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Journal of Clinical and Translational Hepatology最新文献

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Serum Iron Overload Activates the SMAD Pathway and Hepcidin Expression of Hepatocytes via SMURF1. 血清铁超载通过 SMURF1 激活 SMAD 通路和肝细胞的 Hepcidin 表达
IF 3.6 3区 医学
Journal of Clinical and Translational Hepatology Pub Date : 2024-03-28 Epub Date: 2024-02-04 DOI: 10.14218/JCTH.2023.00440
Ning Zhang, Pengyao Yang, Yanmeng Li, Qin Ouyang, Fei Hou, Guixin Zhu, Bei Zhang, Jian Huang, Jidong Jia, Anjian Xu
{"title":"Serum Iron Overload Activates the SMAD Pathway and Hepcidin Expression of Hepatocytes via SMURF1.","authors":"Ning Zhang, Pengyao Yang, Yanmeng Li, Qin Ouyang, Fei Hou, Guixin Zhu, Bei Zhang, Jian Huang, Jidong Jia, Anjian Xu","doi":"10.14218/JCTH.2023.00440","DOIUrl":"10.14218/JCTH.2023.00440","url":null,"abstract":"<p><strong>Background and aims: </strong>Liver iron overload can induce hepatic expression of bone morphogenic protein (BMP) 6 and activate the BMP/SMAD pathway. However, serum iron overload can also activate SMAD but does not induce BMP6 expression. Therefore, the mechanisms through which serum iron overload activates the BMP/SMAD pathway remain unclear. This study aimed to clarify the role of SMURF1 in serum iron overload and the BMP/SMAD pathway.</p><p><strong>Methods: </strong>A cell model of serum iron overload was established by treating hepatocytes with 2 mg/mL of holo-transferrin (Holo-Tf). A serum iron overload mouse model and a liver iron overload mouse model were established by intraperitoneally injecting 10 mg of Holo-Tf into C57BL/6 mice and administering a high-iron diet for 1 week followed by a low-iron diet for 2 days. Western blotting and real-time PCR were performed to evaluate the activation of the BMP/SMAD pathway and the expression of hepcidin.</p><p><strong>Results: </strong>Holo-Tf augmented the sensitivity and responsiveness of hepatocytes to BMP6. The E3 ubiquitin-protein ligase SMURF1 mediated Holo-Tf-induced SMAD1/5 activation and hepcidin expression; specifically, SMURF1 expression dramatically decreased when the serum iron concentration was increased. Additionally, the expression of SMURF1 substrates, which are important molecules involved in the transduction of BMP/SMAD signaling, was significantly upregulated. Furthermore, <i>in vivo</i> analyses confirmed that SMURF1 specifically regulated the BMP/SMAD pathway during serum iron overload.</p><p><strong>Conclusions: </strong>SMURF1 can specifically regulate the BMP/SMAD pathway by augmenting the responsiveness of hepatocytes to BMPs during serum iron overload.</p>","PeriodicalId":15484,"journal":{"name":"Journal of Clinical and Translational Hepatology","volume":"12 3","pages":"227-235"},"PeriodicalIF":3.6,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10899870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139996412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Onset Time, Number, Type, and Sequence of Extrahepatic Organ Failure on Prognosis of Acute-on-chronic Liver Failure. 肝外器官衰竭的发病时间、数量、类型和顺序对急性慢性肝衰竭预后的影响
IF 3.6 3区 医学
Journal of Clinical and Translational Hepatology Pub Date : 2024-03-28 Epub Date: 2024-01-31 DOI: 10.14218/JCTH.2023.00379
Shaotian Qiu, Qian Zhang, Jiaxuan Hu, Lewei Wang, Rui Chen, Yingying Cao, Fang Liu, Zhenjun Yu, Caiyan Zhao, Liaoyun Zhang, Wanhua Ren, Shaojie Xin, Yu Chen, Zhongping Duan, Tao Han
{"title":"Impact of Onset Time, Number, Type, and Sequence of Extrahepatic Organ Failure on Prognosis of Acute-on-chronic Liver Failure.","authors":"Shaotian Qiu, Qian Zhang, Jiaxuan Hu, Lewei Wang, Rui Chen, Yingying Cao, Fang Liu, Zhenjun Yu, Caiyan Zhao, Liaoyun Zhang, Wanhua Ren, Shaojie Xin, Yu Chen, Zhongping Duan, Tao Han","doi":"10.14218/JCTH.2023.00379","DOIUrl":"10.14218/JCTH.2023.00379","url":null,"abstract":"<p><strong>Background and aims: </strong>The impact of the characteristics of extrahepatic organ failure (EHOF) including the onset time, number, type, and sequence on the prognosis of acute-on-chronic liver failure (ACLF) patients remains unknown. This study aimed to identify the association between the characteristics of EHOF and the prognosis of ACLF patients.</p><p><strong>Methods: </strong>ACLF subjects enrolled at six hospitals in China were included in the analysis. The risk of mortality based on the characteristics of EHOF was evaluated. Survival of study groups was compared by Kaplan-Meier analysis and log-rank tests.</p><p><strong>Results: </strong>A total of 736 patients with ACLF were included. EHOF was observed in 402 patients (54.6%), of which 295 (73.4%) developed single EHOF (SEHOF) and 107 (26.6%) developed multiple EHOF (MEHOF). The most commonly observed EHOF was coagulation failure (47.0%), followed by renal (13.0%), brain (4.9%), respiratory (4.3%), and circulatory (2.3%) failure. Survival analysis found that MEHOF or SEHOF patients with brain failure had a worse prognosis. However, no significant outcome was found in the analysis of the effect of onset time and sequence of failed organs on prognosis. Patients were further divided into three risk subgroups by the EHOF characteristics. Kaplan-Meier analysis showed that risk stratification resulted in the differentiation of patients with different risks of mortality both in the training and validation cohorts.</p><p><strong>Conclusions: </strong>The mortality of ACLF patients was determined by the number and type, but not the onset time and sequence of EHOF. Risk stratification applicable to clinical practice was established.</p>","PeriodicalId":15484,"journal":{"name":"Journal of Clinical and Translational Hepatology","volume":"12 3","pages":"257-265"},"PeriodicalIF":3.6,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10899869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139996409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic Biomarkers for Hepatocellular Carcinoma Based on Serine and Glycine Metabolism-related Genes. 基于丝氨酸和甘氨酸代谢相关基因的肝细胞癌预后生物标志物
IF 3.6 3区 医学
Journal of Clinical and Translational Hepatology Pub Date : 2024-03-28 Epub Date: 2024-02-09 DOI: 10.14218/JCTH.2023.00457
Xufan Cai, Fang Xu, Zhaohong Wang, Hui Chen, Shengzhang Lin
{"title":"Prognostic Biomarkers for Hepatocellular Carcinoma Based on Serine and Glycine Metabolism-related Genes.","authors":"Xufan Cai, Fang Xu, Zhaohong Wang, Hui Chen, Shengzhang Lin","doi":"10.14218/JCTH.2023.00457","DOIUrl":"10.14218/JCTH.2023.00457","url":null,"abstract":"<p><strong>Background and aims: </strong>Targeted therapy and immunotherapy have emerged as treatment options for hepatocellular carcinoma (HCC) in recent years. The significance of serine and glycine metabolism in various cancers is widely acknowledged. This study aims to investigate their correlation with the prognosis and tumor immune microenvironment (TIME) of HCC.</p><p><strong>Methods: </strong>Based on the public database, different subtypes were identified by cluster analysis, and the prognostic model was constructed through regression analysis. The gene expression omnibus (GEO) data set was used as the validation set to verify the performance of the model. The survival curve evaluated prognostic ability. CIBERSORT was used to evaluate the level of immune cell infiltration, and maftools analyzed the mutations. DsigDB screened small molecule compounds related to prognostic genes.</p><p><strong>Results: </strong>HCC was found to have two distinct subtypes. Subsequently, we constructed a risk score prognostic model through regression analysis based on serine and glycine metabolism-related genes (SGMGs). A nomogram was constructed based on risk scores and other clinical factors. HCC patients with a higher risk score showed a poor prognosis, and there were significant differences in immune cell infiltration between the high- and low-risk groups. In addition, three potential drugs associated with prognostic genes, streptozocin, norfloxacin, and hydrocotarnine, were identified.</p><p><strong>Conclusions: </strong>This study investigated the expression patterns of SGMGs and their relationship with tumor characteristics, resulting in the development of a novel model for predicting the prognosis of HCC patients. The study provides a reference for clinical prognosis prediction and treatment of HCC patients.</p>","PeriodicalId":15484,"journal":{"name":"Journal of Clinical and Translational Hepatology","volume":"12 3","pages":"266-277"},"PeriodicalIF":3.6,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10899868/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139996411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Late-onset Cholestasis with Paucity of Portal Area Secondary to HNF1β Deficiency in Adulthood: A Case Report. 继发于成人 HNF1β 缺乏症的晚发性胆汁淤积症伴门静脉区缺失：病例报告。
IF 3.6 3区 医学
Journal of Clinical and Translational Hepatology Pub Date : 2024-03-28 Epub Date: 2024-02-19 DOI: 10.14218/JCTH.2023.00464
Xuemei Zhang, Kun Liu, Xiaona Lu, Wenlan Zheng, Jia Shi, Shihan Yu, Hai Feng, Zhuo Yu
{"title":"Late-onset Cholestasis with Paucity of Portal Area Secondary to HNF1β Deficiency in Adulthood: A Case Report.","authors":"Xuemei Zhang, Kun Liu, Xiaona Lu, Wenlan Zheng, Jia Shi, Shihan Yu, Hai Feng, Zhuo Yu","doi":"10.14218/JCTH.2023.00464","DOIUrl":"10.14218/JCTH.2023.00464","url":null,"abstract":"<p><p>Hepatocyte nuclear factor 1β (HNF1β) is essential for biliary development, while its genetic defect triggers the dysplasia of interlobular bile ducts, leading to life-threatening hepatitis and cholestasis. To date, this disorder has mainly been documented in neonates. Here, we report a case of cholestasis in an adult patient caused by a <i>de novo HNF1β</i> mutation. A liver biopsy revealed remarkable shrinkage of the portal area accompanied by a decrease or absence of interlobular bile ducts, veins, and arteries in the portal area. Our case showed that an <i>HNF1β</i> defect could induce late-onset cholestasis with paucity of the portal area in adulthood.</p>","PeriodicalId":15484,"journal":{"name":"Journal of Clinical and Translational Hepatology","volume":"12 3","pages":"327-331"},"PeriodicalIF":3.6,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10899876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139996410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Novel Algorithm for Streamlining Diagnosis of Advanced Liver Fibrosis in CHB Patients with Concurrent Hepatic Steatosis. 简化合并肝脏脂肪变性的慢性阻塞性肺病患者晚期肝纤维化诊断的新算法。
IF 3.6 3区 医学
Journal of Clinical and Translational Hepatology Pub Date : 2024-02-28 Epub Date: 2024-01-29 DOI: 10.14218/JCTH.2023.00362
Xiaoming Xu, Fajuan Rui, Wenjing Ni, Chao Wu, Junping Shi, Jie Li
{"title":"A Novel Algorithm for Streamlining Diagnosis of Advanced Liver Fibrosis in CHB Patients with Concurrent Hepatic Steatosis.","authors":"Xiaoming Xu, Fajuan Rui, Wenjing Ni, Chao Wu, Junping Shi, Jie Li","doi":"10.14218/JCTH.2023.00362","DOIUrl":"https://doi.org/10.14218/JCTH.2023.00362","url":null,"abstract":"<p><p></p>","PeriodicalId":15484,"journal":{"name":"Journal of Clinical and Translational Hepatology","volume":"12 2","pages":"222-226"},"PeriodicalIF":3.6,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10851070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139722872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum: Osteopontin Promotes Macrophage M1 Polarization by Activation of the JAK1/STAT1/HMGB1 Signaling Pathway in Nonalcoholic Fatty Liver Disease. 更正：骨蛋白通过激活非酒精性脂肪肝中的 JAK1/STAT1/HMGB1 信号通路促进巨噬细胞 M1 极化。
IF 3.6 3区 医学
Journal of Clinical and Translational Hepatology Pub Date : 2024-01-28 Epub Date: 2023-11-13 DOI: 10.14218/JCTH.2021.00474C
{"title":"Corrigendum: Osteopontin Promotes Macrophage M1 Polarization by Activation of the JAK1/STAT1/HMGB1 Signaling Pathway in Nonalcoholic Fatty Liver Disease.","authors":"","doi":"10.14218/JCTH.2021.00474C","DOIUrl":"https://doi.org/10.14218/JCTH.2021.00474C","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.14218/JCTH.2021.00474.].</p>","PeriodicalId":15484,"journal":{"name":"Journal of Clinical and Translational Hepatology","volume":"12 1","pages":"119-121"},"PeriodicalIF":3.6,"publicationDate":"2024-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10794274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139512483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unique Genetic Features of Lean NAFLD: A Review of Mechanisms and Clinical Implications. 瘦型非酒精性脂肪肝的独特遗传特征：机制与临床意义综述。
IF 3.6 3区 医学
Journal of Clinical and Translational Hepatology Pub Date : 2024-01-28 Epub Date: 2023-08-25 DOI: 10.14218/JCTH.2023.00252
Jasmine Tidwell, George Y Wu
{"title":"Unique Genetic Features of Lean NAFLD: A Review of Mechanisms and Clinical Implications.","authors":"Jasmine Tidwell, George Y Wu","doi":"10.14218/JCTH.2023.00252","DOIUrl":"10.14218/JCTH.2023.00252","url":null,"abstract":"<p><p>Non-alcoholic fatty liver disease (NAFLD) affects 25% of the global population. About 20% have a normal body mass index (BMI) and a variant known as lean NAFLD. Unlike typical NAFLD cases associated with obesity and diabetes, lean NAFLD causes liver disease by mechanisms not related to excess weight or insulin resistance. Genetic disorders are among the major factors in developing lean NAFLD, and genome-wide association studies have identified several genes associated with the condition. This review aims to increase awareness by describing the genetic markers linked to NAFLD and the defects involved in developing lean NAFLD.</p>","PeriodicalId":15484,"journal":{"name":"Journal of Clinical and Translational Hepatology","volume":"12 1","pages":"70-78"},"PeriodicalIF":3.6,"publicationDate":"2024-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10794266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139512486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improving the Conversion Success Rate of Hepatocellular Carcinoma: Focus on the Use of Combination Therapy with a High Objective Response Rate 提高肝细胞癌的转阴成功率：关注客观反应率高的联合疗法的应用
IF 3.6 3区 医学
Journal of Clinical and Translational Hepatology Pub Date : 2024-01-10 DOI: 10.14218/jcth.2023.00403
Qi-Feng Chen, Song Chen, Minshan Chen, N. Lyu, Ming Zhao
{"title":"Improving the Conversion Success Rate of Hepatocellular Carcinoma: Focus on the Use of Combination Therapy with a High Objective Response Rate","authors":"Qi-Feng Chen, Song Chen, Minshan Chen, N. Lyu, Ming Zhao","doi":"10.14218/jcth.2023.00403","DOIUrl":"https://doi.org/10.14218/jcth.2023.00403","url":null,"abstract":"","PeriodicalId":15484,"journal":{"name":"Journal of Clinical and Translational Hepatology","volume":"7 6","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139439477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immune Regulatory Networks and Therapy of γδ T Cells in Liver Cancer: Recent Trends and Advancements 肝癌中的γδT 细胞免疫调节网络与治疗：最新趋势和进展
IF 3.6 3区 医学
Journal of Clinical and Translational Hepatology Pub Date : 2024-01-08 DOI: 10.14218/jcth.2023.00355
Kunli Yin, Kai-Jian Chu, Ming Li, Yu-Xin Duan, Yanxi Yu, Meiqing Kang, Da Fu, Rui Liao
{"title":"Immune Regulatory Networks and Therapy of γδ T Cells in Liver Cancer: Recent Trends and Advancements","authors":"Kunli Yin, Kai-Jian Chu, Ming Li, Yu-Xin Duan, Yanxi Yu, Meiqing Kang, Da Fu, Rui Liao","doi":"10.14218/jcth.2023.00355","DOIUrl":"https://doi.org/10.14218/jcth.2023.00355","url":null,"abstract":"","PeriodicalId":15484,"journal":{"name":"Journal of Clinical and Translational Hepatology","volume":"5 3","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139446758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hepatocellular Carcinoma Incidence and Mortality in the USA by Sex, Age, and Race: A Nationwide Analysis of Two Decades 美国按性别、年龄和种族分列的肝细胞癌发病率和死亡率：二十年来的全国性分析
IF 3.6 3区 医学
Journal of Clinical and Translational Hepatology Pub Date : 2024-01-02 DOI: 10.14218/jcth.2023.00356
Yazan Abboud, Mohamed Ismail, Hamza Khan, Esli Medina-Morales, S. Alsakarneh, F. Jaber, Nikolaos T. Pyrsopoulos
{"title":"Hepatocellular Carcinoma Incidence and Mortality in the USA by Sex, Age, and Race: A Nationwide Analysis of Two Decades","authors":"Yazan Abboud, Mohamed Ismail, Hamza Khan, Esli Medina-Morales, S. Alsakarneh, F. Jaber, Nikolaos T. Pyrsopoulos","doi":"10.14218/jcth.2023.00356","DOIUrl":"https://doi.org/10.14218/jcth.2023.00356","url":null,"abstract":"","PeriodicalId":15484,"journal":{"name":"Journal of Clinical and Translational Hepatology","volume":"121 22","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139390679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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