Journal of Cardiovascular Electrophysiology最新文献

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Impact of Recurrence-to-Repeat Ablation Time on Long-Term Efficacy and Safety of Patients With Paroxysmal Atrial Fibrillation: Time Matters. 反复消融时间对阵发性心房颤动患者长期疗效和安全性的影响:时间问题。
IF 2.3 3区 医学
Journal of Cardiovascular Electrophysiology Pub Date : 2025-05-27 DOI: 10.1111/jce.16742
Yuen Hoong Phang, Ting-Yung Chang, Shih-Lin Chang, Yenn-Jiang Lin, Li-Wei Lo, Yu-Feng Hu, Fa-Po Chung, Chin-Yu Lin, Ling Kuo, Chih-Min Liu, Shih-Ann Chen
{"title":"Impact of Recurrence-to-Repeat Ablation Time on Long-Term Efficacy and Safety of Patients With Paroxysmal Atrial Fibrillation: Time Matters.","authors":"Yuen Hoong Phang, Ting-Yung Chang, Shih-Lin Chang, Yenn-Jiang Lin, Li-Wei Lo, Yu-Feng Hu, Fa-Po Chung, Chin-Yu Lin, Ling Kuo, Chih-Min Liu, Shih-Ann Chen","doi":"10.1111/jce.16742","DOIUrl":"https://doi.org/10.1111/jce.16742","url":null,"abstract":"<p><strong>Background: </strong>Rhythm control with catheter ablation has been established in the management of atrial fibrillation (AF), but the recurrence of AF remains significant. Several studies have demonstrated the benefits of repeat catheter ablation in patients with recurrent AF. However, the optimal timing for repeat ablation to minimize adverse atrial remodeling following recurrence has not been adequately investigated. In this study, we aimed to determine if an optimal timing for repeat catheter ablation existed in patients with recurrent AF.</p><p><strong>Method: </strong>We retrospectively screened 1131 patients receiving AF ablation at Taipei Veterans General Hospital and enrolled patients with paroxysmal AF undergoing repeat ablation procedures. Finally, 65 patients were enrolled for further analysis and patients are separated into two groups according to analysis of receiver operating characteristic (ROC) curve of recurrence to repeat ablation time (RAT).</p><p><strong>Result: </strong>After analysis, the optimal RAT was 222 days, around 7.5 months, with a sensitivity of 56% and a specificity of 78% for 2nd recurrence. KM survival curve also demonstrated Group 2 (RAT ≥ 222) had higher recurrence of atrial arrhythmias after 2nd ablation (p = 0.01). In multivariable analysis, RAT was shown to be an independent predictor of long-term outcome in patient with AF.</p><p><strong>Conclusion: </strong>Our study suggests that early repeat ablation might be advantageous in managing AF, extending arrhythmia-free intervals, and potentially preventing progression to more persistent arrhythmic forms. Given AF's progressive nature, these results advocate for early intervention strategies aimed at minimizing adverse atrial remodeling and enhancing quality of life for patients.</p>","PeriodicalId":15178,"journal":{"name":"Journal of Cardiovascular Electrophysiology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Periprocedural Safety of Interventional Electrophysiological Procedures in Octogenarians and Nonagenarians. 八九十岁及九十岁老人介入电生理手术的围手术期安全性。
IF 2.3 3区 医学
Journal of Cardiovascular Electrophysiology Pub Date : 2025-05-26 DOI: 10.1111/jce.16689
Vanessa Sciacca, Jakob Feldt, Laura Rottner, Christian-Hendrik Heeger, Christian Sohns, Bruno Reissmann, Ardan M Saguner, Francesco Santoro, Roland R Tilz, Tilman Maurer, Andreas Rillig, Feifan Ouyang, Dominik Linz, Kevin Vernooy, Philipp Sommer, Arian Sultan, Stephan Willems, Karl-Heinz Kuck, Andreas Metzner, Thomas Fink
{"title":"Periprocedural Safety of Interventional Electrophysiological Procedures in Octogenarians and Nonagenarians.","authors":"Vanessa Sciacca, Jakob Feldt, Laura Rottner, Christian-Hendrik Heeger, Christian Sohns, Bruno Reissmann, Ardan M Saguner, Francesco Santoro, Roland R Tilz, Tilman Maurer, Andreas Rillig, Feifan Ouyang, Dominik Linz, Kevin Vernooy, Philipp Sommer, Arian Sultan, Stephan Willems, Karl-Heinz Kuck, Andreas Metzner, Thomas Fink","doi":"10.1111/jce.16689","DOIUrl":"https://doi.org/10.1111/jce.16689","url":null,"abstract":"<p><strong>Background: </strong>Catheter ablation is an established treatment for cardiac arrhythmia. There is a lack of data on invasive electrophysiological (EP) procedures in aged patients.</p><p><strong>Methods: </strong>Consecutive patients ≥ 80 years who underwent catheter ablation or left atrial appendage closure procedures between January 2005 and December 2017 in a high-volume center were retrospectively studied and compared to a matched control group of individuals < 80 years of age.</p><p><strong>Results: </strong>The aged group consisted of 486 patients who underwent 566 procedures at a mean age of 82.7 ± 2.5 years (range 80-95 years). A cohort of 480 patients aged < 80 years (mean age 64.1 ± 13.3 years) with 566 procedures served as a control group. Performed procedures were atrial arrhythmia ablation including atrial fibrillation treatment (n = 366, 64.7%), cavotricuspid isthmus ablation (n = 139, 24.6%), ablation of ventricular arrhythmias (n = 57, 10.1%), and left atrial appendage closure (n = 12, 2.1%). There were numerically more procedures with major complications after treatment of elderly patients (32 [5.7%] vs. 21 [3.5%] procedures, p = 0.12), as well as numerically more procedures accompanied by intrahospital deaths (6 [1.1%] vs. 1 [0.2%] procedure, p = 0.12). The rate of minor complications was significantly higher in aged patients as compared to younger controls (31 [5.1%] vs. 17 [20%] procedures, p = 0.039).</p><p><strong>Conclusion: </strong>Invasive EP procedures in octogenarians and nonagenarians are feasible, however a significantly higher incidence of minor periprocedural complications and a trend toward more severe complications and intrahospital fatalities were observed compared to younger patients. These findings support an individual risk-benefit assessment for elderly individuals before invasive EP treatments are conducted.</p>","PeriodicalId":15178,"journal":{"name":"Journal of Cardiovascular Electrophysiology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Imaging-Aided VT Ablation. Long-Term Results From a Pilot Study. 成像辅助VT消融。一项初步研究的长期结果
IF 2.3 3区 医学
Journal of Cardiovascular Electrophysiology Pub Date : 2025-05-26 DOI: 10.1111/jce.16741
Benjamin Sacristan, Hubert Cochet, Benjamin Bouyer, Romain Tixier, Josselin Duchateau, Nicolas Derval, Thomas Pambrun, Marine Arnaud, Jan Charton, Geoffroy Ditac, Allan Plant, John Fitzgerald, Soumaya Sdiri-Cheniti, Laurens Verhaege, Michel Montaudon, Mélèze Hocini, Michel Haissaguerre, Maxime Sermesant, Pierre Jais, Frederic Sacher
{"title":"Imaging-Aided VT Ablation. Long-Term Results From a Pilot Study.","authors":"Benjamin Sacristan, Hubert Cochet, Benjamin Bouyer, Romain Tixier, Josselin Duchateau, Nicolas Derval, Thomas Pambrun, Marine Arnaud, Jan Charton, Geoffroy Ditac, Allan Plant, John Fitzgerald, Soumaya Sdiri-Cheniti, Laurens Verhaege, Michel Montaudon, Mélèze Hocini, Michel Haissaguerre, Maxime Sermesant, Pierre Jais, Frederic Sacher","doi":"10.1111/jce.16741","DOIUrl":"https://doi.org/10.1111/jce.16741","url":null,"abstract":"<p><strong>Background: </strong>Ventricular tachycardia (VT) ablation has become a cornerstone of patient care, especially for post-MI VT. Several strategies have proven effective for achieving rhythm control in this population, but the workflow is highly variable and depends on the physician's experience.</p><p><strong>Aim: </strong>This study describes the initial systematic experience of VT ablation targeting wall thickness heterogeneity on a cardiac computed tomography (CT) scanner used as a surrogate for mapped VT isthmii.</p><p><strong>Methods: </strong>Consecutive patients with post-MI VT, a CT scan, and a first VT ablation were included from January 2017 to May 2022. Targets were identified based on wall thickness heterogeneity. After image integration, ablation with > 10 grams, 40-50 W was performed with the aim of blocking the CT channels/render them non-capturable. Only then was inducibility tested. Inducible VT, if any, were conventionally mapped and ablated with the aim of reaching non-inducibility.</p><p><strong>Results: </strong>Thirty-nine patients (97.4% male, age: mean LVEF 35 ± 10%) were included. The mean number of identified CT Channels was 3.6 ± 1.8/patient. Non-inducibility was achieved in 19 (48.7%) of patients after initial imaging-guided ablation, while at least one VT could be induced in 19 (48.7%). Among these patients, 4 had VT related to unblocked or reconnected CT-determined VT channels, and 15 from other areas (border zone), typically with faster cycle length. After further mapping and ablation, 3 (7.7%) patients remained inducible. Mean radiofrequency time was 35 ± 19 min for CT Channels ablation, with an additional 11 ± 8 min for supplementary ablation (global mean RF time 35 ± 19 min). With a mean follow-up of 47.8 ± 24.3 months, 61.9% (95% CI: 44.0%-75.5%) remained VT free.</p><p><strong>Conclusion: </strong>CT-guided ablation represents a feasible and safe strategy for VT ablation in patients with an ischemic cardiomyopathy.</p>","PeriodicalId":15178,"journal":{"name":"Journal of Cardiovascular Electrophysiology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prospective Evaluation of Superior Vena Cava Isolation as an Adjunct to Pulmonary Vein Re-Isolation During Paroxysmal Atrial Fibrillation Repeat Procedures. 在阵发性心房颤动重复手术中,上腔静脉隔离辅助肺静脉再隔离的前瞻性评价。
IF 2.3 3区 医学
Journal of Cardiovascular Electrophysiology Pub Date : 2025-05-23 DOI: 10.1111/jce.16708
Benjamin De Becker, Louisa O'Neill, Gabriela Hilfiker, Maarten De Smet, Clara Francois, Milad El Haddad, René Tavernier, Mattias Duytschaever, Jean-Benoît Le Polain De Waroux, Sébastien Knecht
{"title":"Prospective Evaluation of Superior Vena Cava Isolation as an Adjunct to Pulmonary Vein Re-Isolation During Paroxysmal Atrial Fibrillation Repeat Procedures.","authors":"Benjamin De Becker, Louisa O'Neill, Gabriela Hilfiker, Maarten De Smet, Clara Francois, Milad El Haddad, René Tavernier, Mattias Duytschaever, Jean-Benoît Le Polain De Waroux, Sébastien Knecht","doi":"10.1111/jce.16708","DOIUrl":"https://doi.org/10.1111/jce.16708","url":null,"abstract":"<p><strong>Background: </strong>The superior vena cava (SVC) is a prominent non-pulmonary vein trigger of atrial fibrillation (AF). Its isolation has been shown to be effective in paroxysmal AF (PAF) originating from SVC.</p><p><strong>Objective: </strong>In this study, focusing on repeat procedures for recurrent PAF post-PVI, we aimed to evaluate the added value of empirical SVC isolation to PV antral re-isolation, when at least one PV reconnection is demonstrated.</p><p><strong>Methods: </strong>Patients with recurrent PAF referred for redo procedures, and exhibiting PV reconnection, were randomly assigned to undergo either PVI alone (group 1) or PVI and SVC isolation (group 2). The primary outcome was the recurrence rate at 1-year while procedural time, fluoroscopy time, complications rate, and the presence of scar during LA mapping were secondary outcomes.</p><p><strong>Results: </strong>Eighty-two patients were randomized in the study (39 in group 1 and 43 in group 2). The median age was 65 ± 9 in group 1 and 62 ± 11 in group 2 (p = 0.3). The time from first AF episode to the repeat procedure was 76 and 52 months, respectively (p = 0.7). 31 patients in group 1 and 35 patients in group 2 had more than one reconnected vein. There were no significant differences in procedural and fluoroscopy times between groups. At 12-months, freedom from atrial tachyarrhythmia was achieved in 69% patients in group 1% and 76% patients in group 2 (HR 0.7, 95% CI: 0.3-1.7).</p><p><strong>Conclusion: </strong>It is unknown whether empirical addition of SVC isolation to PVI improves freedom of recurrence for the treatment of recurrent PAF after previous PVI. Given the small study population, the addition of SVC isolation requires further investigation in a larger randomized trial.</p>","PeriodicalId":15178,"journal":{"name":"Journal of Cardiovascular Electrophysiology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Modular Approach for Leadless Pacing. 无引线起搏的模块化方法。
IF 2.3 3区 医学
Journal of Cardiovascular Electrophysiology Pub Date : 2025-05-23 DOI: 10.1111/jce.16740
Wissam Mekary, Sonya Vijayvargiya, Celine Mouawad, Neal K Bhatia, Anand D Shah, Stacy B Westerman, Michael S Lloyd, Miguel A Leal, Faisal M Merchant, Mikhael F El-Chami
{"title":"A Modular Approach for Leadless Pacing.","authors":"Wissam Mekary, Sonya Vijayvargiya, Celine Mouawad, Neal K Bhatia, Anand D Shah, Stacy B Westerman, Michael S Lloyd, Miguel A Leal, Faisal M Merchant, Mikhael F El-Chami","doi":"10.1111/jce.16740","DOIUrl":"https://doi.org/10.1111/jce.16740","url":null,"abstract":"<p><strong>Introduction: </strong>The AVEIR leadless pacemaker (LP) is a novel device that can function as a single atrial/ventricular or dual-chamber pacemaker. The introduction of single-chamber atrial LP has allowed electrophysiologists to treat patients with sinus node dysfunction with this device instead of implanting a dual-chamber transvenous pacemaker.</p><p><strong>Methods: </strong>We retrospectively identified all patients who underwent AVEIR LPs' implantation at Emory Healthcare between 2022 and 2025. Baseline characteristics, indications for pacing, and procedure outcomes were retrieved from electronic medical records. The device's electrical characteristics were reported from routine interrogations done at our device clinic.</p><p><strong>Results: </strong>Between 2022 and 2025, 89 patients underwent implantation of 37 single-chamber atrial AVEIR, 34 single-chamber ventricular AVEIR, and 18 dual-chamber devices. Patients were followed for a median duration of 4.7 months [2;9]. The rate of major complications was 3.4% and minor complications 1.1%. Two patients with ventricular LP required upgrade to cardiac resynchronization therapy-defibrillator (CRT-D) due to pacing-induced cardiomyopathy (2.3%). One patient (2.7%) with a standalone atrial LP developed atrial fibrillation with slow ventricular response requiring the addition of a ventricular LP 10 months postimplantation.</p><p><strong>Conclusion: </strong>In our center, we adopted a modular pacing approach for leadless pacing. This strategy focuses on minimizing the amount of hardware in the heart. This reduces complications such as perforation and dislodgment while optimizing battery longevity, which is affected by i2i communication.</p>","PeriodicalId":15178,"journal":{"name":"Journal of Cardiovascular Electrophysiology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Taking a Detour: Step-by-Step Alternative Approaches to Transseptal Access. 绕道:一步一步的跨隔通道替代方法。
IF 2.3 3区 医学
Journal of Cardiovascular Electrophysiology Pub Date : 2025-05-23 DOI: 10.1111/jce.16711
Worawan B Limpitikul, Vincent Wu, Kei Yamada, Gregory F Michaud, William J Hucker, Moussa Mansour, E Kevin Heist, Alan Hanley
{"title":"Taking a Detour: Step-by-Step Alternative Approaches to Transseptal Access.","authors":"Worawan B Limpitikul, Vincent Wu, Kei Yamada, Gregory F Michaud, William J Hucker, Moussa Mansour, E Kevin Heist, Alan Hanley","doi":"10.1111/jce.16711","DOIUrl":"https://doi.org/10.1111/jce.16711","url":null,"abstract":"<p><p>Transseptal puncture via a femoral vein and inferior vena cava (IVC) is a commonly performed procedure in multiple electrophysiology studies that require access to the left atrium or left ventricle. However, the standard approach is impossible in certain anatomies with IVC obstruction, such as congenital IVC interruption with azygos continuation and acquired obstruction. Here, we describe a step-by-step approach to alternative methods for transseptal access, including the transhepatic approach and superior approach from either the internal jugular vein or axillary vein. With careful review of multi-modal imaging and multidisciplinary preprocedural planning, these methods are feasible and safe alternatives to transseptal access.</p>","PeriodicalId":15178,"journal":{"name":"Journal of Cardiovascular Electrophysiology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Deep Learning-Based Multimodal Fusion Model for Recurrence Prediction in Persistent Atrial Fibrillation Patients. 基于深度学习的多模态融合模型用于持续性房颤复发预测。
IF 2.3 3区 医学
Journal of Cardiovascular Electrophysiology Pub Date : 2025-05-23 DOI: 10.1111/jce.16733
Li Chen, Xujian Feng, Haonan Chen, Biqi Tang, Quan Fang, Taibo Chen, Cuiwei Yang
{"title":"A Deep Learning-Based Multimodal Fusion Model for Recurrence Prediction in Persistent Atrial Fibrillation Patients.","authors":"Li Chen, Xujian Feng, Haonan Chen, Biqi Tang, Quan Fang, Taibo Chen, Cuiwei Yang","doi":"10.1111/jce.16733","DOIUrl":"https://doi.org/10.1111/jce.16733","url":null,"abstract":"<p><strong>Background: </strong>The long-term success rate of atrial fibrillation (AF) ablation remains a significant clinical challenge, particularly in patients with persistent atrial fibrillation (Persistent AF, PeAF). The recurrence risk in PeAF patients is influenced by various factors, which complicates the prediction of ablation outcomes. While clinical characteristics provide important references for risk assessment, the predictive accuracy of existing methods is limited and they fail to fully leverage the rich information contained in electrocardiogram (ECG) signals. Integrating clinical features with ECG signals holds promise for enhancing recurrence prediction accuracy and supporting personalized management.</p><p><strong>Methods: </strong>This study conducted a retrospective analysis of PeAF patients who underwent radiofrequency catheter ablation treatment between 2016 and 2019. A multimodal fusion framework based on a residual block network structure was proposed, integrating preprocedural AF rhythm 12-lead ECG signals, clinical scores, and baseline characteristics of the patients to construct a deep learning model for predicting the risk of postablation recurrence in PeAF patients. A fivefold cross-validation method was used to partition the data set for model training and testing.</p><p><strong>Results: </strong>The fusion model was evaluated on a cohort of 77 PeAF patients, achieving good predictive performance with an average AUC of 0.74, and a maximum of 0.82. It significantly outperformed traditional clinical scoring systems and single-modal models based solely on ECG signals. Additionally, the model demonstrated lower variance (0.08), reflecting its robustness and stability with small sample sizes.</p><p><strong>Conclusion: </strong>This study innovatively combines AF rhythm ECG signals with clinical characteristics to construct a deep learning model for predicting the recurrence risk in PeAF patients after radiofrequency catheter ablation. The results show that this method effectively improves prediction performance and provides support for personalized clinical decision-making, with significant potential for clinical application.</p>","PeriodicalId":15178,"journal":{"name":"Journal of Cardiovascular Electrophysiology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-Term Impact of GLP-1 Receptor Agonists on AF Recurrence After Ablation in Obese Patients. GLP-1受体激动剂对肥胖患者消融后房颤复发的长期影响。
IF 2.3 3区 医学
Journal of Cardiovascular Electrophysiology Pub Date : 2025-05-23 DOI: 10.1111/jce.16737
Harsh Patel, Aakash Sheth, Ambica Nair, Bhavin Patel, Samarth Thakkar, Bharat Narasimhan, Nishaki Mehta, Zain Azad, Gurukripa N Kowlgi, Christopher V Desimone, Kostantinos Siontis, Sourbha S Dani, Mohammed Rafa Labedi, Abhishek J Deshmukh
{"title":"Long-Term Impact of GLP-1 Receptor Agonists on AF Recurrence After Ablation in Obese Patients.","authors":"Harsh Patel, Aakash Sheth, Ambica Nair, Bhavin Patel, Samarth Thakkar, Bharat Narasimhan, Nishaki Mehta, Zain Azad, Gurukripa N Kowlgi, Christopher V Desimone, Kostantinos Siontis, Sourbha S Dani, Mohammed Rafa Labedi, Abhishek J Deshmukh","doi":"10.1111/jce.16737","DOIUrl":"https://doi.org/10.1111/jce.16737","url":null,"abstract":"<p><strong>Background: </strong>Obesity is an important risk factor associated with atrial fibrillation (AF). The impact of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) on recurrent AF among patients undergoing catheter ablation is not well described.</p><p><strong>Objective: </strong>This study aimed to evaluate the effect of GLP-1 RA on the recurrence of AF among obese patients after catheter ablation.</p><p><strong>Methods: </strong>Utilizing the TriNetX research network, we identified patients aged over 18 with obesity (BMI ≥ 30) who underwent AF ablation from January 1, 2015, to December 1, 2022, using Current Procedural Terminology codes. Patients were categorized based on their baseline GLP-1 RA use. Through propensity-score matching, each cohort comprised 1558 patients. The primary outcome encompassed a composite of cardioversion, initiation of new antiarrhythmic drug (AAD) therapy, or redo AF ablation. Additional outcomes during the 12-month follow-up included AF readmission, heart failure readmissions, readmissions due to ischemic stroke, and mortality, with a separate analysis done for patients with BMI > 40.</p><p><strong>Results: </strong>GLP-1 RA use in patients with obesity undergoing AF ablation was linked to a significantly reduced risk of cardioversion, new AAD therapy, and the need for redo AF ablation (hazard ratio [HR] 0.72 [0.65-0.80]; p < 0.001). At 12 months, individuals on GLP-1 agonists exhibited a lower likelihood of mortality (HR 0.61 [0.40-0.93]; p < 0.001). Although all other secondary outcomes were lower in the GLP-1 RA group, there was no significant difference in ischemic stroke between the groups. These results were consistent among patients with BMI > 40, although apart from ischemic stroke, there was no difference in mortality between the two groups.</p><p><strong>Conclusion: </strong>The utilization of GLP-1 RA in individuals with obesity is linked to a decreased likelihood of arrhythmia recurrence following AF ablation, leading to a reduced requirement for cardioversion, AAD therapy, or redo AF ablation.</p>","PeriodicalId":15178,"journal":{"name":"Journal of Cardiovascular Electrophysiology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early Results of the New Pamira ICD Lead. 新帕米拉ICD导联的早期结果。
IF 2.3 3区 医学
Journal of Cardiovascular Electrophysiology Pub Date : 2025-05-22 DOI: 10.1111/jce.16724
Adrian Bystriansky, Michael Ilan, Ulrich Gerk, Béla Merkely, Attila Kónyi, Martin Winterhalter, Jozsef Faluközy, Nicholas Jackson, Avishag Laish-Farkash, Nils Jenke, Lars Anneken
{"title":"Early Results of the New Pamira ICD Lead.","authors":"Adrian Bystriansky, Michael Ilan, Ulrich Gerk, Béla Merkely, Attila Kónyi, Martin Winterhalter, Jozsef Faluközy, Nicholas Jackson, Avishag Laish-Farkash, Nils Jenke, Lars Anneken","doi":"10.1111/jce.16724","DOIUrl":"https://doi.org/10.1111/jce.16724","url":null,"abstract":"<p><strong>Introduction: </strong>A new implantable cardioverter-defibrillator (ICD) lead with a polyurethane cover added for improved long-term reliance was investigated in a post-market study.</p><p><strong>Methods: </strong>The prospective BIO|MASTER Pamira study is designed to evaluate the new Pamira ICD lead in patients undergoing de-novo ICD or cardiac resynchronization therapy (CRT-D) implantation. We report first data from implantation and 6-month follow-up.</p><p><strong>Results: </strong>Despite its slightly larger diameter, the lead demonstrated similar or improved handling during implantation compared to its predecessor without polyurethane cover.</p><p><strong>Conclusion: </strong>All results from implantation and short-term follow-up aligned with expectations. To show an improved reliance, long-term data will be required.</p>","PeriodicalId":15178,"journal":{"name":"Journal of Cardiovascular Electrophysiology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Cold Spark: A Novel Synergistic Paradigm With Pulsed Field Cryoablation. 冷火花:脉冲场冷冻消融的新型协同范例。
IF 2.3 3区 医学
Journal of Cardiovascular Electrophysiology Pub Date : 2025-05-21 DOI: 10.1111/jce.16736
Leonid Maizels, Peter M Kistler
{"title":"The Cold Spark: A Novel Synergistic Paradigm With Pulsed Field Cryoablation.","authors":"Leonid Maizels, Peter M Kistler","doi":"10.1111/jce.16736","DOIUrl":"https://doi.org/10.1111/jce.16736","url":null,"abstract":"","PeriodicalId":15178,"journal":{"name":"Journal of Cardiovascular Electrophysiology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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