Ciro Indolfi, Piergiuseppe Agostoni, Francesco Barillà, Andrea Barison, Stefano Benenati, Grzegorz Bilo, Giuseppe Boriani, Natale Daniele Brunetti, Paolo Calabrò, Stefano Carugo, Michela Casella, Michele Ciccarelli, Marco Matteo Ciccone, Gaetano Maria De Ferrari, Gianluigi Greco, Giovanni Esposito, Emanuela T Locati, Andrea Mariani, Marco Merlo, Saverio Muscoli, Savina Nodari, Iacopo Olivotto, Stefania Paolillo, Alberto Polimeni, Aldostefano Porcari, Italo Porto, Carmen Spaccarotella, Carmine Dario Vizza, Nicola Leone, Gianfranco Sinagra, Pasquale Perrone Filardi, Antonio Curcio
{"title":"Expert consensus document on artificial intelligence of the Italian Society of Cardiology.","authors":"Ciro Indolfi, Piergiuseppe Agostoni, Francesco Barillà, Andrea Barison, Stefano Benenati, Grzegorz Bilo, Giuseppe Boriani, Natale Daniele Brunetti, Paolo Calabrò, Stefano Carugo, Michela Casella, Michele Ciccarelli, Marco Matteo Ciccone, Gaetano Maria De Ferrari, Gianluigi Greco, Giovanni Esposito, Emanuela T Locati, Andrea Mariani, Marco Merlo, Saverio Muscoli, Savina Nodari, Iacopo Olivotto, Stefania Paolillo, Alberto Polimeni, Aldostefano Porcari, Italo Porto, Carmen Spaccarotella, Carmine Dario Vizza, Nicola Leone, Gianfranco Sinagra, Pasquale Perrone Filardi, Antonio Curcio","doi":"10.2459/JCM.0000000000001716","DOIUrl":"10.2459/JCM.0000000000001716","url":null,"abstract":"<p><p>Artificial intelligence (AI), a branch of computer science focused on developing algorithms that replicate intelligent behaviour, has recently been used in patients management by enhancing diagnostic and prognostic capabilities of various resources such as hospital datasets, electrocardiograms and echocardiographic acquisitions. Machine learning (ML) and deep learning (DL) models, both key subsets of AI, have demonstrated robust applications across several cardiovascular diseases, from the most diffuse like hypertension and ischemic heart disease to the rare infiltrative cardiomyopathies, as well as to estimation of LDL cholesterol which can be achieved with better accuracy through AI. Additional emerging applications are encountered when unsupervised ML methodology shows promising results in identifying distinct clusters or phenotypes of patients with atrial fibrillation that may have different risks of stroke and response to therapy. Interestingly, since ML techniques do not analyse the possibility that a specific pathology can occur but rather the trajectory of each subject and the chain of events that lead to the occurrence of various cardiovascular pathologies, it has been considered that DL, by resembling the complexity of human brain and using artificial neural networks, might support clinical management through the processing of large amounts of complex information; however, external validity of algorithms cannot be taken for granted, while interpretability of the results may be an issue, also known as a \"black box\" problem. Notwithstanding these considerations, facilities and governments are willing to unlock the potential of AI in order to reach the final step of healthcare advancements while ensuring that patient safety and equity are preserved.</p>","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":"26 5","pages":"200-215"},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Artificial-intelligence-enhanced ECG: a potential solution to limitations of ECG in detecting left ventricular dysfunction after chemotherapy.","authors":"Hong-Mi Choi, Youngjin Cho","doi":"10.2459/JCM.0000000000001725","DOIUrl":"https://doi.org/10.2459/JCM.0000000000001725","url":null,"abstract":"","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":"26 5","pages":"224-226"},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"News from American College of Cardiology Congress: Chicago 2025.","authors":"Domenico Simone Castiello, Ciro Indolfi","doi":"10.2459/JCM.0000000000001726","DOIUrl":"https://doi.org/10.2459/JCM.0000000000001726","url":null,"abstract":"","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":"26 5","pages":"195-199"},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The relevance of Killip class in ST-segment elevation myocardial infarction patients: implications on treatment timing and in-hospital mortality.","authors":"Valentina Bernardini, Davide Cao, Giulio Stefanini","doi":"10.2459/JCM.0000000000001720","DOIUrl":"https://doi.org/10.2459/JCM.0000000000001720","url":null,"abstract":"","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":"26 5","pages":"248-250"},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rachele Manzo, Giuseppe Comentale, Federica Ilardi, Anna Franzone, Emanuele Pilato, Giovanni Esposito
{"title":"Mitral-aortic intervalvular fibrosa pseudoaneurysm: a sneaky complication mimicking early prosthesis degeneration.","authors":"Rachele Manzo, Giuseppe Comentale, Federica Ilardi, Anna Franzone, Emanuele Pilato, Giovanni Esposito","doi":"10.2459/JCM.0000000000001721","DOIUrl":"https://doi.org/10.2459/JCM.0000000000001721","url":null,"abstract":"","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":"26 5","pages":"251-252"},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Irene Borzillo, Fabrizio D Ascenzo, Emanuele Ravetti, Marco Balducci, Riccardo Pilia, Matteo Michelone, Giuseppe Annoni, Alessandra Toscano, Giuseppe Giannino, Gaetano Maria De Ferrari, Ovidio De Filippo
{"title":"Lipoprotein(a) in youth and childhood as a marker of cardiovascular risk stratification: a meta-analysis.","authors":"Irene Borzillo, Fabrizio D Ascenzo, Emanuele Ravetti, Marco Balducci, Riccardo Pilia, Matteo Michelone, Giuseppe Annoni, Alessandra Toscano, Giuseppe Giannino, Gaetano Maria De Ferrari, Ovidio De Filippo","doi":"10.2459/JCM.0000000000001718","DOIUrl":"https://doi.org/10.2459/JCM.0000000000001718","url":null,"abstract":"<p><strong>Background and aims: </strong>Lipoprotein(a) [Lp(a)] is recognized as a risk factor for atherosclerotic cardiovascular diseases (ASCVD), yet its impact during childhood and youth remains understudied. This study aims to evaluate the role of Lp(a) as an independent risk factor for premature ASCVD among young patients.</p><p><strong>Methods: </strong>PubMed, Scopus, and CINAHL Complete databases were systematically searched from inception to 12 December 2023 for adjusted observational studies examining the impact of Lp(a) in young patients. Premature coronary artery disease (CAD) and premature arterial stroke were designed as primary endpoints, while the association with family history of premature CAD and familial hypercholesterolemia were secondary endpoints.</p><p><strong>Results: </strong>Fourteen studies, encompassing 9923 patients, were included in the analysis. Nine studies assessed Lp(a) as an independent risk factor for premature CAD. Meta-analysis revealed Lp(a) to be significantly associated with premature CAD [odds ratio (OR) 1.07, 95% confidence interval (CI) 1.01-1.13, P = 0.02]. Four studies revealed that the high levels of Lp(a) were associated with a more than two-fold increased risk of arterial stroke (OR 2.51; 95% CI 1.51-4.16, P = 0.004). However, insufficient studies were retrieved to perform a metanalysis for the secondary endpoints.</p><p><strong>Conclusion: </strong>Findings from adjusted observational studies suggest that Lp(a) serves as a risk factor for premature CAD and for arterial stroke in the youngest population.</p>","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":"26 5","pages":"227-234"},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Looking for lipoprotein(a) in youngsters: a call to action.","authors":"Claudio Bilato, Marco Zuin, Gianluca Rigatelli","doi":"10.2459/JCM.0000000000001717","DOIUrl":"https://doi.org/10.2459/JCM.0000000000001717","url":null,"abstract":"","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":"26 5","pages":"235-239"},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Is catheter ablation the first line treatment of ventricular tachycardia after myocardial infarction?","authors":"Antonio Curcio, Antonio Frontera, Michela Casella","doi":"10.2459/JCM.0000000000001712","DOIUrl":"10.2459/JCM.0000000000001712","url":null,"abstract":"","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":" ","pages":"169-171"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anastase Dzudie, Benyass Aatif, Lambert T Appiah, Habib Gamra, Mouhamed Cherif Mboup, Redouane Nedjar, Roland N'Guetta, Mohamed Jeilan, Okechukwu S Ogah, Fausto Pinto, Zainab Raissouni, Giuseppe M C Rosano
{"title":"Chronic coronary syndrome in Africa: current management and service challenges, and opportunities for optimizing patient care.","authors":"Anastase Dzudie, Benyass Aatif, Lambert T Appiah, Habib Gamra, Mouhamed Cherif Mboup, Redouane Nedjar, Roland N'Guetta, Mohamed Jeilan, Okechukwu S Ogah, Fausto Pinto, Zainab Raissouni, Giuseppe M C Rosano","doi":"10.2459/JCM.0000000000001707","DOIUrl":"10.2459/JCM.0000000000001707","url":null,"abstract":"<p><p>African populations have traditionally been considered at relatively low risk of cardiovascular diseases (CVD), such as chronic coronary syndrome (CCS), but this is rapidly changing in association with ageing populations, uncontrolled urbanization and lack of control of classical CV risk factors. In sub-Saharan Africa, CVD deaths have increased by more than 50% in the past three decades. For CCS care, limited availability of clinical expertise, diagnostic facilities, and access to optimal medical therapy (OMT), lack or inadequate reimbursement of healthcare costs, and scarcity of universal health coverage (UHC) are major challenges. Cardiologists from 11 African countries, meeting through the AFEX: ACT ON Angina programme, with the endorsement of the World Heart Federation, identified the need to: engage clinicians, patients, and the media to raise awareness of CCS and angina, and encourage lifestyle modification and risk factor control, as well as early referral of high-risk individuals; develop care pathways to address growing demand, including cross-border and online collaboration where local expertise is unavailable; optimize the use of treatment budgets by adapting and implementing international guidelines according to local priorities, and avoiding prescription of nonevidence-based medicines; initiate collaborative research into the nature of CCS in African countries and potential differences in risk factors, presentation, and treatment response compared with Europe and North America whose experience forms the basis of international guidelines. A roadmap is proposed to guide future developments in CCS care and support best practices across Africa.</p>","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":"26 4","pages":"172-181"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143575863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}