Journal of Cellular Biotechnology最新文献_第8页

HepG2 cells with recombinant cytochrome P450 enzyme overexpression: Their use and limitation as in vitro liver model 重组细胞色素P450酶过表达HepG2细胞:作为体外肝脏模型的应用和局限性

Journal of Cellular Biotechnology Pub Date : 2019-01-01 DOI: 10.3233/JCB-189013

Susanne Steinbrecht, S. Kammerer, J. Küpper

引用次数: 10

Erythrocyte aggregation in relation to plasma proteins and lipids 红细胞聚集与血浆蛋白和脂质的关系

Journal of Cellular Biotechnology Pub Date : 2019-01-01 DOI: 10.3233/JCB-189014

A. Krüger-Genge, R. Sternitzky, G. Pindur, M. Rampling, R. Franke, F. Jung

引用次数: 15

Regulation of A375 melanoma cell adhesion and migration by EphB4 and EphrinB2 – insights from co-culture experiments EphB4和EphrinB2对黑色素瘤A375细胞粘附和迁移的调控——来自共培养实验的见解

Journal of Cellular Biotechnology Pub Date : 2019-01-01 DOI: 10.3233/JCB-189011

Christin Neuber, M. Laube, C. Mamat, B. Belter, Jens Pietzsch

引用次数: 0

Cellular models of erythrocytes for studying the effect of gasotransmitters on their microrheology 研究气体递质对红细胞微流变学影响的红细胞模型

Journal of Cellular Biotechnology Pub Date : 2019-01-01 DOI: 10.3233/JCB-189009

A. V. Muravyov, I. Tikhomirova, P. Avdonin, S. V. Bulaeva, Yulia Malysheva, N. Kislov

引用次数: 5

Spirulina platensis, a super food? 螺旋藻，一种超级食物?

Journal of Cellular Biotechnology Pub Date : 2019-01-01 DOI: 10.3233/JCB-189012

F. Jung, A. Krüger-Genge, P. Waldeck, J. Küpper

{"title":"Spirulina platensis, a super food?","authors":"F. Jung, A. Krüger-Genge, P. Waldeck, J. Küpper","doi":"10.3233/JCB-189012","DOIUrl":"https://doi.org/10.3233/JCB-189012","url":null,"abstract":"Spirulina platensis, a multicelluar, photosynthetic prokaryote (algae) contains a high amount of proteins, vitamins and minerals superior to many foods as e.g. soybeans. Thus, Spirulina platensis was recognized as nutritious food by the United Nations World Food Conference. Due to the high amount of nutritive ingredients Spirulina has a long history as dietary supplement. In addition, spirulina platensis is also efficiently used as forage with known effects on flesh, egg and plumage color, milk yield and fertility. The versatile utilization of the alga can be explained on the one hand with the nutrient levels and on the other hand with recognized effects as anti-viral, anti-bacterial, anti-oxidant, anti-diabetic, anti-cancer and anti-inflammatory substance. Therefore, this alga is named as “superfood”. Beyond, these algae convert carbon dioxide into organic substances and produce oxygen during their growth in alkaline and saline water thereby not wasting fresh water allowing the production in barren areas. Despite this diverse use of Spirulina platensis due to its beneficial properties, many basic mechanisms on a molecular and cellular level are not well understood and should be explored in future studies.","PeriodicalId":15286,"journal":{"name":"Journal of Cellular Biotechnology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/JCB-189012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70024582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 90

Protein spectrum of blood plasma in patients with diabetes mellitus type II 2型糖尿病患者血浆蛋白谱分析

Journal of Cellular Biotechnology Pub Date : 2018-09-21 DOI: 10.3233/JCB-179009

V. Ionova, V. B. Lantsova, E. Tkach, R. Ziganshin, V. Shender, E. Weaver, V. Paskova, N. Antonova, I. Strokov

引用次数: 1

Actin type and distribution in erythrocytes 肌动蛋白在红细胞中的类型和分布

Journal of Cellular Biotechnology Pub Date : 2018-09-21 DOI: 10.3233/JCB-179014

A. Krüger-Genge, F. Jung, J. Küpper, Christian Lehmann, R. Franke

引用次数: 1

Effect of the preventative allopurinol therapy within the framework of the peripheral blood stem cell donation 外周血干细胞捐献框架内预防性别嘌呤醇治疗的效果

Journal of Cellular Biotechnology Pub Date : 2018-09-21 DOI: 10.3233/JCB-179013

E. Müller, Miriam Hübner, S. Kuderer, Marie Prechtl, J. Rox, J. Fischer, F. Wenzel

引用次数: 1

Influence of polymerized siloxane coating on growth and biofilm formation of aerobic grown nosocomial bacteria 聚合硅氧烷涂层对好氧医院细菌生长及生物膜形成的影响

Journal of Cellular Biotechnology Pub Date : 2018-09-21 DOI: 10.3233/JCB-179010

Ann-Kathrin Niebergall, S. Pfeiffer, C. Gruber, H. Sievers, A. Nies, A. Kehlen, B. Hiebl

引用次数: 1

Human hepatocyte systems for in vitro toxicology analysis 用于体外毒理学分析的人肝细胞系统

Journal of Cellular Biotechnology Pub Date : 2018-09-21 DOI: 10.3233/JCB-179012

S. Kammerer, J. Küpper

{"title":"Human hepatocyte systems for in vitro toxicology analysis","authors":"S. Kammerer, J. Küpper","doi":"10.3233/JCB-179012","DOIUrl":"https://doi.org/10.3233/JCB-179012","url":null,"abstract":"Drug induced liver injury (DILI) is still the leading single cause of drug failure during clinical phases and after market approval. Currently, many laboratories aim to develop appropriate in vitro systems to predict drug hepatotoxicity. Primary human hepatocytes are still the gold standard, but they have substantial disadvantages such as rapid dedifferentiation in vitro and lack of cell proliferation. In addition to primary human hepatocytes, liver cancer-derived cell lines such as HepG2, cytochrome P450 (CYP450) overexpressing HepG2 cell clones and HepaRG were studied intensively. In contrast to HepG2, HepaRG show promising characteristics of differentiated primary human hepatocytes, but they represent only one donor. There is some hope that this lack of donor variability can be solved by the use of iPS-derived hepatocytes. However, iPS technology still seems to need some improvement to produce physiologically relevant hepatocytes. Upcyte hepatocytes represent the most recent technical advancement combining some features of primary human hepatocytes such as physiological activity and donor variability with the ability of cell lines for extended proliferation. Altogether, more work is needed to develop and validate appropriate in vitro systems for precise prediction of DILI risk.","PeriodicalId":15286,"journal":{"name":"Journal of Cellular Biotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/JCB-179012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49273795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27