung adenocarcinoma cell lines, i.e. lung moderately differentiated adenocarcinoma (LC-2/ad), lung poorly differentiated adenocarcinoma (PC-14), and lung well-differentiated bronchogenic adenocarcinoma (HLC-1). The IC50s of CuNPs@C. officinalis were 297, 328, and 514 µg/mL against PC-14, LC-2/ad, and HLC-1 cell lines, respectively. The viability of malignant lung cell line reduced dose-dependently in the presence of CuNPs@C. officinalis. It seems that the anti-human lung adenocarcinoma effect of recent nanoparticles is due to their antioxidant effects.","PeriodicalId":15673,"journal":{"name":"Journal of Experimental Nanoscience","volume":"17 1","pages":"285 - 296"},"PeriodicalIF":2.8,"publicationDate":"2022-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47511244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Synthesis, crystal structure, hirshfeld surface analysis, molecular docking and molecular dynamics studies of novel olanzapinium 2,5-dihydroxybenzoate as potential and active antipsychotic compound 新型抗精神病活性化合物2，5-二羟基苯甲酸奥氮平的合成、晶体结构、hirshfeld表面分析、分子对接和分子动力学研究

IF 2.8 4区材料科学

Journal of Experimental Nanoscience Pub Date : 2022-04-15 DOI: 10.1080/17458080.2022.2063278

V. Natchimuthu, Mohnad Abdalla, Manasi Yadav, Ishita Chopra, Anushka Bhrdwaj, K. Sharma, S. Ravi, K. Ravikumar, K. Alzahrani, T. Hussain, Anuraj Nayarisseri

{"title":"Synthesis, crystal structure, hirshfeld surface analysis, molecular docking and molecular dynamics studies of novel olanzapinium 2,5-dihydroxybenzoate as potential and active antipsychotic compound","authors":"V. Natchimuthu, Mohnad Abdalla, Manasi Yadav, Ishita Chopra, Anushka Bhrdwaj, K. Sharma, S. Ravi, K. Ravikumar, K. Alzahrani, T. Hussain, Anuraj Nayarisseri","doi":"10.1080/17458080.2022.2063278","DOIUrl":"https://doi.org/10.1080/17458080.2022.2063278","url":null,"abstract":"Abstract The antipsychotic drug Olanzapine was crystallized with aromatic acid, 2,5-dihydroxybenzoic acid in isopropyl alcohol by slow evaporation which led to the formation of olanzapinium 2,5-dihydroxybenzoate crystalline salt. The structure of the compound was characterized by 1H-NMR, 13C-NMR, and single-crystal X-ray diffraction analysis. The Hirshfeld analyses were performed to quantify the order and nature of intermolecular interactions in the crystal network. Employing computational approaches, the compound was tested for its affinity against antipsychotic activity by molecular docking and molecular dynamic simulation to attest the conformational stability over time step of 100 ns. Besides, bioactivity and ADMET properties were also predicted to ratify the result. The compound asserted neither carcinogenic nor mutagenic activity and has high oral bioavailability. Hence, this synthesized novel compound Olanzapinium 2,5-dihydroxybenzoate recognized in the study possesses high potential as an effective antipsychotic compound, and can further be examined for its efficiency by in vivo studies. The synthesized compound was submitted to NCBI PubChem database using accession substance ID: 441329256. The crystal structure was submitted to CCDC (Cambridge Crystallographic Data Centre) with submission ID: 2010899.","PeriodicalId":15673,"journal":{"name":"Journal of Experimental Nanoscience","volume":"17 1","pages":"247 - 273"},"PeriodicalIF":2.8,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43370103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genotoxicity and in vitro investigation of Gefitinib-loaded polycaprolactone fabricated nanoparticles for anticancer activity against NCI-H460 cell lines 吉非替尼聚己内酯纳米颗粒抗NCI-H460细胞的遗传毒性及体外研究

IF 2.8 4区材料科学

Journal of Experimental Nanoscience Pub Date : 2022-04-12 DOI: 10.1080/17458080.2022.2060501

Sankha Bhattacharya

{"title":"Genotoxicity and in vitro investigation of Gefitinib-loaded polycaprolactone fabricated nanoparticles for anticancer activity against NCI-H460 cell lines","authors":"Sankha Bhattacharya","doi":"10.1080/17458080.2022.2060501","DOIUrl":"https://doi.org/10.1080/17458080.2022.2060501","url":null,"abstract":"Abstract For non-small cell lung cancer (NSCLC) treatment, a BCS class II drug, Gefitinib, was widely used. Due to poor bioavailability, uncontrollable drug release, Gefitinib witnessed side effects. To circumvent such associated problems, optimized Gefitinib encapsulated polycaprolactone (PCL) nanoparticles with three different molecular weights of PCL (average Mn∼10,000, Mn∼45,000 & Mn∼80,000) were developed using Box–Behnken design while understanding the influence of critical process parameters of the nanoparticles. For morphological characterizations, SEM, TEM, AFM were used. Hemocompatibility, platelet aggregation, and erythrocyte membrane integrity tests were used to test nanoparticles for biocompatibility; excellent biocompatibility was reported during these tests. The in-vitro drug release studies confirmed that Gefitinib-PCL10,000NPs, Gefitinib-PCL45,000NPs, and Gefitinib-PCL80,000 NPs, show significant initial burst effects, and later nanoparticles possessed zero-order kinetics. The genotoxicity of PCL nanoparticles was assessed by cytokinesis-block micronucleus (CBMN) assay, indicating DNA damage in NCI-H460 cell and micronuclei and nuclear buds’ formation. Further, reactive oxygen species studies, MTT cytotoxicity assays at 24 & 48 h, stability, in-vitro cellular uptake of optimized fluorescent Gefitinib PCL80,000NPs, and apoptosis studies were also carried out. As a result, investigating stable Gefitinib-loaded poly-caprolactone (PCL) nanoparticles could open up new research avenues, potentially lowering side effects and improving Gefitinib's profile in the treatment of NSCLC.","PeriodicalId":15673,"journal":{"name":"Journal of Experimental Nanoscience","volume":"17 1","pages":"214 - 246"},"PeriodicalIF":2.8,"publicationDate":"2022-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44381540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

RETRACTED ARTICLE: Preparation of hollow Aux-Cu2O nanospheres by galvanic replacement to enhance the selective electrocatalytic CO2 reduction to ethanol 电取代法制备空心氧化铜纳米球，提高CO2电催化还原乙醇的选择性

IF 2.8 4区材料科学

Journal of Experimental Nanoscience Pub Date : 2022-04-08 DOI: 10.1080/17458080.2021.2005246

Li-Jie Zhang, Ying Zhang, Hongtao Wang, Jianbing Chen, Zhongqi Cao

{"title":"RETRACTED ARTICLE: Preparation of hollow Aux-Cu2O nanospheres by galvanic replacement to enhance the selective electrocatalytic CO2 reduction to ethanol","authors":"Li-Jie Zhang, Ying Zhang, Hongtao Wang, Jianbing Chen, Zhongqi Cao","doi":"10.1080/17458080.2021.2005246","DOIUrl":"https://doi.org/10.1080/17458080.2021.2005246","url":null,"abstract":"Abstract Electrocatalytic CO2 reduction to fuel is one of the important ways to solve energy and environmental problems. In this work, the preparation of hollow Aux-Cu2O electrocatalyst and the performance of electrocatalytic CO2 reduction to ethanol were studied. Hollow Cu2O nanospheres were prepared by a soft template method, and Aux-Cu2O composites were prepared by galvanic replacement. The characterization results of XRD and XPS reveal that Cu+ is the main chemical state of Cu in the catalysts. The results of electroactive surface area demonstrate that the electroactive surface area of Au0.51-Cu2O is the largest. The performance evaluation of electrocatalytic CO2 reduction shows that the Faraday efficiency of H2 on Au0.51-Cu2O is the lowest (∼19.5%) and the Faraday efficiency of ethanol can reach ∼18.8% at −1.2 V vs. RHE. Compared with hollow Cu2O nanospheres, Aux-Cu2O catalysts have an earlier onset for ethanol production and promote the CO2 reduction to ethanol with high efficiency, while the hydrogen evolution reaction is significantly inhibited. Our study demonstrates an effective approach to develop Cu-based electrocatalysts favourable toward ethanol in electrocatalytic CO2 reduction.","PeriodicalId":15673,"journal":{"name":"Journal of Experimental Nanoscience","volume":"17 1","pages":"173 - 186"},"PeriodicalIF":2.8,"publicationDate":"2022-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44407029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4