Journal of Diabetology最新文献

{"title":"Tirzepatide as a novel therapeutic option for patients with type 2 diabetes: A pooled analysis of subgroups of SURPASS 1-5 trials","authors":"M. Abdalla, Ireneous N. Soyiri, S. Atkin, T. Sathyapalan","doi":"10.4103/jod.jod_16_23","DOIUrl":"https://doi.org/10.4103/jod.jod_16_23","url":null,"abstract":"","PeriodicalId":15627,"journal":{"name":"Journal of Diabetology","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79224634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Papular lesions in a diabetic patient with COVID-19: A case report from India","authors":"Ashish S. Dengra, Jigyasa Dengra, F. Farishta, Ramchandani Gd","doi":"10.4103/jod.jod_70_22","DOIUrl":"https://doi.org/10.4103/jod.jod_70_22","url":null,"abstract":"","PeriodicalId":15627,"journal":{"name":"Journal of Diabetology","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77218853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucagon in the gut – brain axis","authors":"Rakesh M Parikh, Banshi Saboo, Viswanathan Mohan, Abdul Basit, Amit Gupta, Jayant K Panda, Mithun Bhartia, Pinar Topsever","doi":"10.4103/jod.jod_103_23","DOIUrl":"https://doi.org/10.4103/jod.jod_103_23","url":null,"abstract":"The intricate relationship between the gut and the brain has long captured the imagination of scientists, philosophers, and clinicians alike. Over the past few decades, research has unveiled a complex and bidirectional communication network that connects these seemingly distinct organs, giving rise to the concept of the gut–brain axis. This axis represents a dynamic and multifaceted system through which the gut and the brain exchange signals, impacting not only digestive processes but also a wide array of physiological and neurological functions. From influencing appetite and mood to playing a role in metabolic regulation, the gut–brain axis has emerged as a crucial nexus in understanding human health and well-being. This chapter delves into the intricate mechanisms that underlie the gut–brain axis, exploring its components and pathways with a special focus on the role played by glucagon. By unraveling the mysteries of this axis, we gain valuable insights into how our body’s diverse systems collaborate to maintain a delicate balance and how disturbances within this axis can contribute to a range of health conditions.","PeriodicalId":15627,"journal":{"name":"Journal of Diabetology","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135662400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prof. M. Viswanathan: The pride of Asia in diabetology","authors":"Satyavani Kumpatla, Vijay Viswanathan, Ambady Ramachandran, Viswanathan Mohan","doi":"10.4103/jod.jod_108_23","DOIUrl":"https://doi.org/10.4103/jod.jod_108_23","url":null,"abstract":"Dear Editor, Prof. M. Viswanathan (Prof. MV) was not just a doyen in the field of diabetes but also an astute clinician, teacher, researcher, and administrator. He made substantial contributions to diabetes care and research for nearly five decades. He was one of the most internationally recognized research scientists in India of his time. Prof. MV published more than 250 peer-reviewed research papers in prestigious national and international journals. His work propelled India to the forefront of diabetes care and research, and he played a pivotal role in elevating the nation’s status in this field. Born on August 26, 1923, in Kerala, India to Mr. A. K. Menon and Dr. M. Madhavi Amma (who was one of the first doctors of Kerala), Prof. MV’s career in medicine was greatly influenced by his mother. He pursued medicine at Stanley Medical College, Madras graduating in 1946, and worked as a House Physician. At a time, when diabetes was not regarded as a special field of study, he established the first organized diabetes clinic in India in 1948 at the Stanley Medical College. His dedication led to his promotion as Hon. Asst. Prof of Medicine and later as Hon. Prof of Medicine at the same college. In 1952, he married Sarada, who provided unwavering support throughout his life. Prof. MV voluntarily left government service with a view to setting up a hospital and research center devoted to clinical research in diabetes, the first of its kind in India. He also built up his private practice as a full-time Diabetologist. His achievements include the prestigious Dr.B.C.Roy National Award in 1982 for the development of the specialty of diabetology in India by the Medical Council of India. He has the unique honor of being the organizing secretary of three successive Association of Physicians of India (API) conferences. He held the posts of President, Association of Physicians of India, and President of the Scientific Section of the Diabetes Association of India with great distinction. He was also a member of the American Diabetes Association, British Diabetic Association, International Diabetes Federation, European Association for Study of Diabetes (EASD), and the Research Society for Study of Diabetes in India (RSSDI). At his center, Prof. MV created a modern reference library with well-organized resources for diabetes education and research. He also maintained a unique medical records system which served as a database for most of his long-term research findings. Many institutions sought his guidance in setting up modern and well-organized record-keeping departments. Prof. MV research efforts garnered numerous national and international honors and awards. He organized scientific conferences in India and also presented his research work at seminars and conferences worldwide. His primary objectives were to ensure high-quality diabetes research in India and more importantly to prevent and conquer diabetes. He pursued these goals relentlessly and with a missionary z","PeriodicalId":15627,"journal":{"name":"Journal of Diabetology","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135703814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of Tadalafil and Tadalafil + Dapoxetine in managing sexual dysfunction in individuals with type-2 diabetes mellitus: A clinical study","authors":"V. Chavda, S. Jha, T. Gandhi, A. Patel, Hiren Raninga, Amol Chaudhari, D. Hasnani","doi":"10.4103/jod.jod_123_22","DOIUrl":"https://doi.org/10.4103/jod.jod_123_22","url":null,"abstract":"Objective: The present study was aimed to evaluate effect of metabolic parameters on erectile dysfunction (ED) in individuals with type-2 diabetes mellitus (T2DM) and to assess the efficacy of Tadalafil and Tadalafil + Dapoxetine combination. Materials and Methods: A prospective, observational, cross-sectional, bicentric study included 216 males with T2DM who are not treated with phosphodiesterase 5 inhibitors and without chronic kidney disease. The data were obtained from demographic questionnaire, clinical laboratory reports of glycometabolic parameters namely body mass index (BMI), hemoglobin A1c (HbA1c), testosterone, vitamin B12 (VitB12), and lipid profile and analyses of the International Index of Erectile Function (IIEF) questionnaire. The effect of physical and metabolic parameters on IIEF sub-domains namely erectile function; orgasmic function; sexual desire (SD); intercourse satisfaction; and overall satisfaction was evaluated. A statistical significance was evaluated using χ2 test or t-test. Result: SD is most significantly lower in subjects with imbalanced physiological and metabolic characteristics including BMI, HbA1c, testosterone, VitB12, triglyceride, high-density lipoprotein, and low-density lipoprotein. Both Tadalafil and Tadalafil + Dapoxetine significantly improved almost all IIEF parameters without any pronounced effect of either. Similarly, both the treatments improved all the IIEF parameters for subjects with high BMI except for SD. In subjects with cardiac comorbidities, the use of either treatment significantly enhanced all the IIEF scores. Conclusion: The findings of this study outline the need of careful examination of sexual dysfunction in healthcare clinics for diabetic individuals. An imbalanced physiological and metabolic profile leads to ED in individuals with T2DM. Additionally, the presence of co-morbidities further elevates the odds of ED prevalence. The treatment with Tadalafil and Tadalafil + Dapoxetine drug combination shows promising results in improving the ED but a study with larger pool of subjects is needed to determine the additional benefits of Dapoxetine.","PeriodicalId":15627,"journal":{"name":"Journal of Diabetology","volume":"29 1","pages":"48 - 55"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87149416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of serum galectin-3 levels in patients with gestational diabetes mellitus","authors":"S. Baldane, M. Çelik, M. Korez, Emine Gul Baldane, S. Abuşoğlu, Unlu Ali, S. Ipekci, L. Kebapçılar","doi":"10.4103/jod.jod_84_22","DOIUrl":"https://doi.org/10.4103/jod.jod_84_22","url":null,"abstract":"Objective: This study was aimed to compare serum galectin-3 (Gal-3) levels in gestational diabetes mellitus (GDM) and healthy pregnant women and to evaluate the relationship between insulin resistance parameters and serum Gal-3 levels. Materials and Methods: Fifty-nine pregnant women who were screened for GDM with oral glucose tolerance tests (OGTT) at the 24th–28th gestational weeks were included in the study. According to the results of OGTT, 34 pregnant women were included in the GDM group and 25 pregnant women were included in the control group. Results: Serum Gal-3 value was found to be similar in the GDM and control group (P < 0.471). However, there was a significant positive association between Gal-3 and fasting insulin (r = 0.509, P < 0.001) and homeostasis model assessment of insulin resistance (HOMA-IR) (r = 0.479, P < 0.001) in the whole pregnancies, and between Gal-3 levels and fasting insulin (r = 0.608, P < 0.001), HOMA-IR (r = 0.609, P < 0.001), and OGTT 60 min glucose (r = 0.444, P = 0.016) in the GDM patients. Conclusions: There was no difference in the last trimester serum Gal-3 levels between GDM and healthy pregnant women. However, a significant positive correlation was determined between Gal-3 and fasting insulin, HOMA-IR, and OGTT 60 min glucose values in the GDM group, and fasting insulin and HOMA-IR values in whole pregnancies. The results of our study support previous data reporting the relationship between Gal-3 and GDM through insulin resistance.","PeriodicalId":15627,"journal":{"name":"Journal of Diabetology","volume":"55 1","pages":"28 - 33"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79254957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of gamma irradiation on the 24-h glycemic responses of parboiled brown rice diets in Asian Indian adults: A randomized cross-over study","authors":"S. Shobana, Rajagopal Gayathri, Mathiyazhagan Jayanthan, V. Sudha, S. Jamdar, N. Malleshi, Kamala Krishnaswamy, Ranjit Mohan Anjana, R. Unnikrishnan, V. Mohan","doi":"10.4103/jod.jod_81_22","DOIUrl":"https://doi.org/10.4103/jod.jod_81_22","url":null,"abstract":"Background: The nutritional importance of brown rice (BR) is well established. Despite several nutritional benefits of BR, its consumption remains limited due to long cooking time and limited shelf-life. BR can be subjected to processing to improve shelf-life. Gamma irradiation is one such strategy, but it could induce changes in the grain and thus affect its glycemic properties. Aims and objectives: The aim of this study was to look at the 24-h glycemic response of irradiated and non-irradiated BR-based iso-caloric diets in Asian Indians. Methods: Fifteen (mean body mass index: 24 ± 2.6 kg/m2) Asian Indian adults without diabetes, aged 25–39 years, participated in this randomized cross-over study. Iso-caloric diets were prepared with two varieties (ADT 43 and Swarna) of parboiled gamma-irradiated brown rice with 750–820 Gy dosage (IBR) and non-irradiated brown rice (NIBR). After the participants consumed these diets, 24-h glycemic responses were recorded using a continuous glucose monitoring system. The mean positive change from baseline glucose concentration was calculated as the incremental area under the curve (IAUC) for both the diets. Results: The percentage difference in 24-h average IAUC was 10% lower in the IBR diets when compared with NIBR diets, irrespective of the variety of BR (P = 0.56). In the case of ADT 43 rice variety, both IBR and NIBR diets showed similar IAUC (P = 0.68). However, the IBR of Swarna rice variety showed 21% lower IAUC when compared with the NIBR diet (P = 0.21). Comparing the IBR varieties, Swarna showed 21% lower IAUC than ADT 43 (P = 0.21), whereas between NIBR varieties, only 0.79% difference was observed between ADT 43 and Swarna (P = 0.93). Conclusions: Gamma irradiation of parboiled BR did not produce significant differences in the 24-h glycemic responses for BR-based diets. Swarna variety was better than ADT 43 with regard to glycemic response. Judicious application of radiation technology to BR varieties may help in shelf-life extension without affecting the glycemic properties.","PeriodicalId":15627,"journal":{"name":"Journal of Diabetology","volume":"43 1 1","pages":"20 - 27"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76914413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health literacy, medication belief, and demographic factors as correlates of medication adherence in person with diabetes mellitus","authors":"O. Olorunfemi","doi":"10.4103/jod.jod_4_23","DOIUrl":"https://doi.org/10.4103/jod.jod_4_23","url":null,"abstract":"","PeriodicalId":15627,"journal":{"name":"Journal of Diabetology","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88293819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Historical perspectives of glucagon’s discovery and early research","authors":"Debashish Brahmachari, Shabeen Naz Masood, Umaira Aziz, Tatjana Milenkovic, Manoj Chawla, A G Unnikrishnan, Sujoy Ghosh, João Raposo, Banshi Saboo, Viswanathan Mohan","doi":"10.4103/jod.jod_107_23","DOIUrl":"https://doi.org/10.4103/jod.jod_107_23","url":null,"abstract":"Abstract This review article looks at the historical journey of the discovery of glucagon and the initial stages of research that paved the way for a comprehensive understanding of its physiological significance. Glucagon, an essential peptide hormone produced by the pancreas, plays a pivotal role in maintaining glucose homeostasis. Tracing the trajectory of its discovery from its initial identification to the unraveling of its complex functions, this article offers a detailed analysis of the early scientific endeavors, and collaborations that contributed to shaping our understanding of glucagon’s pivotal role. By exploring the historical context, controversies, and advancements, this review sheds light on the evolution of endocrinological knowledge and its profound implications for diabetes research and treatment strategies.","PeriodicalId":15627,"journal":{"name":"Journal of Diabetology","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135703807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Centenary of glucagon discovery and birth centenary of a pioneer in diabetology in India","authors":"Banshi Saboo, Akhtar Hussain, Abdul Basit, Viswanathan Mohan","doi":"10.4103/jod.jod_109_23","DOIUrl":"https://doi.org/10.4103/jod.jod_109_23","url":null,"abstract":"Dear Editor, We are very happy to present a special issue of the Journal of Diabetology (JOD) which is dedicated to the centenary celebrations of two major events. The year 2023 marks the birth centenary of Prof. M. Viswanathan, considered the “Father of Diabetology in India.” 2023 also marks the centenary of the discovery of the enigmatic hormone, glucagon. To mark these two very special occasions, JOD is proud to present a special tribute to Prof. M. Viswanathan, written by his two sons, Dr. V. Mohan and Dr. Vijay Viswanathan, and his son-in-law, Dr. A. Ramachandran, all of whom were personally mentored by Prof. M. Viswanathan. We dedicate this issue to Prof. M. Viswanathan whose contributions are legendary. He is credited with starting the specialty of Diabetology in India. This year also marks the centenary of the discovery of glucagon, the pancreatic hormone produced by the alpha cells of the islets of Langerhans. To commemorate the centenary of glucagon, we invited specialists from different parts of the world to contribute articles for a special issue dedicated to glucagon. This includes historical aspects, including its discovery, and goes on to describe its increasing role today in the management of both diabetes and obesity. We are very grateful to the authors who have contributed articles for the special issue of JOD at short notice. We do hope you will enjoy reading about this oft-forgotten, but important, hormone, glucagon. Financial support and sponsorship Nil. Conflicts of interest There are no conflicts of interest.","PeriodicalId":15627,"journal":{"name":"Journal of Diabetology","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135703811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}