Journal of Dermatology and Dermatologic Surgery最新文献

{"title":"Prevalence of topical corticosteroid use without prescription in Saudi Arabia: A cross-sectional study","authors":"S. Al-Aojan, Alanoud Al-Marzoug, Abdulrahman Alaujan, Samiah Abanmi, M. Aljasser","doi":"10.4103/jdds.jdds_21_21","DOIUrl":"https://doi.org/10.4103/jdds.jdds_21_21","url":null,"abstract":"Background: Misuse of topical corticosteroids (TCS) is common and constitutes a serious problem in many parts of the world where they can be obtained without prescription. Limited studies have been performed in Saudi Arabia to address this issue. Purpose: We aim to study the prevalence, predisposing factors, and adverse consequences of TCS use without prescription in Saudi Arabia. Methods: A cross-sectional study was performed using an Arabic questionnaire distributed through social media applications in May 2020 in Saudi Arabia. Individuals aged 18 years and above who used TCS within the last 2 years were included. The questionnaire consisted of detailed questions about TCS use and demographic information. Results: A total of 720 participants completed the questionnaire. TCS were used without prescription by 43.1% of respondents. Being female was the only identified risk factor for the use of TCS without prescription. The main reason for purchasing TCS without prescription was that the problem seemed too trivial to consult a physician (36.6%). The most common conditions for which TCS were used were treatment of pruritus without skin disease (23.7%) and cosmetic reasons (19.9%). Side effects were reported in 25.6% of participants. The most common side effects were hypopigmentation, itching, redness, and skin sensitivity. Conclusion: The use of TCS without prescription is prevalent in Saudi Arabia. We recommend that local health authorities regulate the use of TCS.","PeriodicalId":15535,"journal":{"name":"Journal of Dermatology and Dermatologic Surgery","volume":"1 1","pages":"76 - 79"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89042921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of viral skin disease: An increased burden in childhood and a correlation with atopic dermatitis and gross domestic product","authors":"S. Himed, S. Muddasani, Alan Fleischer","doi":"10.4103/jdds.jdds_23_21","DOIUrl":"https://doi.org/10.4103/jdds.jdds_23_21","url":null,"abstract":"Background: Viral cutaneous infections have impact globally due to several factors, including changing rates of atopic dermatitis (AD), vaccination rates, and access to trained dermatologists. Furthermore, advancements in treatments and access to vaccinations suggest an association between the wealth of countries and the burden of their disease. Purpose: The overall purpose of this study is to better understand the global impact of viral skin disease across differing demographics and time periods, as well as the burden in relation to national wealth. Methods: In this article, the prevalence, incidence, and years lived with disability (YLDs) were analyzed for viral cutaneous infections in 195 countries from 1990 to 2019, using the global burden of disease dataset. Furthermore, the disease burden was assessed as a function of gross-domestic product (GDP) and AD. Results: The prevalence of individuals affected by viral skin diseases is approximately 154 million globally. Young children (1–9 years old) were more likely to be affected. The age-standardized prevalence rates per 100,000 in the Americas and Asia decreased between 1990 and 2019 from 2819 to 2650 and from 2074 to 1906, respectively. This decrease was outside the 95% uncertainty interval. Increased GDP predicted increased prevalence and YLD (P < 0.0001). There was a relationship between 1 year lived with disability per capita of AD and an increase of 0.14 (0.07, 0.21) cases of viral skin diseases (P = 0.002). Conclusion: The increase in disease burden with increased GDP may be correlated to decreased access to dermatologists in developing countries. An increased burden with AD is likely due to skin barrier and immune regulatory dysfunction. The morbidity of skin diseases demonstrates the need for increased access to vaccination campaigns and dermatologic care across developing nations.","PeriodicalId":15535,"journal":{"name":"Journal of Dermatology and Dermatologic Surgery","volume":"5 1","pages":"65 - 69"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88808204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary cutaneous gamma-delta T-cell lymphoma: Two cases and a review of the literature","authors":"Matthew L. Hrin, Megan Newsom, R. Ghamrawi, A. Niehaus, Steven R. Feldman, J. Sigmon, L. Strowd","doi":"10.4103/jdds.jdds_54_21","DOIUrl":"https://doi.org/10.4103/jdds.jdds_54_21","url":null,"abstract":"Background: Primary cutaneous gamma delta T cell lymphoma (PCGD TCL) is a rare and rapidly progressive cutaneous malignancy that can be diagnostically challenging. Purpose: To improve characterization of the clinical and histologic features of PCGD-TCL. Methods: We present two patients with PCGD TCL and review an additional 97 PCGD TCL cases from the English literature. Results: A 51 year old male with biopsy proven psoriasis and a previously healthy 31 year old male with vitiligo developed PCGD-TCL. Initial biopsy specimens in both patients suggested tumor stage mycosis fungoides (MF), but subsequent histopathology confirmed PCGD TCL. Ninety-seven patients were identified in the literature, mostly males (53%) with a mean age of 55.2 years. Lesions most commonly involved the lower (60%) and upper (30%) extremities and existed a mean of 26 months before diagnosis. The most common immunohistochemical markers were EBV(-), CD3(+), CD4(-), CD5(-), CD7(-), CD8(-), CD30(-), CD56(+), granzyme-B(+), perforin(+), and βF1(-). Radiation and CHOP chemotherapy were the most common interventions and 52% of patients died. Conclusion: PCGD TCL is a devastating disease that can clinically and histologically mimic more common dermatologic conditions, such as psoriasis and MF, and its diagnosis may require multiple biopsies and review by a multi specialty pathology team.","PeriodicalId":15535,"journal":{"name":"Journal of Dermatology and Dermatologic Surgery","volume":"44 1","pages":"54 - 58"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90225231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factor structure of the Bengali version of atopic dermatitis burden scale for adults: A cross-sectional study","authors":"Ekta Agrawal, A. Gautam, A. Shaikh, S. Dutta, S. Dey, S. Mukherjee, Sangita Saha, Sanjukta Mandal, Shubhamoy Ghosh, M. Koley, S. Saha","doi":"10.4103/jdds.jdds_145_20","DOIUrl":"https://doi.org/10.4103/jdds.jdds_145_20","url":null,"abstract":"Background: Atopic dermatitis (AD) is associated with increased burden and reduced health-related quality of life (HRQoL); however, there is no available Bengali questionnaire assessing the same. Purpose: We aimed to develop the Bengali version of the questionnaire and examine its cross-cultural adaptability considering linguistic equivalence. Methods: A multicentric, mixed methods, cross-sectional study was conducted through the consecutive sampling at the outpatients of three homeopathy hospitals in West Bengal. The Bengali version of the questionnaire was produced by standardized forward-backward translations. Psychometric analysis was run to examine its factor structure, validity, and reliability. Reliability was examined using internal consistency (n = 230). Construct validity was examined by the exploratory factor analysis (EFA; n = 115) using the principal component analysis (PCA; varimax rotation). Subsequently, confirmatory factor analysis (CFA; n = 115) was performed to verify the model fit. Results: The internal consistency (Cronbach's α =0.876 (95% confidence interval 0.851–0.898)), test-retest reliability and concurrent validity – all were within the acceptable limits. The Kaiser-Meyer-Olkin (KMO = 0.793) and Bartlett's test of sphericity (Chi-square: 1038.981 at 153° of freedom, P < 0.001) both suggested adequacy of the sample. In factor analysis using varimax, all the items loaded above the prespecified value of 0.4 and identified five components, explaining 68.3% of the variation. The goodness-of-fit of the 5-components model in CFA was also acceptable (comparative fit index = 0.858, Tucker Lewis index = 0.823, root mean square error of approximation = 0.102, and standardized root mean square residual = 0.188). Conclusion: The Bengali version of the questionnaire consisting of 18 items and framed within five components appeared to be a valid and reliable instrument measuring disease burden and HRQoL in adults suffering from AD.","PeriodicalId":15535,"journal":{"name":"Journal of Dermatology and Dermatologic Surgery","volume":"69 1","pages":"102 - 113"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81375290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy and neonatal outcome with maternal exposure to finasteride: Case series","authors":"Hessah BinJadeed, Abdulmajeed M Alajlan","doi":"10.4103/jdds.jdds_33_21","DOIUrl":"https://doi.org/10.4103/jdds.jdds_33_21","url":null,"abstract":"Background: Finasteride, a type II 5-α reductase inhibitor, is approved for the management of benign prostate hyperplasia and male pattern hair loss. Finasteride is used off-label for female pattern hair loss. In utero fetal exposure to finasteride might lead to external genital anomalies in males. Purpose: The aim of this study is to assess the outcomes of in utero finasteride exposure. Methods: We report seven pregnant women with maternal exposure to finasteride. A detailed history was obtained from patients after delivery. Results: In one woman who was pregnant with twin boys, one boy died at the 16th week of gestation and the other delivered at the 34th week of gestation with hypospadias. Another woman had threatened abortion and delivered a normal healthy baby girl. A third had induced elective abortion in the 9th week of gestation. The outcomes of the other four pregnancies were completely healthy, three girls and one boy. Conclusion: External genital anomalies may occur in male fetuses exposed in utero to finasteride depending on the timing of exposure.","PeriodicalId":15535,"journal":{"name":"Journal of Dermatology and Dermatologic Surgery","volume":"49 1","pages":"84 - 86"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87027534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dental decay and salivary flow in patients taking systemic isotretinoin: A prospective study","authors":"Norah Alkanhal, Mohammed Aldaij, Haya F. Alkanhal, M. Al-Haddab, Fawziah Alfaifi","doi":"10.4103/jdds.jdds_122_20","DOIUrl":"https://doi.org/10.4103/jdds.jdds_122_20","url":null,"abstract":"Background: Isotretinoin causes dryness of the mucous membranes. Medications altering the salivary flow are a risk factor for dental caries. Purpose: To prospectively assess caries and salivary flow in patients taking systemic isotretinoin. Methods: Twenty-four patients treated with 0.5 mg/kg of isotretinoin every day for 8 months were studied. The control group was the same patients before start taking oral Isotretinoin. Salivary flow, buffer capacity, bacterial tests, and caries status based on the decay, missing, and filled teeth (DMFT) index were assessed. Results: At baseline, there was slight to moderate calculus on the teeth. DMFT index, stimulated saliva flow, and bacterial tests for Streptococcus mutans increased during isotretinoin treatment (P < 0.05). There was no significant difference (P > 0.05) in buffering capacity or Lactobacillus. Conclusion: Systemic isotretinoin increased the DMFT index and bacteria rate and decreased salivary flow that might lead to dental caries.","PeriodicalId":15535,"journal":{"name":"Journal of Dermatology and Dermatologic Surgery","volume":"45 1","pages":"80 - 83"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73126128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microneedling: A means of collagen induction therapy","authors":"P. Nair, J. Tandel","doi":"10.4103/jdds.jdds_126_20","DOIUrl":"https://doi.org/10.4103/jdds.jdds_126_20","url":null,"abstract":"Background: Collagen induction therapy is a form of microneedling. It is cheap and effective and has less side effects than other alternative therapies. Purpose: It is done using dermaroller for the treatment of scars, wrinkles, stretch marks, hair growth, and transdermal delivery of substances like lipopeptides and antiaging products. Methods: It acts by stimulating collagen production, produces microwounds and thus release of various inflammatory mediators. It also increases electric potential, thus inducing cellular activity with release of cytokines and growth factors leading to wound healing with collagen induction. Results: There are various new modified instruments, and combination with other modalities of treatment increases its utility in different dermatological and cosmetic conditions. Conclusions: Microneedling is a simple, inexpensive procedure with no down time and good results in acne scars, hair loss and wrinkles.","PeriodicalId":15535,"journal":{"name":"Journal of Dermatology and Dermatologic Surgery","volume":"78 1","pages":"49 - 53"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79063119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Public knowledge and attitude toward vitiligo in Saudi Arabia: A cross-sectional study","authors":"M. Algarni, Waleed A Alqarni, L. Alghanemi, M. Alnashri, Rand G. Alghanemi, N. Mleeh","doi":"10.4103/jdds.jdds_134_20","DOIUrl":"https://doi.org/10.4103/jdds.jdds_134_20","url":null,"abstract":"Background: Knowledge and positive attitude toward vitiligo would foster support for affected individuals, improving their sense of well-being and possibly treatment outcome. Purpose: To evaluate the levels of public knowledge and attitude toward vitiligo among Saudis. Methods: A cross-sectional study among 12,181 participants. Data were collected using a self-administered questionnaire enquiring about knowledge, attitude, and perceptions in vitiligo. Results: The response rate was 95.4%. Most respondents had heard about vitiligo (96.9%). The median knowledge score was four out of eight and median attitude score was six out of eight. Social media/Internet was the most commonly reported source of information (34.7%), followed by family/friends/acquaintances (30%). Higher proportions of correct responses were recorded regarding the noninfectious nature of vitiligo (85.0%) and whether vitiligo was dangerous or connected to skin cancer (63.4%). However, unsatisfactory responses were found regarding the immunological basis of the condition: only 24.3% knew that vitiligo was an immune disease and 24.5% knew about the role of heredity in vitiligo. The majority of respondents did not mind employing patients with vitiligo (89.0%). Only 40.6% responded that they would marry someone with vitiligo. Positive attitude was significantly common in respondents aged 31–50 years (P < 0.01), women (P < 0.01), and those who had a university degree or higher (P < 0.05). Conclusion: Although overall attitude toward vitiligo patients was positive, there were gaps in the knowledge, particularly regarding the nature of the disease. More awareness and education are required to improve attitude toward vitiligo patients, with an aim to improve their overall well-being.","PeriodicalId":15535,"journal":{"name":"Journal of Dermatology and Dermatologic Surgery","volume":"70 1","pages":"59 - 64"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78209652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of life and psychological aspects of patients with hidradenitis suppurativa in Saudi Arabia: A hospital-based multi-center study","authors":"S. Alsharif, Zakaria Khan, Fahad Almuntashri, Ahmad Alghamdi","doi":"10.4103/jdds.jdds_30_21","DOIUrl":"https://doi.org/10.4103/jdds.jdds_30_21","url":null,"abstract":"Background: Hidradenitis suppurativa (HS) is a chronic recurrent painful auto-inflammatory skin disease of the terminal hair follicle, causing nodules, abscesses, sinus tracts, and scars on intertriginous areas. Purpose: This study aims is to determine the effect of HS on patients' psychology and quality of life in the Makkah population. Methods: This is a cross-sectional, multi-center study conducted on HS patients who visited the dermatology clinic during 2017−2020. A total of 165 patients participated in the study by completing a questionnaire consisting of demographic data, the dermatology life quality index, depression, anxiety, and stress score. Results: In total, 147 patients were included in the final analysis, and the mean age of the participants was 32.0 ± 10.6. HS had a very large effect on the quality of life of 32% of the participants. Quality of life was worse with the number of flares per year (P < 0.003) and with axillary and perianal involvement, (P < 0.018 and P < 0.024, respectively). Moreover, a higher level of depression was associated with a higher body mass index (P < 0.020). Conclusion: HS had a large effect on the quality of life regardless of Hurley stage and was correlated with the number of flares per year and area of disease involvement.","PeriodicalId":15535,"journal":{"name":"Journal of Dermatology and Dermatologic Surgery","volume":"1 1","pages":"95 - 101"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90127119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prurigo pigmentosa: A case report with clinical, dermoscopic, and histological findings","authors":"S. Samarkandy, Bader Alharbi, BaselBandar Almalki, Samer A Alamri","doi":"10.4103/jdds.jdds_37_20","DOIUrl":"https://doi.org/10.4103/jdds.jdds_37_20","url":null,"abstract":"Prurigo pigmentosa (PP) was originally reported in Japan. It is an uncommon inflammatory skin disorder that usually involves the neck and trunk and characterized by a sudden eruption of pruritic indurated macules, papules, and Vescio papules that involute, leaving a reticulated pigmentation. It commonly affects young adult females. PP was initially thought to have a predilection for the Asian race, however several cases have been reported worldwide. The exact etiology of PP is yet unclear. However, it has been associated with ketosis and a ketogenic diet. Oral antibiotic is a major treatment in this disorder, while topical steroid and antihistamines are not successful.","PeriodicalId":15535,"journal":{"name":"Journal of Dermatology and Dermatologic Surgery","volume":"1 1","pages":"134 - 136"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85537622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}