G. S. Mahmoud, Raghed H. Rashed, Afrah Jabbar Lazim, Heyam Aziz Mohammed
{"title":"The Effects of Capparis Spinosa Leaves on The Histological Findings Associated With The Exposure of Mice to Trichloroacetic Acid","authors":"G. S. Mahmoud, Raghed H. Rashed, Afrah Jabbar Lazim, Heyam Aziz Mohammed","doi":"10.55145/ajbms.2022.1.1.004","DOIUrl":"https://doi.org/10.55145/ajbms.2022.1.1.004","url":null,"abstract":"The present work was conducted to study the possible protective role of Capparis spinosa leaves\u0000and their efficacy against hematological and histological alterations resulted in an animal model intoxicated with\u0000trichloroacetis acid ( TCA).\u0000Hundred male mice 20-26 gm were divided into 5 groups ; control group , group II treated oraly with honey ( 40 mg /\u0000Kg body weight for 3 weeks ) , group III treated orally with a mixture of Capparis spinosa leaves powder and honey (\u000040 mg/ Kg for 3 weeks) , group IV treated with TCA in drinking water ( 500 mg / Kg fpr 3 and 6 weeks , then left for\u00003 weeks for recovery) and group V ( Regeneration group ) treated with TCA for 6 weeks then treated with a mixture\u0000of Capparis and honey ( 40 gm /Kg for 3 weeks).\u0000Histological examination of spleen sections of mice treated with TCA revealed obvious pathological findings\u0000including disorganization of lymphoid follicles , hyperplasia in white pulp , depletion of lymphocyts in red pulp\u0000with subcapsular edema , some necrotic cells in white and red pulp , increasing megakarycoytes, haemosiderosis and\u0000fibrosis in red pulp and in some lymphoid follocles. Administration of a mixture of Capparis spinosa leaves powder\u0000and honey lessened most of the pathological lesions in mice intoxicated with TCA","PeriodicalId":151138,"journal":{"name":"Al-Salam Journal for Biochemical and Medical Science","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117144930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}