Journal of cancer research and therapeutics最新文献_第5页

TSPYL5 inhibits the tumorigenesis of colorectal cancer cells in vivo by triggering DNA damage. TSPYL5通过触发DNA损伤在体内抑制结直肠癌细胞的肿瘤发生。

IF 1.3 4区医学

Journal of cancer research and therapeutics Pub Date : 2023-08-01 DOI: 10.4103/jcrt.jcrt_1098_21

Chao Huang, Peng Ruan, Chunping He, Rui Zhou

{"title":"TSPYL5 inhibits the tumorigenesis of colorectal cancer cells in vivo by triggering DNA damage.","authors":"Chao Huang, Peng Ruan, Chunping He, Rui Zhou","doi":"10.4103/jcrt.jcrt_1098_21","DOIUrl":"https://doi.org/10.4103/jcrt.jcrt_1098_21","url":null,"abstract":"Context: Testis-specific protein Y-encoded-like 5 (TSPYL5) suppresses several cancers in vivo, including colorectal cancer (CRC); however, its mechanism and role in CRC cell tumorigenesis in vivo remain unknown.Aims: To elucidate the molecular mechanisms of colorectal cancer and find new therapeutic targets to improve CRC patient outcomes.Settings and design: Male mice (4 weeks old, 16-22 g) were housed in sterile cages in a temperature-controlled room (20-25°C) with a 12 h light/dark cycle and ad libitum food and water.Methods and materials: TSPYL5 overexpressing or non-overexpressing HCT116 cells were used to create a nude mouse tumor model. Tumor tissue was evaluated histologically after hematoxylin and eosin (H and E) staining. TUNEL staining assessed tumor cell apoptosis. Ki67 expression in excised tumor tissue was measured by immunohistochemistry. Western blotting examined double-stranded break (DBS)-associated protein expression in vivo.Statistical analysis used: IBM SPSS Statistics for Windows, Version 21.0 was used for all analyses (IBM Corp., Armonk, NY, USA). At least three independent experiments yield a mean value ± standard deviation. Unpaired Student's t-tests compared groups. One-way analysis of variance and Dunnett's test were used to compare groups with a P value < 0.5.Results: TSPYL5 overexpression inhibited CRC cell tumorigenicity and damaged tumor cells in vivo. TSPYL5 overexpression also significantly increased Bax and p-H2AX (early double-stranded break indicators) and decreased Ki67, Bcl-2, and peroxisome proliferator-activated receptor expression.Conclusions: Collectively, TSPYL5 overexpression inhibited the tumorigenicity of CRC cells in vivo by inducing DNA damage.","PeriodicalId":15208,"journal":{"name":"Journal of cancer research and therapeutics","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10237274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatric granular cell tumor of the larynx: A case report and literature review. 小儿喉部颗粒细胞瘤1例报告及文献复习。

IF 1.3 4区医学

Journal of cancer research and therapeutics Pub Date : 2023-08-01 DOI: 10.4103/jcrt.jcrt_2096_22

Jing Ke, Junwei Xiong, Juhong Zhang, Haiyu Ma, Wei Yuan

引用次数: 0

Clinical features and prognosis of advanced intra- and extra-pulmonary neuroendocrine carcinomas. 晚期肺内、肺外神经内分泌癌的临床特点及预后。

IF 1.3 4区医学

Journal of cancer research and therapeutics Pub Date : 2023-08-01 DOI: 10.4103/jcrt.jcrt_2443_22

Xiao-Yun Chen, Ning-Jing Guo, Pei-Lin Guo, Fan Yang, Qiong Luo, Sheng Yang, Xiang-Qi Chen

{"title":"Clinical features and prognosis of advanced intra- and extra-pulmonary neuroendocrine carcinomas.","authors":"Xiao-Yun Chen, Ning-Jing Guo, Pei-Lin Guo, Fan Yang, Qiong Luo, Sheng Yang, Xiang-Qi Chen","doi":"10.4103/jcrt.jcrt_2443_22","DOIUrl":"https://doi.org/10.4103/jcrt.jcrt_2443_22","url":null,"abstract":"Objective: We examined the clinical features and prognosis of advanced intra- and extra-pulmonary neuroendocrine carcinomas (NECs) to offer additional guidance for the clinical treatment of small-cell lung cancer (SCLC), which is a type of advanced intrapulmonary NEC (IPNECs).Materials and methods: The clinical data and survival of 123 patients with advanced IPNECs and extrapulmonary NECs (EPNECs) were obtained. We retrospectively examined the corresponding clinical diagnosis and treatment and investigated the significant factors influencing the survival prognosis of patients with NECs.Results: There were 90 cases of IPNECs (including 81 cases of SCLC), and 33 cases of EPNECs. The median overall survival (OS) of IPNECs was significantly longer than that of the EPNECs in the gastrointestinal tract and in the other regions (P < 0.05). The median OS of patients with other IPNECs was longer than that of patients with SCLC (P > 0.05). Multivariate analysis demonstrated that age, liver metastasis, number of cycles of first-line chemotherapy, and chest radiotherapy were risk factors influencing OS in patients with NECs (P < 0.05).Conclusions: The survival of IPNECs was significantly longer than that of EPNECs in the gastrointestinal tract and other regions. Nevertheless, patients with advanced NECs who were older and had liver metastases had a poorer prognosis. Multidisciplinary treatments including multicycle chemotherapy and a combination of chemotherapy and radiotherapy should function significantly in extending the survival of NECs.","PeriodicalId":15208,"journal":{"name":"Journal of cancer research and therapeutics","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10182179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ozone attenuates chemotherapy-induced peripheral neuropathy via upregulating the AMPK-SOCS3 axis. 臭氧通过上调AMPK-SOCS3轴来减弱化疗诱导的周围神经病变。

IF 1.3 4区医学

Journal of cancer research and therapeutics Pub Date : 2023-08-01 DOI: 10.4103/jcrt.jcrt_912_23

Xiao-Tao Zhang, Li-Juan Zong, Ru-Meng Jia, Xin-Miao Qin, Shi-Rong Ruan, Lin-Lin Lu, Ping Wang, Liang Hu, Wen-Tao Liu, Yang Yang, Yan Li

{"title":"Ozone attenuates chemotherapy-induced peripheral neuropathy via upregulating the AMPK-SOCS3 axis.","authors":"Xiao-Tao Zhang, Li-Juan Zong, Ru-Meng Jia, Xin-Miao Qin, Shi-Rong Ruan, Lin-Lin Lu, Ping Wang, Liang Hu, Wen-Tao Liu, Yang Yang, Yan Li","doi":"10.4103/jcrt.jcrt_912_23","DOIUrl":"https://doi.org/10.4103/jcrt.jcrt_912_23","url":null,"abstract":"Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a severe adverse reaction to chemotherapeutics, which seriously affects the outcome of chemotherapy and patients' quality of life. Although it is commonly seen, it lacks effective treatment. Our previous study found that ozone could alleviate neuropathic pain. Damage-associated molecular patterns (DAMPs) or Toll-like receptor 4 (TLR4) or tissue factor (TF)-mediated neuroinflammation and microcirculation disturbance is the main reason for CIPN. Suppressors of cytokine signaling (SOCS) 3 is an endogenous negative feedback regulator of inflammation via TLR4 inhibition.Materials and methods: Oxaliplatin (L-OHP) was used to establish mice's CIPN model. Nociceptive responses were assessed by observing the ICR mice's incidence of foot regression in mechanical indentation response experiments. Cell signaling assays were performed by Western blotting and immunohistochemistry. The mouse leukemia cells of monocyte-macrophage line RAW 264.7 were cultured to investigate the effects of ozone administration on macrophage.Results: Ozone decreased the expression of TF in the blood and sciatic nerve. It upregulated the adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK)-SOCS3 axis to relieve CIPN and inhibit TF expression in vivo. SOCS3 expression was induced by ozone to inhibit the p38/TF signaling in RAW 246.7 cells. Ozone also prevented L-OHP-induced sciatic nerve demyelination. Microglia activation was inhibited, and c-Fos and calcitonin gene-related peptide (CGRP) expression was decreased in the spinal dorsal horn via ozone.Conclusions: In this study, we demonstrated that ozone could alleviate CIPN by upregulating the AMPK-SOCS3 axis to inhibit TF expression, which is a potential treatment for CIPN.","PeriodicalId":15208,"journal":{"name":"Journal of cancer research and therapeutics","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10182183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of disease-associated microbiota in hepatocellular carcinoma. 肝细胞癌中疾病相关微生物群的特征

IF 1.3 4区医学

Journal of cancer research and therapeutics Pub Date : 2023-08-01 DOI: 10.4103/jcrt.jcrt_139_22

Pengfei Sun, Zhongchao Li, Bo Zhang

{"title":"Characterization of disease-associated microbiota in hepatocellular carcinoma.","authors":"Pengfei Sun, Zhongchao Li, Bo Zhang","doi":"10.4103/jcrt.jcrt_139_22","DOIUrl":"https://doi.org/10.4103/jcrt.jcrt_139_22","url":null,"abstract":"Aims: This study aimed to investigate the differences in the composition of microbial communities and related functions in hepatocellular carcinoma (HCC) tumours and matched normal tissues were investigated.Methods and material: Tumour tissues and matched normal samples were collected from 30 HCC patients. Genomic DNA was collected and subjected to sequencing of the V3 + V4 region of the 16S rRNA gene. The microbial community profiles and metabolic pathway predictions of the different groups were characterized and compared.Results: Tumour and adjacent tissues had similar microbiota compositions but differed in abundance. Proteobacteria and Firmicutes abundance decreased and Cyanobacteria and Acidobacteria abundance increased in the tumour tissue. The microbial community diversity was higher in the tumour tissues than in adjacent samples, with potentially more dominant taxa in the adjacent tissues, including Firmicutes, Proteobacteria, and Actinobacteria. Acidobacteria, Cyanobacteria, and Chloroflexi were the dominant microbes in tumour tissues. A total of 46 metabolic pathways were identified. Global and overview maps were the most abundant pathways, followed by carbohydrate metabolism, energy metabolism, metabolism of cofactors and vitamins, and membrane transport. The top 50 most highly correlated microbial genera included Klebsiella, Rhodococcus, Ochrobactrum, and Azoarcus. Fonticella, Haloimpatiens, Brevibacterium, and Acidothermus were positively correlated with other microbial genera. The microbiota of adjacent tissues was more robust in the network analysis.Conclusions: This study revealed differences in microbial composition between HCC tumour tissues and normal tissues and differences in microbial abundance associated with different metabolic functions. Cyanobacteria, Proteobacteria, and Actinobacteria may play important roles in HCC.","PeriodicalId":15208,"journal":{"name":"Journal of cancer research and therapeutics","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10534200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-power green-light laser endoscopic submucosal dissection for non-muscle-invasive bladder cancer: A technical improvement and its initial application. 高功率绿光激光内镜下粘膜下剥离治疗非肌肉浸润性膀胱癌的技术改进及初步应用。

IF 1.3 4区医学

Journal of cancer research and therapeutics Pub Date : 2023-08-01 DOI: 10.4103/jcrt.jcrt_674_22

Jilu Zheng, Feifan Liu, Keqin Zhang, Yuzhu Xiang, Lianjun Li, Haiyang Zhang, Yinan Zhang, Ning Suo, Zilong Wang, Chenglin Han, Xunbo Jin, Muwen Wang, Chunxiao Wei, Ji Chen

{"title":"High-power green-light laser endoscopic submucosal dissection for non-muscle-invasive bladder cancer: A technical improvement and its initial application.","authors":"Jilu Zheng, Feifan Liu, Keqin Zhang, Yuzhu Xiang, Lianjun Li, Haiyang Zhang, Yinan Zhang, Ning Suo, Zilong Wang, Chenglin Han, Xunbo Jin, Muwen Wang, Chunxiao Wei, Ji Chen","doi":"10.4103/jcrt.jcrt_674_22","DOIUrl":"https://doi.org/10.4103/jcrt.jcrt_674_22","url":null,"abstract":"Background: The technique of laser en bloc resection of bladder tumor (ERBT) has been a valuable alternative technique to transurethral resection of bladder tumor (TURBT). However, the combination of laser ERBT and endoscopic submucosal dissection (ESD) technique has not been well studied. Here, a novel technique integrating a high-power green-light laser with ESD was presented. This study aimed to evaluate the safety and efficacy of high-power green-light laser endoscopic submucosal dissection (HPL-ESD) for the treatment of primary non-muscle-invasive bladder cancer (NMIBC).Materials and methods: From January 2015 to December 2018, a total of 56 patients with NMIBC underwent HPL-ESD. All tumors were transurethral en bloc resected in the ESD technique. Perioperative clinical data were retrospectively collected and analyzed.Results: All operations were safely performed by the technique of HPL-ESD without blood transfusion. The mean tumor diameter was 2.04 ± 0.65 cm, ranging from 0.5 to 3.5 cm. The mean operative time was 28.39 ± 16.04 min. The average serum hemoglobin decrease was 0.88 ± 0.54 g/dL. The mean postoperative catheterization time was 2.88 ± 0.94 days. The pathologic stages included pTa (32 cases), and pT1 (24 cases). Double-J stent indwelling was not performed for four patients whose tumors were adjacent to the ureteral orifice and no postoperative hydronephrosis was observed. Only one case of ectopic bladder tumor recurred due to irregular bladder irrigation during the 36-month follow-up.Conclusion: HPL-ESD is a safe and effective alternative for the treatment of primary NMIBCs, especially for tumors adjacent to the ureteral orifice.","PeriodicalId":15208,"journal":{"name":"Journal of cancer research and therapeutics","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10182176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bilateral Wilms tumor in a patient with a horseshoe and duplex kidney: A case report. 双肾马蹄肾双侧肾母细胞瘤1例。

IF 1.3 4区医学

Journal of cancer research and therapeutics Pub Date : 2023-08-01 DOI: 10.4103/jcrt.jcrt_415_23

Xuemin Wu, Guoqiang Du, Zhaoquan Liu, Rongde Wu, Wei Liu

引用次数: 0

Transvaginal natural orifice specimen extraction surgery for 3D laparoscopic radical cystectomy: A cohort study. 经阴道自然孔标本提取手术用于三维腹腔镜根治性膀胱切除术:一项队列研究。

IF 1.3 4区医学

Journal of cancer research and therapeutics Pub Date : 2023-08-01 DOI: 10.4103/jcrt.jcrt_1612_22

Liyuan Wu, Qinxin Zhao, Feiya Yang, Mingshuai Wang, Nianzeng Xing

{"title":"Transvaginal natural orifice specimen extraction surgery for 3D laparoscopic radical cystectomy: A cohort study.","authors":"Liyuan Wu, Qinxin Zhao, Feiya Yang, Mingshuai Wang, Nianzeng Xing","doi":"10.4103/jcrt.jcrt_1612_22","DOIUrl":"https://doi.org/10.4103/jcrt.jcrt_1612_22","url":null,"abstract":"Objective: Transvaginal natural orifice specimen extraction surgery (NOSES) has been widely used in laparoscopic surgery due to its benefits. However, laparoscopic radical cystectomy (LRC) with NOSES has rarely been reported.Materials and methods: A retrospective analysis of 25 patients who underwent 3D LRC with NOSES from November 2014 to November 2019 was performed. The clinical and perioperative related data, peri and postoperative complications, and oncologic outcomes were recorded.Results: Surgery was successfully completed in 25 patients, and none were converted to open surgery. Mean total operative time was 294.1 ± 48.80 min. Mean NOSES time was12 ± 6.48 min. The median post-op hospital stay was 10.5 d (range 6-27 d). The median visual analog pain score on post-op day 1, 2, and 3 was 2, 2, and 1, respectively. Thirteen patients had 30-day complications (3 had Clavien grade I and 11 had Clavien grade II). Pelvic floor distress inventory-short form 20 (PFDI-20) was 9.8 ± 1.9 after three months (compared with pre-PFDI-20, P = 0.06) and 9.3 ± 1.2 after six months (compared with pre-PFDI-20, P = 0.15). At the mean follow-up of 24.7 ± 12.05 months (range 11-60 months), one patient (4%) had recurrence, two (8%) had metastasis, and one (4%) died.Conclusion: Transvaginal NOSES in 3D LRC is safe and feasible. Understanding the female vagina anatomy and comprehending the techniques is conducive to avoid incision-related complications. NOSES is minimally invasive with good cosmetic outcomes with few surgical complications or affecting pelvic floor function.","PeriodicalId":15208,"journal":{"name":"Journal of cancer research and therapeutics","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10237273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of core needle biopsy and fine-needle aspiration methods in CT-guided percutaneous sampling of pancreatic tumors. ct引导下胰腺肿瘤经皮穿刺穿刺活检与细针穿刺方法的比较。

IF 1.3 4区医学

Journal of cancer research and therapeutics Pub Date : 2023-08-01 DOI: 10.4103/jcrt.jcrt_1290_22

Jingjing Liu, Wei Huang, Shenjie Wang, Zhiyuan Wu, Ziyin Wang, Xiaoyi Ding, Zhongmin Wang

{"title":"Comparison of core needle biopsy and fine-needle aspiration methods in CT-guided percutaneous sampling of pancreatic tumors.","authors":"Jingjing Liu, Wei Huang, Shenjie Wang, Zhiyuan Wu, Ziyin Wang, Xiaoyi Ding, Zhongmin Wang","doi":"10.4103/jcrt.jcrt_1290_22","DOIUrl":"https://doi.org/10.4103/jcrt.jcrt_1290_22","url":null,"abstract":"Aims: To compare the diagnostic efficacy and safety of CT-guided percutaneous core needle biopsy (CNB) and fine-needle aspiration (FNA) for pancreatic lesions.Methods and material: A total of 176 patients with 176 pancreatic lesions who visited our hospital between January 2016 and March 2021 were retrospectively analyzed. They were divided into three groups: FNA group A (<1.5 cm between the lesion and great vessels necessitating FNA), FNA group B, and CNB (the latter two with ≥1.5 cm between the lesion and great vessels necessitating FNA). The sensitivity, specificity, positive predictive value, negative predictive value, accuracy, and postoperative. The statistical analysis was done using Statistical Package for the Social Sciences version 17.0.Results: One hundred and seventy six patient's specimens all met the requirements. There were no statistically significant differences in sensitivity, specificity, positive predictive value, negative predictive value, and accuracy between the CNB group and FNA group B, (P > 0.05). Thirteen samples submitted for genetic testing (5 in CNB group, 4 in each of the FNA groups A and B) all met the standards of next-generation sequencing gene detection. The main complications of these groups included abdominal pain, fever, and hyperamylasemia.Conclusions: CT-guided percutaneous FNA and CNB have similar diagnostic efficacy for pancreatic biopsy. Furthermore, FNA has a wide range of puncture indications and is very safe. Like CNB, the obtained tissue through FNA can be genetically tested to guide clinical treatment.","PeriodicalId":15208,"journal":{"name":"Journal of cancer research and therapeutics","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10237277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microwave ablation for the treatment of peripheral ground-glass nodule-like lung cancer: Long-term results from a multi-center study. 微波消融治疗外周磨玻璃结节样肺癌:一项多中心研究的长期结果

IF 1.3 4区医学

Journal of cancer research and therapeutics Pub Date : 2023-08-01 DOI: 10.4103/jcrt.jcrt_1436_23

Xia Yang, Yong Jin, Zhengyu Lin, Xiaoguang Li, Guanghui Huang, Yang Ni, Wenhong Li, Xiaoying Han, Min Meng, Jin Chen, Qingfeng Lin, Zhixin Bie, Chuntang Wang, Yuliang Li, Xin Ye

{"title":"Microwave ablation for the treatment of peripheral ground-glass nodule-like lung cancer: Long-term results from a multi-center study.","authors":"Xia Yang, Yong Jin, Zhengyu Lin, Xiaoguang Li, Guanghui Huang, Yang Ni, Wenhong Li, Xiaoying Han, Min Meng, Jin Chen, Qingfeng Lin, Zhixin Bie, Chuntang Wang, Yuliang Li, Xin Ye","doi":"10.4103/jcrt.jcrt_1436_23","DOIUrl":"https://doi.org/10.4103/jcrt.jcrt_1436_23","url":null,"abstract":"Introduction: Microwave ablation (MWA) is an effective and safe approach for the treatment of ground-glass nodule (GGN)-like lung cancer, but long-term follow-up is warranted. Therefore, this multi-center retrospective study aimed to evaluate the results of MWA for the treatment of peripheral GGN-like lung cancer with a long-term follow-up.Materials and methods: From June 2013 to January 2018, a total of 87 patients (47 males and 40 females, mean age 64.6 ± 10.2 years) with 87 peripheral lung cancer lesions showing GGN (mean long axis diameter, 17 ± 5 mm) underwent computed tomography (CT)-guided percutaneous MWA. All GGN-like lung cancers were histologically verified. The primary endpoints were local progression-free survival (LPFS) and overall survival (OS). The secondary endpoints were cancer-specific survival (CSS) and complications.Results: During a median follow-up of 65 months, both the 3-year and 5-year LPFS rates were 96.6% and 96.6%. The OS rate was 94.3% at 3 years and 84.9% at 5 years, whereas the 3-year and 5-year CSS rates were 100% and 100%, respectively. No periprocedural deaths were observed. Complications were observed in 49 patients (51.6%). Grade 3 or higher complications included pneumothorax, pleural effusion, hemorrhage, and pulmonary infection, which were identified in ten (10.5%), two (2.1%), two (2.1%), and one (1.1%) patient, respectively.Conclusions: CT-guided percutaneous MWA is an effective, safe, and potentially curative treatment regimen for GGN-like lung cancer.","PeriodicalId":15208,"journal":{"name":"Journal of cancer research and therapeutics","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10182182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0