Journal of College of Medical Sciences-nepal最新文献_第5页

Neutrophils - to - Lymphocytes Ratio and Clinical Outcomes in Patients with Kidney Diseases in COVID 19 COVID - 19肾病患者中性粒细胞与淋巴细胞比值及临床预后

Journal of College of Medical Sciences-nepal Pub Date : 2023-06-30 DOI: 10.3126/jcmsn.v19i2.55781

Deepak Sharma, Hari Prasad Upadhyay, Taranath Sharma, Madhav Ghimire, Bandana Aryal, Mira Kakshapati

{"title":"Neutrophils - to - Lymphocytes Ratio and Clinical Outcomes in Patients with Kidney Diseases in COVID 19","authors":"Deepak Sharma, Hari Prasad Upadhyay, Taranath Sharma, Madhav Ghimire, Bandana Aryal, Mira Kakshapati","doi":"10.3126/jcmsn.v19i2.55781","DOIUrl":"https://doi.org/10.3126/jcmsn.v19i2.55781","url":null,"abstract":"Introduction: Kidney Disease is structural and functional abnormality of Nephrons, where abrupt deterioration to progressive decline in Kidney function leads to acute to chronic Kidney Disease, respectively. The objective of this research was to find the Neutrophil-to-Lymphocyte ratio and Clinical outcomes of patients with Kidney Diseases in COVID-19.Methods: A descriptive cross-sectional study was conducted in the Department of Nephrology of College of Medical Sciences and Teaching Hospital, Bharatpur-10, Chitwan from 2021-04-01 to 2021-06-29 in among 31 Covid-19 positive cases. Collected data was entered and analyzed by using SPSS 20.Results: In this study 58% were male while 42% were female. Among the total cases 35.48% cases had NRL ratio <8 while 65.52% cases had NRL ratio ≥8. Among total cases 48.38% were discharged whereas, 51.62% were declared dead. Also, among those cases whose NRL ratio <8, 27.27%were declared dead while in NRL≥8, 65% cases were declared dead during treatment.Conclusions: In Covid-19 cases early diagnosis and supportiv e treatment, prognosis could be good. Regular follow-up could give insight about kidney function whereas in case Covid-19 various awareness programme and practice to prevent should be implied.","PeriodicalId":15436,"journal":{"name":"Journal of College of Medical Sciences-nepal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136369294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation Between Body Fat Composition and Blood Pressure Level Among Medical Students in a Tertiary Care Teaching Hospital In Pokhara, Nepal 尼泊尔博卡拉某三级护理教学医院医学生体脂组成与血压水平的相关性

Journal of College of Medical Sciences-nepal Pub Date : 2023-06-30 DOI: 10.3126/jcmsn.v19i2.48509

Indu Tiwari, Anshu Bhattarai, Poonam Karmacharya, Preetu Gurung

{"title":"Correlation Between Body Fat Composition and Blood Pressure Level Among Medical Students in a Tertiary Care Teaching Hospital In Pokhara, Nepal","authors":"Indu Tiwari, Anshu Bhattarai, Poonam Karmacharya, Preetu Gurung","doi":"10.3126/jcmsn.v19i2.48509","DOIUrl":"https://doi.org/10.3126/jcmsn.v19i2.48509","url":null,"abstract":"IntroductionIncrease in body fat is a common finding in young adults due to sedentary lifestyle and unhealthy dietary habits predisposing an individual to increase in blood pressure which is a common cause of cardiovascular morbidity and mortality. This study aimed to determine the association between body fat composition and BP level in young adults.MethodsA cross sectional study was conducted among 350 students of Manipal College of Medical Sciences from January to June, 2020. A structured proforma was used to collect the required information about the subjects and measurement of height, weight, waist and hip circumference, BP was done following standard methods. Body fat percentage was assessed by skinfold thickness.ResultsThe prevalence of were overweight and obesity was found to be 35.14%. Systolic, diastolic and combined hypertension was found in 64.7%, 53.26% and 57.64% respectively, in overweight and obese population. Increase in body fat percentage in boys and increase in waist hip ratio in girls showed no correlation with increase in systolic, diastolic and mean arterial pressure. However, increase in BMI was strongly correlated (p<0.05) with increase in all the measures of blood pressure- systolic, diastolic and mean arterial pressure.ConclusionsBody mass index is a better predictor of increased blood pressure level than body fat percentage and waist hip ratio.","PeriodicalId":15436,"journal":{"name":"Journal of College of Medical Sciences-nepal","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136369165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Description of the Five-day Orientation Program for Enrolling Undergraduate Medical Students for the Academic Year 2022 at Gandaki Medical College in Pokhara, Nepal 尼泊尔博卡拉甘达基医学院2022学年招生本科医科学生为期五天的入学指导计划

Journal of College of Medical Sciences-nepal Pub Date : 2023-06-30 DOI: 10.3126/jcmsn.v19i2.55934

Soni Bista, Bijayata Shrestha, Sabita Paudel, Nuwadatta Subedi

引用次数: 0

Pre-Malignant Lesions of Cervix in Female Attending a Tertiary Hospital of Nepal 在尼泊尔三级医院就诊的女性子宫颈恶性病变

Journal of College of Medical Sciences-nepal Pub Date : 2023-06-30 DOI: 10.3126/jcmsn.v19i2.55971

Buddhi Kumar Shrestha, Chin Bahadur Pun, Subha Shrestha, Alok Chandra Mahato, Deeva Shrestha

{"title":"Pre-Malignant Lesions of Cervix in Female Attending a Tertiary Hospital of Nepal","authors":"Buddhi Kumar Shrestha, Chin Bahadur Pun, Subha Shrestha, Alok Chandra Mahato, Deeva Shrestha","doi":"10.3126/jcmsn.v19i2.55971","DOIUrl":"https://doi.org/10.3126/jcmsn.v19i2.55971","url":null,"abstract":"Introduction: Cervical cancer is killing Nepali women in gross even though cervical cancer is preventable with time-tested screening strategies in Nepal. Detection of premalignant lesions of cervix is preliminary step for early treatment and to minimise the tragedy of death. The aim of this research is to corelate the Pap smear, colposcopy and guided biopsy findings with histopathology to detect premalignant lesion of cervix.Methods: A prospective observational study conducted among 145 women attending gynaecology OPD with symptoms during reproductive age 21-65 years. Collection of Pap smear was conducted by conventional method, colposcopy and guided biopsy in selected women were performed and the sample was sent to pathology department for histopathological confirmation.Results:The pre-malignant lesions in cytology were ASCUS (Atypical Squamous Cells of Undetermined Significance) 11%, ASC-H (Atypical Squamous cell- cannot exclude High Grade)1.3 %, LSIL (Low Grade Intraepithelial Lesion)28.2 %, and HSIL (High Grade Intraepithelial Lesion) 7.5 %. The colposcopy detected 54.4% atypical transformation zone. The histopathology detected Cervical Intra-epithelial Neoplasia I (CIN I) 26.1%, CIN II 11.7%, and CIN III 7.5%. The sensitivity of Pap smear and colposcopy was 83%, the specificity of Pap smear was 88%, and colposcopy was 98%.The positive predictive value(PPV)were 89% and 98 %, negative predictive value(NPV) were 81%and 83%.and accuracy was 88 % and 98% in Cytology and Colposcopy.Conclusions:Pap smear and colposcopy were effective tools to detect premalignant lesions of cervix in comparison to histopathological findings.","PeriodicalId":15436,"journal":{"name":"Journal of College of Medical Sciences-nepal","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136369301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinicopathological Profile of Colorectal Cancers in a Tertiary Care Hospital of Central, Nepal 尼泊尔中部三级医院结直肠癌的临床病理分析

Journal of College of Medical Sciences-nepal Pub Date : 2023-06-30 DOI: 10.3126/jcmsn.v19i2.55980

Sagar Khatiwada, Narayan Prasad Belbase, Binay Timilsina, Prasun Yadav, Sushim Bhujel, Nischal Shrestha, Hari Prasad Upadhyay

{"title":"Clinicopathological Profile of Colorectal Cancers in a Tertiary Care Hospital of Central, Nepal","authors":"Sagar Khatiwada, Narayan Prasad Belbase, Binay Timilsina, Prasun Yadav, Sushim Bhujel, Nischal Shrestha, Hari Prasad Upadhyay","doi":"10.3126/jcmsn.v19i2.55980","DOIUrl":"https://doi.org/10.3126/jcmsn.v19i2.55980","url":null,"abstract":"IntroductionThere is an increasing incidence of colorectal carcinoma (CRC) in developing countries like Nepal. The objective of this research is to study the CRC its demography, mode of presentation, type of surgery, complications and Histopathological evaluation (HPE) after surgery.MethodsThis was a retrospective descriptive observational study at College of Medical Sciences, Bharatpur, Nepal. Patients diagnosed with colorectal cancer admitted to gastrointestinal surgery department from July 2019 to June 2022 (3 years) were included. Data of patients were retrieved from hospital records. Pre-operative, intra-operative and post-operative diagnosis of CRC on HPE were also included in the study.ResultsOut of 52 CRC, males were 30 (57.7%) and females were 22 (42.3%), mean age was 52.7 years. Overall, left colon was affected in 33 (63.5%) and right in 19 (36.5%). More than one quarter of patients 14 (26.9%), had disease recurrence by 6 months follow-up. HPE revealed half of the disease condition as adenocarcinoma, moderately differentiated in (50%) cases.ConclusionsColorectal cancer is predominant in male patients and older age group. Incidence is high in younger people <40 years and low in extreme age group >80 years. Meticulous surgery is the only proven cure for malignancy.","PeriodicalId":15436,"journal":{"name":"Journal of College of Medical Sciences-nepal","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136369164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of Denture Cleanliness among Complete Denture Wearer in Chitwan Chitwan地区全口义齿佩戴者义齿清洁度评价

Journal of College of Medical Sciences-nepal Pub Date : 2023-06-30 DOI: 10.3126/jcmsn.v19i2.55332

Rajib Chaulagain, Smriti Narayan Thakur, Srijana Mishra Sapkota, Bibek Khanal, Anisha Pandey

{"title":"Assessment of Denture Cleanliness among Complete Denture Wearer in Chitwan","authors":"Rajib Chaulagain, Smriti Narayan Thakur, Srijana Mishra Sapkota, Bibek Khanal, Anisha Pandey","doi":"10.3126/jcmsn.v19i2.55332","DOIUrl":"https://doi.org/10.3126/jcmsn.v19i2.55332","url":null,"abstract":"Introduction: Oral cleanliness is important for all to maintain the overall health status. It is also important for the old aged edentulous people with dentures. The complete dentures are custom made device which are the replacement for the missing all tooth of mouth. Many microorganisms adhere to the surfaces of dentures and form denture plaque and calculus. They are there due to inadequate denture hygiene maintenance. This study was performed with the aim of assessing cleanliness of complete dentures among the denture wearers.Methods :A descriptive cross-sectional study conducted among 140 complete denture in the Department of Prosthodontics and Maxillofacial Prosthetics at Chitwan Medical College and Hospital. A convenience sampling method was used in this study. After taking the sociodemographic information and other information related to dentures, the participants dentures were evaluated with disclosing agent. The stained dentures were then assessed according to the Denture Cleanliness Index. Data was analyzed by using descriptive statistical tools in SPSS-16 and results were presented in form of tables.Results: The mean age of 140 patients was 71.39±5.80 years. There were 81 (57.9%) females and 59 (42.1) males. About 27 (19.3%) denture wearers did not remove dentures from their mouth at night. Among total, 81 (57.9%) of participants brushed their dentures with water. Denture Cleanliness Index scores of 2 was observed in 64 (45.8%) of denture wearers. Conclusions: It can be concluded that majority of participants had uncleaned dentures suggesting the need ofproper denture hygiene instructions and routinely follow-up for the cleanliness of dentures and their overall intraoral health status whether or not there were denture stomatitis.","PeriodicalId":15436,"journal":{"name":"Journal of College of Medical Sciences-nepal","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136369302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful Pregnancy Outcome in Uterus Didelphys: A Rare Case Report 子宫畸形的成功妊娠结局:罕见病例报告

Journal of College of Medical Sciences-nepal Pub Date : 2023-06-30 DOI: 10.3126/jcmsn.v19i2.55960

None Sharmila Poudel

引用次数: 0

Rectal Foreign Body Causing Perforation: A Case Report 直肠异物致穿孔1例

Journal of College of Medical Sciences-nepal Pub Date : 2023-05-01 DOI: 10.3126/jcmsn.v19i1.54169

Nischal Shrestha, N. Belbase, Sushim Bhujel, Sagar Khatiwada, Binaya Timilsina, Nishnata Koirala

引用次数: 0

MRI Evaluation in Acute Spinal Trauma in Tertiary Center of Nepal 尼泊尔三级中心急性脊柱创伤的MRI评价

Journal of College of Medical Sciences-nepal Pub Date : 2023-05-01 DOI: 10.3126/jcmsn.v19i1.53465

R. Acharya, Pramod Kumar Chhetri, V. Natraj Prasad, K. Thapa, M. Mishra, Arati Ghimire

{"title":"MRI Evaluation in Acute Spinal Trauma in Tertiary Center of Nepal","authors":"R. Acharya, Pramod Kumar Chhetri, V. Natraj Prasad, K. Thapa, M. Mishra, Arati Ghimire","doi":"10.3126/jcmsn.v19i1.53465","DOIUrl":"https://doi.org/10.3126/jcmsn.v19i1.53465","url":null,"abstract":"IntroductionSpine injury is one of the leading caused for disability in Nepal. Patients with trauma relatedspine injury leads to neurological dysfunction, focal deficits and even fatal life threating events.The timely intervention in acute spinal trauma injury could save the patients from disability andmortality risk. Imaging modalities like Xray, CT Scan and MRI helps in diagnosis and managementof spinal trauma. MRI plays crucial role in detection of spinal cord and soft tissue injuries. It issuperior than CT scan in evaluation of spinal cord injuries, ligament, soft issue structures, disc,and occult osseous injuries. The objective of this research is to evaluate MRI in acute spinal traumain tertiary center of Nepal.\u0000MethodsThis is descriptive hospital based observational study in those patients who were admitted andreferred in hospital for MRI with acute spinal trauma injury. Data were analysed by SPSS 2022.\u0000ResultsAcute spinal trauma is most common in male with ratio of 1.7 with the mean±SD of age was foundto be 50.98±19.26 years. Most common mode of injury were fall injury (76%). Most common spinalregion involved were lumbar (42%) followed by thoracic (36%), dorso-lumbar (14%) and cervical(8%) region respectively. Spinal cord contusion with edema, disc rupture, paravertebral collectionand ligament injury were seen. Most common type of fractures were simple compression fracture(72%), followed by burst fracture (16%), both (6%) and listhesis and sub/dislocations (6%). Spinalcord injury were seen in 22%, followed by disc rupture, paravertebral collection and ligamentinjury.\u0000ConclusionsMRI helps in evaluating vertebrae, spinal cord, ligament and disc injuries. We can assess the cordcontusion, edema and canal compression. It provides involvement, extension and severity of cordinjury. It endowed about outcome of surgery as well as conservative management in patient ofspinal injury.","PeriodicalId":15436,"journal":{"name":"Journal of College of Medical Sciences-nepal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42484658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Characterization of Moraxella Catarrhalis and it's Antibiotics Susceptibility Patterns from Different Respiratory Tract Infection Patient's Clinical Samples 不同呼吸道感染患者临床样本中卡他莫拉的分子特征及其耐药性模式

Journal of College of Medical Sciences-nepal Pub Date : 2023-05-01 DOI: 10.3126/jcmsn.v19i1.53460

B. Jha, H. Upadhyay, S. Mahadevamurthy, J. Sudisha

{"title":"Molecular Characterization of Moraxella Catarrhalis and it's Antibiotics Susceptibility Patterns from Different Respiratory Tract Infection Patient's Clinical Samples","authors":"B. Jha, H. Upadhyay, S. Mahadevamurthy, J. Sudisha","doi":"10.3126/jcmsn.v19i1.53460","DOIUrl":"https://doi.org/10.3126/jcmsn.v19i1.53460","url":null,"abstract":"IntroductionMoraxella catarrhalis is a gram negative, oxidase positive, cocci mainly causing upper and lowerrespiratory tract infections. The RND family efflux pumps lead to multidrug resistance in most ofthe gram negative bacteria. One of the well- known pumps in M. catarrhalis is arcAB and oprMsystem. The objective of this study was to investigate the antibiotic resistance in M. catarrhalis andto determine its resistance dependence on the efflux pump.\u0000MethodsIn this study, 283 different respiratory tract infection samples processed out of that 73 were confirmedby biotyping and molecular characterization as a M. catarrhalis. The antibiotic susceptibility testswere performed by disc diffusion method according to CLSI. Molecular characterization formultidrug resistance isolates was also done along with genes responsible for efflux pumps. PCRwas done M. catarrhalis and acrAB and oprM genes. The factor for association of efflux pump withantibiotic resistance was investigated using phenylalanine argine β-naphthylamide.\u0000ResultsThe antibiotics susceptibility result showed 12 out of 73 isolates were MDR, selectively takenfor PCR using 16SrRNA specific primer. The MDR isolates were further confirmed by PCR. Theamplification results of acra, acrb and oprm genes for the M. catarrhalis having multidrug resistancegenes by PCR band size products seen on 2% agrose gel. The highest resistance towards the drugsviz penicillin, ampicillin, amoxicillin, amoxiclave, cotrimoxazole, cefazolin, cefuroxime, ceftrixoneand cefepime were seen in M. catarrhalis.\u0000ConclusionsThe result showed that Moraxella catarrhalis is one of the major causes for respiratory tract infection.The drug resistance in this species is increasing day by day. The 90% of isolates have acrAB andoprM genes for efflux pump responsible for multiple drug resistance. The efflux pump inhibitorhas important clinical significance for the proper treatment.","PeriodicalId":15436,"journal":{"name":"Journal of College of Medical Sciences-nepal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48038427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0