The Excitement of Discovery: Selected Papers of Alexander Rich最新文献

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Spontaneous assembly of a self-complementary oligopeptide to form a stable macroscopic membrane 自互补寡肽自发组装形成稳定的宏观膜
The Excitement of Discovery: Selected Papers of Alexander Rich Pub Date : 2018-11-01 DOI: 10.1142/9789813272682_0052
Shuguang Zhang, Todd C. Holmes, C. Lockshin, Alexander Rich
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引用次数: 0
A Z-DNA binding domain present in the human editing enzyme, double-stranded RNA adenosine deaminase 存在于人类编辑酶,双链RNA腺苷脱氨酶中的Z-DNA结合域
The Excitement of Discovery: Selected Papers of Alexander Rich Pub Date : 2018-11-01 DOI: 10.1142/9789813272682_0033
A. Herbert, J. Alfken, Yang-Gyun Kim, I. Mian, K. Nishikura, Alexander Rich
{"title":"A Z-DNA binding domain present in the human editing enzyme, double-stranded RNA adenosine deaminase","authors":"A. Herbert, J. Alfken, Yang-Gyun Kim, I. Mian, K. Nishikura, Alexander Rich","doi":"10.1142/9789813272682_0033","DOIUrl":"https://doi.org/10.1142/9789813272682_0033","url":null,"abstract":"","PeriodicalId":150391,"journal":{"name":"The Excitement of Discovery: Selected Papers of Alexander Rich","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127759344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gene-V Product of Bacteriophage fd: Structure of a DNA-unwinding Protein and Its Complexes with DNA 噬菌体基因v产物:DNA解绕蛋白的结构及其与DNA的复合物
The Excitement of Discovery: Selected Papers of Alexander Rich Pub Date : 2018-11-01 DOI: 10.1142/9789813272682_0049
A. Mcpherson, F. Jurna, A. Wang, F. Kolpak, I. Molineux, A. Rich
{"title":"Gene-V Product of Bacteriophage fd: Structure of a DNA-unwinding Protein and Its Complexes with DNA","authors":"A. Mcpherson, F. Jurna, A. Wang, F. Kolpak, I. Molineux, A. Rich","doi":"10.1142/9789813272682_0049","DOIUrl":"https://doi.org/10.1142/9789813272682_0049","url":null,"abstract":"","PeriodicalId":150391,"journal":{"name":"The Excitement of Discovery: Selected Papers of Alexander Rich","volume":"125 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134398670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Crystal structure of an Okazaki fragment at 2-Å resolution 2-Å分辨率下冈崎碎片的晶体结构
The Excitement of Discovery: Selected Papers of Alexander Rich Pub Date : 2018-11-01 DOI: 10.1142/9789813272682_0041
M. Egli, N. Usman, Shuguang Zhang, A. Rich
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引用次数: 0
Electron Microscope Studies of Ribosomal Clusters Synthesizing Hemoglobin 核糖体簇合成血红蛋白的电镜研究
The Excitement of Discovery: Selected Papers of Alexander Rich Pub Date : 2018-11-01 DOI: 10.1142/9789813272682_0014
J. R. Warner, Alexander Rich, C. Hall
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引用次数: 0
Structure of collagen 胶原蛋白的结构
The Excitement of Discovery: Selected Papers of Alexander Rich Pub Date : 2018-11-01 DOI: 10.1142/9789813272682_0013
Shuguang Zhang
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引用次数: 0
Synthesis by Ribosomes of Viral Coat Protein containing Ester Linkages 含酯键病毒外壳蛋白的核糖体合成
The Excitement of Discovery: Selected Papers of Alexander Rich Pub Date : 2018-11-01 DOI: 10.1142/9789813272682_0019
S. Fahnestock, Alexander Rich
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引用次数: 0
HUMAN GENOME SEQUENCING AND ETHICAL PROBLEMS OF THE TWENTY-FIRST CENTURY 人类基因组测序和21世纪的伦理问题
The Excitement of Discovery: Selected Papers of Alexander Rich Pub Date : 2018-11-01 DOI: 10.1142/9789813272682_0059
A. Rich
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引用次数: 0
Crystalline Transfer RNA: The Three-Dimensional Patterson Function at 12-Angstrom Resolution 晶体转移RNA:三维帕特森函数在12埃分辨率
The Excitement of Discovery: Selected Papers of Alexander Rich Pub Date : 2018-11-01 DOI: 10.1142/9789813272682_0020
Shuguang Zhang
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引用次数: 0
Sugar Pucker and Nucleic Acid Structure 糖皱和核酸结构
The Excitement of Discovery: Selected Papers of Alexander Rich Pub Date : 2018-11-01 DOI: 10.1142/9789813272682_OTHERS05
M. Egli
{"title":"Sugar Pucker and Nucleic Acid Structure","authors":"M. Egli","doi":"10.1142/9789813272682_OTHERS05","DOIUrl":"https://doi.org/10.1142/9789813272682_OTHERS05","url":null,"abstract":"DNA and RNA are acids, contain bases, form salts and are held together by sugars. In DNA, the sugar is 2′-deoxyribose and in RNA it is ribose. By the time I joined Alex’s lab in 1989, the important role of the sugar in determining the shape and function of the nucleic acids had long been recognized. As recounted in a short paper titled “The double helix: a tale of two puckers” (Rich, 2003), Alex made a string of discoveries that paved the way to a deeper understanding of how the sugar influences the conformation of DNA and RNA. Early fiber diffraction images had revealed two forms of the DNA duplex and it was later found that these were based on different conformations of the sugar moiety. In the B-form, the C2′-atom is out of the plane on the same side as the nucleobase (C2′-endo, Fig. 1A). In the A-form, the C3′-atom is out of the plane and the sugar conformation is C3′-endo (Fig. 1B). The change in sugar pucker has many consequences, including the duplex shape, groove widths and depths, intrastrand phosphate-phosphate distances and backbone hydration. Although DNA models based on fiber diffraction patterns led to an understanding of how sugar conformation affects the architecture of the double helix, single crystal diffraction studies of mini-helices [RNA (Rosenberg et al., 1973)] and oligonucleotides at high resolution later routinely allowed accurate visualization of the sugar pucker. The discoveries that poly(A) and poly(U) (Rich & Davies, 1956) and poly(A) and poly(dT) (Rich, 1960) could be hybridized had a tremendous impact, considering past and present applications as well as structure and stability of the nucleic acids. Thus, it became clear that the canonical RNA duplex resembled the DNA A-form and that DNA could adapt to RNA — but not the other way around — in a DNA:RNA hybrid duplex. We found later that a single ribonucleotide in an oligo2′-deoxyribonucleotide could drive the entire duplex into the A-form (Egli et al., 1993). As well, an Okazaki fragment, a chimeric RNA-DNA strand paired to DNA, was found to adopt a regular A-form in the crystal (Egli et al., 1992). However, the conclusion that every DNA:RNA hybrid is of the A-form is wrong and in reality, the","PeriodicalId":150391,"journal":{"name":"The Excitement of Discovery: Selected Papers of Alexander Rich","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132733501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
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