Journal of Cardiovascular Medicine最新文献

{"title":"Impact of total ischemic time on prognosis in non-ST- elevation acute coronary syndrome.","authors":"Maddalena Immobile Molaro, Fiorenzo Simonetti, Raffaele Piccolo","doi":"10.2459/JCM.0000000000001699","DOIUrl":"10.2459/JCM.0000000000001699","url":null,"abstract":"","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":"26 3","pages":"107-109"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Which Brugada patient deserves continuous ECG monitoring through implantable loop recorder? An evidence update.","authors":"Pierangelo Calvelli, Natascia Cerrato, Carla Giustetto, Andrea Saglietto, Matteo Anselmino, Antonio Curcio","doi":"10.2459/JCM.0000000000001696","DOIUrl":"10.2459/JCM.0000000000001696","url":null,"abstract":"<p><p>Brugada syndrome (BrS) is a genetic condition that increases the risk of life-threatening arrhythmias, which can result in sudden cardiac death (SCD). Implantable loop recorders (ILRs) have become a key tool in managing patients with unexplained syncope, and guidelines advise their use in individuals with recurrent, unexplained syncope or palpitations. However, the role of ILRs in inherited arrhythmic conditions like BrS remains a topic of debate. Most patients newly diagnosed with BrS show no symptoms, but around 30% may experience symptoms such as syncope or palpitations, which can arise from arrhythmic issues or other causes like neurally mediated reflexes. Accurately assessing the cause of these symptoms is crucial to evaluate the risk of SCD. This document aims to examine current evidence on the role of ILR implantation in patients with BrS. The most frequent arrhythmias recorded by ILR are supraventricular arrhythmias and conduction disorders; ventricular arrhythmias, usually nonsustained, are rarely recorded. Symptoms-to-rhythm correlation by ILR can have therapeutic implications in case of recorded arrhythmias (initiation of drug therapy, ablation procedures or defibrillator/pace-maker implantation), provide reassurance in patients without rhythm disorders documented and improve their quality of life. However, given the low rate of detected arrhythmias, the clinical value of ILR in asymptomatic patients needs further evaluation.</p>","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":"26 2","pages":"64-71"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Echocardiographic index of left ventricular performance for prognostication in transthyretin cardiac amyloidosis: the central role of stroke volume index.","authors":"Matteo Serenelli, Anna Cantone, Beatrice Dal Passo, Federico Sanguettoli, Gioele Fabbri, Gabriele Guidi Colombi, Daniele Maio, Matteo Arzenton, Martina Vitali, Rita Pavasini, Gianluca Campo","doi":"10.2459/JCM.0000000000001690","DOIUrl":"10.2459/JCM.0000000000001690","url":null,"abstract":"<p><strong>Introduction: </strong>Cardiac amyloidosis typically causes restrictive cardiomyopathy, in which the impairment of diastolic function is dominant. Echocardiography provides prognostic information through some important parameters: left ventricular ejection fraction (LVEF) and global longitudinal strain (GLS). However, LVEF often remains preserved despite disease progression, and GLS is not routinely performed as it is limited by suboptimal image quality. The stroke volume index (SVi) has already been shown to correlate with mortality in heart failure patients; still, its prognostic role in transthyretin cardiac amyloidosis (TTR-CA) is poorly studied.</p><p><strong>Purpose: </strong>This prospective study aimed to evaluate the role of SVi in predicting mortality and heart failure hospitalizations in patients with cardiac amyloidosis, comparing it to other parameters of left ventricular performance.</p><p><strong>Methods: </strong>Baseline clinical transthoracic echocardiogram and laboratory data were collected prospectively in 115 patients with diagnosed TTR-CA. The outcome was the occurrence of the composite of heart failure hospitalization and death and its association with SVi, LVEF, GLS and MCF was tested by Cox proportional hazard modelling.</p><p><strong>Results: </strong>Over a mean follow-up of 16.1 months (interquartile range 7.4-24.9 months), 29 patients died, and 19 were hospitalized for heart failure. SVi was associated with the composite outcome of death and heart failure hospitalization [hazard ratio 0.96; 95% confidence interval (CI) 0.93-0.99] and remained an independent predictor of outcome after adjustment for NAC stage, mitral regurgitation degree, age and the use of disease-modifying treatment. The best cut-off of SVi to predict outcome was 35 ml/m2 (hazard ratio 2.30; 95% CI 1.03-5.17).</p><p><strong>Conclusion: </strong>SVi is superior to LVEF, MCF, and GLS for prognostication in patients with TTR amyloidosis.</p>","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":"26 2","pages":"81-87"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The 'Predatory Journal': the quality vs. quantity of the publications.","authors":"Ciro Indolfi","doi":"10.2459/JCM.0000000000001706","DOIUrl":"10.2459/JCM.0000000000001706","url":null,"abstract":"","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":"26 2","pages":"63"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac amyloidosis: when to suspect and how to confirm.","authors":"Michele Emdin, Alberto Aimo, Yu Fu Ferrari Chen, Marco Merlo, Aldostefano Porcari, Giuseppe Vergaro, Gianfranco Sinagra","doi":"10.2459/JCM.0000000000001695","DOIUrl":"10.2459/JCM.0000000000001695","url":null,"abstract":"<p><p>Diagnosing cardiac amyloidosis (CA) is challenging because of its phenotypic heterogeneity, multiorgan involvement requiring interaction among experts in different specialties and subspecialties, lack of a single noninvasive diagnostic tool, and still limited awareness in the medical community. Missing or delaying the diagnosis of CA may profoundly impact on patients' outcomes, as potentially life-saving treatments may be omitted or delayed. The suspicion of CA should arise when \"red flags\" for this condition are present, together with increased left ventricular wall thickness. The diagnosis of CA requires amyloid typing and differentiation between the two most common forms, light chain (AL) and either mutated or wild-type transthyretin cardiac amyloidosis (ATTR-CA), which is critical to guide a specific treatment. Scientific societies worldwide focus on the importance of red flags, and on the prompt initiation of the diagnostic process with bone tracer uptake and the search of a monoclonal protein. An extra-cardiac or endomyocardial tissue biopsy is needed when a monoclonal protein has been detected and/or cardiac bone tracer uptake is absent or weak. Finally, all patients diagnosed with ATTR-CA should undergo genetic testing to search for TTR gene mutations.</p>","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":"26 2","pages":"102-105"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis of atrial cardiomyopathy: from the electrocardiogram to the new opportunities with multimodality imaging.","authors":"Martina Belli, Davide Margonato, Francesca Romana Prandi, Lucy Barone, Saverio Muscoli, Dalgisio Lecis, Rocco Mollace, Domenico Sergi, João L Cavalcante, Stamatios Lerakis, Francesco Barillà","doi":"10.2459/JCM.0000000000001694","DOIUrl":"10.2459/JCM.0000000000001694","url":null,"abstract":"<p><p>Atrial cardiomyopathy (AC) has been defined by the European Heart Rhythm Association as \"Any complex of structural, architectural, contractile, or electrophysiologic changes in the atria with the potential to produce clinically relevant manifestations\".1 The left atrium (LA) plays a key role in maintaining normal cardiac function; in fact atrial dysfunction has emerged as an essential determinant of outcomes in different clinical scenarios, such as valvular diseases, heart failure (HF), coronary artery disease (CAD) and atrial fibrillation (AF). A comprehensive evaluation, both anatomical and functional, is routinely performed in cardiac imaging laboratories. Recent advances in imaging techniques offer opportunities for evaluation of LA function, fundamental in clinical practice for early cardiovascular (CV) risk estimation, choice of therapeutic intervention and follow up. In this review we explore the concept of AC, its diagnosis through a multimodal approach, ranging from the historical electrocardiogram to the latest CV imaging techniques and its clinical implications.</p>","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":"26 2","pages":"88-101"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional assessment in angina and non-obstructive coronary arteries: from microvascular resistance reserve to subtypes of coronary microvascular dysfunction.","authors":"Domenico Galante, Andrea Viceré, Ciro Pollio Benvenuto, Vincenzo Viccaro, Chiara Giuliana, Simona Todisco, Gennaro Capalbo, Rocco Montone, Enrico Romagnoli, Cristina Aurigemma, Carlo Trani, Francesco Burzotta, Filippo Crea, Antonio Maria Leone","doi":"10.2459/JCM.0000000000001689","DOIUrl":"10.2459/JCM.0000000000001689","url":null,"abstract":"<p><strong>Aims: </strong>Coronary microvascular dysfunction (CMD) is a heterogeneous condition defined by reduced coronary flow reserve (CFR). The new index 'microvascular resistance reserve' (MRR) has been developed, but its role is unclear. We investigate the relationships between functional indices in ANOCA (angina and non-obstructive coronary arteries) patients and evaluate the hemodynamic features of different CMD subtypes.</p><p><strong>Methods: </strong>We enrolled consecutive ANOCA patients assessed by using the bolus thermodilution technique. CFR, index of microcirculatory resistance (IMR) and MRR were estimated and correlated with each other. Patients were divided into two groups based on CMD presence (CFR < 2.5). Subsequently, high-hyperaemic-resistance (HHR) and low-hyperaemic-resistance (LHR) CMD subtypes were defined according to IMR values (cut-off 25). Microvascular flow and resistance were estimated both at rest and during hyperaemia with Tmnrest/IMRrest and Tmnhyp/IMR, respectively. All functional indices were compared between groups.</p><p><strong>Results: </strong>In total, 108 patients were enrolled: 66 patients in the normal group (CFR ≥ 2.5), 20 in the HHR-CMD group (CFR < 2.5 and IMR ≥ 25) and 22 in the LHR-CMD group (CFR < 2.5 and IMR < 25). MRR strongly correlated (r = 0.968, P < 0.01) with CFR, showing a good discriminatory power (area under the curve = 0.97) and accuracy (85%) for detecting CMD. LHR-CMD patients showed reduced microvascular resistance (IMRrest 34.3 ± 15.1, P < 0.01) and increased resting flow (Tmnrest 0.37 ± 0.17, P < 0.01), while HHR-CMD patients had impaired hyperaemic flow (Tmnhyp 0.45 ± 0.24 P < 0.01). MRR was reduced in CMD patients (P < 0.01), with no differences between CMD subtypes (P = 0.66).</p><p><strong>Conclusions: </strong>In ANOCA patients, MRR and CFR are strongly correlated and could be considered as functionally interchangeable tools. IMR is crucial for differentiating CMD endotypes.</p>","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":"26 2","pages":"72-80"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"'Shining' infective endocarditis with a 'ring of fire' in the spleen.","authors":"Cesare Michele Iacovitti, Marco Cuzzocrea, Gaetano Paone, Giorgio Treglia","doi":"10.2459/JCM.0000000000001687","DOIUrl":"https://doi.org/10.2459/JCM.0000000000001687","url":null,"abstract":"","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":"26 1","pages":"38-39"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left atrial volumetric/mechanical coupling index and atrial fibrillation in the embolic stroke of undetermined source.","authors":"Giacomo Mugnai, Alberto Comuzzi, Sara De Giovanni, Ilaria Armani, Giovanni Benfari, Cecilia Zivelonghi, Bruna Bolzan, Sofia Capocci, Manuel Cappellari, Luca Tomasi, Flavio Ribichini","doi":"10.2459/JCM.0000000000001682","DOIUrl":"10.2459/JCM.0000000000001682","url":null,"abstract":"<p><strong>Introduction: </strong>Nowadays, no clear predictors of atrial fibrillation in patients with embolic stroke of undetermined source (ESUS) are known. Some echocardiographic parameters have been proposed as potential predictors of atrial fibrillation in patients with ESUS. The ratio between left atrial volume and tissue Doppler (TDI) a' provides the left atrial volumetric/mechanical coupling index (LACI) and represents a feasible surrogate for left atrial function, and might be useful to identify atrial fibrillation in this subset of patients.</p><p><strong>Methods and results: </strong>All consecutive patients having undergone an implantable loop recorder (ILR) for ESUS between 2017 and 2022 were retrospectively enrolled. All patients were followed through remote monitoring and telephone visit for a minimum follow-up of 6 months.A total number of 129 patients (mean age: 72.2 ± 8.8 years; 55% of men) were analyzed. Patients developing atrial fibrillation presented higher baseline LACI (5.53 ± 2.52 vs. 3.25 ± 1.19, P < 0.001). The multivariate analysis showed that LACI was independently and significantly associated with atrial fibrillation (hazard ratio = 1.21, 95% confidence interval 1.09-1.32, P < 0.01). The best cut-off value of LACI was found to be 4.24.</p><p><strong>Discussion: </strong>Our data confirm that LACI is independently associated with atrial fibrillation in patients with ILR following ESUS, accounting for clinical or echocardiographic factors.</p>","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":"26 1","pages":"58-61"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Should we start using colchicine for secondary prevention of acute and chronic coronary syndromes after 2024 European society of cardiology guidelines?","authors":"Massimo Imazio","doi":"10.2459/JCM.0000000000001688","DOIUrl":"10.2459/JCM.0000000000001688","url":null,"abstract":"","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":"26 1","pages":"4-7"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}