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Preparation of dense/spherical fine particle by spray dryer 利用喷雾干燥机制备致密/球形细颗粒
Journal of Analytical & Pharmaceutical Research Pub Date : 2024-02-13 DOI: 10.15406/japlr.2024.10.00433
Hirano Hiroyuki, Yamahara Hiroshi
{"title":"Preparation of dense/spherical fine particle by spray dryer","authors":"Hirano Hiroyuki, Yamahara Hiroshi","doi":"10.15406/japlr.2024.10.00433","DOIUrl":"https://doi.org/10.15406/japlr.2024.10.00433","url":null,"abstract":"Fine particle granulation using a spray dryer was performed to prepare with a high drug content, a spherical shape, and a smooth surface. Since the target particle size was less than 200 μm, a rotary disk atomizer was adopted and a slurry was chosen as the spray liquid. When 5-aminosalicylic acid used as a model drug, hydroxypropyl cellulose, and sodium chloride were added in the slurry and was spray dried, the desired size of particles were obtained. Then, the obtained particles were coated with an enteric polymer, no dissolution of the drug in the 1st solution was observed, indicating no disruption occurred during coating.","PeriodicalId":150348,"journal":{"name":"Journal of Analytical & Pharmaceutical Research","volume":"39 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139840331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preparation of dense/spherical fine particle by spray dryer 利用喷雾干燥机制备致密/球形细颗粒
Journal of Analytical & Pharmaceutical Research Pub Date : 2024-02-13 DOI: 10.15406/japlr.2024.10.00433
Hirano Hiroyuki, Yamahara Hiroshi
{"title":"Preparation of dense/spherical fine particle by spray dryer","authors":"Hirano Hiroyuki, Yamahara Hiroshi","doi":"10.15406/japlr.2024.10.00433","DOIUrl":"https://doi.org/10.15406/japlr.2024.10.00433","url":null,"abstract":"Fine particle granulation using a spray dryer was performed to prepare with a high drug content, a spherical shape, and a smooth surface. Since the target particle size was less than 200 μm, a rotary disk atomizer was adopted and a slurry was chosen as the spray liquid. When 5-aminosalicylic acid used as a model drug, hydroxypropyl cellulose, and sodium chloride were added in the slurry and was spray dried, the desired size of particles were obtained. Then, the obtained particles were coated with an enteric polymer, no dissolution of the drug in the 1st solution was observed, indicating no disruption occurred during coating.","PeriodicalId":150348,"journal":{"name":"Journal of Analytical & Pharmaceutical Research","volume":"1 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139780590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A rapid HPTLC fingerprinting technique for identifying the various geo-floral origins of honeys 快速 HPTLC 指纹识别技术，用于确定蜂蜜的各种地理花源
Journal of Analytical & Pharmaceutical Research Pub Date : 2024-02-06 DOI: 10.15406/japlr.2024.13.00432
A. Hazra, B. Chakraborty, Srikanta Pandit, T. Sur
{"title":"A rapid HPTLC fingerprinting technique for identifying the various geo-floral origins of honeys","authors":"A. Hazra, B. Chakraborty, Srikanta Pandit, T. Sur","doi":"10.15406/japlr.2024.13.00432","DOIUrl":"https://doi.org/10.15406/japlr.2024.13.00432","url":null,"abstract":"Honey has several nutritional and therapeutic uses due to the presence of different bioactive compounds.These substances are derived from floral nectar. Therefore, it becomes essential to identify the distinct chemical profiles of honey samples. The aim of this research was to provide an accurate, straightforward, and sensitive HPTLC approach for different types of honey verification. Eight mono floral honeys (mustard, eucalyptus, litchi, orange, tea, Indian plum, black plum and pineapple) were collected from different origin of West Bengal (eastern India) and examined. Standard procedures were followed to check the quality of each honey.The flora was identified by microscopically examining the pollen found in honeys. High-performance thin layer chromatography (HPTLC) was used to analyze lipophilic fractions of each honey. Chromatographic results identified distinct patterns of bands with specific Rf values for each type of mono floral honey. HPTLC is a simple and effective method for routine analysis and verification. It can serve as authentication for different types of honey.","PeriodicalId":150348,"journal":{"name":"Journal of Analytical & Pharmaceutical Research","volume":"42 11-12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139862026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A rapid HPTLC fingerprinting technique for identifying the various geo-floral origins of honeys 快速 HPTLC 指纹识别技术，用于确定蜂蜜的各种地理花源
Journal of Analytical & Pharmaceutical Research Pub Date : 2024-02-06 DOI: 10.15406/japlr.2024.13.00432
A. Hazra, B. Chakraborty, Srikanta Pandit, T. Sur
{"title":"A rapid HPTLC fingerprinting technique for identifying the various geo-floral origins of honeys","authors":"A. Hazra, B. Chakraborty, Srikanta Pandit, T. Sur","doi":"10.15406/japlr.2024.13.00432","DOIUrl":"https://doi.org/10.15406/japlr.2024.13.00432","url":null,"abstract":"Honey has several nutritional and therapeutic uses due to the presence of different bioactive compounds.These substances are derived from floral nectar. Therefore, it becomes essential to identify the distinct chemical profiles of honey samples. The aim of this research was to provide an accurate, straightforward, and sensitive HPTLC approach for different types of honey verification. Eight mono floral honeys (mustard, eucalyptus, litchi, orange, tea, Indian plum, black plum and pineapple) were collected from different origin of West Bengal (eastern India) and examined. Standard procedures were followed to check the quality of each honey.The flora was identified by microscopically examining the pollen found in honeys. High-performance thin layer chromatography (HPTLC) was used to analyze lipophilic fractions of each honey. Chromatographic results identified distinct patterns of bands with specific Rf values for each type of mono floral honey. HPTLC is a simple and effective method for routine analysis and verification. It can serve as authentication for different types of honey.","PeriodicalId":150348,"journal":{"name":"Journal of Analytical & Pharmaceutical Research","volume":"70 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139802384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of single granule release characteristics of controlled release granules with porous ethylcellulose membrane 评估多孔乙基纤维素膜控释颗粒的单粒释放特性
Journal of Analytical & Pharmaceutical Research Pub Date : 2024-01-18 DOI: 10.15406/japlr.2024.13.00431
Hirano Hiroyuki, Yamahara Hiroshi
{"title":"Evaluation of single granule release characteristics of controlled release granules with porous ethylcellulose membrane","authors":"Hirano Hiroyuki, Yamahara Hiroshi","doi":"10.15406/japlr.2024.13.00431","DOIUrl":"https://doi.org/10.15406/japlr.2024.13.00431","url":null,"abstract":"A basic dissolution study of single granule in a controlled-release capsule formulations was conducted. Controlled-release granules were prepared using porous Ethylcellulose membranes, and single granule dissolution profiles was compared with those of the Japanese pharmacopoeia (JP) paddle method. Dissolution profile from one granule was found to be dependent on the solubility of the drug.","PeriodicalId":150348,"journal":{"name":"Journal of Analytical & Pharmaceutical Research","volume":"105 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139614640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complexes formed between polyelectrolyte and acetylated cationic dendrimers 聚电解质与乙酰化阳离子树状大分子之间形成络合物
Journal of Analytical & Pharmaceutical Research Pub Date : 2023-05-26 DOI: 10.15406/japlr.2023.12.00427
Raghad Natsha, K. Qamhieh
{"title":"Complexes formed between polyelectrolyte and acetylated cationic dendrimers","authors":"Raghad Natsha, K. Qamhieh","doi":"10.15406/japlr.2023.12.00427","DOIUrl":"https://doi.org/10.15406/japlr.2023.12.00427","url":null,"abstract":"Gene therapies are receiving a revival, especially because of the potential for use in cancer and infectious disease vaccination. However, effectively condensing and maintaining deoxyribonucleic acid (DNA) carriers for gene therapy are used, such as dendrimers. The penetrable sphere model developed by Qamhieh et al., explain the interaction between linear polyelectrolyte (LPE) and an ion-penetrable sphere was employed to study the complexation of negatively charged DNA and acetylated dendrimer. Throughout the study, we emphasized the effect of acetylation on two types of complexations: single dendrimer-DNA chain complex and multiple dendrimers-DNA chain complex. The interaction between three different DNA lengths: L = 90 nm of 265; L = 184 nm of 541 bp; and L = 680 nm of 2000 bp individually with the poly (amido amine) (PAMAM) dendrimer of generation 5 was studied. For a single dendrimer-DNA complex, the number of condensed monomers around the dendrimer and the fraction of optimal length wrapping around the dendrimer was studied. It was found that by increasing acetylation, the number of condensed monomers and the fraction of optimal length decreased. For multiple dendrimers-DNA complex, the optimal length wrapping around the dendrimer and the linker that forms between complexes were studied. As a result, with increasing acetylation, the will shorten while the linker will increase significantly. The acetylation also affected the number of turns wrapping around the dendrimer and the net charge of the complex for single and multiple dendrimer-DNA complexes, and it was found that the longer the chain length, the more turns there are around the dendrimer. The net charge of all complexes was negative due to increased acetylation. In this study, it is revealed that the developed model is suitable for demonstrating the complexation between the dendrimer and the DNA.","PeriodicalId":150348,"journal":{"name":"Journal of Analytical & Pharmaceutical Research","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133179234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cancer: A problem of public health in Brazil 癌症:巴西公共卫生的一个问题
Journal of Analytical & Pharmaceutical Research Pub Date : 2023-01-10 DOI: 10.15406/japlr.2023.12.00416
R. Bonilha Dezena, Bruno Henrique Prudencio Gomes, Mariana Bertini Teixeira, Clezio Rodrigues de Carvalho Abreu
{"title":"Cancer: A problem of public health in Brazil","authors":"R. Bonilha Dezena, Bruno Henrique Prudencio Gomes, Mariana Bertini Teixeira, Clezio Rodrigues de Carvalho Abreu","doi":"10.15406/japlr.2023.12.00416","DOIUrl":"https://doi.org/10.15406/japlr.2023.12.00416","url":null,"abstract":"Cancer being one of the most important causes of death, investments in research and innovation to better understand the mechanisms of this pathology and, consequently, the development of new therapies are extremely important and necessary to benefit patients and save lives.","PeriodicalId":150348,"journal":{"name":"Journal of Analytical & Pharmaceutical Research","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126148963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The power of non-specificity in cleaning validation 非特异性在清洁验证中的作用
Journal of Analytical & Pharmaceutical Research Pub Date : 2022-09-22 DOI: 10.15406/japlr.2022.11.00408
R. Bonilha Dezena, Paulo César Pires Rosa
{"title":"The power of non-specificity in cleaning validation","authors":"R. Bonilha Dezena, Paulo César Pires Rosa","doi":"10.15406/japlr.2022.11.00408","DOIUrl":"https://doi.org/10.15406/japlr.2022.11.00408","url":null,"abstract":"","PeriodicalId":150348,"journal":{"name":"Journal of Analytical & Pharmaceutical Research","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125205698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The physicochemical analysis and health benefits of fresh and branded honey produced in delta state, Nigeria 尼日利亚三角洲州生产的新鲜蜂蜜和品牌蜂蜜的理化分析和健康益处
Journal of Analytical & Pharmaceutical Research Pub Date : 2022-06-22 DOI: 10.15406/japlr.2022.11.00403
G. Edo, Favour Ogheneoruese Onoharigho, ghenerume Lucky Emakpor, Patrick Othuke Akpoghelie
{"title":"The physicochemical analysis and health benefits of fresh and branded honey produced in delta state, Nigeria","authors":"G. Edo, Favour Ogheneoruese Onoharigho, ghenerume Lucky Emakpor, Patrick Othuke Akpoghelie","doi":"10.15406/japlr.2022.11.00403","DOIUrl":"https://doi.org/10.15406/japlr.2022.11.00403","url":null,"abstract":"This research is aimed to investigate and evaluate the physicochemical characteristic of different honey produced in Delta State, Nigeria, to confirm its economical and nutritional quality in comparison with the international standard. The quality of fresh and branded honey samples produced in Delta State was assessed using physicochemical and mineral analysis. Eight fresh honey (FHs) samples and eight branded honey (BHs) samples were collected from the Autonomous Province of Delta State, Nigeria. The tested parameters were pH, free acidity, electrical conductivity, color intensity, moisture, ash, proline, diastase, HMF, invertase, glucose, fructose, sucrose, lipid and mineral content. A qualitative test (Fiehe, Lund and Lugol) was performed to test the purity of honey. Both honey samples displayed good physicochemical properties. The concentration level of sugars was higher in the branded honey in comparison to fresh honey samples. The physicochemical parameters of fresh and branded honey were in concordance with the international standard.","PeriodicalId":150348,"journal":{"name":"Journal of Analytical & Pharmaceutical Research","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122310915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Inhibition potential of the major secondary metabolites isolated from anacardium occidentale against Mpro enzyme from COVID-19 virus using molecular docking and dynamics studies 利用分子对接和动力学研究了西心包主要次级代谢物对新冠病毒Mpro酶的抑制潜力
Journal of Analytical & Pharmaceutical Research Pub Date : 2022-03-03 DOI: 10.15406/japlr.2022.11.00399
António Pereira, L. L. Bezerra, M. Marinho, Emanuel Paula Magalhães, Ramon Rppb de Menezes, T. L. Sampaio, P. Bandeira, Carla FC Fernandes, E. S. Marinho, Alexandre MR Teixeira, H. S. dos Santos
{"title":"Inhibition potential of the major secondary metabolites isolated from anacardium occidentale against Mpro enzyme from COVID-19 virus using molecular docking and dynamics studies","authors":"António Pereira, L. L. Bezerra, M. Marinho, Emanuel Paula Magalhães, Ramon Rppb de Menezes, T. L. Sampaio, P. Bandeira, Carla FC Fernandes, E. S. Marinho, Alexandre MR Teixeira, H. S. dos Santos","doi":"10.15406/japlr.2022.11.00399","DOIUrl":"https://doi.org/10.15406/japlr.2022.11.00399","url":null,"abstract":"The sanitary emergency installed in the world generated by the pandemic COVID-19 instigates the search for scientific strategies to mitigate the damage caused by the disease to different sectors of society. The disease caused by the coronavirus, SARS-CoV-2, reached 216 countries/territories, where about 20 million people were reported with the infection, and more than 740,.000 died. Given the situation, research involving the development and validation of new antiviral molecules, especially against the SARS-CoV-2 virus, is highly relevant. In this work, a in silico study was carried out to evaluate the inhibitory power of phytoconstituents from Anacardium occidentale L. against Mpro enzyme from COVID-19 virus. The molecular docking simulations were performed to understand interactions between some phytochemicals present in A. occidentale against the Mpro enzyme from SARS-CoV-2, the amentoflavone and agathisflavone molecules showed the best affinity energy in the value of -8.0 kcal/mol and -8.3 kcal/mol, respectively. The molecular dynamics results indicated that the agathisflavone ligand had interactions more stable and a highest interaction potential energy with the Mpro enzyme than the amentoflavone ligand.","PeriodicalId":150348,"journal":{"name":"Journal of Analytical & Pharmaceutical Research","volume":"136 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116408762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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