Journal of clinical trials最新文献_第6页

Erythrocyte Sedimentation Rate and Gamma-glutamyl Transpeptidase Combined are Potent Predictors of Survival and Tumor Characteristics inHepatocellular Carcinoma Patients 红细胞沉降率和γ -谷氨酰转肽酶联合是肝细胞癌患者生存和肿瘤特征的有效预测因子

Journal of clinical trials Pub Date : 2020-01-01 DOI: 10.35248/2167-0870.20.10.425

B. Carr, H. Akkız, H. Bag, Guerra, R. Donghia, K. Yalcin, Ümit Karaoğullarından, E. Altntaş, A. Özakyol, H. Şimşek, Balaban Hy, A. Balkan, A. Uyankoglu, N. Ekin

{"title":"Erythrocyte Sedimentation Rate and Gamma-glutamyl Transpeptidase Combined are Potent Predictors of Survival and Tumor Characteristics inHepatocellular Carcinoma Patients","authors":"B. Carr, H. Akkız, H. Bag, Guerra, R. Donghia, K. Yalcin, Ümit Karaoğullarından, E. Altntaş, A. Özakyol, H. Şimşek, Balaban Hy, A. Balkan, A. Uyankoglu, N. Ekin","doi":"10.35248/2167-0870.20.10.425","DOIUrl":"https://doi.org/10.35248/2167-0870.20.10.425","url":null,"abstract":"Introduction: Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are acute phase reactants and gamma-glutamyl transpeptidase (GGT) is a liver enzyme that is associated with prognosis in patients with hepatocellular carcinoma (HCC). Objective: To evaluate the value of ESR and GGT singly and together in HCC prognosis and as predictors of tumor aggressiveness parameters. Methods: The database from a large cohort of Turkish HCC patients was examined retrospectively for the prognostic usefulness of blood ESR and GGT levels and the associated patient subgroup characteristics. Results: Patients with low vs. high blood ESR or GGT values had greater than double survival, with hazard ratios (HR) by Cox regression of 1.543 and 1.833 respectively. The combination of ESR plus GGT was associated with a 3- fold survival difference and an HR of 2.410. Patients with high vs. low ESR plus GGT levels had significantly greater maximum tumor diameters, alpha-fetoprotein levels, multifocality and percent of patients with portal vein thrombosis. Significant survival differences were also found for patients with low serum alpha-fetoprotein levels. Addition of CRP levels to the ESR plus GGT combination added further discriminant survival information, but for greater computational complexity. Conclusions: ESR plus GGT is a useful and powerful prognosticator in HCC patients, including those with low alpha-fetoprotein levels and significantly associates with all the tumor parameters of HCC patients.","PeriodicalId":15375,"journal":{"name":"Journal of clinical trials","volume":"204 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76023339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Sinking of Clinical Trials! How Wrong done by a Virus could have Undermine Rigor and Compromises Response to Emergency 临床试验的沉沦!病毒的错误行为如何破坏了对紧急情况的严谨性和妥协

Journal of clinical trials Pub Date : 2020-01-01 DOI: 10.35248/2167-0870.20.S3.002

F. Trémolières

引用次数: 0

Epdimiology and Complications of Total Thyroidctomy in Aseer Central Hospital 亚洲中心医院甲状腺全切除术的流行病学及并发症分析

Journal of clinical trials Pub Date : 2020-01-01 DOI: 10.35248/2167-0870.20.10.395

Abdulaziz Qobty, Saad Alqarni, S. Alnami, R. Traad, R. Shaker, Shahad Almutiri, M. Alhayan, Njood Alnahdi, Nadia Alhariri

{"title":"Epdimiology and Complications of Total Thyroidctomy in Aseer Central Hospital","authors":"Abdulaziz Qobty, Saad Alqarni, S. Alnami, R. Traad, R. Shaker, Shahad Almutiri, M. Alhayan, Njood Alnahdi, Nadia Alhariri","doi":"10.35248/2167-0870.20.10.395","DOIUrl":"https://doi.org/10.35248/2167-0870.20.10.395","url":null,"abstract":"Background: Total Thyroidectomy is common procedure among patients with thyroid disorders including malignancies, thyrotoxicosis, multi-nodular goiter and chronic thyroiditis. There are many complications that recorded after this procedure which is more related to surgeon experience and nature of disorder. Among these disorders, hematoma, recurrent laryngeal nerve injury and hypocalcaemia are the most frequent. Modern thyroidectomy is focused on the mortality of surgery by preventing damage to adjacent structures, such as parathyroid glands and recurrent laryngeal nerve. Aim of the study: To assess the clinical presentation and post-operative complications among total thyroidectomy cases in Aseer Central Hospital [ACH]. Methodology: A retrospective record based descriptive approach was used through reviewing medical records of all cases that underwent total thyroidectomy for different indications in Aseer Central Hospital [ACH] during the period from 2000 to 2019. Data extracted throng pre-structured questionnaire including patient's bio-clinical data, preoperative symptoms and complications of the procedure. Results: The study included 150 cases. One hundred and thirteen cases [75.3%] aged above 40 years. The main compliant recorded for the cases was neck swelling which was recorded among 56% of the cases followed with dysphagia. About 91% of the cases recorded post-operative complications. Scar was the most recorded complication followed with hypocalcaemia. Conclusion and recommendations: In conclusion, the study revealed that neck swelling was the most recorded clinical finding with dysphagia. Majority of cases recorded post-operative complications mainly scar and hypocalcaemia.","PeriodicalId":15375,"journal":{"name":"Journal of clinical trials","volume":"77 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83922433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Human Challenge Trial and Expedite Vaccine Development: Ethical Issues 人体挑战试验和加速疫苗开发:伦理问题

Journal of clinical trials Pub Date : 2020-01-01 DOI: 10.35248/2167-0870.20.S4.E002

H. Sophia

引用次数: 0

Current Challenges in Clinical Trials 当前临床试验面临的挑战

Journal of clinical trials Pub Date : 2020-01-01 DOI: 10.35248/2167-0870.20.10.E410

M. Schlund

引用次数: 0

Transcatheter Intervention for Late Complications after Aortic Coarctation Surgical Repair 经导管介入治疗主动脉缩窄手术修复后的晚期并发症

Journal of clinical trials Pub Date : 2020-01-01 DOI: 10.35248/2167-0870.20.10.402

Wail Alkashkari, Saad Albugami, Mohammed W Althobaiti, Mawaddah Alfouti, J. Alrahimi, A. Kinsara, Atif Alzahrani, J. Fern, Ez, Adel Tash, Hayam Aburemish

引用次数: 5

Assessment of the Relationship between Galectine-3 and Cardiac Functions in Patients with Chronic Heart Failure 半乳糖凝集素-3与慢性心力衰竭患者心功能关系的评价

Journal of clinical trials Pub Date : 2020-01-01 DOI: 10.35248/2167-0870.20.10.408

Saud M. Elsaughier, M. Salama, A. Hanafy, M. Ahmed, A. Ibrahim

{"title":"Assessment of the Relationship between Galectine-3 and Cardiac Functions in Patients with Chronic Heart Failure","authors":"Saud M. Elsaughier, M. Salama, A. Hanafy, M. Ahmed, A. Ibrahim","doi":"10.35248/2167-0870.20.10.408","DOIUrl":"https://doi.org/10.35248/2167-0870.20.10.408","url":null,"abstract":"Background: HF biomarkers have growing importance in daily clinical practice as well as in clinical trials. Several biomarkers are used for diagnosis and prognosis of HF patients. Recently, Galectine-3 has been proposed for diagnosis and prognosis of HF. In this study we aimed to determine the relationship between galectine-3 level and cardiac functions in patients with chronic heart failure and its correlation with clinical manifestations. Methods: The current study enrolled 90 patients with chronic heart failure and then divided according to ejection fraction (EF) into two groups , group I included 60 patients with clinical manifestation of HF and EF 50%.serum levels of Galectine-3 were measured in all patients with heart failure. Results: Level of galectine-3 was significantly increasing with advancing in NYHA classes [p value <0.001), while it had insignificant negative correlation with ejection fraction (r=0.06; P=0.51) and the Level of galactin-3 was significantly increasing with advancing in diastolic dysfunction grade (P= <0.001) Conclusion: Plasma galectine-3 concentration can be used as a biomarker to aid in clinical staging and severity of heart failure.","PeriodicalId":15375,"journal":{"name":"Journal of clinical trials","volume":"41 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80224877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autologous Platelet Rich Plasma (A-PRP) in Unexplained Infertility: A Revolution in Reproductive Medicine 自体富血小板血浆(A- prp)治疗不明原因不孕症:生殖医学的一场革命

Journal of clinical trials Pub Date : 2020-01-01 DOI: 10.35248/2167-0870.20.10.394

N. Garg

{"title":"Autologous Platelet Rich Plasma (A-PRP) in Unexplained Infertility: A Revolution in Reproductive Medicine","authors":"N. Garg","doi":"10.35248/2167-0870.20.10.394","DOIUrl":"https://doi.org/10.35248/2167-0870.20.10.394","url":null,"abstract":"Background: Any treatment for unknown infertility is empiric by default, and the broad range of treatment, including expectant management, superovulation, IUI, IVF and IVF–intracytoplasmic sperm injection, reflects the uncertainty with this diagnosis. There are limited data to support the efficacy of many of these treatments, and no uniform protocol exists in clinical practice. Autologous platelet rich plasma (A-PRP) can be a novel technique which has never been explored before much in this field. Objective: To compare autologous platelet rich plasma with expectant management in cases of unexplained infertility. Materials and methods: All cases (50) of primary unexplained infertility were treated with either A-PRP or by expectant management on the basis of their endometrial thickness (7 mm). All cases of thin endometrium (<7 mm) were subjected to A-PRP (25 cases). Whereas rest of the cases (25 in number) was monitored as per expectant management protocol for a maximum of three cycles after which they were switched over to being treated with PRP. The main outcomes measured were number of follicles, endometrial thickness, pregnancy rate and miscarriage rates. The statistical analysis was evaluated with IBM SPSS Statistics for Windows, Version 24.0, IBM Corp, and Chicago, IL. Results: Out of 46 patients, 25 patients (54.35%) got conceived with a single dose of intra-uterine autologous platelet rich plasma injection, which was found to be statistically highly significant. The correlation analysis with Spearman’s Rank correlation coefficient (rho ρ) was 0.891 which show highly positive correlation between intrauterine autologous platelet rich plasma injection and pregnancy rate and 0.247 which show weakly positive correlation between expectant management and pregnancy rate. Conclusion: Autologous platelet rich plasma (A-PRP) is a novel technique than can treat unexplained infertility with favorable outcomes.","PeriodicalId":15375,"journal":{"name":"Journal of clinical trials","volume":"16 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74028173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Smartphone Application-Enabled Daily Intervention for Patients with Nonalcoholic Steatohepatitis: A Feasibility Study 智能手机应用每日干预对非酒精性脂肪性肝炎患者的影响:一项可行性研究

Journal of clinical trials Pub Date : 2020-01-01 DOI: 10.35248/2167-0870.20.10.412

Masaya Sato, Shin Suzuki, R. Tateishi, M. Kinoshita, Takuma Nakatsuka, T. Ogawa, R. Nakagawa, Kohta Satake, Y. Yatomi, K. Koike

{"title":"Effect of Smartphone Application-Enabled Daily Intervention for Patients with Nonalcoholic Steatohepatitis: A Feasibility Study","authors":"Masaya Sato, Shin Suzuki, R. Tateishi, M. Kinoshita, Takuma Nakatsuka, T. Ogawa, R. Nakagawa, Kohta Satake, Y. Yatomi, K. Koike","doi":"10.35248/2167-0870.20.10.412","DOIUrl":"https://doi.org/10.35248/2167-0870.20.10.412","url":null,"abstract":"Background and Aims: The incidences of end-stage liver disease and hepatocellular carcinoma arising from nonalcoholic steatohepatitis (NASH) are rapidly increasing. Although weight reduction is recommended as an initial treatment, no pharmacologic treatments for this condition are presently available. The aims of the current study were(1) to develop a smartphone application-based intervention for weight reduction in NASH patients, and (2) to evaluate the feasibility of using this application in daily clinical practice. Methods: We developed a mobile phone application for NASH patients (NASH App). We then prospectively enrolled 9 clinically diagnosed NASH patients and applied a 24-week intervention using the NASH App in addition to the usual follow-up with laboratory and imaging studies. The use of the NASH App by the patients and the changes in weight and biomarkers were evaluated after the 24-week intervention. Results: The mean patient age was 37.67 years, and 7 patients (77.78%) were male. The mean BMI was 29.63 kg/m2. Seven patients completed the counseling provided by the NASH App. Since one patient was lost to follow-up, the comparison between pre- and post-intervention values was performed for 8 patients. A post-intervention weight reduction was observed in 7 patients, and this weight reduction was statistically significant (p=0.02).Normalization of the ALT level (<30 U/L) was observed in two patients. Conclusion: The NASH App intervention for NASH patients is feasible and acceptable. Further studies using a control arm and a larger population are needed to confirm the efficacy of the NASH App.","PeriodicalId":15375,"journal":{"name":"Journal of clinical trials","volume":"25 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82499596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Trials during Covid-19 Covid-19期间的临床试验

Journal of clinical trials Pub Date : 2020-01-01 DOI: 10.35248/2167-0870.20.10.E415

Abigail Mk

引用次数: 1