中国医师杂志最新文献

{"title":"Research progress of circadian rhythm disorder in cancer survivors","authors":"Jianfei Xie, Lu Wang, Panpan Xiao, Lijun Li, Siqi He, Jianda Zhou, Qian Sun, S. Andy","doi":"10.3760/CMA.J.CN431274-20191231-01491","DOIUrl":"https://doi.org/10.3760/CMA.J.CN431274-20191231-01491","url":null,"abstract":"Circadian rhythm disorder is a common physiological change of cancer survivors, which is mainly manifested in rest activity rhythm change, sleep wake disorder and the decrease of sleep efficiency at night, which further affect their physiological, psychological outcome and disease outcome. This paper reviews the concept, mechanism, influence and intervention methods of circadian rhythm disorder in cancer patients, in order to provide references for effective intervention of circadian rhythm disorder in cancer survivors. \u0000 \u0000Key words: \u0000Neoplasms; Survivors; Circadian rhythm; Review","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":"3 1","pages":"474-477"},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84349128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salmon calcitonin combined with vitamin D3 in the treatment of hyperparathyroidism secondary to chronic renal insufficiency","authors":"Jing Gu, Lu Gao","doi":"10.3760/CMA.J.CN431274-20181115-02089","DOIUrl":"https://doi.org/10.3760/CMA.J.CN431274-20181115-02089","url":null,"abstract":"Objective \u0000To explore the efficacy of salmon calcitonin combined with vitamin D3 in the treatment of chronic renal insufficiency and secondary hyperthyroidism and its effects on bone calcium metabolism. \u0000 \u0000 \u0000Methods \u0000A total of 40 patients with chronic renal failure who underwent hemodialysis in our blood purification center from September 2017 to December 2017 were selected for the study and were divided into treatment group (20 cases) and control group (20 cases) according to the random number table method. Patients in control group were given conventional treatment + calcitriol orally, and patients in treatment group were given subcutaneous injection of salmon calcitonin on the basis of control group. The course of treatment in both groups was 12 weeks. The clinical efficacy and clinical symptoms improvement, serum calcium, serum phosphorus and parathyroid hormone (iPTH) as well as the adverse reactions were compared between the two groups. The Kidney Disease Targeted Areas (KDTA) and Visual Analogue Pain Score (VAS) were used to evaluate the patients' quality of life and bone pain. \u0000 \u0000 \u0000Results \u0000The effective rate in treatment group was significantly higher than that in control group (95.00% vs 65.00%) (P 0.05). \u0000 \u0000 \u0000Conclusions \u0000The treatment effect of salmon calcitonin combined with vitamin D3 on chronic renal insufficiency secondary hyperthyroidism is obvious, and the clinical symptoms such as bone pain are improved obviously. It is believed that salmon calcitonin is related to the regulation of calcium, phosphorus and bone metabolism. \u0000 \u0000 \u0000Key words: \u0000Renal insufficiency, chronic; Hyperparathyroidism, secondary; Salmon calcitonin; Vitamin D3","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":"3 1","pages":"416-420"},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90292012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laparoscopic hepatectomy in special liver segments","authors":"Jian-Wei Li, Shu-guo Zheng, Li Cao","doi":"10.3760/CMA.J.CN431274-20200306-00240","DOIUrl":"https://doi.org/10.3760/CMA.J.CN431274-20200306-00240","url":null,"abstract":"Laparoscopic hepatectomy has been gradually accepted by liver surgeons because of its advantages such as minimal invasive approach. However, laparoscopic hepatectomy in special liver segments ( Ⅰ, Ⅳa, Ⅶ, Ⅷ) isn't carried out due to difficult technology and high risk. In this paper, the operative strategies and key points of laparoscopic hepatectomy were discussed in special liver segments based on relevant literature and our own experience. \u0000 \u0000Key words: \u0000Laparoscopy; Hepatectomy; Specific region","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":"8 1","pages":"328-330"},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83038029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The functions and mechanisms of BLACAT1 in malignant tumors","authors":"Shuwa Xu, Hao-Ming Xia, Zewei Gao, R. Huang, Enyu Tang, Xing-ming Jiang","doi":"10.3760/CMA.J.CN431274-20190401-00375","DOIUrl":"https://doi.org/10.3760/CMA.J.CN431274-20190401-00375","url":null,"abstract":"Long non-coding RNAs (lncRNAs) are a kind of transcripts which are longer than 200nt and have not protein-coding ability due to the lack of an open reading frame. However, lncRNAs can be involved in tumorigenesis and progression in various ways at the transcriptional and post-transcriptional levels. Bladder cancer associated transcript 1 (BLACAT1) as a lncRNA located on human chromosome 1q32.1, is ectopic expression in various tumors (bladder cancer, gastric malignant tumor, lung carcinoma, et al) and can regulate tumor cell proliferation, anti-apoptosis, invasion and metastasis by different mechanisms leading to occurrence and development of tumors. In this review, we summarized current studies of the functions and mechanisms of BLACAT1 in malignant tumors. \u0000 \u0000Key words: \u0000RNA, long noncoding; Bladder cancer associated transcript 1; Neoplasms; Therapeutic target; Review","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":"66 1","pages":"469-473"},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89410755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of breast tissue marker on MRI evaluation for breast lesions and clinical significance","authors":"Haiqing Liu, Hanchen Zhang, Ziliang Cheng, W. Zeng, C. Gong, Yue Hu, Zhuo Wu","doi":"10.3760/CMA.J.CN431274-20190104-00025","DOIUrl":"https://doi.org/10.3760/CMA.J.CN431274-20190104-00025","url":null,"abstract":"Objective \u0000This study compares the magnetic resonance imaging (MRI) appearance of two types of breast tissue markers to investigate the appropriate clinical application of the markers. \u0000 \u0000 \u0000Methods \u0000Breast MRI of 69 patients (78 masses) with breast tissue markers had been placed were analyzed retrospectively from November 2015 to August 2018 in our hospital. The sizes and shapes of breast tissue markers were assessed in axial fat-suppressed T2-weighted images, T1-weighted images and contrast-enhanced T1-weighed images. \u0000 \u0000 \u0000Results \u0000The length of the coil nickel-free stainless steel markers were greater than ribbon titanium markers, with statistical difference in fat-suppressed T2-weighted images (P=0.039). In contrast-enhanced T1-weighted images, all coil nickel-free stainless steel markers showed >6 mm diameter and round shape, and ribbon titanium markers showed >6 mm diameter (n=20) or ≤6 mm diameter (n=8), and round (n=20), dot (n=7) or band (n=1) shapes. The categories of sizes and shapes in two types of breast tissue markers both had statistical significance (P<0.001, P<0.001). \u0000 \u0000 \u0000Conclusions \u0000Small breast lesions with breast tissue markers are not suitable for MRI evaluation. The artifact of ribbon titanium markers is smaller than coil nickel-free stainless steel markers, so they have less impact for lesions. The choice of the breast tissue markers and image evaluation methods should depend on the different clinical conditions. \u0000 \u0000 \u0000Key words: \u0000Magnetic resonance imaging; Breast neoplasms; Fiducial markers; Titanium; Stainless steel","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":"27 1","pages":"337-341"},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88580033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An integrated strategy of TCM and western medicine to prevent and treat acute abdomen during the outbreak of COVID-19","authors":"Guolei Li, Guoliang Tan, Yuan-hua Liu, Zhao Xu, H. Feng, Yali Zhang, Wei-Hong Xing, Zhi-feng Xu","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.02.002","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.02.002","url":null,"abstract":"At present, the prevention and control of the COVID-19 is still severe, its pathogen SARS-CoV-2 is highly infectious and pathogenic, and the population is generally susceptible. Thus, it requires a higher standard to diagnose and treat patients with acute abdomen. The first step is to carry out procedures to identify whether the patient is infected or not. Those who are not infected can go through the normal treating procedures. For patients diagnosed with COVID-19 or suspected patients, the second step is to achieve classified diagnoses and treatments, and to adopt a treating plan that integrates TCM and western medicine. In order to protect patients and medical staff, the COVID-19 in hospital transmission must be avoided. For patients with COVID-19 who need emergency surgery, we must strictly comply with the hospital's protection regulations, closely coordinate the relevant departments of surgery, perform the three-level protection, operate in accordance with the principle of damage control in the negative pressure surgery room, and return to the isolation ward according to the prevention and control process after operation. For units without surgical conditions, patients should be transferred to hospital in time on the premise of maximum damage control, and patients must not be delayed for timely diagnosis and treatment due to the epidemic. Key words: Novel coronavirus; Pneumonia, viral; Acute abdominal diseases; Traditional Chinese and Western Medicine","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":"13 1","pages":"166-169"},"PeriodicalIF":0.0,"publicationDate":"2020-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82453873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The correlation between the expression of LncRNA-OVAAL and the recurrence and prognosis of uterine papillary serous carcinoma after operation","authors":"Wei Huang, H. Miao, Lin-hui Peng","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.02.013","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.02.013","url":null,"abstract":"Objective \u0000To investigate the relationship between long non-coding ovarian adenocarcinoma amplified RNA (LncRNA-OVAAL) and tumor recurrence and prognosis in uterine papillary serous carcinoma (UPSC). \u0000 \u0000 \u0000Methods \u0000From May 2012 to November 2016, 32 patients with UPSC in our hospital were selected as observation group, and 30 patients with other benign diseases were selected as control group. Real-time polymerase chain reaction (PCR) was used to detect the expression of LncRNA-OVAAL in the enrolled patients. The receiver operating characteristic (ROC) curve was used to analyze the cutoff value of LncRNA-OVAAL. The relationship between LncRNA-OVAAL expression and clinicopathological features was analyzed. The cumulative survival rate was calculated and survival analysis was performed. The Cox risk regression model was used to analyze the single-factor and multi-factor analysis of prognosis and overall survival rate. \u0000 \u0000 \u0000Results \u0000The expression of LncRNA-OVAAL in patients with UPSC was elevated, which was related to age, vascular invasion, menopause, recurrence and preoperative serum human epididymis protein 4 (HE4) and carbohydrate antigen 125 (CA125) (P<0.05). High expression of LncRNA-OVAAL was a risk factor for postoperative recurrence and overall survival in patients with UPSC (P<0.05). \u0000 \u0000 \u0000Conclusions \u0000The high expression of LncRNA-OVAAL has a certain evaluation value for predicting postoperative recurrence and prognosis in patients with UPSC. \u0000 \u0000 \u0000Key words: \u0000RNA, long noncoding; Uterine papillary serous carcinoma; Neoplasm recurrence; Prognosis","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":"48 1","pages":"216-219"},"PeriodicalIF":0.0,"publicationDate":"2020-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86713902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progresses of the way to improve umbilical cord blood stem cells homing and engraftment","authors":"Miao Zhou, Ping Zhang, G. Ouyang","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.02.043","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.02.043","url":null,"abstract":"Umbilical cord blood is an alternative hematopoietic stem cell source has been widely recognized. Initially, umbilical cord blood transplantation was limited, given the low engraftment. So the method of improving cord blood homing and engraftment has been widely studied in various fields. This paper briefly reviews the progress of main researches in recent years. \u0000 \u0000Key words: \u0000Cord blood stem cell transplantation; Homing; Engraftment; Review","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":"4 1","pages":"317-320"},"PeriodicalIF":0.0,"publicationDate":"2020-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86636252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis on clinical efficacy and influencing factors of decitabine-based regimens in patients with myelodysplastic syndrome-refractory anemia with excess blasts","authors":"Jiale Ma, Yan Wang, L. Xiang, Luqun Wang, Jie Fu, Pu Zhang, Xiao-Ling Li","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.02.023","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.02.023","url":null,"abstract":"Objective \u0000To analyze the clinical efficacy, safety and influencing factors of decitabine (DAC)-based regimens in patients with myelodysplastic syndrome-refractory anemia with excess blasts (MDS-RAEB). \u0000 \u0000 \u0000Methods \u0000We performed a retrospective analysis of 63 patients with MDS-RAEB treated with DAC, evaluated the clinical efficacy and adverse reactions, and analyzed the influencing factors affecting survival. \u0000 \u0000 \u0000Results \u0000Among 63 patients, 23 were RAEB-1 and 40 were RAEB-2. The median treatment was 4 (2-13) courses. The total effective rate of DAC for MDS-RAEB was 58.7%(37/63), and the complete response rate was 20.6%(13/63). Among 37 patients who were effective, 20 (54.1%) patients performed efficacy after 2 courses. The median course of treatment to achieve the best effect was 3.5 (3-4) courses. With a median follow-up of 14 (2-68) months, 63 patients had a overall survival rate (OS) of 84.2% and a 1-year progression-free survival rate (PFS) of 73%. In univariate analysis, the factors that prolonged OS were that the best effect after medication was stable disease (SD) (to achieve complete remission, partial remission, complete bone marrow remission, hematological improvement) (P=0.009) and no thrombocytopenia at first diagnosis (P=0.019), the factor that prolongs PFS is the best effect above SD (P=0.003). Multivariate analysis suggested that the factors affecting OS and PFS were the best curative effects above SD (P=0.015 vs P=0.008). The adverse effects of decitabine in the treatment of MDS-RAEB were mainly bone marrow suppression and pulmonary infection. \u0000 \u0000 \u0000Conclusions \u0000Decitabine is an effective and well-tolerated drug in the treatment of MDS-RAEB. Response to decitabine treatment is one of the independent factors affecting the prognosis. \u0000 \u0000 \u0000Key words: \u0000Anemia, refractory, with excess of blasts; Drug therapy, combination; Decitabine; Prognosis; Factor analysis, statistical","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":"72 1","pages":"258-262"},"PeriodicalIF":0.0,"publicationDate":"2020-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86358267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on the debate about laparoscopic surgery for early-stage cervical cancer","authors":"Jing Cai, Zehua Wang","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.02.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.02.003","url":null,"abstract":"In the past two decades, laparoscopic surgery has been increasingly used in the treatment of early-stage cervical cancer because of equal survival and faster recovery compared to abdominal surgery. Recently, a phase III randomized controlled clinical trial revealed unexpected results that minimally invasive surgery was associated with significantly increased risks for tumor recurrence and death in patients with early-stage cervical cancer, causing a great debate worldwide. Herein, we highlighted the key points in the debate and tossed out several ideas on how to face and deal with the controversy. \u0000 \u0000Key words: \u0000Uterine cervical neoplasms; Early-stage tumor; Laparoscopy","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":"15 1","pages":"170-174"},"PeriodicalIF":0.0,"publicationDate":"2020-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73636241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}