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Journal of dermatological science最新文献

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Recombinant human thioredoxin ameliorates imiquimod-induced psoriasis-like dermatitis in mice. 重组人硫氧还蛋白可改善咪喹莫特诱导的小鼠银屑病样皮炎。
IF 3.8 3区 医学
Journal of dermatological science Pub Date : 2024-07-01 DOI: 10.1016/j.jdermsci.2024.07.002
A. Mostafa, Kenji Sakurai, T. Murata, T. Dainichi, Hai Tian, Junji Yodoi, K. Kabashima
{"title":"Recombinant human thioredoxin ameliorates imiquimod-induced psoriasis-like dermatitis in mice.","authors":"A. Mostafa, Kenji Sakurai, T. Murata, T. Dainichi, Hai Tian, Junji Yodoi, K. Kabashima","doi":"10.1016/j.jdermsci.2024.07.002","DOIUrl":"https://doi.org/10.1016/j.jdermsci.2024.07.002","url":null,"abstract":"","PeriodicalId":15641,"journal":{"name":"Journal of dermatological science","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141704647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contribution to the peripheral vasculopathy and endothelial cell dysfunction by CXCL4 in Systemic Sclerosis. 在系统性硬化症中，CXCL4对周围血管病变和内皮细胞功能障碍的贡献。
IF 4.6 3区 医学
Journal of dermatological science Pub Date : 2020-07-13 DOI: 10.21203/rs.3.rs-41064/v1
Zhixing Jiang, Chen Chen, Sen Yang, Hang He, Xiaoxia Zhu, Minrui Liang
{"title":"Contribution to the peripheral vasculopathy and endothelial cell dysfunction by CXCL4 in Systemic Sclerosis.","authors":"Zhixing Jiang, Chen Chen, Sen Yang, Hang He, Xiaoxia Zhu, Minrui Liang","doi":"10.21203/rs.3.rs-41064/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-41064/v1","url":null,"abstract":"BACKGROUND\u0000CXCL4, a chemokine with anti-angiogenic property, is involved in systemic sclerosis (SSc) related pulmonary arterial hypertension (PAH).\u0000\u0000\u0000OBJECTIVE\u0000To investigated the contribution of CXCL4 to SSc development by focusing on the correlation of circulatory CXCL4 levels with their peripheral vasculopathy, and the effect of CXCL4 on endothelial cell dysfunction and the potential signaling.\u0000\u0000\u0000METHODS\u0000We measured the plasma CXCL4 levels in 58 patients with SSc, 10 patients with the very early diagnosis of SSc (VEDOSS), and 80 healthy controls (HCs). Then, CXCL4 concentrations were correlated with clinical features, especially the peripheral vasculopathy. These observations were further validated in an additional cohort. Moreover, we studied the anti-angiogenic effects of CXCL4 and the underlying downstream signaling in human umbilical vein endothelial cells (HUVECs) in vitro.\u0000\u0000\u0000RESULTS\u0000Circulating CXCL4 levels were 103.62 % higher in patients with SSc and 201.51 % higher in patients with VEDOSS than matched HCs, which were confirmed in two independent cohorts. CXCL4 levels were associated with digital ulcers (DU) and nailfold videocapillaroscopy (NVC) abnormalities in SSc. The proliferation, migration, and tube formation of HUVECs were inhibited by CXCL4 or SSc derived plasma, which reversed by CXCL4 neutralizing antibody, but failed by CXCR3 inhibitor. CXCL4 downregulated the transcription factor Friend leukaemia integration factor-1 (Fli-1) via c-Abl signaling. Furthermore, CXCL4 blocked the transforming growth factor (TGF) -β or platelet-derived growth factor (PDGF) induced cell proliferation of HUVECs.\u0000\u0000\u0000CONCLUSIONS\u0000CXCL4 may contribute to peripheral vasculopathy in SSc by downregulating Fli-1 via c-Abl signaling in endothelial cells and interfering angiogenesis.","PeriodicalId":15641,"journal":{"name":"Journal of dermatological science","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2020-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85463837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Chronic infection with the protozoan Toxoplasma gondii prevents the development of experimental atopic dermatitis in mice. 弓形虫原生动物慢性感染可预防小鼠实验性特应性皮炎的发生。
IF 4.6 3区 医学
Journal of dermatological science Pub Date : 2019-11-02 DOI: 10.1016/j.jdermsci.2019.10.007
Matías Perrone Sibilia, María de Los Angeles Aldirico, A. Soto, M. S. Picchio, Vanesa R. Sánchez, Nadia Arcon, R. Moretta, V. Martín, S. Vanzulli, I. Fenoy, A. Goldman
{"title":"Chronic infection with the protozoan Toxoplasma gondii prevents the development of experimental atopic dermatitis in mice.","authors":"Matías Perrone Sibilia, María de Los Angeles Aldirico, A. Soto, M. S. Picchio, Vanesa R. Sánchez, Nadia Arcon, R. Moretta, V. Martín, S. Vanzulli, I. Fenoy, A. Goldman","doi":"10.1016/j.jdermsci.2019.10.007","DOIUrl":"https://doi.org/10.1016/j.jdermsci.2019.10.007","url":null,"abstract":"","PeriodicalId":15641,"journal":{"name":"Journal of dermatological science","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2019-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73198277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Possible therapeutic applicability of galectin-9 in cutaneous T-cell lymphoma. 半凝集素-9在皮肤t细胞淋巴瘤中可能的治疗适用性。
IF 4.6 3区 医学
Journal of dermatological science Pub Date : 2019-09-16 DOI: 10.1016/j.jdermsci.2019.09.004
R. Nakajima, T. Miyagaki, H. Kamijo, T. Oka, Naomi Shishido-Takahashi, H. Suga, M. Sugaya, S. Sato
{"title":"Possible therapeutic applicability of galectin-9 in cutaneous T-cell lymphoma.","authors":"R. Nakajima, T. Miyagaki, H. Kamijo, T. Oka, Naomi Shishido-Takahashi, H. Suga, M. Sugaya, S. Sato","doi":"10.1016/j.jdermsci.2019.09.004","DOIUrl":"https://doi.org/10.1016/j.jdermsci.2019.09.004","url":null,"abstract":"","PeriodicalId":15641,"journal":{"name":"Journal of dermatological science","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2019-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80574037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Apremilast mechanism of efficacy in systemic-naive patients with moderate plaque psoriasis: Pharmacodynamic results from the UNVEIL study. 阿普雷米司特治疗中度斑块型银屑病的机制:揭幕研究的药效学结果。
IF 4.6 3区 医学
Journal of dermatological science Pub Date : 2019-09-10 DOI: 10.1016/j.jdermsci.2019.09.003
B. Strober, A. Alikhan, B. Lockshin, Rebecca Shi, J. Cirulli, P. Schafer
{"title":"Apremilast mechanism of efficacy in systemic-naive patients with moderate plaque psoriasis: Pharmacodynamic results from the UNVEIL study.","authors":"B. Strober, A. Alikhan, B. Lockshin, Rebecca Shi, J. Cirulli, P. Schafer","doi":"10.1016/j.jdermsci.2019.09.003","DOIUrl":"https://doi.org/10.1016/j.jdermsci.2019.09.003","url":null,"abstract":"","PeriodicalId":15641,"journal":{"name":"Journal of dermatological science","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2019-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77360070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Meeting Report: Japan – Singapore International Skin Conference, Singapore April 10-12, 2019 会议报告:日本-新加坡国际皮肤会议，新加坡，2019年4月10日至12日
IF 4.6 3区 医学
Journal of dermatological science Pub Date : 2019-05-01 DOI: 10.1016/j.jdermsci.2019.05.006
{"title":"Meeting Report: Japan – Singapore International Skin Conference, Singapore April 10-12, 2019","authors":"","doi":"10.1016/j.jdermsci.2019.05.006","DOIUrl":"https://doi.org/10.1016/j.jdermsci.2019.05.006","url":null,"abstract":"","PeriodicalId":15641,"journal":{"name":"Journal of dermatological science","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73302344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Obituary: Stephen I. Katz, MD, PhD (1941–2018) 讣告:Stephen I. Katz, MD, PhD (1941-2018)
IF 4.6 3区 医学
Journal of dermatological science Pub Date : 2019-02-01 DOI: 10.1016/s0923-1811(19)30057-x
M. Amagai
{"title":"Obituary: Stephen I. Katz, MD, PhD (1941–2018)","authors":"M. Amagai","doi":"10.1016/s0923-1811(19)30057-x","DOIUrl":"https://doi.org/10.1016/s0923-1811(19)30057-x","url":null,"abstract":"","PeriodicalId":15641,"journal":{"name":"Journal of dermatological science","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74537209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long non-coding RNAs regulate cellular responses to ultraviolet light in a wavelength-dependent manner 长链非编码rna以波长依赖的方式调节细胞对紫外线的反应
IF 4.6 3区 医学
Journal of dermatological science Pub Date : 2017-05-01 DOI: 10.1016/J.JDERMSCI.2017.02.225
K. Yo, T. Ruenger
{"title":"Long non-coding RNAs regulate cellular responses to ultraviolet light in a wavelength-dependent manner","authors":"K. Yo, T. Ruenger","doi":"10.1016/J.JDERMSCI.2017.02.225","DOIUrl":"https://doi.org/10.1016/J.JDERMSCI.2017.02.225","url":null,"abstract":"","PeriodicalId":15641,"journal":{"name":"Journal of dermatological science","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76655223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TPA inhibits melanoma growth through inactivation of STAT3 through protein tyrosine phosphatases TPA通过酪氨酸蛋白磷酸酶抑制STAT3的失活来抑制黑色素瘤的生长
IF 4.6 3区 医学
Journal of dermatological science Pub Date : 2017-05-01 DOI: 10.1016/J.JDERMSCI.2017.02.275
T. Iwasaki, M. Yamauchi, Zhu Liang, Ayano Itai, Masanobu Sakaguchi, T. Nagano, S. Kamada, M. Oka
{"title":"TPA inhibits melanoma growth through inactivation of STAT3 through protein tyrosine phosphatases","authors":"T. Iwasaki, M. Yamauchi, Zhu Liang, Ayano Itai, Masanobu Sakaguchi, T. Nagano, S. Kamada, M. Oka","doi":"10.1016/J.JDERMSCI.2017.02.275","DOIUrl":"https://doi.org/10.1016/J.JDERMSCI.2017.02.275","url":null,"abstract":"","PeriodicalId":15641,"journal":{"name":"Journal of dermatological science","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78155803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
TLR signaling regulates the expression of serine protease inhibitors in epidermal keratinocytes TLR信号调节表皮角质形成细胞中丝氨酸蛋白酶抑制剂的表达
IF 4.6 3区 医学
Journal of dermatological science Pub Date : 2017-05-01 DOI: 10.1016/J.JDERMSCI.2017.02.209
S. Sugimoto, S. Morizane, S. Sugihara, M. Kobashi, K. Iwatsuki
{"title":"TLR signaling regulates the expression of serine protease inhibitors in epidermal keratinocytes","authors":"S. Sugimoto, S. Morizane, S. Sugihara, M. Kobashi, K. Iwatsuki","doi":"10.1016/J.JDERMSCI.2017.02.209","DOIUrl":"https://doi.org/10.1016/J.JDERMSCI.2017.02.209","url":null,"abstract":"","PeriodicalId":15641,"journal":{"name":"Journal of dermatological science","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75250723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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