{"title":"Ultrasound Assisted Regioselective Synthesis of Polyhydrospiro [indoline-3,3’-pyrrolizine]-2-one Library via Multicomponent Cycloaddition Reaction","authors":"V. Tripathi","doi":"10.33980/JBCC.2019.V05I01.010","DOIUrl":"https://doi.org/10.33980/JBCC.2019.V05I01.010","url":null,"abstract":"Present work demonstrates the ultrasound mediated synthesis of new Hexahydrospiro[indoline-3,3’pyrrolizine]-2-one derivatives in excellent yields via [3+2] cycloaddtion reaction in regioselective manner under ultrasonic irradiation. Multicomponent reaction of substituted 3-cinnamoyl-4-hydroxy-6-methyl-2H-pyran-2-one, isatin, L-proline was utilized for synthesis of spiro framework in regioselective manner at room temperature. All the synthesized hexahydrospiro molecules were characterized by H and C NMR, IR spectra, mass spectra and elemental analysis. Regioselective nature of reaction was explained on the basis of secondary orbital interactions. We have developed a very simple and facile methodology that has great importance in synthetic chemistry.","PeriodicalId":15083,"journal":{"name":"Journal of Biological and chemical Chronicles","volume":"110 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85231711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}