Journal of Coloproctology最新文献_第10页

Journal of Coloproctology Pub Date : 2022-06-01 DOI: 10.1055/s-0042-1749085

Bruno Lorenzo Scolaro, G. B. Pereira, Fangio Ferrari, Letícia Dall'Agnol, Lívia de Aragon Arias, Anisio de Souza Neto

引用次数: 0

Safety and Efficacy of Ustekinumab in the Treatment of Crohn Disease: A Systematic Review and Meta-analysis Ustekinumab治疗克罗恩病的安全性和有效性：系统评价和荟萃分析

Journal of Coloproctology Pub Date : 2022-06-01 DOI: 10.1055/s-0041-1730264

M. Khorshid, A. Cordie, S. Abd-Elsalam

{"title":"Safety and Efficacy of Ustekinumab in the Treatment of Crohn Disease: A Systematic Review and Meta-analysis","authors":"M. Khorshid, A. Cordie, S. Abd-Elsalam","doi":"10.1055/s-0041-1730264","DOIUrl":"https://doi.org/10.1055/s-0041-1730264","url":null,"abstract":"\u0000 Background and Aims The present systematic review and meta-analysis was designed to estimate the safety and effectiveness of ustekinumab in the treatment of Crohn disease (CD) in clinical trials and observational studies.\u0000 Methods We retrieved all the related publications from the PubMed, Cochrane, EBSCO, Google Scholar and EMBASE databases using a systematic search strategy. We only included clinical trials and observational studies that were published in English.\u0000 Results Only 31 studies that met the eligibility criteria out of the 733 identified studies were included. The overall clinical response rate in the cohort studies was of 0.539 (95% confidence interval [95%CI]: 0.419–0.659), and in the clinical trials it was of 0.428 (95%CI: 0.356–0.501). The pooled clinical remission rate was of 0.399 (95%CI: 0.295–0.503) in randomized control trials (RCTs,) and of 0.440 (95%CI: 0.339–0.542) in cohort studies. The rate of adverse effects was of 0.158 (95%CI: 0.109–0.207) in cohort studies and of 0.690 (95%CI: 0.633–0.748) in RCTs.\u0000 Conclusion Ustekinumab is effective in the treatment of CD. However, more research is required on the safety profiles because there was considerable variation among the included studies.","PeriodicalId":15408,"journal":{"name":"Journal of Coloproctology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49580605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Presentation Patterns and Outcomes in Patients with Colorectal Cancer Seeking the Emergency Department for Consultation 寻求急诊科会诊的结直肠癌患者的表现模式和结果

Journal of Coloproctology Pub Date : 2022-05-30 DOI: 10.1055/s-0042-1757772

Caroline D. Simanke, Eduardo DaCás, Danilo S. Bussyguin, Ana Clara Belizário, Eduardo D. de Alencar, F. Tomasich, T. Skare, R. Nisihara

{"title":"Presentation Patterns and Outcomes in Patients with Colorectal Cancer Seeking the Emergency Department for Consultation","authors":"Caroline D. Simanke, Eduardo DaCás, Danilo S. Bussyguin, Ana Clara Belizário, Eduardo D. de Alencar, F. Tomasich, T. Skare, R. Nisihara","doi":"10.1055/s-0042-1757772","DOIUrl":"https://doi.org/10.1055/s-0042-1757772","url":null,"abstract":"Abstract Background Patients with colorectal cancer may seek the emergency department for symptoms related to chemotherapy and radiotherapy side effects as well as those from the disease itself and from surgery complications. Objectives To establish the epidemiological and clinical profile of colorectal cancer patients that look for consultations in the emergency department. Methods Retrospective study of emergency room charts from colorectal cancer patients that consulted in a single oncological hospital for the period of 1 year. Results Four hundred and forty-six consultations were identified (49.5% males and 50.5% females) with a mean age of 63 years and with advanced disease (most with tumor, node, metastases [TNM] stages III and IV). The most common complaint was abdominal pain (27.5%), followed by nausea (4.7%; more commonly seen in females with p = 0.03) and bladder symptoms (4.7%; more commonly seen in males, with p = 0.003). Infections (10.3%) and acute abdominal pain (9.1%) were the most frequent diagnoses. About 18% of them were admitted to the hospital and 80% were discharged home. Conclusion The profile of patients with colorectal cancer seeking the emergency department comprises patients with advanced disease and a similar proportion of males and females. Symptom-driven complaints were the most frequent reason for consultations.","PeriodicalId":15408,"journal":{"name":"Journal of Coloproctology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45311312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Way to Start Transanal Total Mesorectal Excision for Rectal Cancer 直肠癌经肛门全肠系膜切除术的一种方法

Journal of Coloproctology Pub Date : 2022-04-19 DOI: 10.1055/s-0042-1743245

Ruben Martins, T. Revez, H. Morais, P. Henriques, N. Cardoso, I. Manso, Lina Leote, Martins dos Santos

{"title":"A Way to Start Transanal Total Mesorectal Excision for Rectal Cancer","authors":"Ruben Martins, T. Revez, H. Morais, P. Henriques, N. Cardoso, I. Manso, Lina Leote, Martins dos Santos","doi":"10.1055/s-0042-1743245","DOIUrl":"https://doi.org/10.1055/s-0042-1743245","url":null,"abstract":"\u0000 Introduction The optimal rectal cancer care is achieved by a multidisciplinary approach, with a high-quality surgical resection, with complete mesorectal excision and adequate margins. New approaches like the transanal total mesorectal excision (TaTME) aim to achieve these goals, maximizing the sphincter preservation ratio, with good oncologic and functional results. This report describes a way to implement TaTME without a proctor, presents the first case series of this approach in a center experienced in rectal cancer, and compares the results with those of the international literature.\u0000 Methods We performed a retrospective study of the first 10 consecutive patients submitted to TaTME for rectal cancer at our institution. The primary outcomes were postoperative complications, pathological specimen quality and local recurrence rate. The results and performance were compared with the outcomes of a known structured program with proctorship and with the largest meta-analysis on this topic.\u0000 Results All patients had locally advanced cancer; therefore, all underwent neoadjuvant therapy. A total of 30% had postoperative complications, without mortality or re-admissions. In comparison with the structured training program referred, no differences were found in postoperative complications and reintervention rates, resulting in a similar quality of resection. Comparing these results with those of the largest meta-analysis on the subject, no differences in the postoperative complication rates were found, and very similar outcomes regarding anastomotic leaks and oncological quality of resection were registered.\u0000 Conclusion The results of this study validate the safety and effectiveness of our pathway regarding the implementation of the TaTME approach, highlighting the fact that it should be done in a center with proficiency in minimally invasive rectal surgery.","PeriodicalId":15408,"journal":{"name":"Journal of Coloproctology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46638398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of Complex Fistula-in-ano by Interception of Fistula Track with Application of Ksharasutra (IFTAK): A Novel Technique 应用Ksharasutra (IFTAK)阻断瘘道治疗复杂瘘管:一种新技术

Journal of Coloproctology Pub Date : 2022-04-18 DOI: 10.1055/s-0042-1756145

M. Sahu, Ashish Sharma

{"title":"Management of Complex Fistula-in-ano by Interception of Fistula Track with Application of Ksharasutra (IFTAK): A Novel Technique","authors":"M. Sahu, Ashish Sharma","doi":"10.1055/s-0042-1756145","DOIUrl":"https://doi.org/10.1055/s-0042-1756145","url":null,"abstract":"Abstract Objective Despite all the technological advances, successful management of complex fistula-in-ano is still a challenge due to recurrence and incontinence. The present study evaluates the outcomes of a novel technique, Interception of Fistula Track with Application of Ksharasutra (IFTAK) in terms of success rate and degree of incontinence. Methods In the present prospective study, 300 patients with complex fistula-in-ano were treated by the IFTAK technique, whose surgical steps include: incision at the anterior or posterior midline perianal area, identification and interception of the fistulous track at the level of the external sphincter, rerouting the track (and extensions) at the site of interception, and application of a ksharasutra (medicated seton) in the proximal track (from the site of interception to the internal opening) that is laid open gradually, with the resulting wound healing with minimum scarring. The distal track is allowed to heal spontaneously. Results There were 227 trans-sphincteric and 73 intersphincteric varieties of fistula with supralevator extension in 23 cases, of which 130 were recurrent fistulas, 29 had horseshoe track, while 25 had blind fistula with no cutaneous opening. The mean duration of the ksharasutra application was 8.11 ± 3.86 weeks with an overall success rate of 93.33% at the 1-year follow-up. A total of 3.67% of the cases reported with a mild impairment of continence on the Wexner incontinence scoring system. Pre- and postoperative anal manometry evaluation showed minimal reduction in median basal and squeeze pressures. Conclusion The IFTAK technique is a minimally invasive, daycare surgical procedure for the management of complex fistula-in-ano with low recurrence and minimal sphincter damage.","PeriodicalId":15408,"journal":{"name":"Journal of Coloproctology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43719424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Impact of the Vertical Division of the Rectum on the Decrease in Reloading of the Endostapler for a Complete Division in Colorectal Cancer 直肠垂直分切对减少结直肠癌完全分切吻合器重装的影响

Journal of Coloproctology Pub Date : 2022-03-10 DOI: 10.1055/s-0042-1757771

Yasser A. Debakey, Amr A. Nofal, Sayed S. Sheier, Ayman Hanafy, A. R. Abdalwahab, T. Hashem, Sara Albastaki

{"title":"Impact of the Vertical Division of the Rectum on the Decrease in Reloading of the Endostapler for a Complete Division in Colorectal Cancer","authors":"Yasser A. Debakey, Amr A. Nofal, Sayed S. Sheier, Ayman Hanafy, A. R. Abdalwahab, T. Hashem, Sara Albastaki","doi":"10.1055/s-0042-1757771","DOIUrl":"https://doi.org/10.1055/s-0042-1757771","url":null,"abstract":"Abstract Background Despite several improvements in surgical techniques, the intracorporeal division of the distal end of the rectum is still challenging, particularly when it is too deep in a narrow pelvis. Even though it helps avoid spillage, the double-stapling technique (DST) raises concerns regarding safety and anastomotic leakage if multiple stapler firings are essential to complete the rectal division. Objective To assess the feasibility of vertically dividing the rectum and its impact in reducing the number of reloads essential for that division in non-low rectal cancer patients undergoing total mesorectal excision (TME). Materials and Methods A retroprospective study. Results From January 2017 to November 2021, a total of 123 patients with sigmoid and rectal cancers were enrolled in the present study; their data were collected and analyzed, and 21 patients were excluded. The remaining sample of 102 subjects was composed of 47 male (46%) and 55 female (54%) patients with a median age of 54 years (range: 30 to 78 years). Only 1 reload was enough to complete the rectal division in 82 (80.39%) cases, and 2 reloads were used in the remaining 20 (19.61%) patients. Anastomotic leakage was clinically evident in 4 cases (3.9%). No statically significant difference was observed when firing one or two staplers. No 30-day mortality was recorded in this series. Conclusion Our early experience indicates that this type of division has a real advantage in terms of decreasing the number of reloads needed and, in turn, lowering the incidence of anastomotic leakage after partial mesorectal excision (PME) or TME when applied with proper patient selection.","PeriodicalId":15408,"journal":{"name":"Journal of Coloproctology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46440266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Value of Terminal Ileum Intubation During Colonoscopy 回肠末端插管在结肠镜检查中的价值

Journal of Coloproctology Pub Date : 2022-03-01 DOI: 10.1055/s-0041-1739298

Nawal Alkhalidi, Abdulhadi Alrubaie, R. E. Rezqallah, Maitham Kenber

{"title":"The Value of Terminal Ileum Intubation During Colonoscopy","authors":"Nawal Alkhalidi, Abdulhadi Alrubaie, R. E. Rezqallah, Maitham Kenber","doi":"10.1055/s-0041-1739298","DOIUrl":"https://doi.org/10.1055/s-0041-1739298","url":null,"abstract":"It is uncertain whether terminal ileum intubation should be performed routinely during colonoscopy, as there is uncertainty regarding its diagnostic value. The aim of the present study is to assess the diagnostic yield of terminal ileum intubation during colonoscopy according to indications for colonoscopy. This is a cross-sectional study in which the results of 294 total colonoscopy procedures were reviewed; ileal intubation was performed in 269 (91.49%) patients. The indications for colonoscopy, the results of ileoscopy, and the histopathological results of ileal biopsies were evaluated.A total of 54 (20%) out of 269 patients who had successful intubation into the terminal ileum showed macroscopic abnormalities on the terminal ileum. Biopsies were positive in 4 out of 54 (7.4%); all were of Crohn disease. Two were erosions (9.5%.) and 2 were ulcers (18.8%). The two erosions were presented as abdominal pain, abdominal pain and alternating bowel motion. Those with ulcers were presented with diarrhea and perianal disease.\u0000 Conclusions Considering the low diagnostic yield of ileal intubation during colonoscopy, the decision to perform ileoscopy or not during colonoscopy needs to be made on a case-by-case basis. However, routine ileal intubation, brief attempts should be considered despite low diagnostic yield.","PeriodicalId":15408,"journal":{"name":"Journal of Coloproctology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"58145393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between Fecal Incontinence and Lower Urinary Tract Symptoms and their Impact on the Quality of Life of Patients with Prostate Cancer 癌症前列腺患者大便失禁与下尿路症状的关系及其对生活质量的影响

Journal of Coloproctology Pub Date : 2022-03-01 DOI: 10.1055/s-0042-1742620

Natália Burgos Freire Azevedo, G. Abreu

{"title":"Association between Fecal Incontinence and Lower Urinary Tract Symptoms and their Impact on the Quality of Life of Patients with Prostate Cancer","authors":"Natália Burgos Freire Azevedo, G. Abreu","doi":"10.1055/s-0042-1742620","DOIUrl":"https://doi.org/10.1055/s-0042-1742620","url":null,"abstract":"\u0000 Objective To evaluate the association of fecal incontinence (FI) and lower urinary tract symptoms (LUTS) in patients diagnosed with initial prostate cancer (PC) and after any therapeutic approach (surgery and radiotherapy).\u0000 Methods Cross-sectional study using the Cleveland Clinic Incontinence Score (CCIS), the Fecal Incontinence Quality of Life (FIQL) questionnaire, and the International Consultation on Incontinence Questionnaire Overactive Bladder (ICIQ-OAB).\u0000 Results A total of 84 patients with PC were included: 40 of them had not started treatment, 31 were submitted to radical prostatectomy (RP), and 13 were submitted to radiotherapy (RT). Those submitted to RT presented higher scores on the ICIQ-OAB (p = 0.01). When comparing the whole sample reagarding the patients with and without FI, we observed that the incontinents presented a higher frequency of urinary incontinence (UI) (p < 0.001). Moreover, when comparing patients with/without FI within their treatment groups regarding the presence of UI and FIQL scores, we identified that patients undergoing RP presented an association between UI and FI (p < 0.001) and a greater impact of FI on the FIQL (p < 0.001).\u0000 Conclusion Patients submitted to RT present more intense LUTS. Moreover, patients with FI present a higher association with UI, and this association is more marked in those with FI submitted to RP.","PeriodicalId":15408,"journal":{"name":"Journal of Coloproctology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46684633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutics in Radiation-induced Proctopathy: A Systematic Review 放射诱发直肌病的治疗:系统综述

Journal of Coloproctology Pub Date : 2022-03-01 DOI: 10.1055/s-0041-1742258

Nathália Nascentes Coelho dos Santos Omer, I. D. Araújo, G. M. G. Cruz, Fabio G Rodrigues

{"title":"Therapeutics in Radiation-induced Proctopathy: A Systematic Review","authors":"Nathália Nascentes Coelho dos Santos Omer, I. D. Araújo, G. M. G. Cruz, Fabio G Rodrigues","doi":"10.1055/s-0041-1742258","DOIUrl":"https://doi.org/10.1055/s-0041-1742258","url":null,"abstract":"Malignant neoplasms are increasingly prevalent in the daily clinical practice. Up to 61% of patients with pelvic malignancies undergo pelvic radiotherapy in different doses, which may cause intestinal damage, and the rectum is the segment most frequently affected due to its fixed position in the pelvis. Currently, there are several strategies to minimize the effects of radiation on the tissues surrounding the neoplastic site; despite those strategies, radiotherapy can still result in serious damage to organs and structures, and these injuries accompany patients throughout their lives. One of the most common damages resulting from pelvic radiotherapy is acute proctitis.The diagnosis is confirmed by visualizing the rectal mucosa through rigid or flexible rectosigmoidoscopy and colonoscopy. The objective of the present study was to review the forms of radiation-induced proctopathytherapy, and to evaluate the results of each method to propose a standardization for the treatment of this pathology. Despite the prevalence of radiation-induced proctopathy, there is no definitive standardized treatment strategy so far. The first approach can be tried with local agents, such as mesalazine and formalin. For refractory cases, control can usually be achieved with argon plasma coagulation, hyperbaric oxygen, and radiofrequency ablation therapies. Regarding the study of radiation-induced proctopathy, there is a lack of robust studies with large samples and standardized therapies to be compared. There is a lack of double-blinded, randomized controlled studies to determine a definitive standard treatment algorithm.","PeriodicalId":15408,"journal":{"name":"Journal of Coloproctology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41843308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physiotherapeutic Approaches to Treat Anal Incontinence in Women after Obstetric Trauma 产科创伤后女性肛门失禁的物理治疗方法

Journal of Coloproctology Pub Date : 2022-02-14 DOI: 10.1055/s-0042-1742621

M. Freitas, Lara Elma Franco Moura, Denise Saquetto, Iane Castro Rodrigues, Valéria Conceição Passos de Carvalho, S. Uchôa

{"title":"Physiotherapeutic Approaches to Treat Anal Incontinence in Women after Obstetric Trauma","authors":"M. Freitas, Lara Elma Franco Moura, Denise Saquetto, Iane Castro Rodrigues, Valéria Conceição Passos de Carvalho, S. Uchôa","doi":"10.1055/s-0042-1742621","DOIUrl":"https://doi.org/10.1055/s-0042-1742621","url":null,"abstract":"\u0000 Introduction Anal incontinence is defined as the loss of voluntary control of fecal matter or gases with a recurrence period longer than 3 months in individuals aged ≥ 4 years; it has a female predominance. Among the treatment modalities is pelvic physiotherapy, the second line of treatment, which promotes the reeducation, coordination, and strengthening of the muscles of the pelvic floor to enable patients to return to their regular activities of daily living.\u0000 Objective To perform a systematic review on the physiotherapeutic treatments used in women between the ages of 18 and 65 years with a diagnosis of anal incontinence.\u0000 Material and methods Clinical studies written in Portuguese, Spanish and English were searched on the the following databases: Science Direct, Medical Literature Analysis and Retrieval System Online (Medline) via PubMed, Physiotherapy Evidence Database (PEDro), Scientific Electronic Library Online (SciELO), and Scopus.\u0000 Results Of the 998 articles found, only 4 studies met the inclusion criteria of the present systematic review. The physiotherapeutic approaches to treat women with anal incontinence are biofeedback, Kegel exercises, electrostimulation, and training of the pelvic floor muscles. The average score on the PEDro scale was of 6.25, which indicates that the methodological quality was good.\u0000 Conclusion Although pelvic physiotherapy is effective to treat anal incontinence, it must be promoted through the performance of evidence-based scientific research.","PeriodicalId":15408,"journal":{"name":"Journal of Coloproctology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47189195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0