Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine最新文献_第5页

In vivo-in vitro comparison of deposition in three mouth-throat models with Qvar and Turbuhaler inhalers. Qvar和Turbuhaler吸入器在三种口腔咽喉模型中沉积的体内外比较。

Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine Pub Date : 2007-01-01 DOI: 10.1089/jam.2007.0584

Yu Zhang, Kyle Gilbertson, Warren H Finlay

{"title":"In vivo-in vitro comparison of deposition in three mouth-throat models with Qvar and Turbuhaler inhalers.","authors":"Yu Zhang, Kyle Gilbertson, Warren H Finlay","doi":"10.1089/jam.2007.0584","DOIUrl":"https://doi.org/10.1089/jam.2007.0584","url":null,"abstract":"In vitro polydisperse aerosol deposition in three mouth-throat models, namely, the USP (United States Pharmacopeia) mouth-throat (induction port), idealized mouth-throat, and highly idealized mouth-throat, was investigated experimentally. Aerosol particles emitted from two commercial inhalers, Qvar (pMDI) and Turbuhaler (DPI), were used. The in vitro deposition results in these three mouth-throat models were compared with in vivo data available from the literature. For the DPI, mouth-throat deposition was 57.3 +/- 4.5% for the USP mouth-throat, 67.8 +/- 2.2% for the idealized mouth-throat, and 69.3 +/- 1.1% for the highly idealized mouth-throat, which are all relatively close to the in vivo value of 65.8 +/- 10.1%. In contrast, for the pMDI, aerosol deposition in the idealized mouth-throat (25.8 +/- 4.2%) and the highly idealized mouth-throat (24.9 +/- 2.8%) agrees with the in vivo data (29.0 +/- 18.0%) reported in the literature better than that for the USP mouth-throat (12.2 +/- 2.7%). In both cases, the USP mouth-throat gives the lowest deposition among the three mouth-throat models studied. In summary, both the idealized mouth-throat and highly idealized mouth-throat improve the accuracy of predicted mean in vivo deposition in the mouth-throat region. This result hints at the potential applicability of either the idealized mouth-throat or highly idealized mouth-throat as a future USP mouth-throat standard to provide mean value prediction of in vivo mouth-throat deposition.","PeriodicalId":14878,"journal":{"name":"Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine","volume":"20 3","pages":"227-35"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/jam.2007.0584","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40993680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 110

Increased granulocyte-colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF) levels in BAL fluid from patients with sulfur mustard gas-induced pulmonary fibrosis. 硫芥子气诱导肺纤维化患者BAL液中粒细胞集落刺激因子(G-CSF)和粒细胞巨噬细胞集落刺激因子(GM-CSF)水平升高。

Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine Pub Date : 2007-01-01 DOI: 10.1089/jam.2007.0590

Ali Emad, Yasaman Emad

{"title":"Increased granulocyte-colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF) levels in BAL fluid from patients with sulfur mustard gas-induced pulmonary fibrosis.","authors":"Ali Emad, Yasaman Emad","doi":"10.1089/jam.2007.0590","DOIUrl":"https://doi.org/10.1089/jam.2007.0590","url":null,"abstract":"The objective of this article was to show the role of cytokines in the pathogenesis of pulmonary fibrosis due to sulfur mustard gas inhalation. Eighteen veterans with mustard gas-induced pulmonary fibrosis and 18 normal patients were used as controls. Bronchoalveolar larvage (BAL) and analyses of BAL fluids for cellular and cytokine levels were performed. There was a significant difference in granulocyte colony stimulating factor (G-CSF) level in the BAL fluid of patients and the controls (p < 0.0001). Granulocyte-macrophage colony stimulating pulmonary fibrosis (GM-CSF) BAL levels were significantly increased in patients with pulmonary fibrosis (PF) in comparison with controls (p < 0.0001). Patients with PF have highly significant increases in IL-8 level compared to controls (87.94 +/- 59.63 vs. 8.66 +/- 6.97 g/mL(1); p < 0.0001) as well. IL-8 and G-CSF levels in BAL fluid correlate only with the percentage and the absolute number of neutrophils of the BAL fluid in patients with PF (p = 0.02/p = 0.01; p = 0.01/p = 0.01; respectively). A significant correlation was found between GM-CSF BAL fluid level and the percentage and the absolute number of the BAL fluid eosinophils (p = 0.04 and p = 0.03). Neutrophils alveolitis, the presence of eosinophils, and higher concentrations of interleukin-8, G-CSF, and GM-CSF in BAL fluid are associated with the development of fibrosis in sulfur mustard victims.","PeriodicalId":14878,"journal":{"name":"Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine","volume":"20 3","pages":"352-60"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/jam.2007.0590","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40994706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Validity of in vitro tests on aqueous spray pumps as surrogates for nasal deposition, absorption, and biologic response. 水喷雾泵作为鼻沉积、吸收和生物反应替代品的体外试验的有效性。

Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine Pub Date : 2006-01-01 DOI: 10.1089/jam.2006.19.510

Julie D Suman, Beth L Laube, Richard Dalby

{"title":"Validity of in vitro tests on aqueous spray pumps as surrogates for nasal deposition, absorption, and biologic response.","authors":"Julie D Suman, Beth L Laube, Richard Dalby","doi":"10.1089/jam.2006.19.510","DOIUrl":"https://doi.org/10.1089/jam.2006.19.510","url":null,"abstract":"This research investigated the impact of the full range of in vitro spray characterization tests described in the FDA Draft Bioequivalence Guidance on nasal deposition pattern, pharmacokinetics, and biological response to nicotine administered by two aqueous nasal spray pumps in human volunteers. Nicotine was selected as a model drug (even though it is not locally acting) based on its ability to alter cardiac function and available plasma assay. Significant differences in pump performance-including mean volume diameters, spray angle, spray width, and ovality ratios-were observed between the two pumps. There were no significant differences in deposition pattern, or pharmacokinetic or pharmacodynamic response to the nasally administered nicotine. Although there were statistical differences in the in vitro tests between the two pumps, these differences did not result in significant alterations in the site of droplet deposition within the nose, the rate and extent of nicotine absorption, or the physiologic response it induced. These results suggest that current measures of in vitro performance, particularly spray angle and spray pattern (ovality), may not be clinically relevant. Additional research is needed to define what spray pump characteristics are likely to produce differences in deposition pattern and drug response.","PeriodicalId":14878,"journal":{"name":"Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine","volume":"19 4","pages":"510-21"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/jam.2006.19.510","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26465829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 37

Lung deposition of mannitol powder aerosol in healthy subjects. 甘露醇粉末气雾剂在健康人肺中的沉积。

Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine Pub Date : 2006-01-01 DOI: 10.1089/jam.2006.19.522

William Glover, Hak-Kim Chan, Stefan Eberl, Evangelia Daviskas, Sandra Anderson

{"title":"Lung deposition of mannitol powder aerosol in healthy subjects.","authors":"William Glover, Hak-Kim Chan, Stefan Eberl, Evangelia Daviskas, Sandra Anderson","doi":"10.1089/jam.2006.19.522","DOIUrl":"https://doi.org/10.1089/jam.2006.19.522","url":null,"abstract":"Mannitol as a dry powder aerosol is used for bronchoprovocation testing and to enhance mucus clearance in people with excessive airway secretions. The dose and distribution of the deposited aerosol in the lung was investigated using fast single photon emission tomography (SPECT) imaging. Mannitol powder (3 microm particle size) was produced by spray drying and radiolabeled with (99m)Tc-DTPA. Approximately 60 mg of radiolabeled mannitol (containing 52-68 MBq of (99m)Tc-DTPA) was administered to 10 healthy subjects using the Inhalator dry powder inhaler (DPI), and SPECT images (1 min each) were collected. Thirteen percent to 31% of the dose of mannitol loaded in the inhaler deposited in the lungs and the deposited dose correlated positively with the peak inhalation air flow. The regional aerosol lung distribution, as expressed by the penetration index (i.e., ratio of peripheral to central deposition in the lung) varied from 0.31 to 0.88, which however showed no dependency on any flow parameters. The variation in response to the same dose of mannitol within the asthmatic population may in part be explained by these findings.","PeriodicalId":14878,"journal":{"name":"Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine","volume":"19 4","pages":"522-32"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/jam.2006.19.522","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26465830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 30

Aerosol drug delivery with helium oxygen gas mixtures to the human lungs. 带氦气和氧气混合物的气雾剂药物输送到人体肺部。

Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine Pub Date : 2006-01-01 DOI: 10.1089/jam.2006.19.580

J Heyder

引用次数: 0

Aerosol sampling methods in workplace and ambient environments. 工作场所和环境中的气溶胶取样方法。

Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine Pub Date : 2006-01-01 DOI: 10.1089/jam.2006.19.434

Mahmoud Abdel-Salam

引用次数: 11

Comparison of SPECT aerosol deposition data with twenty-four-hour clearance measurements. SPECT气溶胶沉降数据与24小时间隙测量的比较。

Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine Pub Date : 2006-01-01 DOI: 10.1089/jam.2006.19.261

John S Fleming, Matthew Quint, Livia Bolt, Ted B Martonen, Joy H Conway

{"title":"Comparison of SPECT aerosol deposition data with twenty-four-hour clearance measurements.","authors":"John S Fleming, Matthew Quint, Livia Bolt, Ted B Martonen, Joy H Conway","doi":"10.1089/jam.2006.19.261","DOIUrl":"https://doi.org/10.1089/jam.2006.19.261","url":null,"abstract":"Three-dimensional (3D) radionuclide imaging provides detailed information on the distribution of inhaled aerosol material within the body. Analysis of the data can provide estimates of the deposition per airway generation. Information on regional distribution of deposited aerosol can also be obtained from 24-hour clearance measurements. In this study, a nebulizer was used to deliver a radiolabeled aerosol to nine human subjects. Single photon emission computed tomography (SPECT) has been used to assess the distribution of aerosol deposition per airway generation. The deposition pattern was also estimated using measurements of the aerosol remaining in the lung 24 h after inhalation. The error in the SPECT value was assessed by simulation and that in the 24-h clearance value by repeat analysis. The mean fraction of lung deposition in the conducting airway (CADF) from SPECT was 0.21. The corresponding 24-h clearance value was 0.23. These values were not significantly different. There was a weak but non-significant correlation between the SPECT and 24-h measurements (r = 0.49). The standard error of the difference was 0.11. The corresponding errors on the SPECT and 24-h clearance measurements were 0.04 and 0.05, respectively. There was no systematic difference between the values of conducting airways deposition obtained from 24-h measurements and SPECT. However, there were random differences on individual subjects, which were larger than the estimated measurement errors.","PeriodicalId":14878,"journal":{"name":"Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine","volume":"19 3","pages":"261-7"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/jam.2006.19.261","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26358901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Ultrafine particle-lung interactions: does size matter? 超细颗粒与肺的相互作用:大小重要吗?

Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine Pub Date : 2006-01-01 DOI: 10.1089/jam.2006.19.74

Wolfgang G Kreyling, Manuela Semmler-Behnke, Winfried Möller

{"title":"Ultrafine particle-lung interactions: does size matter?","authors":"Wolfgang G Kreyling, Manuela Semmler-Behnke, Winfried Möller","doi":"10.1089/jam.2006.19.74","DOIUrl":"https://doi.org/10.1089/jam.2006.19.74","url":null,"abstract":"Epidemiological studies continue to indicate associations between exposure to increased concentrations of ambient fine and ultrafine particles and adverse health effects in susceptible individuals. The ultrafine particle fraction in the ambient atmosphere seems to play a specific role. Yet, the dosimetry (including deposition patterns in the respiratory tract and, particularly, the biokinetic fate of ultrafine particles) is not fully understood. In contrast to fine particles, inhaled ultrafine particles seem to follow different routes in the organism. Cardiovascular effects observed in epidemiological studies triggered the discussion on enhanced translocation of ultrafine particles from the respiratory epithelium towards circulation and subsequent target organs, such as heart, liver, and brain, eventually causing adverse effects on cardiac function and blood coagulation, as well as on functions of the central nervous system. Current knowledge on systemic translocation of ultrafine particles in humans and animal models is reviewed. Additionally, an estimate of accumulating particle numbers in secondary target organs during chronic exposure is extrapolated from long-term translocation data obtained from rats. Toxicological studies aim to provide the biological plausibility of health effects of ultrafine particles and to identify cascades of mechanisms that are causal for the gradual transition from the physiological status towards pathophysiologcal alterations and eventually chronic disease. Considering the interaction between insoluble ultrafine particles and biological systems (such as body fluids, proteins, and cells), there still are gaps in the current knowledge on how ultrafine particles may cause adverse reactions. This paper reviews the current concept of interactions between insoluble ultrafine particles and biological systems.","PeriodicalId":14878,"journal":{"name":"Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine","volume":"19 1","pages":"74-83"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/jam.2006.19.74","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25916759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 354

Characterization of regional and local deposition of inhaled aerosol drugs in the respiratory system by computational fluid and particle dynamics methods. 用计算流体和粒子动力学方法表征吸入气溶胶药物在呼吸系统中的局部和局部沉积。

Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine Pub Date : 2006-01-01 DOI: 10.1089/jam.2006.19.329

Arpád Farkas, Imre Balásházy, Katalin Szocs

{"title":"Characterization of regional and local deposition of inhaled aerosol drugs in the respiratory system by computational fluid and particle dynamics methods.","authors":"Arpád Farkas, Imre Balásházy, Katalin Szocs","doi":"10.1089/jam.2006.19.329","DOIUrl":"https://doi.org/10.1089/jam.2006.19.329","url":null,"abstract":"The present work describes the local deposition patterns of therapeutic aerosols in the oropharyngeal airways, healthy and diseased bronchi and alveoli using computational fluid and particle dynamics techniques. A user-enhanced computational fluid dynamics commercial finite- volume software package was used to compute airflow fields, deposition efficiencies, and deposition patterns of therapeutic aerosols along the airways. Adequate numerical meshes, generated in different airway sections, enabled us to more precisely define trajectories and local deposition patterns of inhaled particles than before. Deposition patterns show a high degree of heterogeneity of deposition along the airways, being more uniform for nanoparticles compared to micro-particles in the whole respiratory system at all inspiratory flow rates. Extrathoracic and tracheobronchial deposition fractions of nanoparticles decrease with increasing flow rates. However, vice versa happens to the micron-size particles, that is, the deposition fraction is higher at high flow rates. Both airway constrictions and the presence of tumors significantly increased the deposition efficiencies compared to the deposition efficiencies in healthy airways by a factor ranging from 1.2 to 4.4. In alveoli, the deposition patterns are strongly influenced by particle size and direction of gravity. This study demonstrated that numerical modeling can be a powerful tool in the aerosol drug delivery optimization. Present results may be integrated in future aerosol drug therapy protocols.","PeriodicalId":14878,"journal":{"name":"Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine","volume":"19 3","pages":"329-43"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/jam.2006.19.329","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26359394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 61

Administration of aerosolized drugs to infants by a hood: a three-dimensional numerical study. 婴儿通过面罩雾化给药:三维数值研究。

Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine Pub Date : 2006-01-01 DOI: 10.1089/jam.2006.19.533

Tal Shakked, David M Broday, David Katoshevski, Israel Amirav

{"title":"Administration of aerosolized drugs to infants by a hood: a three-dimensional numerical study.","authors":"Tal Shakked, David M Broday, David Katoshevski, Israel Amirav","doi":"10.1089/jam.2006.19.533","DOIUrl":"https://doi.org/10.1089/jam.2006.19.533","url":null,"abstract":"Using a hood for aerosol delivery to infants was found to be effective and user-friendly compared to the commonly used face mask. The currently available hood design has an even greater potential in terms of efficiency, and a numerical simulation can serve as a tool for its optimization. The present study describes the development and utilization of a numerical simulation for studying the transport and fate of the aerosol particles and the carrier gas within a three-dimensional realistic representation of the hood and the infant's head. The study further incorporates realistic breathing patterns, with a longer expiration phase than an inspiration phase. Both nose and mouth breathing are simulated. While the base case assumes that the funnel that delivers the aerosol within the hood is perpendicular to the infant's face, more realistic scenarios include a funnel that is slanted with respect to the infant face, the infant's head taking a general position with respect to the funnel, and the funnel and the head being both tilted. A good agreement is found between computation and experimental results. As expected, the most efficient drug delivery, 18%, is achieved when the funnel is normal to the infant's face. The quantitative evaluation of different scenarios presented in this work increases the knowledge of physicians, nurses, and parents regarding the efficacy of the treatment, in terms of the actual amount of drug inhaled under various modes of function of the device.","PeriodicalId":14878,"journal":{"name":"Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine","volume":"19 4","pages":"533-42"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/jam.2006.19.533","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26465831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15