Journal of Computational Biophysics and Chemistry最新文献_第9页

Computational Screening of D-π-A Structured with Acceptor Tuned Metal-Free Organic Dye Molecules for DSSCs 用于DSSC的受体调谐无金属有机染料分子D-π-A结构的计算筛选

IF 2.2 4区化学

Journal of Computational Biophysics and Chemistry Pub Date : 2022-12-01 DOI: 10.1142/s2737416523500138

A. Arunkumar, P. Anbarasan, M. Shkir, V. Balasubramani

引用次数: 1

Unveiling Attributes of Human 15-Lipoxygenase-1 as a Potential Candidate for Prostate Cancer Drug Development Using in Silico Approaches 揭示人15-脂氧合酶-1作为前列腺癌症药物开发的潜在候选物在硅方法中的作用

IF 2.2 4区化学

Journal of Computational Biophysics and Chemistry Pub Date : 2022-11-30 DOI: 10.1142/s2737416523500060

Shirin Fathi, A. Sakhteman, Aida Solhjoo

{"title":"Unveiling Attributes of Human 15-Lipoxygenase-1 as a Potential Candidate for Prostate Cancer Drug Development Using in Silico Approaches","authors":"Shirin Fathi, A. Sakhteman, Aida Solhjoo","doi":"10.1142/s2737416523500060","DOIUrl":"https://doi.org/10.1142/s2737416523500060","url":null,"abstract":"Prostate carcinoma is one of the most commonly diagnosed visceral malignancies and the fifth leading cause of cancer-related mortality in males. Reportedly, a series of dietary lipids are identified as 1-cis-4-cis-pentadiene polyunsaturated fatty acids (PUFAs), which play a dominant role in prostate carcinogenesis. Four species of human lipoxygenases (LOXs), a family of nonheme iron-containing enzymes, mediate the deoxygenation of the aforementioned PUFAs. 15-LOX-1 in particular metabolizes the [Formula: see text]-6 lipids and generates certain metabolites (e.g., 13-(S)-hydroxyoctadecaenoic acid) which results in vascular homeostasis, cell proliferation and tissue differentiation in the prostate. Furthermore, in prostate cancer (PCa), the expression of 15-LOX-1 is elevated and positively correlated with the Gleason score of the tumor (an indicator of the disease severity). As membrane receptors, kinases and transcriptional factors are all affected by carcinogenic signals of 15-LOX-1, therapeutic agents that directly inhibit this enzyme can be advantageous in the treatment of PCa. To our knowledge, there are limited effective treatments for PCa, and there is no therapy for its metastatic condition. In this respect, 15-LOX-1, as an appropriate candidate for drug development, was subjected to homology modeling, phylogenic assessment, cross-docking analysis and molecular dynamics (MD) simulation to identify an eligible inhibiting agent amongst a library of 30 potential targeting compounds for PCa management.","PeriodicalId":15603,"journal":{"name":"Journal of Computational Biophysics and Chemistry","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46288457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stratified Bioconvective Jet Flow of Williamson Nanofluid in Porous Medium in the Presence of Arrhenius Activation Energy Arrhenius活化能存在下Williamson纳米流体在多孔介质中的分层生物转化射流

IF 2.2 4区化学

Journal of Computational Biophysics and Chemistry Pub Date : 2022-11-25 DOI: 10.1142/s2737416523400069

V. Puneeth, S. Manjunatha, M. S. Anwar, M. Oreijah, Kamel Geudri, O. Bafakeeh, A. Galal

{"title":"Stratified Bioconvective Jet Flow of Williamson Nanofluid in Porous Medium in the Presence of Arrhenius Activation Energy","authors":"V. Puneeth, S. Manjunatha, M. S. Anwar, M. Oreijah, Kamel Geudri, O. Bafakeeh, A. Galal","doi":"10.1142/s2737416523400069","DOIUrl":"https://doi.org/10.1142/s2737416523400069","url":null,"abstract":"Due to the higher coefficients of heat and mass transfer, the jet flow has become an effective source for the transfer of heat and mass in various industries. Due to these high coefficients, the heat and mass transfer rates will be high in the appliances equipped with the jet flow. Further, the existence of the magnetic field helps in controlling the velocity and the presence of the gyrotactic microorganisms ensure proper mixing of nanoparticles. A dilute nanoparticle suspension is assumed so that it will not affect the movement of motile cells that leads to bioconvection. Hence, this paper aims to analyze the characteristics of heat transfer as well as mass transfer of the jet flow of Williamson nanofluid past a porous stretching sheet in the existence of microorganisms. The mathematical model obtained as a result of these assumptions is transformed into nonlinear ordinary differential equations for which acceptable solutions are obtained using the numerical method. The results thus obtained are presented graphically and based on the outcomes, it is perceived that the magnetic field has control over the velocity profile thus influencing the thermal profile. The increase in the Williamson parameter also reduces the velocity of the fluid flow. Further, an increase was noticed in the thermal and concentration profiles of the nanofluid for higher values of thermophoresis parameter and the increase in the porosity reduced the speed of the flow of nanofluid.","PeriodicalId":15603,"journal":{"name":"Journal of Computational Biophysics and Chemistry","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2022-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49394508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Identification of Novel 5-Lipoxygenase-Activating Protein (FLAP) Inhibitors by an Integrated Method of Pharmacophore Virtual Screening, Docking, QSAR and ADMET Analyses 基于药效团虚拟筛选、对接、QSAR和ADMET分析的新型5-脂氧合酶激活蛋白(FLAP)抑制剂鉴定

IF 2.2 4区化学

Journal of Computational Biophysics and Chemistry Pub Date : 2022-11-25 DOI: 10.1142/s2737416523500059

Kamal Rullah, M. Roney, Z. Ibrahim, Nur Farisya Shamsudin, Deri Islami, Q. Ahmed, L. Wai, M. Aluwi

{"title":"Identification of Novel 5-Lipoxygenase-Activating Protein (FLAP) Inhibitors by an Integrated Method of Pharmacophore Virtual Screening, Docking, QSAR and ADMET Analyses","authors":"Kamal Rullah, M. Roney, Z. Ibrahim, Nur Farisya Shamsudin, Deri Islami, Q. Ahmed, L. Wai, M. Aluwi","doi":"10.1142/s2737416523500059","DOIUrl":"https://doi.org/10.1142/s2737416523500059","url":null,"abstract":"This study explored a series of reported 5-lipoxygenase-activating protein (FLAP) inhibitors to understand their structural requirements and identify potential new inhibitor scaffolds through automated unbiased procedures. Docking studies have revealed that inhibitor binding affinity can be influenced by several key binding interactions with Phe114 and Lys116 from chain B and Val21, Phe25, His28 and Lys29 from chain C in the FLAP-binding site. A ligand-based alignment three-dimensional (3D)-quantitative structure–activity relationship (QSAR) was adopted, resulting in a robust model with a statistically significant noncross-validated coefficient ([Formula: see text]), a cross-validated correlation coefficient ([Formula: see text]) and a predictive squared correlation coefficient ([Formula: see text]). Overall, the analysis revealed the important electrostatic and steric attributes responsible for the FLAP inhibitory activity, which appeared to correlate well with the docking results. In addition, two statistically significant two-dimensional (2D)-QSAR models ([Formula: see text], [Formula: see text] and [Formula: see text], [Formula: see text]) were developed by a genetic function approximation (GFA). HypoGen 1, a proposed pharmacophore model, was used for database mining to identify potential new FLAP inhibitors. The bioactivity of the retrieved hits was then evaluated in silico based on the validated QSAR models, followed by pharmacokinetics and toxicity predictions.","PeriodicalId":15603,"journal":{"name":"Journal of Computational Biophysics and Chemistry","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2022-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47990079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Determining Zn(II) binding affinities of the YiiP zinc transporter and UFsc (Uno Ferro Single Chain) Protein with a novel modification of the PKA17 software 用PKA17软件的新修饰测定YiiP锌转运蛋白和UFsc（Uno-Ferro单链）蛋白的Zn（II）结合亲和力

IF 2.2 4区化学

Journal of Computational Biophysics and Chemistry Pub Date : 2022-11-25 DOI: 10.1142/s2737416523500126

George A. Kaminski, Greggory W. Raymond

引用次数: 0

Selectivity Mechanism of Hsp90 Isoform Inhibition through Computational Investigation 计算研究Hsp90异构体抑制的选择性机制

IF 2.2 4区化学

Journal of Computational Biophysics and Chemistry Pub Date : 2022-11-25 DOI: 10.1142/s2737416523500114

Han Xu, Han-xun Wang, Baichun Hu, Yinli Gao, Lanlan Shen, Jian Wang

引用次数: 0

Thermodynamics and heat transfer analysis of magnetized Casson hybrid nanofluid flow via a Riga plate with thermal radiation 磁化卡森混合纳米流体通过热辐射里加板的热力学和传热分析

IF 2.2 4区化学

Journal of Computational Biophysics and Chemistry Pub Date : 2022-11-25 DOI: 10.1142/s2737416523400070

Himanshu Upreti, A. Pandey, Navneet Joshi, O. Makinde

引用次数: 7

Bioinformatics and Molecular dynamics studies on the human DISC1 in complex with the Ndel1 人DISC1与Ndel1复合物的生物信息学和分子动力学研究

IF 2.2 4区化学

Journal of Computational Biophysics and Chemistry Pub Date : 2022-11-18 DOI: 10.1142/s2737416523500084

Mohammad Yaghoubzad-Maleki, Saba Habibi, Emran Heshmati, Khosrow Khalifeh

引用次数: 0

Alkali and Transition Metal Doped 15-crown-5 with Enhanced Non-linear Optical Response: A DFT Study 碱和过渡金属掺杂15-冠-5增强非线性光学响应的DFT研究

IF 2.2 4区化学

Journal of Computational Biophysics and Chemistry Pub Date : 2022-11-18 DOI: 10.1142/s2737416523500096

Naima Rafique, Hillia Fatima, Muhammad Ans, K. Ayub, J. Iqbal

引用次数: 0

Designing of Un-Fused Electron Acceptors with Enhanced Power Conversion Efficiency by Introducing Unique S–O Noncovalent Interaction 通过引入独特的S-O非共价相互作用来设计具有提高功率转换效率的非融合电子受体

IF 2.2 4区化学

Journal of Computational Biophysics and Chemistry Pub Date : 2022-11-14 DOI: 10.1142/s2737416523500035

Muhammad Shahzeb Khan, Hameed ul Haq, S. Ullah, S. E. Z. Syeda, Muhammad Arshad, Bushra Nasrullah

{"title":"Designing of Un-Fused Electron Acceptors with Enhanced Power Conversion Efficiency by Introducing Unique S–O Noncovalent Interaction","authors":"Muhammad Shahzeb Khan, Hameed ul Haq, S. Ullah, S. E. Z. Syeda, Muhammad Arshad, Bushra Nasrullah","doi":"10.1142/s2737416523500035","DOIUrl":"https://doi.org/10.1142/s2737416523500035","url":null,"abstract":"Terminal units’ modification is an effective strategy for designing efficient un-fused nonfullerene acceptors (UF-NFAs) with enhanced power conversion efficiency (PCE). Nowadays, researchers are focused on designing new UF-NFAs that enhance the PCE of organic solar cells. In this line, efforts are being made to design new UF-NFAs for possible application on organic solar cells (OSCs). By doing terminal unit modification of the Cl-4F molecule, we have designed a new series of UF-NFA (ETPJ-1–ETPJ-4). Density functional theory (DFT) and time-dependent density functional theory (TD-DFT) at the B3LYP/6-311G([Formula: see text]) level have been employed for the computation of various geometric and photovoltaic aspects. Energies of highest occupied molecular orbitals (HOMO) and lowest unoccupied molecular orbitals (LUMO) with their band gap suggested that ETPJ-1–ETPJ-4 are effective contributors to the design of the efficient active layer of OSCs. Red-shift (near IR) in the absorption spectrum with easy excitation of exciton has been noted in ETPJ-1–ETPJ-4. Enhanced open circuit voltage with high fill factor percentage (FF%) was also noted for designed systems. Further, the PCE values of the ETPJ-1–ETPJ-4 are better than the reference molecule. So, we recommended a novel kind of unfused nonfullerene acceptors (NFAs) with unique S–O noncovalent interaction for possible application in OSCs.","PeriodicalId":15603,"journal":{"name":"Journal of Computational Biophysics and Chemistry","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44727030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1