Journal of Clinical and Experimental Hepatology最新文献

{"title":"Biochemical Response in Asian Primary Biliary Cholangitis: A Strong Signal, but Not the Whole Story","authors":"Jeanette Pei Xuan Ng, Jarell Jie-Rae Tan, Yu J. Wong","doi":"10.1016/j.jceh.2026.103647","DOIUrl":"10.1016/j.jceh.2026.103647","url":null,"abstract":"","PeriodicalId":15479,"journal":{"name":"Journal of Clinical and Experimental Hepatology","volume":"16 5","pages":"Article 103647"},"PeriodicalIF":3.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149211078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spleen Stiffness Measurement—Waiving Upper Endoscopy With a Small Extra Step","authors":"Yangyue Zhang, Jimmy Che-To Lai","doi":"10.1016/j.jceh.2026.103644","DOIUrl":"10.1016/j.jceh.2026.103644","url":null,"abstract":"","PeriodicalId":15479,"journal":{"name":"Journal of Clinical and Experimental Hepatology","volume":"16 5","pages":"Article 103644"},"PeriodicalIF":3.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149211079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue Highlights","authors":"","doi":"10.1016/S0973-6883(26)00192-1","DOIUrl":"10.1016/S0973-6883(26)00192-1","url":null,"abstract":"","PeriodicalId":15479,"journal":{"name":"Journal of Clinical and Experimental Hepatology","volume":"16 5","pages":"Article 103660"},"PeriodicalIF":3.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149211077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relative Adrenal Insufficiency in Decompensated Cirrhosis With Hyponatremia: Disease Severity Marker or Therapeutic Target?","authors":"Roberta Gagliardi, Salvatore Piano","doi":"10.1016/j.jceh.2026.103580","DOIUrl":"10.1016/j.jceh.2026.103580","url":null,"abstract":"","PeriodicalId":15479,"journal":{"name":"Journal of Clinical and Experimental Hepatology","volume":"16 4","pages":"Article 103580"},"PeriodicalIF":3.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148308287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Nuances in ATP7B Genetic Testing and Interpretation in India” [J Clin Exp Hepatol 16 (1) (2026) 103205]","authors":"Amresh K. Mishra, Moinak Sen Sarma, Amita Moirangthem, Haseena Sait","doi":"10.1016/j.jceh.2026.103582","DOIUrl":"10.1016/j.jceh.2026.103582","url":null,"abstract":"","PeriodicalId":15479,"journal":{"name":"Journal of Clinical and Experimental Hepatology","volume":"16 4","pages":"Article 103582"},"PeriodicalIF":3.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13312014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148352107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting Recompensation in Alcohol, HBV and HCV-associated Decompensated Cirrhosis","authors":"Umang Arora,&nbsp;Ritik Goyal,&nbsp;Ishan Gupta,&nbsp;Sanil Garg,&nbsp;Vishwa Vadodaria,&nbsp;Gurasis Boparai,&nbsp;Rosemary Jha,&nbsp;Shubham Mehta,&nbsp;Hari Narayan,&nbsp;Manas Vaishnav,&nbsp;Sagnik Biswas,&nbsp;Arnav Aggarwal,&nbsp;Sabreena Sheikh,&nbsp;Ayush Agarwal,&nbsp;Shivanand Gamanagatti,&nbsp;Raju Sharma,&nbsp;Shalimar","doi":"10.1016/j.jceh.2026.103581","DOIUrl":"10.1016/j.jceh.2026.103581","url":null,"abstract":"<div><h3>Background</h3><div>Recompensation of cirrhosis represents sustained clinical improvement in decompensated cirrhosis following effective etiological treatment. Baseline predictors can help prognostication in hepatology practice.</div></div><div><h3>Methods</h3><div>We conducted a retrospective study of patients with decompensated cirrhosis due to alcohol-associated (ALD) or viral (HBV or HCV) cirrhosis who received etiology-specific treatment following decompensation. Demographic details, laboratory parameters, and liver stiffness measurement (LSM) parameters were recorded at index decompensation, presentation, and follow-up. Recompensation was defined per Baveno-VII criteria. CT-derived sarcopenia (L3) and vertebral bone density (L1) were obtained when scans were available within 2 years of decompensation. Fine-Gray competing risk regression accounted for death, hepatocellular carcinoma (HCC), and liver transplantation as competing events.</div></div><div><h3>Results</h3><div>Of 244 patients (median age 43 (35–50) years; 78.7% males) with ALD (n = 104), HBV (n = 81), or HCV (n = 59) decompensated cirrhosis, 70 (28.7%) achieved recompensation over a median follow-up of 38 months (IQR 18.5–69). Recompensation was more frequent in HBV(42%) and HCV(35.6%) cirrhosis vs ALD (14.4%, <em>P</em> &lt; 0.001). Recompensated patients had lower MELD score (10.1 vs 14.7, <em>P</em> &lt; 0.001), bilirubin (1.5 vs 2.2 mg/dL, <em>P</em> = 0.006), and INR (1.3 vs 1.5, <em>P</em> = 0.002) at baseline. Univariate competing-risk analysis showed stepwise reduction in recompensation likelihood with increasing MELD category (MELD 10–15: sHR 0.56, MELD &gt;15: sHR 0.34, vs MELD &lt;10). On multivariable analysis, higher platelet count, absence of jaundice at baseline, and HBV etiology were independently associated with recompensation. LSM (n = 145) was numerically lower in recompensated patients (29.3 vs 36.9 kPa, <em>P</em> = 0.1), with greater median decline at follow-up (−20.7% vs 0%, <em>P</em> = 0.007). CT-based measurements (n = 69) showed recompensated patients had lower prevalence of sarcopenia (27.3% vs 59.6%, <em>P</em> = 0.01), higher vertebral bone density (243.1 ± 50.5 vs 196.2 ± 62.8 HU, <em>P</em> = 0.003), and no osteopenia (L1 vertebral body density &lt;150 HU, 0% vs 31.9%, <em>P</em> = 0.003). Three (4.3%) recompensated patients developed HCC.</div></div><div><h3>Conclusion</h3><div>Recompensation occurs in one-fourth of patients with decompensated cirrhosis and is more frequent in viral than alcohol-associated etiologies. Higher platelet count and absence of jaundice at baseline independently predicted recompensation.</div></div>","PeriodicalId":15479,"journal":{"name":"Journal of Clinical and Experimental Hepatology","volume":"16 4","pages":"Article 103581"},"PeriodicalIF":3.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148553862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue Highlights","authors":"","doi":"10.1016/S0973-6883(26)00155-6","DOIUrl":"10.1016/S0973-6883(26)00155-6","url":null,"abstract":"","PeriodicalId":15479,"journal":{"name":"Journal of Clinical and Experimental Hepatology","volume":"16 4","pages":"Article 103623"},"PeriodicalIF":3.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148730417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Redefinition of Fatty Liver Disease: Stigma or Fatphobia?","authors":"Lubna Kamani,&nbsp;Yasser Fouad,&nbsp;Mohammed Eslam","doi":"10.1016/j.jceh.2026.103562","DOIUrl":"10.1016/j.jceh.2026.103562","url":null,"abstract":"","PeriodicalId":15479,"journal":{"name":"Journal of Clinical and Experimental Hepatology","volume":"16 4","pages":"Article 103562"},"PeriodicalIF":3.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148308237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the Liver: Insights into the Liver–Brain Axis in MASLD and MASH","authors":"Shiv R. Patel,&nbsp;Jonathan Smith,&nbsp;Mohammad S. Siddiqui","doi":"10.1016/j.jceh.2026.103597","DOIUrl":"10.1016/j.jceh.2026.103597","url":null,"abstract":"","PeriodicalId":15479,"journal":{"name":"Journal of Clinical and Experimental Hepatology","volume":"16 4","pages":"Article 103597"},"PeriodicalIF":3.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148553864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatic Melioidosis: A State-of-the-Art Review","authors":"Nitin Gupta,&nbsp;Chiranjay Mukhopadhyay,&nbsp;Sundeep Malla,&nbsp;Praveen Kumar Tirlangi","doi":"10.1016/j.jceh.2026.103578","DOIUrl":"10.1016/j.jceh.2026.103578","url":null,"abstract":"<div><div>Hepatic melioidosis is a clinically significant manifestation of <em>Burkholderia pseudomallei</em> infection, increasingly recognised across South and Southeast Asia. It primarily affects diabetic and immunocompromised individuals and is characterised by a subacute to chronic presentation that often mimics other causes of liver abscess. The pathogenesis of hepatic melioidosis reflects the interplay between bacterial virulence mechanisms and impaired host immunity, leading to intracellular persistence and necrotising hepatic lesions. Characteristic imaging features, including the honeycomb and necklace signs, aid in distinguishing melioidosis from pyogenic or amoebic abscesses. Microbiological confirmation remains the diagnostic gold standard but is frequently delayed by misidentification in automated systems. Management requires an intensive phase with intravenous ceftazidime or carbapenems, followed by an eradication phase with trimethoprim–sulfamethoxazole. Drainage is reserved for large, multiloculated abscesses or those that are poorly responsive to antibiotics. Hepatic melioidosis, though underdiagnosed, is an important cause of hepatic abscess in endemic regions. Awareness of its distinctive clinical, radiologic, and microbiologic features is essential for timely diagnosis and optimal management. Strengthening laboratory capacity and clinician familiarity can reduce misdiagnosis, guide appropriate therapy, and improve patient outcomes.</div></div>","PeriodicalId":15479,"journal":{"name":"Journal of Clinical and Experimental Hepatology","volume":"16 4","pages":"Article 103578"},"PeriodicalIF":3.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148345417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}