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Thyrotoxic periodic paralysis complicated with primary aldosteronism. 甲状腺毒性周期性麻痹合并原发性醛固酮增多症。
Japanese journal of medicine Pub Date : 1991-05-01 DOI: 10.2169/internalmedicine1962.30.219
N Yokota, T Uchida, A Sasaki, K Kobayashi, O Kida, Y Yamamoto, T Eto, K Tanaka
{"title":"Thyrotoxic periodic paralysis complicated with primary aldosteronism.","authors":"N Yokota,&nbsp;T Uchida,&nbsp;A Sasaki,&nbsp;K Kobayashi,&nbsp;O Kida,&nbsp;Y Yamamoto,&nbsp;T Eto,&nbsp;K Tanaka","doi":"10.2169/internalmedicine1962.30.219","DOIUrl":"https://doi.org/10.2169/internalmedicine1962.30.219","url":null,"abstract":"<p><p>A 35-year-old man presented with acute onset of bilateral lower extremity weakness after ingesting a large amount of carbohydrates. Laboratory investigation revealed severe hypokalemia (1.9 mEq/l) and hyperthyroidism. The patient also exhibited primary aldosteronism due to a left adrenal adenoma. As a diagnostic tool, paralysis with hypokalemia (2.8 mEq/l) was induced with a glucose infusion. After treatment with methimazole, there were no further episodes of paralysis and subsequent induction of paralysis with glucose was impossible, though primary aldosteronism persisted. These findings indicate that hyperthyroidism played a major role in the development of periodic paralysis, while primary aldosteronism apparently increased the patient's vulnerability to paralytic attacks.</p>","PeriodicalId":14798,"journal":{"name":"Japanese journal of medicine","volume":"30 3","pages":"219-23"},"PeriodicalIF":0.0,"publicationDate":"1991-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2169/internalmedicine1962.30.219","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13080231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Familial primary pulmonary hypertension--report of two siblings. 家族性原发性肺动脉高压——两个兄弟姐妹的报告。
Japanese journal of medicine Pub Date : 1991-05-01 DOI: 10.2169/internalmedicine1962.30.273
K Kodama, M Hamada, Y Shigematsu, M Suzuki, K Hiwada, Y Hayashi, H Hashimoto, H Hashimoto, A Sugita
{"title":"Familial primary pulmonary hypertension--report of two siblings.","authors":"K Kodama,&nbsp;M Hamada,&nbsp;Y Shigematsu,&nbsp;M Suzuki,&nbsp;K Hiwada,&nbsp;Y Hayashi,&nbsp;H Hashimoto,&nbsp;H Hashimoto,&nbsp;A Sugita","doi":"10.2169/internalmedicine1962.30.273","DOIUrl":"https://doi.org/10.2169/internalmedicine1962.30.273","url":null,"abstract":"<p><p>Familial primary pulmonary hypertension was found in two siblings (sister and brother). The woman noted exertional dyspnea at the age of 28 yr. The younger brother noticed exertional dyspnea, cough with bloody sputum and pretibial edema at the age of 38 yr. We diagnosed them as primary pulmonary hypertension as based on hemodynamic and histopathological findings. Regardless of the treatment, both patients died of right-sided heart failure with a short time course. We examined their family members, but there were no other members with primary pulmonary hypertension.</p>","PeriodicalId":14798,"journal":{"name":"Japanese journal of medicine","volume":"30 3","pages":"273-7"},"PeriodicalIF":0.0,"publicationDate":"1991-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2169/internalmedicine1962.30.273","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12994970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Crescentic glomerulonephritis associated with renal amyloidosis. 新月型肾小球肾炎伴肾淀粉样变。
Japanese journal of medicine Pub Date : 1991-05-01 DOI: 10.2169/internalmedicine1962.30.238
S Kiyama, T Sakemi, T Shimokama, N Baba, T Watanabe
{"title":"Crescentic glomerulonephritis associated with renal amyloidosis.","authors":"S Kiyama,&nbsp;T Sakemi,&nbsp;T Shimokama,&nbsp;N Baba,&nbsp;T Watanabe","doi":"10.2169/internalmedicine1962.30.238","DOIUrl":"https://doi.org/10.2169/internalmedicine1962.30.238","url":null,"abstract":"<p><p>A case of crescentic glomerulonephritis associated with renal amyloidosis is reported. A 62-year-old woman with a 6-yr history of rheumatoid arthritis developed rapidly progressive glomerulonephritis associated with renal amyloidosis and crescent formation. Amyloid protein was positively stained with anti-AA antibody and its fibrils were demonstrated by electron microscopy. In connection with epithelial cell proliferation in the capsular space, destruction of the capillary basement membrane was observed at the sites where amyloid fibrils were accumulated, whereas glomerular deposition of immunoglobulin and complement was not detected. It is conceivable that the destruction of the glomerular tufts induced by amyloid deposition may be responsible for the crescent formation.</p>","PeriodicalId":14798,"journal":{"name":"Japanese journal of medicine","volume":"30 3","pages":"238-42"},"PeriodicalIF":0.0,"publicationDate":"1991-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2169/internalmedicine1962.30.238","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13080103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Thyrotropin releasing hormone (TRH)-induced release of 7B2 (neuroendocrine polypeptide) in vivo and in vitro using adenoma cells of a patient with acromegaly. 促甲状腺激素释放激素(TRH)诱导肢端肥大症患者腺瘤细胞体内和体外释放7B2(神经内分泌多肽)。
Japanese journal of medicine Pub Date : 1991-05-01 DOI: 10.2169/internalmedicine1962.30.208
S Natori, H Iguchi, M Ohashi, T Kitamoto, M Chrétien, H Nawata
{"title":"Thyrotropin releasing hormone (TRH)-induced release of 7B2 (neuroendocrine polypeptide) in vivo and in vitro using adenoma cells of a patient with acromegaly.","authors":"S Natori,&nbsp;H Iguchi,&nbsp;M Ohashi,&nbsp;T Kitamoto,&nbsp;M Chrétien,&nbsp;H Nawata","doi":"10.2169/internalmedicine1962.30.208","DOIUrl":"https://doi.org/10.2169/internalmedicine1962.30.208","url":null,"abstract":"<p><p>We demonstrated TRH-induced release of 7B2 (a neuroendocrine polypeptide) in vivo and in vitro (somatotroph adenoma cells) in a patient with acromegaly. The mean basal plasma 7B2 and growth hormone (GH) levels before operation were 142.8 +/- 3.2 ng/l and 52.4 +/- 1.6 micrograms/l (mean +/- SEM), respectively and these levels significantly rose after an i.v. administration of 500 micrograms of thyrotropin releasing hormone (TRH). After the transsphenoidal adenomectomy, the basal level of plasma GH was restored to the normal level and that of plasma 7B2 was slightly decreased. In addition, TRH-induced response of plasma 7B2 and GH disappeared post-operatively. In a primary culture of somatotroph adenoma cells obtained at surgery, TRH significantly induced secretions of both 7B2 and GH. Immunohistochemical studies showed the positive 7B2 and GH immunoreactivities in somatotroph adenoma cells. These findings strongly suggest that the somatotroph adenoma cells in this case produced and released 7B2 concomitant with GH.</p>","PeriodicalId":14798,"journal":{"name":"Japanese journal of medicine","volume":"30 3","pages":"208-12"},"PeriodicalIF":0.0,"publicationDate":"1991-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2169/internalmedicine1962.30.208","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13080229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Myocardial metastasis from primary lung cancer: myocardial infarction-like ECG changes and pathologic findings. 原发性肺癌心肌转移:心肌梗死样心电图改变和病理表现。
Japanese journal of medicine Pub Date : 1991-05-01 DOI: 10.2169/internalmedicine1962.30.213
S Abe, N Watanabe, S Ogura, H Kunikane, H Isobe, E Yamaguchi, M Munakata, Y Kawakami
{"title":"Myocardial metastasis from primary lung cancer: myocardial infarction-like ECG changes and pathologic findings.","authors":"S Abe,&nbsp;N Watanabe,&nbsp;S Ogura,&nbsp;H Kunikane,&nbsp;H Isobe,&nbsp;E Yamaguchi,&nbsp;M Munakata,&nbsp;Y Kawakami","doi":"10.2169/internalmedicine1962.30.213","DOIUrl":"https://doi.org/10.2169/internalmedicine1962.30.213","url":null,"abstract":"<p><p>Myocardial metastasis from neoplastic disease is often clinically unapparent, and very difficult to diagnose. Of 151 consecutive autopsies of lung cancer patients, cardiac metastases were found in 67 patients (44.4%). Myocardial metastasis was found in only 8 patients (11.9%). ECG of patients with myocardial metastasis revealed ST-T wave changes and various types of arrhythmia. ST-T wave changes were observed in 4 with myocardial metastasis, and in 6 without myocardial metastasis (pericardial metastasis alone). ST-T wave changes is not a specific finding of myocardial metastasis. Two very rare cases with myocardial metastasis showing progressive ST segment elevation with a QS pattern are presented. The appearance of ST segment elevation with a QS pattern in clinically stable lung cancer patients without cardiac symptoms suggestive of myocardial injury indicates the possibility of myocardial metastasis. Myocardial metastasis is often elusive, thus careful observation of ECG changes is of primary importance for the antemortem diagnosis.</p>","PeriodicalId":14798,"journal":{"name":"Japanese journal of medicine","volume":"30 3","pages":"213-8"},"PeriodicalIF":0.0,"publicationDate":"1991-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2169/internalmedicine1962.30.213","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13080230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 34
Self-management of nocturnal respiratory insufficiency with a portable ventilator "Pneu-PAC" by an amyotrophic lateral sclerosis patient. 肌萎缩性侧索硬化症患者使用便携式呼吸机“pneupac”自我管理夜间呼吸功能不全。
Japanese journal of medicine Pub Date : 1991-05-01 DOI: 10.2169/internalmedicine1962.30.260
K Hoshino, A Kuroda, Y Mizushima, T Morikage, S Yano
{"title":"Self-management of nocturnal respiratory insufficiency with a portable ventilator \"Pneu-PAC\" by an amyotrophic lateral sclerosis patient.","authors":"K Hoshino,&nbsp;A Kuroda,&nbsp;Y Mizushima,&nbsp;T Morikage,&nbsp;S Yano","doi":"10.2169/internalmedicine1962.30.260","DOIUrl":"https://doi.org/10.2169/internalmedicine1962.30.260","url":null,"abstract":"<p><p>A 76-year-old man with amyotrophic lateral sclerosis was admitted to our hospital because of progressive exertional dyspnea (PaCO2 = 68.5 torr, PaO2 = 62.5 torr). He was put on mechanical ventilation, and thereafter sleep apnea of a central type was recognized. After improvement of general conditions, a portable ventilator \"Pneu-PAC\" was used for the self-management of nocturnal respiratory insufficiency. A portable ventilator might be of clinical benefit for the management of a patient with neuromuscular disorder whose activities of daily living are still functional.</p>","PeriodicalId":14798,"journal":{"name":"Japanese journal of medicine","volume":"30 3","pages":"260-5"},"PeriodicalIF":0.0,"publicationDate":"1991-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2169/internalmedicine1962.30.260","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13080108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Leukotoxin, 9, 10-epoxy-12-octadecenoate: a possible responsible factor in circulatory shock and disseminated intravascular coagulation. 白毒素，9,10 -环氧-12-十八烯酸:循环性休克和弥散性血管内凝血的可能负责因素。
Japanese journal of medicine Pub Date : 1991-05-01 DOI: 10.2169/internalmedicine1962.30.224
Y Hanaki, H Kamiya, M Ohno, M Hayakawa, S Sugiyama, T Ozawa
{"title":"Leukotoxin, 9, 10-epoxy-12-octadecenoate: a possible responsible factor in circulatory shock and disseminated intravascular coagulation.","authors":"Y Hanaki,&nbsp;H Kamiya,&nbsp;M Ohno,&nbsp;M Hayakawa,&nbsp;S Sugiyama,&nbsp;T Ozawa","doi":"10.2169/internalmedicine1962.30.224","DOIUrl":"https://doi.org/10.2169/internalmedicine1962.30.224","url":null,"abstract":"<p><p>We previously demonstrated that neutrophils biosynthesize the Iinoleate epoxide, 9,10-epoxy-12-octadecenoate, from linoleate and hydroxyl radical. This epoxide is highly cytotoxic, and has been termed leukotoxin. We detected leukotoxin in plasma from two patients with infectious endocarditis and circulatory shock. Maximal leukotoxin levels were 580 nmol/ml and 880 nmol/ml, respectively. The leukotoxin levels were affected by hemodialysis or hemofiltration. Disseminated intravascular coagulation was confirmed by blood coagulation studies in these two patients. Leukocytosis was also observed in these patients. In contrast, leukotoxin was not detected in plasma of normal volunteers. Accordingly, leukotoxin synthesized by recruited neutrophils might be a contributory factor in circulatory shock.</p>","PeriodicalId":14798,"journal":{"name":"Japanese journal of medicine","volume":"30 3","pages":"224-8"},"PeriodicalIF":0.0,"publicationDate":"1991-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2169/internalmedicine1962.30.224","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13080232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
A case of Behçet's disease with a rapidly enlarging aneurysm in the common carotid artery. behaperet病伴颈总动脉动脉瘤迅速增大1例。
Japanese journal of medicine Pub Date : 1991-05-01 DOI: 10.2169/internalmedicine1962.30.251
J Suzuki, K Akashi, M Shimada, S Abe, Y Kawakami
{"title":"A case of Behçet's disease with a rapidly enlarging aneurysm in the common carotid artery.","authors":"J Suzuki,&nbsp;K Akashi,&nbsp;M Shimada,&nbsp;S Abe,&nbsp;Y Kawakami","doi":"10.2169/internalmedicine1962.30.251","DOIUrl":"https://doi.org/10.2169/internalmedicine1962.30.251","url":null,"abstract":"<p><p>A 16-year-old boy had incomplete Behçet's disease with common carotid artery aneurysm and an ulcer in the transverse colon. To our knowledge, this complication in the carotid artery has been previously reported in only 6 cases. Arterial repair and high-dose corticosteroid therapy (pulse therapy) were successful.</p>","PeriodicalId":14798,"journal":{"name":"Japanese journal of medicine","volume":"30 3","pages":"251-4"},"PeriodicalIF":0.0,"publicationDate":"1991-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2169/internalmedicine1962.30.251","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13080105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Acute febrile mucocutaneous lymph node syndrome (Kawasaki disease) in adults: case report and review of the literature. 成人急性发热性粘膜皮肤淋巴结综合征(川崎病):病例报告及文献复习。
Japanese journal of medicine Pub Date : 1991-05-01 DOI: 10.2169/internalmedicine1962.30.285
J Tomiyama, Y Hasegawa, Y Kumagai, Y Adachi, K Karasawa
{"title":"Acute febrile mucocutaneous lymph node syndrome (Kawasaki disease) in adults: case report and review of the literature.","authors":"J Tomiyama,&nbsp;Y Hasegawa,&nbsp;Y Kumagai,&nbsp;Y Adachi,&nbsp;K Karasawa","doi":"10.2169/internalmedicine1962.30.285","DOIUrl":"https://doi.org/10.2169/internalmedicine1962.30.285","url":null,"abstract":"<p><p>A 25-year-old female meeting all six criteria for Kawasaki disease is reported. A total of 22 reported cases of adult Kawasaki disease, including the present case, are reviewed. In adult Kawasaki disease, arthralgia, gastrointestinal complications and hepatic dysfunction are seen more frequently than in childhood cases. Cardiac complications are rarely seen in adult Kawasaki disease. Two cases have been positive for anti-nuclear antibody (ANA). The present patient had increased levels of serum IgE and was positive for ANA, suggesting involvement of an immune mechanism. Adult Kawasaki disease is rare but appears to be on the increase; internists treating adults must be aware of this disease.</p>","PeriodicalId":14798,"journal":{"name":"Japanese journal of medicine","volume":"30 3","pages":"285-9"},"PeriodicalIF":0.0,"publicationDate":"1991-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2169/internalmedicine1962.30.285","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13079402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 21
Magnetic resonance imaging in diagnosis and follow-up of minimal thyroid ophthalmopathy. 磁共振成像在轻度甲状腺眼病诊断及随访中的应用。
Japanese journal of medicine Pub Date : 1991-05-01 DOI: 10.2169/internalmedicine1962.30.229
H Matsuo, M Motomura, G Takeo, T Yoshimura, M Tsujihata, S Nagataki
{"title":"Magnetic resonance imaging in diagnosis and follow-up of minimal thyroid ophthalmopathy.","authors":"H Matsuo,&nbsp;M Motomura,&nbsp;G Takeo,&nbsp;T Yoshimura,&nbsp;M Tsujihata,&nbsp;S Nagataki","doi":"10.2169/internalmedicine1962.30.229","DOIUrl":"https://doi.org/10.2169/internalmedicine1962.30.229","url":null,"abstract":"<p><p>We report a case of minimal thyroid ophthalmopathy treated with intravenous methylprednisolone, in which precise identification of the involved muscle was possible with the use of surface coil magnetic resonance (MR) imaging. Intravenous methylprednisolone was more effective than the oral prednisolone as judged by orbital MR imaging. MR imaging is one of the useful tools in the diagnosis and assessment of treatment in this field.</p>","PeriodicalId":14798,"journal":{"name":"Japanese journal of medicine","volume":"30 3","pages":"229-32"},"PeriodicalIF":0.0,"publicationDate":"1991-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2169/internalmedicine1962.30.229","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13080101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
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