JCO Global Oncology最新文献

{"title":"Breast Cancer Among Older Adults in Asia.","authors":"Luisa E Jacomina, Nicola Raphaela Tison, Erin Jay G Feliciano, Maria Jocelyn Kara Magsanoc-Alikpala, Edward Christopher Dee","doi":"10.1200/GO-25-00161","DOIUrl":"https://doi.org/10.1200/GO-25-00161","url":null,"abstract":"","PeriodicalId":14806,"journal":{"name":"JCO Global Oncology","volume":"11 ","pages":"e2500161"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Tolerability of a Low-Dose Continuous Regimen of Regorafenib in Refractory Synovial Sarcomas: A Single-Arm, Phase II Trial From India.","authors":"Sanal Fernandes, Sameer Rastogi, Kanu Priya Bhatia, Shamim A Shamim, Adarsh Barwad, Rambha Pandey, Shivanand Gammanagatti, Ekta Dhamija","doi":"10.1200/GO-24-00558","DOIUrl":"10.1200/GO-24-00558","url":null,"abstract":"<p><strong>Purpose: </strong>Advanced synovial sarcomas are associated with poor outcomes and a lack of efficacious therapeutic agents. The aim of this study was to assess the efficacy and safety of a novel, low-dose, continuous schedule of regorafenib in these patients.</p><p><strong>Methods: </strong>This is a single-arm, Simon 2-stage trial. Patients with synovial sarcomas who had progressed on at least two lines were administered daily regorafenib (80/120 mg alternating once daily per orally). The primary outcome measure was the 3-month progression-free rate (PFR). Quality-of-life (QoL) parameters using the EORTC C-30 questionnaire were assessed at baseline and at 3 months.</p><p><strong>Results: </strong>Twenty-five patients were recruited in the study (14 male and 11 female patients). The median number of previous lines was 2 (2-4) with 76% exposed to pazopanib. The 3-month PFR was 56% with a median progression-free survival of 5 months at a follow-up of 24 months. Grade 3 toxicities seen were hand-foot-skin reaction (52%) and diarrhea (4%). No decline in QoL parameters was seen with regorafenib administration.</p><p><strong>Conclusion: </strong>The low-dose, continuous schedule of regorafenib demonstrated durable responses in a heavily pretreated population of patients with synovial sarcoma and represents a viable therapeutic option in this group.</p>","PeriodicalId":14806,"journal":{"name":"JCO Global Oncology","volume":"11 ","pages":"e2400558"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burden of Breast Cancer Disease Among Older Adults in Asian Countries From 1990 to 2021.","authors":"Min Zhang, Chao Ye, Jing Qiu, Min Zhao, Meimei Cui, Jiayi Chen, Jingjing Jia, Wenjie Yan, Liling Zhu, Limei Luo","doi":"10.1200/GO-24-00523","DOIUrl":"https://doi.org/10.1200/GO-24-00523","url":null,"abstract":"<p><strong>Purpose: </strong>This study used the latest data of Global Burden of Disease (GBD) 2021 to comprehensively analyze the burden of breast cancer among older adults (age >65 years) in Asian countries.</p><p><strong>Methods: </strong>Our focus was on breast cancer metrics in Asia, specifically incidence, prevalence, deaths, and disability-adjusted life years (DALYs) using GBD 2021. Estimated annual percentage changes (EAPCs) were used to quantify the trends of age-standardized rates (ASRs). The decomposition method was explored to examine breast cancer deaths and DALYs as the result of four determinant factors. Nordpred was used to forecast burden trends up to 2044.</p><p><strong>Results: </strong>There were 262,063.05 new cases, 2,742,285.75 prevalence, 115,973.98 deaths, and 2,260,975.34 DALYs of breast cancer among older adults in 2021 in Asia. From 1990 to 2021, the ASRs of breast cancer among older adults were on the rise. Males (EAPC, 4.14; 95% CI, 3.8 to 4.48) had a greater upward trend in age-standardized incident rate than females (EAPC, 2.09; 95% CI, 2.03 to 2.15). The regions and countries with the most significant ASR growth trends of all metrics were high-income Asia-Pacific and Türkiye, respectively. Decomposition analysis of the deaths and DALYs showed population growth was the primary contributing factor. By 2044, the estimated number of breast cancer cases among older adults will continue to increase in Asian countries.</p><p><strong>Conclusion: </strong>Breast cancer among older adults causes a high disease burden in Asia, especially in high-income Asia-Pacific. There is an urgent need for regional cooperation to take effective targeted measures to jointly prevent and control the spread of breast cancer among older adults, especially for male breast cancer.</p>","PeriodicalId":14806,"journal":{"name":"JCO Global Oncology","volume":"11 ","pages":"e2400523"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International Fibrolamellar Cancer Registry: Opportunities and Challenges.","authors":"Layal Al Mahmasani, Marinela Capanu, Kurt Losert, Joanne F Chou, Maeve Aine Lowery, Martina Hennessy, Mathew Ray, Suzanne Chambers, Amin Yaqubie, Andrew Zarski, Imane H El Dika, Joseph S Light, Michael P La Quaglia, Eileen M O'Reilly, Ghassan K Abou-Alfa","doi":"10.1200/GO-24-00532","DOIUrl":"https://doi.org/10.1200/GO-24-00532","url":null,"abstract":"","PeriodicalId":14806,"journal":{"name":"JCO Global Oncology","volume":"11 ","pages":"e2400532"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender Disparities in Oncology: A Report From Four Countries in Latin America.","authors":"Julia Ismael, Paola Montenegro, Bettina Müller, Regina Barragan-Carrillo, Jazmín Hernández-Marín, Edith A Fernández-Figueroa, Jesús Argueta-Donohué, Erika Ruiz-Garcia","doi":"10.1200/GO-24-00554","DOIUrl":"10.1200/GO-24-00554","url":null,"abstract":"<p><strong>Purpose: </strong>Women represent a growing force in oncology but remain underrepresented in high-level positions. Gender-related challenges affect academic progression, research, and clinical practice. This manuscript aims to describes gender-based professional development challenges faced by women in oncology in Latin America (LATAM).</p><p><strong>Materials and methods: </strong>We conducted a multicenter, cross-sectional study among LATAM oncologists using a 27-item questionnaire on the basis of the European Society for Medical Oncology Women for Oncology Survey. Our analysis focused on male-female disparities, excluding other gender identities. Logistic regression models were used to calculated odds ratios (ORs) for gender inequity, wage disparity, workplace and sexual harassment, and family development. Statistical analyses were performed using SPSS version 26, with the significance set at <i>P</i> < .05.</p><p><strong>Results: </strong>We analyzed 254 participants from Argentina, Chile, Mexico, and Peru, mostly females (88%) and based in Mexico (55%). Most were attending physicians (68%), 51.5% worked 41-60 hours, and 33.4% reported gender equity initiatives. Gender inequity was significantly higher among women (83%) than among men (37%), with the female gender identified as a risk factor (OR, 15.67; <i>P</i> < .001). Workplace harassment was reported by 60% of women and 19% of men, whereas sexual harassment was experienced by 34% of women and 16% of men (OR, 2.78; <i>P</i> < .05). Sixty-five percent reported that men had the highest salaries. Logistic regression indicated that working 20-40 hours per week was associated with the likelihood of women having children (OR, 3.0; <i>P</i> < .01), as was working 41-60 hours (OR, 1.97; <i>P</i> < .01). However, holding an attending or resident position was associated with significantly lower childbearing rates.</p><p><strong>Conclusion: </strong>Our findings indicate that Women oncologists in LATAM report experiencing higher rates of gender-based inequity and harassment and remain underrepresented in leadership and high-earning roles.</p>","PeriodicalId":14806,"journal":{"name":"JCO Global Oncology","volume":"11 ","pages":"e2400554"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Genomic Profiling of Indian Patients With Lung Cancer.","authors":"Shivani Sharma, Vanita Noronha, Arti Yadav, Madhvi Mandhania, Sambit K Mohanty, Rahul Katara, Aditi Aggarwal, Sagar Samrat Mohanty, Akash Kumar, Sanjeev Kumar, Vipin Kumar, Kanika Jaggi, Deepak Kumar Sharma, Sanjay Kumar, Vaishalee Apoorva, Akash Pawar, Nandini Menon, Minit Shah, Kumar Prabhash","doi":"10.1200/GO-24-00587","DOIUrl":"https://doi.org/10.1200/GO-24-00587","url":null,"abstract":"<p><strong>Purpose: </strong>Genomic profiling has revolutionized non-small cell lung cancer (NSCLC) therapy, but molecular data on Indian patients with NSCLC are limited.</p><p><strong>Materials and methods: </strong>We analyzed next-generation sequencing (NGS) data of 5,219 Indian patients with lung cancer, tested between May 2022 and August 2023 at CORE Diagnostics, a commercial laboratory in India. Using the PulmoCORE gene panel, we targeted 13 key genes (<i>ALK</i>, <i>BRAF</i>, <i>EGFR</i>, <i>ERBB2</i>, <i>KRAS</i>, <i>MAP2K1</i>, <i>MET</i>, <i>NRAS</i>, <i>PIK3CA</i>, <i>RET</i>, <i>ROS1</i>, <i>TP53</i>, and <i>NTRK</i>) for DNA and RNA sequencing. PD-L1 was tested by immunohistochemistry.</p><p><strong>Results: </strong>Median patient age was 62 years, and 62.5% were male. Common histologies included adenocarcinoma (57.1%), NSCLC not otherwise specified (19.3%), and squamous cell carcinoma (7%). Genomic alterations were detected in 80.6% patients according to the PulmoCORE panel; 64.2% patients had actionable alterations in at least one of the nine biomarkers with Food and Drug Administration-approved targeted therapies, that is, <i>EGFR</i>, <i>KRAS</i>, <i>ALK</i>, <i>ROS1</i>, <i>BRAF</i>, <i>NTRK1/2/3</i>, <i>MET</i>, <i>RET</i>, and <i>ERBB2</i>. Common alterations included <i>TP53</i> (37%), <i>EGFR</i> (34.1%), and <i>KRAS</i> (13.3%), <i>ALK</i> (8.8%), and others below 5%. Alterations were more common in adenocarcinoma (76.4%) than in patients with squamous cell carcinoma (29.9%). Sex and age influenced mutation prevalence, with <i>EGFR</i> mutations more common in females and <i>KRAS</i> in males, while <i>ALK</i>, <i>ROS1</i>, and <i>RET</i> fusions were prevalent in younger adults. Most genomic alterations were mutually exclusive, although 25% patients had co-occurring mutations. PD-L1 positivity was higher in males (28.3%) and more common in patients with squamous cell carcinoma (34.2%).</p><p><strong>Conclusion: </strong>Broad molecular profiling is important to detect actionable alterations in Indian patients with lung cancer, for delivering optimal personalized precision medicine. Our study underscores the fact that NGS should be routinely done before planning therapy in Indian patients with advanced lung cancer.</p>","PeriodicalId":14806,"journal":{"name":"JCO Global Oncology","volume":"11 ","pages":"e2400587"},"PeriodicalIF":3.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of a Symptomatic Screening Program for Early Detection of Gastric Cancer in Roatán, Honduras.","authors":"Jade Tso, Susana Galeas, Brendalee Martinez, Kallie Vallecillo, Mustafa Faleh Abidalhassan, Natan Webster, Heidy Leiva, Mustafa Al-Qaraghli, Cameron Gaskill","doi":"10.1200/GO-24-00574","DOIUrl":"https://doi.org/10.1200/GO-24-00574","url":null,"abstract":"<p><strong>Purpose: </strong>Gastric cancer (GC) is a leading cause of cancer-related death in Central America, with late-stage diagnosis common because of nonspecific early symptoms. Symptomatic screening guidelines validated in high-income settings have been used to identify patients requiring urgent referral for upper GI endoscopy.</p><p><strong>Methods: </strong>This tool was piloted to assess feasibility for early detection of GC at a primary care clinic in Roatán, Honduras. If positive, a referral to endoscopy was placed, and patients contacted monthly for up to 4 months to collect information on demographics, GC risk factors, barriers to receiving endoscopy, and if they received an endoscopy. Provider questionnaires assessed endoscopy capacity and perceived patient barriers.</p><p><strong>Results: </strong>Five hundred patients were screened over 12 months. Nine screened positive, with seven clinically relevant to GC. Of these, four (57%) were female, average age was 49 years (IQR, 18), average number of years lived in Roatán was 29 (IQR, 34), and hypertension (57%) and hyperlipidemia (29%) were the most reported comorbidities. Two (29%) had a family history of cancer, four (57%) had a previous H. pylori infection, six (71%) took medication for acid reflux, and four (57%) had dietary risk factors for GC. All patients cited cost as a barrier to care, while two (29%) each reported difficulty traveling to a facility, lack of knowledge on which facilities did endoscopy, and uncertainty of whether they needed the procedure as other barriers.</p><p><strong>Conclusion: </strong>Although symptomatic screening guidelines are feasible for screening GC in Honduras, limitations in endoscopy access and capacity pose barriers to early diagnosis. These findings highlight the need to increase diagnostic capacity and address financial barriers to endoscopy.</p>","PeriodicalId":14806,"journal":{"name":"JCO Global Oncology","volume":"11 ","pages":"e2400574"},"PeriodicalIF":3.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Gender of the Child on Health Care-Seeking Behavior of Caregivers of Childhood Patients With Cancer: A Mixed-Methods Study.","authors":"Kanu Priya Bhatia, Shuvadeep Ganguly, Archana Sasi, Manraj Singh Sra, Sumit Malhotra, Shubhangi Sharma, Bhavika Tahiliani, Vasudha Verma, Tripti Dhania, Reema Bisht, Swetambri Sharma, Mamta Kumari, Sandeep Agarwala, Sujata Satapathy, Deepam Pushpam, Sameer Bakhshi","doi":"10.1200/GO-24-00325","DOIUrl":"https://doi.org/10.1200/GO-24-00325","url":null,"abstract":"<p><strong>Purpose: </strong>Gender bias against girls may affect health-seeking behavior and outcomes of childhood cancer. This study aimed to study the nature and extent of gender bias in health care among caregivers of childhood patients with cancer and also in community.</p><p><strong>Methods: </strong>This cross-sectional mixed-methods study was conducted in a tertiary cancer hospital and an urban community between July 2021 and July 2023. Qualitative component included 26 in-depth interviews (IDI) and four focus group discussions (FGDs) with caregivers of children with cancer. IDIs and FGDs were conducted by a psychologist and continued until thematic saturation was reached. For quantitative part, a gender-bias questionnaire was finalized which was administered to 230 caregivers in hospital and 311 participants from the community, with children in family.</p><p><strong>Results: </strong>Most participants did not perceive personal gender bias; however, many acknowledged noticing gender bias in others. This bias was linked to girls being considered financial burdens and having reduced marital prospects due to illness. Reducing treatment costs, improving access, and education targeting societal mindsets were suggested measures to mitigate bias. In community, no significant difference was observed among the respondents based on sex of youngest child in family. However, in hospital, caregivers of male children were less likely to offer similar care to a child of opposite sex than that reported by caregivers of female children (<i>P</i> = .01) for ailments like fever/diarrhea. Similar difference was not observed for other health care scenarios.</p><p><strong>Conclusion: </strong>Gender bias against girls, including that in health care access, is influenced by societal norms. Even with little personal perception of bias, there was a significant perceived bias observed in others by the participants. This study identified the existence of gender bias affecting health care choices, including cancer care.</p>","PeriodicalId":14806,"journal":{"name":"JCO Global Oncology","volume":"11 ","pages":"e2400325"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thirty-Year Trends (1991-2020) in Breast Cancer Incidence Rates: Hanoi, Vietnam.","authors":"Giang Nguyen Huong, Hoa L Nguyen, Robert J Goldberg, Mara M Epstein, Jeroan J Allison, Loc Quang Pham, Le Minh Giang, Sang Minh Nguyen, Ngoc Dac Nguyen, Linh Thi Thuy Nguyen, Quang Le Van, Thuan Tran Van, Tran Thanh Huong","doi":"10.1200/GO-24-00570","DOIUrl":"10.1200/GO-24-00570","url":null,"abstract":"<p><strong>Purpose: </strong>Breast cancer is the most common cancer in Vietnam, yet there are limited data on long-term trends and factors influencing its incidence. This study examines 30-year trends (1991-2020) in breast cancer incidence among women in Hanoi, focusing on age, period, and cohort effects.</p><p><strong>Methods: </strong>Data from 28,298 breast cancer cases registered in the Hanoi Cancer Registry between 1991 and 2020 were analyzed. Trend analysis using Joinpoint regression was performed to calculate the average annual percent change (AAPC) in incidence rates, and an age-period-cohort analysis was used to explore underlying trends.</p><p><strong>Results: </strong>The age-standardized incidence rate of breast cancer rose from 15.2 per 100,000 in 1991 to 40.6 per 100,000 in 2020, with an overall AAPC of 4.1% (95% CI, 2.9 to 5.4). Women age 70 years and older experienced the highest increase (AAPC, 6.4% [95% CI, 2.5 to 10.4]) compared with those age 40-49 years (AAPC, 2.6% [95% CI, 2.1 to 3.1]). Incidence rates during 2016-2020 were 1.6 times higher than in 2001-2005. Women born between 1976 and 1980 exhibited significantly higher incidence rates compared with earlier cohorts.</p><p><strong>Conclusion: </strong>Breast cancer incidence in Hanoi has more than doubled over three decades, with significant age, period, and cohort effects. These findings provide insights for the development of targeted breast cancer control strategies, including tailored screening, prevention efforts, and resource allocation to address the growing burden of this disease in Vietnam.</p>","PeriodicalId":14806,"journal":{"name":"JCO Global Oncology","volume":"11 ","pages":"e2400570"},"PeriodicalIF":3.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Whispers After the Cure: Reflections on Marriage and Malignancy in India.","authors":"Vangipuram Harshil Sai","doi":"10.1200/GO-25-00267","DOIUrl":"https://doi.org/10.1200/GO-25-00267","url":null,"abstract":"","PeriodicalId":14806,"journal":{"name":"JCO Global Oncology","volume":"11 ","pages":"e2500267"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}