Journal of Cardiovascular Medicine最新文献_第6页

Mitral regurgitation carries greater prognostic significance than mitral stenosis in patients undergoing transcatheter aortic valve replacement. 在接受经导管主动脉瓣置换术的患者中，二尖瓣反流比二尖瓣狭窄对预后的影响更大。

IF 3 3区医学

Journal of Cardiovascular Medicine Pub Date : 2024-07-01 Epub Date: 2024-05-14 DOI: 10.2459/JCM.0000000000001629

Giovanni Polizzi, Karla Campos, Stephanie Alyse Coulter

{"title":"Mitral regurgitation carries greater prognostic significance than mitral stenosis in patients undergoing transcatheter aortic valve replacement.","authors":"Giovanni Polizzi, Karla Campos, Stephanie Alyse Coulter","doi":"10.2459/JCM.0000000000001629","DOIUrl":"https://doi.org/10.2459/JCM.0000000000001629","url":null,"abstract":"Aims: This study assessed the outcomes of concomitant mitral valve disease and severe aortic stenosis in patients undergoing transcatheter aortic valve replacement (TAVR).Methods: Echocardiographic data of 813 patients with severe aortic stenosis undergoing transfemoral TAVR were collected, and clinical outcomes were analyzed for individuals with mitral stenosis and mitral regurgitation.Results: The final cohort includes 788 patients with severe calcific aortic stenosis. Among single parameters of mitral stenosis, a smaller baseline mitral valve area (MVA) by the continuity equation and higher postprocedural mean mitral gradients (MMG) were associated with an increased risk of death at 1 year (P-values 0.02 and <0.01, respectively), but no correlation with outcomes was demonstrated after multivariate adjustment for major prognosticators. Mitral stenosis (based on MVA + MMG) was not associated with complications or mortality. Mitral regurgitation was present in 94.6% of the population at baseline and regressed by at least one grade post-TAVR in 28% of the patients. The improvement in mitral regurgitation was associated with a greater prosthetic effective orifice area (P-value 0.03). Significant (at least moderate) residual mitral regurgitation was correlated with short-term complications and shown to be an independent predictor of 1-year mortality (P-value 0.02, odds ratio (OR) 5.37, confidence interval 1.34-21.5).Conclusion: Mitral regurgitation has a greater impact on TAVR patients than mitral stenosis as assessed by functional methods.","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":"25 7","pages":"529-538"},"PeriodicalIF":3.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141237808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extremely late drug-eluting stent thrombosis. 极晚期药物洗脱支架血栓形成。

IF 2.9 3区医学

Journal of Cardiovascular Medicine Pub Date : 2024-07-01 Epub Date: 2024-05-29 DOI: 10.2459/JCM.0000000000001621

Michele Coceani, Giovanni Benedetti, Sergio Berti

引用次数: 0

The impact of the Naples Prognostic Score on the short- and long-term prognosis of patients undergoing transcatheter aortic valve implantation. 那不勒斯预后评分对经导管主动脉瓣植入术患者短期和长期预后的影响。

IF 3 3区医学

Journal of Cardiovascular Medicine Pub Date : 2024-07-01 Epub Date: 2024-05-20 DOI: 10.2459/JCM.0000000000001637

Aykun Hakgor, Atakan Dursun, Basak Catalbas Kahraman, Arzu Yazar, Umeyir Savur, Aysel Akhundova, Fatih Erkam Olgun, Busra Guvendi Sengor

{"title":"The impact of the Naples Prognostic Score on the short- and long-term prognosis of patients undergoing transcatheter aortic valve implantation.","authors":"Aykun Hakgor, Atakan Dursun, Basak Catalbas Kahraman, Arzu Yazar, Umeyir Savur, Aysel Akhundova, Fatih Erkam Olgun, Busra Guvendi Sengor","doi":"10.2459/JCM.0000000000001637","DOIUrl":"10.2459/JCM.0000000000001637","url":null,"abstract":"Background: Preoperative systemic inflammation and nutritional status have been shown to affect prognosis in patients undergoing transcatheter aortic valve implantation (TAVI). In this study, we investigated the effect of the Naples Prognostic Score (NPS), which consists of four different parameters including these two components on short- and long-term prognosis in patients undergoing TAVI.Methods: In 343 patients (mean age 78.1 ± 8.4 years, 51.3% female) who underwent TAVI, the NPS score was calculated from the blood tests obtained before the procedure and the study population was divided into three according to the NPS value: those with 0 and 1 were divided into Group-1, those with 2 into Group-2, and those with 3 and 4 into Group-3. The relationship between NPS group and in-hospital adverse events and long-term survival was evaluated.Results: Systolic pulmonary artery pressure, STS score, presence of chronic lung disease and being in NPS Group-3 [adjusted odds ratio (adjOR): 3.93, 95% confidence interval (CI) (1.02-15.17), P = 0.047] were found to be independent predictors of in-hospital mortality. According to the multivariate Cox-regression model, both Group-2 NPS [adjusted hazard ratio (adjHR): 4.81, 95% CI (1.09-21.14), P = 0.037] and Group-3 NPS [adjHR: 10.1, 95% CI (2.31-43.36), P = 0.002] was an independent predictor of 2-year all-cause mortality after TAVI. There was no significant difference in perioperative adverse events between the groups except for postprocedural acute kidney injury. According to receiver-operating characteristic analysis, the optimal predictive value of NPS for in-hospital and long-term mortality was 2.5.Conclusion: In patients who will be candidates for TAVI, NPS is a simple and effective tool for determining both short- and long-term prognosis.","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":" ","pages":"519-528"},"PeriodicalIF":3.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141175803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Edoxaban and/or colchicine for patients with coronavirus disease 2019 managed in the out-of-hospital setting (CONVINCE): a randomized clinical trial. 埃多沙班和/或秋水仙碱用于治疗2019年在院外环境中接受治疗的冠状病毒疾病患者（CONVINCE）：一项随机临床试验。

IF 2.9 3区医学

Journal of Cardiovascular Medicine Pub Date : 2024-07-01 Epub Date: 2024-05-28 DOI: 10.2459/JCM.0000000000001639

Antonio Landi, Nuccia Morici, Pascal Vranckx, Enrico Frigoli, Luca Bonacchini, Barbara Omazzi, Moreno Tresoldi, Claudio Camponovo, Tiziano Moccetti, Stephan Windecker, Marco Valgimigli

引用次数: 0

Systematic review and meta-analysis of the impact of sex on outcomes after aortic valve replacement. 主动脉瓣置换术后性别对疗效影响的系统回顾和荟萃分析。

IF 3 3区医学

Journal of Cardiovascular Medicine Pub Date : 2024-07-01 Epub Date: 2024-05-28 DOI: 10.2459/JCM.0000000000001635

Ryaan El-Andari, Sabin J Bozso, Nicholas M Fialka, Adbulaziz Mohammed Alaklabi, Jimmy J H Kang, Jeevan Nagendran

{"title":"Systematic review and meta-analysis of the impact of sex on outcomes after aortic valve replacement.","authors":"Ryaan El-Andari, Sabin J Bozso, Nicholas M Fialka, Adbulaziz Mohammed Alaklabi, Jimmy J H Kang, Jeevan Nagendran","doi":"10.2459/JCM.0000000000001635","DOIUrl":"10.2459/JCM.0000000000001635","url":null,"abstract":"Aims: In recent years, extensive literature has been produced demonstrating inferior outcomes for women when compared with men undergoing heart valve interventions. Herein, we seek to analyze the literature comparing outcomes between men and women undergoing surgical aortic valve replacement (SAVR).Methods: A systematic literature search of PubMed, MEDLINE, and Embase was conducted for articles comparing differences in outcomes between adult men and women undergoing SAVR. One thousand nine hundred and ninety titles were screened, of which 75 full texts were reviewed, and a total of 19 manuscripts met the inclusion criteria and were included in this review.Results: Pooled estimates of mortality demonstrated that women tended to have lower rates of survival within the first 30 days post-SAVR, although mid-term and long-term mortality did not differ significantly up to 10 years postoperatively. Pooled estimates of postoperative data indicated no difference in the rates of stroke and postoperative bleeding. Rates of aortic valve reoperation and acute kidney injury favored women.Conclusion: Despite the inferior outcomes for women post-SAVR that have been reported in recent years, the results of this meta-analysis demonstrate comparable results between the sexes with comparable mid- to long-term mortality in data pooled from the literature. Although mortality favored men in the short term, rates of aortic valve reoperation and acute kidney injury favored women. Future investigation into this field should focus on identifying discrepancies in diagnosis and initial surgical management in order to address any potential factors contributing to discrepant short-term outcomes.Graphical abstract: http://links.lww.com/JCM/A651.","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":" ","pages":"539-550"},"PeriodicalIF":3.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141160490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of mavacamten in patients with hypertrophic cardiomyopathy. 对肥厚型心肌病患者使用马伐康坦的评估。

IF 2.9 3区医学

Journal of Cardiovascular Medicine Pub Date : 2024-07-01 Epub Date: 2024-05-29 DOI: 10.2459/JCM.0000000000001638

Hui-Ling Liao, Yi Liang, Bo Liang

{"title":"Evaluation of mavacamten in patients with hypertrophic cardiomyopathy.","authors":"Hui-Ling Liao, Yi Liang, Bo Liang","doi":"10.2459/JCM.0000000000001638","DOIUrl":"10.2459/JCM.0000000000001638","url":null,"abstract":"Aims: We aimed to comprehensively assess the safety and efficacy of mavacamten in hypertrophic cardiomyopathy (HCM) patients.Methods: A systematic review and meta-analysis was conducted, and efficacy [changes in postexercise left ventricular outflow tract (LVOT) gradient, left ventricular ejection fraction (LVEF), peak oxygen consumption (pVO 2 ), Kansas City Cardiomyopathy Questionnaire Clinical Summary Score (KCCQ CSS), and the proportion of patients exhibiting an improvement of at least one New York Heart Association (NYHA) functional class from baseline)], safety (total count of treatment-emergent adverse events and SAEs, as well as the proportion of patients experiencing at least one adverse event or SAE), and cardiac biomarkers (NT-proBNP and cTnI) outcomes were evaluated.Results: We incorporated data from four randomized controlled trials, namely EXPLORER-HCM, VALOR-HCM, MAVERICK-HCM, and EXPLORER-CN. Mavacamten demonstrated significant efficacy in reducing the postexercise LVOT gradient by 49.44 mmHg ( P = 0.0001) and LVEF by 3.84 ( P < 0.0001) and improving pVO 2 by 0.69 ml/kg/min ( P = 0.4547), KCCQ CSS by 8.11 points ( P < 0.0001), and patients with at least one NYHA functional class improvement from baseline by 2.20 times ( P < 0.0001). Importantly, mavacamten increased 1.11-fold adverse events ( P = 0.0184) 4.24-fold reduced LVEF to less than 50% ( P = 0.0233) and 1.06-fold SAEs ( P = 0.8631). Additionally, mavacamten decreased NT-proBNP by 528.62 ng/l ( P < 0.0001) and cTnI by 8.28 ng/l ( P < 0.0001).Conclusion: Mavacamten demonstrates both safety and efficacy in patients with HCM, suggesting its potential as a promising therapeutic strategy for this condition. Further research is warranted to confirm these results and explore its long-term effects.","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":" ","pages":"491-498"},"PeriodicalIF":2.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141175779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical complexity of an Italian cardiovascular intensive care unit: the role of mortality and severity risk scores. 意大利心血管重症监护病房的临床复杂性：死亡率和严重性风险评分的作用。

IF 3 3区医学

Journal of Cardiovascular Medicine Pub Date : 2024-07-01 Epub Date: 2024-05-14 DOI: 10.2459/JCM.0000000000001632

Federica Troisi, Pietro Guida, Nicola Vitulano, Adriana Argentiero, Andrea Passantino, Massimo Iacoviello, Massimo Grimaldi

{"title":"Clinical complexity of an Italian cardiovascular intensive care unit: the role of mortality and severity risk scores.","authors":"Federica Troisi, Pietro Guida, Nicola Vitulano, Adriana Argentiero, Andrea Passantino, Massimo Iacoviello, Massimo Grimaldi","doi":"10.2459/JCM.0000000000001632","DOIUrl":"https://doi.org/10.2459/JCM.0000000000001632","url":null,"abstract":"Aims: The identification of patients at greater mortality risk of death at admission into an intensive cardiovascular care unit (ICCU) has relevant consequences for clinical decision-making. We described patient characteristics at admission into an ICCU by predicted mortality risk assessed with noncardiac intensive care unit (ICU) and evaluated their performance in predicting patient outcomes.Methods: A total of 202 consecutive patients (130 men, 75 ± 12 years) were admitted into our tertiary-care ICCU in a 20-week period. We evaluated, on the first 24 h data, in-hospital mortality risk according to Acute Physiology and Chronic Health Evaluation II (APACHE II) and Simplified Acute Physiology Score 3 (SAPS 3); Sepsis related Organ Failure Assessment (SOFA) Score and the Mayo Cardiac intensive care unit Admission Risk Score (M-CARS) were also calculated.Results: Predicted mortality was significantly lower than observed (5% during ICCU and 7% at discharge) for APACHE II and SAPS 3 (17% for both scores). Mortality risk was associated with older age, more frequent comorbidities, severe clinical presentation and complications. The APACHE II, SAPS 3, SOFA and M-CARS had good discriminative ability in distinguishing deaths and survivors with poor calibration of risk scores predicting mortality.Conclusion: In a recent contemporary cohort of patients admitted into the ICCU for a variety of acute and critical cardiovascular conditions, scoring systems used in general ICU had good discrimination for patients' clinical severity and mortality. Available scores preserve powerful discrimination but the overestimation of mortality suggests the importance of specific tailored scores to improve risk assessment of patients admitted into ICCUs.","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":"25 7","pages":"511-518"},"PeriodicalIF":3.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141237806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recommendations for cardiovascular magnetic resonance and computed tomography in congenital heart disease: a consensus paper from the CMR/CCT Working Group of the Italian Society of Pediatric Cardiology and the Italian College of Cardiac Radiology endorsed by the Italian Society of Medical and Interventional Radiology (Part II). 关于先天性心脏病心血管磁共振和计算机断层扫描的建议：意大利儿科心脏病学会和意大利心脏放射学会 CMR/CCT 工作组的共识文件，并得到意大利医学和介入放射学会的认可（第二部分）。

IF 2.9 3区医学

Journal of Cardiovascular Medicine Pub Date : 2024-07-01 Epub Date: 2024-05-31 DOI: 10.2459/JCM.0000000000001628

Pierluigi Festa, Luigi Lovato, Francesco Bianco, Annalisa Alaimo, Emanuela Angeli, Giovanna Baccano, Egidio Barbi, Elena Bennati, Philipp Bonhoeffer, Valentina Bucciarelli, Davide Curione, Paolo Ciliberti, Alberto Clemente, Giovanni Di Salvo, Antonio Esposito, Francesca Ferroni, Alberto Gaeta, Andrea Giovagnoni, Maria Cristina Inserra, Benedetta Leonardi, Simona Marcora, Chiara Marrone, Giuseppe Peritore, Valeria Pergola, Francesca Pluchinotta, Giovanni Puppini, Nicola Stagnaro, Francesca Raimondi, Camilla Sandrini, Gaia Spaziani, Bertrand Tchana, Gianluca Trocchio, Lamia Ait-Ali, Aurelio Secinaro

{"title":"Recommendations for cardiovascular magnetic resonance and computed tomography in congenital heart disease: a consensus paper from the CMR/CCT Working Group of the Italian Society of Pediatric Cardiology and the Italian College of Cardiac Radiology endorsed by the Italian Society of Medical and Interventional Radiology (Part II).","authors":"Pierluigi Festa, Luigi Lovato, Francesco Bianco, Annalisa Alaimo, Emanuela Angeli, Giovanna Baccano, Egidio Barbi, Elena Bennati, Philipp Bonhoeffer, Valentina Bucciarelli, Davide Curione, Paolo Ciliberti, Alberto Clemente, Giovanni Di Salvo, Antonio Esposito, Francesca Ferroni, Alberto Gaeta, Andrea Giovagnoni, Maria Cristina Inserra, Benedetta Leonardi, Simona Marcora, Chiara Marrone, Giuseppe Peritore, Valeria Pergola, Francesca Pluchinotta, Giovanni Puppini, Nicola Stagnaro, Francesca Raimondi, Camilla Sandrini, Gaia Spaziani, Bertrand Tchana, Gianluca Trocchio, Lamia Ait-Ali, Aurelio Secinaro","doi":"10.2459/JCM.0000000000001628","DOIUrl":"10.2459/JCM.0000000000001628","url":null,"abstract":"Cardiovascular magnetic resonance (CMR) and computed tomography (CCT) are advanced imaging modalities that recently revolutionized the conventional diagnostic approach to congenital heart diseases (CHD), supporting echocardiography and often replacing cardiac catheterization. This is the second of two complementary documents, endorsed by experts from the Working Group of the Italian Society of Pediatric Cardiology and the Italian College of Cardiac Radiology of the Italian Society of Medical and Interventional Radiology, aimed at giving updated indications on the appropriate use of CMR and CCT in different clinical CHD settings, in both pediatrics and adults. In this article, support is also given to radiologists, pediatricians, cardiologists, and cardiac surgeons for indications and appropriateness criteria for CMR and CCT in the most referred CHD, following the proposed new criteria presented and discussed in the first document. This second document also examines the impact of devices and prostheses for CMR and CCT in CHD and additionally presents some indications for CMR and CCT exams when sedation or narcosis is needed.","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":"25 7","pages":"473-487"},"PeriodicalIF":2.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141237825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The rational use of mechanical support and drugs in cardiogenic shock based on the cardioprotection paradigm. 基于心脏保护范式，在心源性休克中合理使用机械支持和药物。

IF 3 3区医学

Journal of Cardiovascular Medicine Pub Date : 2024-07-01 Epub Date: 2024-05-31 DOI: 10.2459/JCM.0000000000001627

Federico Pappalardo, Andrea Montisci, Letizia F Bertoldi, Serena Ambrosi, Patrick Hunziker

引用次数: 0

Right ventricular afterload mismatch after transcatheter caval valve implantation for tricuspid regurgitation. 经导管腔瓣膜植入术治疗三尖瓣反流后的右心室后负荷失配。

IF 2.9 3区医学

Journal of Cardiovascular Medicine Pub Date : 2024-06-27 DOI: 10.2459/JCM.0000000000001649

Mauro Gitto, Gulrays Jamie, Stefano Figliozzi, Francesco Tartaglia, Beniamino Rosario Pagliaro, Francesco Cannata, Antonio Mangieri

引用次数: 0