Journal of Dermatological Treatment最新文献_第4页

Comparative effectiveness among available treatments in difficult-to-treat port-wine stains (PWS): a Network Meta-Analysis of observational evidence. 难治性葡萄酒斑(PWS)现有治疗方法的比较疗效:观察性证据的网络荟萃分析。

IF 2.9 4区医学

Journal of Dermatological Treatment Pub Date : 2023-12-01 DOI: 10.1080/09546634.2023.2231582

Sirinda Jamjanya, Voraphol Vejjabhinanta, Krittai Tanasombatkul, Phichayut Phinyo

{"title":"Comparative effectiveness among available treatments in difficult-to-treat port-wine stains (PWS): a Network Meta-Analysis of observational evidence.","authors":"Sirinda Jamjanya, Voraphol Vejjabhinanta, Krittai Tanasombatkul, Phichayut Phinyo","doi":"10.1080/09546634.2023.2231582","DOIUrl":"10.1080/09546634.2023.2231582","url":null,"abstract":"Background: Although pulsed dye laser (PDL) is the treatment of choice for port-wine stains (PWS), clinical resistance to PDL has been observed in 20-30% of cases. Several alternative treatment modalities have been introduced; however, there is still a lack of definite recommendations regarding the optimal treatment for difficult-to-treat PWS.Objective: We aimed to systematically review and analyze the comparative effectiveness among treatments for problematic PWS.Methods & materials: We systematically searched for comparative studies assessing treatments for patients with difficult-to-treat PWS through relevant biomedical databases until August 2022. A Network Meta-Analysis (NMA) was conducted to estimate the odds ratio (OR) for all pairwise comparisons. The primary outcome is the improvement of lesions of more than 25%.Results: Of the 2498 studies identified, six treatments from five studies were available for NMA. Compared with 585 nm short-pulsed dye laser (SPDL), intense pulsed light (IPL) was the most effective in clearing lesions (OR 11.81, 95% CI 2.15 to 64.89, very low confidence rating), followed by 585 nm long-pulsed dye laser (LPDL) (OR 9.95, 95% CI 1.75 to 56.62, very low confidence rating). The 1064 nm NdYAG, 532 nm NdYAG, and LPDL >585 nm exhibited potential superiority over SPDL 585 nm, although statistical significance was not observed.Conclusions: IPL and 585 nm LPDL are likely to be more effective than 585 nm SPDL for treating difficult-to-treat PWS. Well-designed clinical trials are warranted to confirm our findings.","PeriodicalId":15639,"journal":{"name":"Journal of Dermatological Treatment","volume":"34 1","pages":"2231582"},"PeriodicalIF":2.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9830888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systematic review of mesotherapy: a novel avenue for the treatment of hair loss. 中间疗法的系统综述：一种治疗脱发的新途径。

IF 2.9 4区医学

Journal of Dermatological Treatment Pub Date : 2023-12-01 DOI: 10.1080/09546634.2023.2245084

Aditya K Gupta, Shruthi Polla Ravi, Tong Wang, Mesbah Talukder, Michela Starace, Bianca Maria Piraccini

{"title":"Systematic review of mesotherapy: a novel avenue for the treatment of hair loss.","authors":"Aditya K Gupta, Shruthi Polla Ravi, Tong Wang, Mesbah Talukder, Michela Starace, Bianca Maria Piraccini","doi":"10.1080/09546634.2023.2245084","DOIUrl":"10.1080/09546634.2023.2245084","url":null,"abstract":"Mesotherapy is a technique by which lower doses of therapeutic agents and bioactive substances are administered by intradermal injections to the skin. Through intradermal injections, mesotherapy can increase the residence time of therapeutic agents in the affected area, thus allowing for the use of lower doses and longer intervals between sessions which may in turn improve the treatment outcome and patient compliance. This systematic review aims to summarize the current literature that evaluates the efficacy of this technique for the treatment of hair loss and provides an overview of the results observed. Of the 416 records identified, 27 articles met the inclusion criteria. To date, mesotherapy using 6 classes of agents and their combinations have been studied; this includes dutasteride, minoxidil, growth factors or autologous suspension, botulinum toxin A, stem cells, and mesh solutions/multivitamins. While several studies report statistically significant improvements in hair growth after treatment, there is currently a lack of standardized regimens. The emergence of adverse effects after mesotherapy has been reported. Further large-scale and controlled clinical trials are warranted to evaluate the utility of mesotherapy for hair loss disorders.","PeriodicalId":15639,"journal":{"name":"Journal of Dermatological Treatment","volume":"34 1","pages":"2245084"},"PeriodicalIF":2.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10344203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RETRACTED ARTICLE: Secukinumab-induced paradoxical skin lesions, but successful treatment with tofacitinib in SAPHO syndrome: a case report. 撤回文章:secukinumumab诱导的矛盾性皮肤病变，但成功治疗SAPHO综合征的托法替尼:一个病例报告。

IF 2.9 4区医学

Journal of Dermatological Treatment Pub Date : 2023-12-01 Epub Date: 2023-03-20 DOI: 10.1080/09546634.2023.2193662

引用次数: 2

Efficacy and safety of bimekizumab for the treatment of psoriasis: a systematic review and meta-analysis of randomized clinical trials. 比美珠单抗治疗银屑病的疗效和安全性:随机临床试验的系统回顾和荟萃分析

IF 2.9 4区医学

Journal of Dermatological Treatment Pub Date : 2023-12-01 DOI: 10.1080/09546634.2023.2199106

Yuanyuan Qiu, Yang Zhu, Yun Liu, Qiliang Liu

{"title":"Efficacy and safety of bimekizumab for the treatment of psoriasis: a systematic review and meta-analysis of randomized clinical trials.","authors":"Yuanyuan Qiu, Yang Zhu, Yun Liu, Qiliang Liu","doi":"10.1080/09546634.2023.2199106","DOIUrl":"10.1080/09546634.2023.2199106","url":null,"abstract":"Aim: This study aimed to evaluate the efficacy and safety of bimekizumab for psoriasis.Methods: The PubMed, Web of Science, Cochrane Library, and Embase databases were systematically searched until November 20, 2022, to identify randomized controlled trials (RCTs) reporting the efficacy and safety of bimekizumab. The identified studies were screened according to inclusion and exclusion criteria, and a meta-analysis was performed on the selected studies using the Stata (version 17.0) software to investigate the efficacy and safety of bimekizumab.Results: Six studies involving 1252 participants were considered. Compared with the control group which received placebo, the bimekizumab group had a larger number of patients with improvement in Psoriasis Area and Severity Index (PASI) of at least 75% (PASI75) (RR: 20.54, 95%CI: 12.41-33.99; p = .000), at least 90% (PASI90) (RR:16.99, 95%CI: 7.09-40.68; p = .000) and 100%(PASI100) (RR:14.57; 95%CI: 5.26-40.35; p = .000) and a larger number with improvement in Investigator Global Assessment (IGA) response (RR:22.57; 95%CI: 12.74-39.98; p = .000). There was no obvious difference between the bimekizumab and placebo groups in treatment of emergent adverse events (TEAEs) (RR:1.17; 95%CI: 0.93-1.47; p > .05) and serious TEAEs (RR: 0.67; 95%CI: 0.28-1.61; p > .05).Conclusions: Bimekizumab shows promising efficacy for the treatment of psoriasis with favorable safety records.","PeriodicalId":15639,"journal":{"name":"Journal of Dermatological Treatment","volume":"34 1","pages":"2199106"},"PeriodicalIF":2.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9281837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of autologous platelet-rich plasma in androgenetic alopecia in women: a systematic review and meta-analysis. 自体富含血小板血浆在女性雄激素性脱发中的应用：一项系统综述和荟萃分析。

IF 2.9 4区医学

Journal of Dermatological Treatment Pub Date : 2023-12-01 Epub Date: 2022-10-31 DOI: 10.1080/09546634.2022.2138692

Antonio Flávio Queiroz de Oliveira, Francisco Plácido Nogueira Arcanjo, Maria Rosineida Paiva Rodrigues, Ana Augusta Rosa E Silva, Peter Richard Hall

{"title":"Use of autologous platelet-rich plasma in androgenetic alopecia in women: a systematic review and meta-analysis.","authors":"Antonio Flávio Queiroz de Oliveira, Francisco Plácido Nogueira Arcanjo, Maria Rosineida Paiva Rodrigues, Ana Augusta Rosa E Silva, Peter Richard Hall","doi":"10.1080/09546634.2022.2138692","DOIUrl":"10.1080/09546634.2022.2138692","url":null,"abstract":"Objective: To conduct a systematic review and meta-analysis to verify the efficacy of using autologous platelet-rich plasma (PRP) in female pattern alopecia (FPA).Background: Androgenetic alopecia is the leading cause of hair loss in men andwomen and often impacts self-esteem and quality of life.Data sources: MEDLINE/PubMed, Cochrane Library, ClinicalTrials.gov, and EMBASE up to May 2021.Study selection and data extraction: We identified all studies evaluating the effect of PRP in FPA. A narrative synthesis was performed from data on the efficacy of PRP treatment and adverse effects; quantitative results of PRP use compared to control treatment for female androgenetic alopecia (AGA) were synthesized. The outcomes analyzed were terminal density and hair thickness.Results: Seven articles were selected for this review. Meta-analysis showed that PRP-based interventions were able to increase terminal hair density compared to control (standardized mean difference (SMD)=2.98, 95% confidence intervals (CIs)=1.10, 4.85), with no significant increase in hair thickness (SMD = 1.16, 95% CI= -0.96, 3.28). During and after treatment, no major side effects were reported by patients or researchers.Conclusions: The use of autologous PRP injections in female AGA seems to be promising, with more consistent results on terminal hair density. However, caution is recommended in the interpretation of these results until they can be replicated in larger and more representative samples. PROSPERO registration number CRD42021257154.","PeriodicalId":15639,"journal":{"name":"Journal of Dermatological Treatment","volume":"34 1","pages":"2138692"},"PeriodicalIF":2.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10652016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful treatment with amoxicillin-clavulanic acid: cutaneous nocardiosis caused by Nocardia brasiliensis. 阿莫西林-克拉维酸成功治疗:巴西诺卡菌引起的皮肤诺卡菌病。

IF 3.9 4区医学

Journal of Dermatological Treatment Pub Date : 2023-12-01 DOI: 10.1080/09546634.2023.2229467

Youqi Ji, Fang Su, Xin Hong, Mengyuan Chen, Yongze Zhu, Dongqing Cheng, Yumei Ge

{"title":"Successful treatment with amoxicillin-clavulanic acid: cutaneous nocardiosis caused by Nocardia brasiliensis.","authors":"Youqi Ji, Fang Su, Xin Hong, Mengyuan Chen, Yongze Zhu, Dongqing Cheng, Yumei Ge","doi":"10.1080/09546634.2023.2229467","DOIUrl":"10.1080/09546634.2023.2229467","url":null,"abstract":"Aim: To emphasize the role of non-sulfonamides in the treatment of Nocardia infection and reduce the adverse reactions caused by sulfonamides.Methods: We retrospectively analyzed a case of cutaneous nocardiosis in an immunocompetent individual. The colonies obtained by staining the pus in the lesion with antacid and culturing the agar plates were identified by flight mass spectrometry. The pathogenic identification showed Nocardia brasiliensis infection and the patient was treated with amoxicillin-clavulanic acid.Results: After treatment with amoxicillin and clavulanic acid, the ulcer gradually peeled and crusted, leaving dark pigmentation. The patient has finally recovered.Conclusion: Sulfonamides are the first-line antibacterial agents for years in treatment of nocardiosis but are of great toxicity and side effects. This patient was successfully treated with amoxicillin-clavulanic acid and it provided a reference protocol for patients with sulfonamide-resistant Nocardia or sulfonamides intolerance.","PeriodicalId":15639,"journal":{"name":"Journal of Dermatological Treatment","volume":"34 1","pages":"2229467"},"PeriodicalIF":3.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10116624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety and efficacy of hyaluronic acid injectable filler in the treatment of nasolabial fold wrinkle: a randomized, double-blind, self-controlled clinical trial. 透明质酸注射填充物治疗鼻唇沟皱纹的安全性和有效性：一项随机、双盲、自我对照的临床试验。

IF 2.9 4区医学

Journal of Dermatological Treatment Pub Date : 2023-12-01 Epub Date: 2023-09-11 DOI: 10.1080/09546634.2023.2190829

Xing-Zhou Li, Chi-Fu Chiang, Yung-Hsiang Lin, Tim-Mo Chen, Chih-Hsing Wang, Yuan-Sheng Tzeng, Hai-Yan Cui

{"title":"Safety and efficacy of hyaluronic acid injectable filler in the treatment of nasolabial fold wrinkle: a randomized, double-blind, self-controlled clinical trial.","authors":"Xing-Zhou Li, Chi-Fu Chiang, Yung-Hsiang Lin, Tim-Mo Chen, Chih-Hsing Wang, Yuan-Sheng Tzeng, Hai-Yan Cui","doi":"10.1080/09546634.2023.2190829","DOIUrl":"10.1080/09546634.2023.2190829","url":null,"abstract":"Introduction: The injectable skin fillers available for soft tissue augmentation are constantly growing, providing esthetic surgeons with more options in the treatment of scars, lines, and wrinkles. Hyaluronic acid (HA)-derived injectable fillers are ideal to reduce the appearance of nasolabial folding. This study investigated the efficacy and safety of the commercially available HA filler from Maxigen Biotech Inc. (MBI-FD) in the treatment of nasolabial folds (NLFs).Methods: We analyzed 1,4-butanediol diglycidyl ether (BDDE) residues and injection force test and observed the protein content in MBI-FD, and then was cultured in fibroblast L929 cells and examined for cytotoxicity. Finally, 95 healthy participants underwent dermal filler injection therapy to evaluate the efficacy and safety for 24 and 52 weeks, respectively.Results: BDDE residues in MBI-FD was <0.125 µg/mL. MBI-FD was fitted using 27- and 30-G injection needles with an average pushing force of 14.30 ± 2.07 and 36.43 ± 3.11 N, respectively. Sodium hyaluronate protein in MBI-FD was 7.19 µg/g. The cell viabilities of 1× and 0.5× MBI-FD were 83.25% ± 3.58% and 82.23% ± 1.85%, respectively, indicating MBI-FD had no cytotoxicity, and decreased NLF wrinkles with no serious adverse events.Conclusion: MBI-FD is an effective filler for tissue augmentation of the NLFs and may be a suitable candidate as an injectable dermal filler for tissue augmentation in humans in the future.","PeriodicalId":15639,"journal":{"name":"Journal of Dermatological Treatment","volume":" ","pages":"2190829"},"PeriodicalIF":2.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10202837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiple COVID reinfections in a vaccinated psoriatic patient receiving adalimumab. 一名接受阿达木单抗治疗的接种过疫苗的银屑病患者出现多次 COVID 再感染。

IF 2.9 4区医学

Journal of Dermatological Treatment Pub Date : 2023-12-01 Epub Date: 2022-11-22 DOI: 10.1080/09546634.2022.2149237

Omid Zargari, Seyyede Zeinab Azimi

{"title":"Multiple COVID reinfections in a vaccinated psoriatic patient receiving adalimumab.","authors":"Omid Zargari, Seyyede Zeinab Azimi","doi":"10.1080/09546634.2022.2149237","DOIUrl":"10.1080/09546634.2022.2149237","url":null,"abstract":"Currently, psoriasis patients are advised to follow their standard therapeutic regimen, and are advised to be vaccinated against Covid-19. However, the data about the antibody responses, induced by the various kinds of SARS-CoV-2 vaccines in psoriasis patients who require systemic immunosuppressive treatment is scant. In this case report, we describe antibody responses induced by COVID-19 vaccine, in a 26-year-old male patient with psoriasis being treated with anti-TNF biotherapy, adalimumab biosimilar every two weeks. The patient was vaccinated against COVID-19, according to the national protocol. He experienced three episodes of symptomatic COVID-19. His first and second exposures did not result in antibody production. After the third episode of COVID-19, The SARS-CoV-2 anti-spike antibody (IgG) was more than 100 Ru/mL (ELISA; ≥8 Ru/mL is considered positive), and SARS-CoV-2 neutralizing antibody (total) was more than 40 micg/mL (ELISA; ≥2.5 micg/mL is considered positive). This is the first case with weak antibody response to vaccination and multiple episodes of COVID infection in a psoriatic patient with adalimumab biosimilar. However, we cannot assume causality due to the treatment.","PeriodicalId":15639,"journal":{"name":"Journal of Dermatological Treatment","volume":" ","pages":"2149237"},"PeriodicalIF":2.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40705784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects and safety of fire needle adjuvant chemical peels therapy in acne vulgaris: a systematic review and meta-analysis. 火针辅助化学削皮治疗寻常痤疮的疗效和安全性：一项系统综述和荟萃分析。

IF 2.9 4区医学

Journal of Dermatological Treatment Pub Date : 2023-12-01 DOI: 10.1080/09546634.2023.2240455

Jianfeng Zhang, Peng Lin, Chenqi Guo, Cong Ma, Yiting Liu, Yingdong Wang, Yu Zhang

{"title":"Effects and safety of fire needle adjuvant chemical peels therapy in acne vulgaris: a systematic review and meta-analysis.","authors":"Jianfeng Zhang, Peng Lin, Chenqi Guo, Cong Ma, Yiting Liu, Yingdong Wang, Yu Zhang","doi":"10.1080/09546634.2023.2240455","DOIUrl":"10.1080/09546634.2023.2240455","url":null,"abstract":"Background: Acne vulgaris (AV) is a common skin disease. Fire needle is a method of quickly piercing the local skin lesions with red-hot needles for AV. This work aimed to evaluate the efficacy and safety of fire needle combined with chemical peels for AV.Methods: Eight databases including PubMed, EMBASE, Cochrane Library, Web of Science, China National Knowledge Internet, Wanfang, Sinomed, and VIP databases were searched to enrolled randomized controlled trials (RCTs) comparing fire needle therapy combined with chemical peels with chemical peels alone. The risk of bias was evaluated by the Cochrane Collaboration's tool. Statistical analysis was completed by RevMan 5.3 and Stata 14.0.Results: Altogether 18 studies including 1213 patients were enrolled. Compared with chemical peels alone, fire needle adjuvant chemical peels therapy improved the total effective rate (RR = 1.37,95% CI [1.26,1.48], p < 0.00001) and skin lesions (MD = -2.11, 95% CI [-2.74, -1.47], p < 0.00001), and reduced the recurrence rate (RR = 0.50,95% CI [0.33,0.76], p = 0.0009).The application of fire needle was associated with few adverse reactions, all of which were well tolerated and transient.Conclusion: Fire needle adjuvant chemical peels therapy is effective and safe for AV. Nevertheless, more large-scale, well-designed clinical studies are warranted to provide evidence-based medical support.","PeriodicalId":15639,"journal":{"name":"Journal of Dermatological Treatment","volume":"34 1","pages":"2240455"},"PeriodicalIF":2.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9884413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparing the odds of reported depression in psoriasis patients on systemic therapy: a cross-sectional analysis of postmarketing data. 比较接受系统治疗的银屑病患者报告抑郁的几率：上市后数据的横断面分析。

IF 2.9 4区医学

Journal of Dermatological Treatment Pub Date : 2023-12-01 Epub Date: 2023-01-19 DOI: 10.1080/09546634.2022.2152272

Samuel Yeroushalmi, Mimi Chung, Erin Bartholomew, Marwa Hakimi, John Koo

{"title":"Comparing the odds of reported depression in psoriasis patients on systemic therapy: a cross-sectional analysis of postmarketing data.","authors":"Samuel Yeroushalmi, Mimi Chung, Erin Bartholomew, Marwa Hakimi, John Koo","doi":"10.1080/09546634.2022.2152272","DOIUrl":"10.1080/09546634.2022.2152272","url":null,"abstract":"Patients with psoriasis are more likely to experience depression and suicidality compared to non-psoriatic patients, though systemic therapies have been shown to improve depressive symptoms. It is unclear whether or not biologic or oral agents are more effective at improving such depressive symptoms in psoriasis patients, however. We aimed to determine an estimate of the odds of incident depression in psoriasis patients on different systemic therapies by performing a cross-sectional analysis of postmarketing data. The reporting odds ratio (ROR) for 15 different systemic agents was calculated using reports from the Food and Drug Administration Adverse Events Reporting System (FAERS). After excluding brodalumab and apremilast due to high risk of reporting bias, we found oral agents were associated with a significantly higher ROR of depression compared to biologics (OR = 2.42, 95% confidence interval: 1.93-3.04). These results suggest biologics may be more effective at reducing incident depression than oral agents. Future controlled trials are needed to confirm these findings.","PeriodicalId":15639,"journal":{"name":"Journal of Dermatological Treatment","volume":" ","pages":"2152272"},"PeriodicalIF":2.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35260488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0