ISRN Pharmaceutics最新文献_第6页

Accumulation and Elimination of Enrofloxacin and Ciprofloxacin in Tissues of Shrimp Litopenaeus vannamei under Laboratory and Farm Conditions. 实验室和养殖条件下凡纳滨对虾组织中恩诺沙星和环丙沙星的积累和消除

ISRN Pharmaceutics Pub Date : 2012-01-01 DOI: 10.5402/2012/374212

Brisa Marisol Flores-Miranda, Angelica Espinosa-Plascencia, Silvia Gómez-Jiménez, Alonso Alexis López-Zavala, Haydé Hayamaí González-Carrillo, María Del Carmen Bermúdez-Almada

{"title":"Accumulation and Elimination of Enrofloxacin and Ciprofloxacin in Tissues of Shrimp Litopenaeus vannamei under Laboratory and Farm Conditions.","authors":"Brisa Marisol Flores-Miranda, Angelica Espinosa-Plascencia, Silvia Gómez-Jiménez, Alonso Alexis López-Zavala, Haydé Hayamaí González-Carrillo, María Del Carmen Bermúdez-Almada","doi":"10.5402/2012/374212","DOIUrl":"https://doi.org/10.5402/2012/374212","url":null,"abstract":"This study aimed to quantify the accumulation and elimination of Enrofloxacin (ENRO) and Ciprofloxacin (CIPRO) in cultivated Litopenaeus vannamei under controlled laboratory and farm conditions. Laboratory- and farm-raised shrimp were given feed supplemented with 200 mg/kg ENRO for 14 days, followed by a 16-day diet without antibiotics. The levels of ENRO and CIPRO were analyzed by High Performance Liquid Chromatography (HPLC). In the laboratory, ENRO concentrations in the muscle and hepatopancreas reached a maximum (C(max)) of 0.54 ± 0.26 μg/g and 3.52 ± 1.9 μg/g, respectively; C(max) values for CIPRO in the laboratory were 0.18 ± 0.13 μg/g (muscle) and 1.05 ± 0.20 μg/g (hepatopancreas). In farmed shrimp, C(max) values for ENRO were 0.36 ± 0.17 μg/g muscle and 1.60 ± 0.82 μg/g in the hepatopancreas; CIPRO C(max) values were 0.03 ± 0.02 μg/g (muscle) and 0.36 ± 0.08 μg/g (hepatopancreas). Two to fourteen days were necessary to eliminate both antibiotics from muscular tissue and four to more fourteen days for complete elimination of the antibiotics from the hepatopancreas. These results should be considered in terms of minimum concentrations necessary to inhibit Vibrio bacteria to determine whether the current use of this antibiotic is effective in controlling disease.","PeriodicalId":14802,"journal":{"name":"ISRN Pharmaceutics","volume":"2012 ","pages":"374212"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/374212","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9380459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Antibacterial Activity of Fistulin: A Protease Inhibitor Purified from the Leaves of Cassia fistula. 决明子叶蛋白酶抑制剂瘘管素的抑菌活性研究。

ISRN Pharmaceutics Pub Date : 2012-01-01 DOI: 10.5402/2012/584073

I Arulpandi, R Sangeetha

引用次数: 24

Chemical Composition and Insecticidal Activity of Essential Oil from Coriandrum sativum Seeds against Tribolium confusum and Callosobruchus maculatus. 芫荽籽精油的化学成分和杀虫活性对混淆蒺藜和大胼胝虫的作用

ISRN Pharmaceutics Pub Date : 2012-01-01 Epub Date: 2012-11-25 DOI: 10.5402/2012/263517

Abbas Khani, Tahere Rahdari

{"title":"Chemical Composition and Insecticidal Activity of Essential Oil from Coriandrum sativum Seeds against Tribolium confusum and Callosobruchus maculatus.","authors":"Abbas Khani, Tahere Rahdari","doi":"10.5402/2012/263517","DOIUrl":"10.5402/2012/263517","url":null,"abstract":"The biological activity of essential oil extracted from coriander, Coriandrum sativum L. (Apiaceae), seeds against adults of Tribolium confusum Duval (Coleoptera: Tenebrionidae) and Callosobruchus maculatus F. (Coleoptera: Bruchidae) was investigated in a series of laboratory experiments. Fumigant toxicity was assessed at 27 ± 1°C and 65 ± 5% R.H., in dark condition. Dry seeds of the plant were subject to hydrodistillation using a Clevenger-type apparatus. The composition of essential oil was analyzed by gas chromatography mass spectrometry. The predominant components in the oil were linalool (57.57%) and geranyl acetate (15.09%). The mortality of 1-7-day-old adults of the insect pests increased with concentration from 43 to 357 μL/L air and with exposure time from 3 to 24 h. In the probit analysis, LC(50) values (lethal concentration for 50% mortality) showed that C. maculatus (LC(50) = 1.34 μL/L air) was more susceptible than T. confusum (LC(50) = 318.02 μL/L air) to seed essential oil of this plant. The essential oil of C. sativum can play an important role in stored grain protection and reduce the risks associated with the use of synthetic insecticides.","PeriodicalId":14802,"journal":{"name":"ISRN Pharmaceutics","volume":"2012 ","pages":"263517"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3512302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9376751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antioxidant Activity of β-Glucan. β-葡聚糖的抗氧化活性。

ISRN Pharmaceutics Pub Date : 2012-01-01 Epub Date: 2012-02-19 DOI: 10.5402/2012/125864

Kyoko Kofuji, Ayumi Aoki, Kazufumi Tsubaki, Masanori Konishi, Takashi Isobe, Yoshifumi Murata

引用次数: 122

Modulating Anti-MicroRNA-21 Activity and Specificity Using Oligonucleotide Derivatives and Length Optimization. 利用寡核苷酸衍生物和长度优化调节抗microrna -21的活性和特异性。

ISRN Pharmaceutics Pub Date : 2012-01-01 Epub Date: 2012-02-07 DOI: 10.5402/2012/407154

Andrés Muñoz-Alarcón, Peter Guterstam, Cristian Romero, Mark A Behlke, Kim A Lennox, Jesper Wengel, Samir El Andaloussi, Ulo Langel

{"title":"Modulating Anti-MicroRNA-21 Activity and Specificity Using Oligonucleotide Derivatives and Length Optimization.","authors":"Andrés Muñoz-Alarcón, Peter Guterstam, Cristian Romero, Mark A Behlke, Kim A Lennox, Jesper Wengel, Samir El Andaloussi, Ulo Langel","doi":"10.5402/2012/407154","DOIUrl":"https://doi.org/10.5402/2012/407154","url":null,"abstract":"MicroRNAs are short, endogenous RNAs that direct posttranscriptional regulation of gene expression vital for many developmental and cellular functions. Implicated in the pathogenesis of several human diseases, this group of RNAs provides interesting targets for therapeutic intervention. Anti-microRNA oligonucleotides constitute a class of synthetic antisense oligonucleotides used to interfere with microRNAs. In this study, we investigate the effects of chemical modifications and truncations on activity and specificity of anti-microRNA oligonucleotides targeting microRNA-21. We observed an increased activity but reduced specificity when incorporating locked nucleic acid monomers, whereas the opposite was observed when introducing unlocked nucleic acid monomers. Our data suggest that phosphorothioate anti-microRNA oligonucleotides yield a greater activity than their phosphodiester counterparts and that a moderate truncation of the anti-microRNA oligonucleotide improves specificity without significantly losing activity. These results provide useful insights for design of anti-microRNA oligonucleotides to achieve both high activity as well as efficient mismatch discrimination.","PeriodicalId":14802,"journal":{"name":"ISRN Pharmaceutics","volume":" ","pages":"407154"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/407154","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30551403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Formulation and in vitro evaluation of ufasomes for dermal administration of methotrexate. 甲氨蝶呤皮肤给药用异速体的配方及体外评价。

ISRN Pharmaceutics Pub Date : 2012-01-01 DOI: 10.5402/2012/873653

Arvind Sharma, Sandeep Arora

引用次数: 42

Lipoidal soft hybrid biocarriers of supramolecular construction for drug delivery. 用于药物传递的超分子结构脂质软杂化生物载体。

ISRN Pharmaceutics Pub Date : 2012-01-01 DOI: 10.5402/2012/474830

Dinesh Kumar, Deepak Sharma, Gurmeet Singh, Mankaran Singh, Mahendra Singh Rathore

{"title":"Lipoidal soft hybrid biocarriers of supramolecular construction for drug delivery.","authors":"Dinesh Kumar, Deepak Sharma, Gurmeet Singh, Mankaran Singh, Mahendra Singh Rathore","doi":"10.5402/2012/474830","DOIUrl":"https://doi.org/10.5402/2012/474830","url":null,"abstract":"Lipid-based innovations have achieved new heights during the last few years as an essential component of drug development. The current challenge of drug delivery is liberation of drug agents at the right time in a safe and reproducible manner to a specific target site. A number of novel drug delivery systems has emerged encompassing various routes of administration, to achieve controlled and targeted drug delivery. Microparticulate lipoidal vesicular system represents a unique technology platform suitable for the oral and systemic administration of a wide variety of molecules with important therapeutic biological activities, including drugs, genes, and vaccine antigens. The success of liposomes as drug carriers has been reflected in a number of liposome-based formulations, which are commercially available or are currently undergoing clinical trials. Also, novel lipid carrier-mediated vesicular systems are originated. This paper has focused on the lipid-based supramolecular vesicular carriers that are used in various drug delivery and drug targeting systems.","PeriodicalId":14802,"journal":{"name":"ISRN Pharmaceutics","volume":"2012 ","pages":"474830"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/474830","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9376263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 39

Development of film dosage form containing allopurinol for prevention and treatment of oral mucositis. 预防和治疗口腔黏膜炎用别嘌呤醇薄膜剂型的研制。

ISRN Pharmaceutics Pub Date : 2012-01-01 DOI: 10.5402/2012/764510

Yoshifumi Murata, Kyoko Kofuji, Norihisa Nishida, Ryosei Kamaguchi

引用次数: 11

Molecular-field-based three-dimensional similarity studies on quinoline-based CNS active agents. 基于分子场的喹啉类中枢神经系统活性物质三维相似性研究。

ISRN Pharmaceutics Pub Date : 2011-01-01 Epub Date: 2011-09-07 DOI: 10.5402/2011/186943

Alka Bali

引用次数: 1

Improving the isotretinoin photostability by incorporating in microemulsion matrix. 微乳基质中掺入异维a酸提高其光稳定性。

ISRN Pharmaceutics Pub Date : 2011-01-01 Epub Date: 2011-07-14 DOI: 10.5402/2011/838016

Mrunali R Patel, Rashmin B Patel, Jolly R Parikh, Bharat G Patel

引用次数: 15