Journal of Cancer Metastasis and Treatment最新文献_第2页

Chemoprevention of neuroblastoma: progress and promise beyond uncertainties. 神经母细胞瘤的化学预防：不确定因素之外的进展与希望。

IF 1.9

Journal of Cancer Metastasis and Treatment Pub Date : 2023-01-01 Epub Date: 2023-03-31 DOI: 10.20517/2394-4722.2022.40

Natarajan Aravindan, Mohan Natarajan, Dinesh Babu Somasundaram, Sheeja Aravindan

{"title":"Chemoprevention of neuroblastoma: progress and promise beyond uncertainties.","authors":"Natarajan Aravindan, Mohan Natarajan, Dinesh Babu Somasundaram, Sheeja Aravindan","doi":"10.20517/2394-4722.2022.40","DOIUrl":"10.20517/2394-4722.2022.40","url":null,"abstract":"Neuroblastoma is the most common extracranial solid tumor in children and comprises one-tenth of all childhood cancer deaths. The current clinical therapy for this deadly disease is multimodal, involving an induction phase with alternating regimens of high-dose chemotherapeutic drugs and load reduction surgery; a consolidation phase with more intensive chemotherapy, radiotherapy, and stem cell transplant; and a maintenance phase with immunotherapy and immune-activating cytokine treatment. Despite such intensive treatment, children with neuroblastoma have unacceptable life quality and survival, warranting preventive measures to regulate the cellular functions that orchestrate tumor progression, therapy resistance, metastasis, and tumor relapse/recurrence. Globally, active efforts are underway to identify novel chemopreventive agents, define their mechanism(s) of action, and assess their clinical benefit. Some chemoprevention strategies (e.g., retinoids, difluoromethylornithine) have already been adopted clinically as part of maintenance phase therapy. Several agents are in the pipeline, while many others are in preclinical characterization. Here we review the classes of chemopreventive agents investigated for neuroblastoma, including cellular events targeted, mode(s) of action, and the level of development. Our review: (i) highlights the pressing need for new and improved chemopreventive strategies for progressive neuroblastoma; (ii) lists the emerging classes of chemopreventive agents for neuroblastoma; and (iii) recognizes the relevance of targeting dynamically evolving hallmark functions of tumor evolution (e.g., survival, differentiation, lineage transformation). With recent gains in the understanding of tumor evolution processes and preclinical and clinical efforts, it is our strong opinion that effective chemopreventive strategies for aggressive neuroblastoma are a near reality.","PeriodicalId":15167,"journal":{"name":"Journal of Cancer Metastasis and Treatment","volume":"1 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10798790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67652086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immune responses elicited by ssRNA(-) oncolytic viruses in the host and in the tumor microenvironment. ssRNA(-)溶瘤病毒在宿主和肿瘤微环境中引发的免疫应答。

Journal of Cancer Metastasis and Treatment Pub Date : 2023-01-01 Epub Date: 2023-04-04 DOI: 10.20517/2394-4722.2022.92

Yonina Bykov, Gloria Dawodu, Aryana Javaheri, Adolfo Garcia-Sastre, Sara Cuadrado-Castano

{"title":"Immune responses elicited by ssRNA(-) oncolytic viruses in the host and in the tumor microenvironment.","authors":"Yonina Bykov, Gloria Dawodu, Aryana Javaheri, Adolfo Garcia-Sastre, Sara Cuadrado-Castano","doi":"10.20517/2394-4722.2022.92","DOIUrl":"10.20517/2394-4722.2022.92","url":null,"abstract":"Oncolytic viruses (OVs) are at the forefront of biologicals for cancer treatment. They represent a diverse landscape of naturally occurring viral strains and genetically modified viruses that, either as single agents or as part of combination therapies, are being evaluated in preclinical and clinical settings. As the field gains momentum, the research on OVs has been shifting efforts to expand our understanding of the complex interplay between the virus, the tumor and the immune system, with the aim of rationally designing more efficient therapeutic interventions. Nowadays, the potential of an OV platform is no longer defined exclusively by the targeted replication and cancer cell killing capacities of the virus, but by its contribution as an immunostimulator, triggering the transformation of the immunosuppressive tumor microenvironment (TME) into a place where innate and adaptive immunity players can efficiently engage and lead the development of tumor-specific long-term memory responses. Here we review the immune mechanisms and host responses induced by ssRNA(-) (negative-sense single-stranded RNA) viruses as OV platforms. We focus on two ssRNA(-) OV candidates: Newcastle disease virus (NDV), an avian paramyxovirus with one of the longest histories of utilization as an OV, and influenza A (IAV) virus, a well-characterized human pathogen with extraordinary immunostimulatory capacities that is steadily advancing as an OV candidate through the development of recombinant IAV attenuated platforms.","PeriodicalId":15167,"journal":{"name":"Journal of Cancer Metastasis and Treatment","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67652994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advanced breast cancer metastasized in the brain: treatment standards and innovations. 晚期乳腺癌脑转移：治疗标准与创新。

IF 1.9

Journal of Cancer Metastasis and Treatment Pub Date : 2023-01-01 Epub Date: 2023-06-14 DOI: 10.20517/2394-4722.2022.125

Elizabeth Klaas, Eric Sung, Esaan Azizi, Melanie Martinez, Arnav Barpujari, Jeffery Roberts, Brandon Lucke-Wold

引用次数: 0

Promising therapeutic potential of tumor suppressor microRNAs for malignant pleural mesothelioma. 肿瘤抑制microrna治疗恶性胸膜间皮瘤的潜力。

IF 1.4

Journal of Cancer Metastasis and Treatment Pub Date : 2022-01-01 Epub Date: 2022-12-05 DOI: 10.20517/2394-4722.2022.70

Shivani Dixit, Agnes Y Choi, Anand Singh, Karthik Pittala, Nathan Pruett, Chuong D Hoang

引用次数: 0

Bone marrow niches in myelodysplastic syndromes. 骨髓增生异常综合征中的骨髓壁龛。

IF 1.4

Journal of Cancer Metastasis and Treatment Pub Date : 2021-01-01 Epub Date: 2021-07-14 DOI: 10.20517/2394-4722.2021.120

Giovanna Tosato, Jing-Xin Feng, Hidetaka Ohnuki, Minji Sim

{"title":"Bone marrow niches in myelodysplastic syndromes.","authors":"Giovanna Tosato, Jing-Xin Feng, Hidetaka Ohnuki, Minji Sim","doi":"10.20517/2394-4722.2021.120","DOIUrl":"10.20517/2394-4722.2021.120","url":null,"abstract":"Genetic and epigenetic lesions within hematopoietic cell populations drive diverse hematological malignancies. Myelodysplastic syndromes (MDS) are a group of myeloid neoplasms affecting the hematopoietic stem cells characterized by recurrent genetic abnormalities, myelodysplasia (a pathological definition of abnormal bone marrow structure), ineffective hematopoiesis resulting in blood cytopenia, and a propensity to evolve into acute myelogenous leukemia. Although there is evidence that the accumulation of a set of genetic mutations is an essential event in MDS, there is an increased appreciation of the contribution of specific microenvironments, niches, in the pathogenesis of MDS and response to treatment. In physiologic hematopoiesis, niches are critical functional units that maintain hematopoietic stem and progenitor cells and regulate their maturation into mature blood cells. In MDS and other hematological malignancies, altered bone marrow niches can promote the survival and expansion of mutant hematopoietic clones and provide a shield from therapy. In this review, we focus on our understanding of the composition and function of hematopoietic niches and their role in the evolution of myeloid malignancies, with an emphasis on MDS.","PeriodicalId":15167,"journal":{"name":"Journal of Cancer Metastasis and Treatment","volume":"7 ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8570581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39598837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

B cell infiltration is highly associated with prognosis and an immune-infiltrated tumor microenvironment in neuroblastoma. B细胞浸润与神经母细胞瘤的预后和免疫浸润肿瘤微环境高度相关。

IF 1.9

Journal of Cancer Metastasis and Treatment Pub Date : 2021-01-01 Epub Date: 2021-06-06 DOI: 10.20517/2394-4722.2021.72

Evelien Schaafsma, Chongming Jiang, Chao Cheng

{"title":"B cell infiltration is highly associated with prognosis and an immune-infiltrated tumor microenvironment in neuroblastoma.","authors":"Evelien Schaafsma, Chongming Jiang, Chao Cheng","doi":"10.20517/2394-4722.2021.72","DOIUrl":"https://doi.org/10.20517/2394-4722.2021.72","url":null,"abstract":"Aim: Neuroblastoma is the most common extracranial solid tumor in children. Recent advances in immunotherapy Approaches, including in neuroblastoma, have shown the important role of the immune system in mounting an effective anti-tumor response. In this study, we aimed to provide a comprehensive investigation of immune cell infiltration in neuroblastoma utilizing a large number of gene expression datasets.Methods: We inferred immune cell infiltration using an established immune inference method and evaluated the association between immune cell abundance and patient prognosis as well as common chromosomal abnormalities found in neuroblastoma. In addition, we evaluated co-infiltration patterns among distinct immune cell types.Results: The infiltration of naïve B cells, NK cells, and CD8+ T cells was associated with improved patient prognosis. Naïve B cells were the most consistent indicator of prognosis and associated with an active immune tumor microenvironment. Patients with high B cell infiltration showed high co-infiltration of other immune cell types and the enrichment of immune-related pathways. The presence of high B cell infiltration was associated with both recurrence-free and overall survival, even after adjusting for clinical variables.Conclusion: In this study, we have provided a comprehensive evaluation of immune cell infiltration in neuroblastoma using gene expression data. We propose an important role for B cells in the neuroblastoma tumor microenvironment and suggest that B cells can be used as a prognostic biomarker to predict recurrence-free and overall survival independently of currently utilized prognostic variables.","PeriodicalId":15167,"journal":{"name":"Journal of Cancer Metastasis and Treatment","volume":"7 34","pages":""},"PeriodicalIF":1.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39366254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Leelamine suppresses cMyc expression in prostate cancer cells in vitro and inhibits prostate carcinogenesis in vivo. Leelamine体外抑制前列腺癌细胞cMyc表达，体内抑制前列腺癌发生。

IF 1.9

Journal of Cancer Metastasis and Treatment Pub Date : 2021-01-01 Epub Date: 2021-03-26 DOI: 10.20517/2394-4722.2021.08

Krishna B Singh, Eun-Ryeong Hahm, Shivendra V Singh

{"title":"Leelamine suppresses cMyc expression in prostate cancer cells in vitro and inhibits prostate carcinogenesis in vivo.","authors":"Krishna B Singh, Eun-Ryeong Hahm, Shivendra V Singh","doi":"10.20517/2394-4722.2021.08","DOIUrl":"https://doi.org/10.20517/2394-4722.2021.08","url":null,"abstract":"Aim: Leelamine (LLM) inhibits growth of human prostate cancer cells but the underlying mechanism is not fully understood. The present study was undertaken to determine the effect of LLM on cMyc, which is overexpressed in a subset of human prostate cancers.Methods: The effect of LLM on cMyc expression and activity was determined by western blotting/confocal microscopy and luciferase reporter assay, respectively. A transgenic mouse model of prostate cancer (Hi-Myc) was used to determine chemopreventive efficacy of LLM.Results: Exposure of androgen sensitive (LNCaP) and castration-resistant (22Rv1) human prostate cancer cells to LLM resulted in downregulation of protein and mRNA levels of cMyc. Overexpression of cMyc partially attenuated LLM-mediated inhibition of colony formation, cell viability, and cell migration in 22Rv1 and/or PC-3 cells. LLM treatment decreased protein levels of cMyc targets (e.g., lactate dehydrogenase), however, overexpression of cMyc did not attenuate these effects. A trend for a decrease in expression level of cMyc protein was discernible in 22Rv1 xenografts from LLM-treated mice compared with control mice. The LLM treatment (10 mg/kg body weight, 5 times/week) was well-tolerated by Hi-Myc transgenic mice. The incidence of high-grade prostatic intraepithelial neoplasia, adenocarcinoma in situ, and microinvasion was lower in LLM-treated Hi-Myc mice but the difference was not statistically significant.Conclusion: The present study reveals that LLM inhibits cMyc expression in human prostate cancer cells in vitro but concentrations higher than 10 mg/kg may be required to achieve chemoprevention of prostate cancer.","PeriodicalId":15167,"journal":{"name":"Journal of Cancer Metastasis and Treatment","volume":"7 ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8513473/pdf/nihms-1687102.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39527182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Advances in Cancer Early Diagnosis with Liquid Biopsy-based Approaches. 基于液体活检的癌症早期诊断研究进展。

IF 1.9

Journal of Cancer Metastasis and Treatment Pub Date : 2021-01-01 Epub Date: 2021-04-23

Wei Zhang

引用次数: 0

The multifunctional role of Notch signaling in multiple myeloma. Notch信号在多发性骨髓瘤中的多功能作用。

IF 1.9

Journal of Cancer Metastasis and Treatment Pub Date : 2021-01-01 Epub Date: 2021-04-14 DOI: 10.20517/2394-4722.2021.35

Hayley M Sabol, Jesus Delgado-Calle

引用次数: 8

Diverse roles of bitter melon (Momordica charantia) in prevention of oral cancer. 苦瓜（Momordica charantia）在预防口腔癌方面的多种作用。

IF 1.9

Journal of Cancer Metastasis and Treatment Pub Date : 2021-01-01 Epub Date: 2021-03-09 DOI: 10.20517/2394-4722.2020.126

Subhayan Sur, Ratna B Ray

{"title":"Diverse roles of bitter melon (Momordica charantia) in prevention of oral cancer.","authors":"Subhayan Sur, Ratna B Ray","doi":"10.20517/2394-4722.2020.126","DOIUrl":"10.20517/2394-4722.2020.126","url":null,"abstract":"Oral squamous cell carcinoma (OSCC) is one of the common lethal malignancies which is increasing rapidly in the world. Increasing risks from alcohol and tobacco habits, lack of early detection markers, lack of effective chemotherapeutic agents, recurrence and distant metastasis make the disease more complicated to manage. Laboratory-based studies and epidemiological studies indicate important roles of nutraceuticals to manage different cancers. The plant bitter melon (Momordica charantia) is a good source of nutrients and bio-active phytochemicals such as triterpenoids, triterpene glycosides, phenolic acids, flavonoids, lectins, sterols and proteins. The plant is widely grown in Asia, Africa, and South America. Bitter melon has traditionally been used as a folk medicine and Ayurvedic medicine in Asian culture to treat diseases such as diabetes, since ancient times. The crude extract and some of the isolated pure compounds of bitter melon show potential anticancer effects against different cancers. In this review, we shed light on its effect on OSCC. Bitter melon extract has been found to inhibit cell proliferation and metabolism, induce cell death and enhance the immune defense system in the prevention of OSCC in vitro and in vivo. Thus, bitter melon may be used as an attractive chemopreventive agent in progression towards OSCC clinical study.","PeriodicalId":15167,"journal":{"name":"Journal of Cancer Metastasis and Treatment","volume":"7 ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39702204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0