JMIR Research Protocols最新文献

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Optimizing Self-Monitoring in a Digital Weight Loss Intervention (Spark): Protocol for a Factorial Randomized Trial. 在数字减肥干预(Spark)中优化自我监测:一项阶乘随机试验方案。
IF 1.5
JMIR Research Protocols Pub Date : 2025-09-23 DOI: 10.2196/75629
Michele L Patel, Abby C King, Lisa G Rosas, Gary G Bennett, Linda M Collins, John A Gallis, Amanda B Zeitlin, Priya S Talreja, Phoebe C Crosthwaite, Kayla A Collins, Annalisa W Lim, Trudy S Kim
{"title":"Optimizing Self-Monitoring in a Digital Weight Loss Intervention (Spark): Protocol for a Factorial Randomized Trial.","authors":"Michele L Patel, Abby C King, Lisa G Rosas, Gary G Bennett, Linda M Collins, John A Gallis, Amanda B Zeitlin, Priya S Talreja, Phoebe C Crosthwaite, Kayla A Collins, Annalisa W Lim, Trudy S Kim","doi":"10.2196/75629","DOIUrl":"10.2196/75629","url":null,"abstract":"<p><strong>Background: </strong>Self-monitoring is a vital component of behavioral obesity treatment. It often involves tracking dietary intake, physical activity, and body weight. However, the optimal combination of self-monitoring strategies that maximizes weight loss is unknown. To address this gap, we leverage a framework called the multiphase optimization strategy, which facilitates the identification of an intervention's \"active ingredients\" that promote weight loss and its \"inactive ingredients\" that have little impact, thus adding unnecessary patient effort and time demands.</p><p><strong>Objective: </strong>This study aims to examine the unique and combined weight loss effects of 3 popular self-monitoring strategies (tracking dietary intake, steps, and body weight).</p><p><strong>Methods: </strong>Spark was an optimization-randomized clinical trial that used a 2 × 2 × 2 full factorial design with 8 experimental conditions. Participants, US adults with overweight or obesity (N=176), were randomized to receive 0-3 self-monitoring strategies in a 6-month fully digital weight loss intervention. For each assigned strategy, participants were instructed to self-monitor daily via commercially available digital tools (a mobile app, wearable activity tracker, and smart scale) and received a corresponding goal (eg, a daily calorie goal) and weekly automated feedback. All participants received core intervention components, including weekly lessons and action plans informed by Social Cognitive Theory, to promote healthy eating and physical activity. Assessments occurred at baseline and at 1, 3, and 6 months. Weight was assessed objectively via a smart scale. The primary aim is to test the main effects of the 3 self-monitoring components and their interactions on weight change from baseline to 6 months. Secondary outcomes include change in BMI, caloric intake, diet quality, physical activity, and health-related quality of life, as well as 1- and 3-month weight change and the relation between self-monitoring engagement and weight change. Patterns of engagement will be operationalized as the percentage of days of self-monitoring during the 6-month intervention. Moderators of weight loss success will be explored to understand whether certain subgroups of individuals benefit more from specific self-monitoring strategies. We also conducted a separate embedded experiment to test the impact of a self-directed web-based orientation session on 6-month trial retention. After the intervention, semistructured qualitative interviews were conducted with a subset of participants to elucidate factors that impact engagement and its link to weight loss.</p><p><strong>Results: </strong>Recruitment occurred from September 2023 to November 2024. Data collection was completed in June 2025. Data analysis is ongoing.</p><p><strong>Conclusions: </strong>This trial will provide evidence as to which self-monitoring strategies are the \"active ingredients\" in a fully digital weig","PeriodicalId":14755,"journal":{"name":"JMIR Research Protocols","volume":"14 ","pages":"e75629"},"PeriodicalIF":1.5,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Utility of Early Intervention Including the 5-Step Precision Medicine Method in First-Episode Psychosis: Protocol for a Cohort Study With Nested Economic and Process Evaluations. 包括五步精准医学方法在内的早期干预在首发精神病中的临床应用:一项具有嵌套经济和过程评估的队列研究方案
IF 1.5
JMIR Research Protocols Pub Date : 2025-09-23 DOI: 10.2196/74408
Jesús Pérez, David Heredero Jung, Óscar Gonzalo, Belén García Berrocal, Carmen García Cerdán, Pablo Salas Aranda, Alejandro de la Sota Pérez, Sandra Milagros Lorenzo Hernández, Elena Marcos Vadillo, Rocío García García, Vanesa Berdión Marcos, Ana Maciá Casas, Belén Refoyo Matellán, Berta Bote Bonaechea, Llanyra García Ullán, Carolina Lorenzo Romo, Carmen Martín Gómez, Concha Turrión Gómez, María Isidoro García
{"title":"Clinical Utility of Early Intervention Including the 5-Step Precision Medicine Method in First-Episode Psychosis: Protocol for a Cohort Study With Nested Economic and Process Evaluations.","authors":"Jesús Pérez, David Heredero Jung, Óscar Gonzalo, Belén García Berrocal, Carmen García Cerdán, Pablo Salas Aranda, Alejandro de la Sota Pérez, Sandra Milagros Lorenzo Hernández, Elena Marcos Vadillo, Rocío García García, Vanesa Berdión Marcos, Ana Maciá Casas, Belén Refoyo Matellán, Berta Bote Bonaechea, Llanyra García Ullán, Carolina Lorenzo Romo, Carmen Martín Gómez, Concha Turrión Gómez, María Isidoro García","doi":"10.2196/74408","DOIUrl":"10.2196/74408","url":null,"abstract":"<p><strong>Background: </strong>Psychotic disorders such as schizophrenia present a significant challenge to health care systems due to their high disability rates and treatment costs. With discontinuation rates for antipsychotics reaching over 40% in the first year and 80% after 3 years, it is crucial to tailor antipsychotic selection and dosing early in treatment. Personalized precision psychiatry, underpinned by pharmacogenetics, holds considerable potential in individualizing antipsychotic treatment for patients with first-episode psychosis. An internationally pioneering method called 5-step precision medicine (5SPM) focuses on the application of pharmacogenetics to clinical practice. The recently launched Prevention and Early Intervention in Mental Health (PRINT) program in Salamanca, Spain, integrates this method to enhance early intervention for adolescents and young people with first-episode psychosis.</p><p><strong>Objective: </strong>The Clinical Utility of Early Intervention Including the 5SPM Method in First-Episode Psychosis (CLUMP) project aims to explore whether an early intervention model of personalized precision psychiatry including pharmacogenetics improves adherence to antipsychotic medicines and, therefore, clinical and functional outcomes in young people experiencing the first episode of a psychotic illness.</p><p><strong>Methods: </strong>To achieve our objectives, we shall compare adherence to the first prescribed antipsychotic medication and clinical and functional outcomes between patients with first-episode psychosis. We shall compare 2 cohorts: cohort 1 will receive the recently introduced PRINT program including the 5SPM method, and cohort 2 will have received standard care provided by mental health services before the PRINT program implementation. The primary outcome to measure treatment adherence will be all-cause discontinuation proportions during the 1-year follow-up. Secondary outcome measures will include pragmatic efficacy, tolerability, and functional outcome measures. For additional comparative purposes, we shall analyze the environmental, clinical, and pharmacogenetic information of patients with psychotic disorders of more than 5 years of evolution and with other mental disorders whose data are currently stored and have been ethically approved for research use. A total of 300 patients will be included in the study. Analyses will include descriptive statistics, comparison tests, Kaplan-Meier survival curves, multivariate log rank tests, qualitative analysis, and cost-benefit evaluation.</p><p><strong>Results: </strong>Ethics approval was obtained in June 2023. Recruitment for the CLUMP project began in January 2025, and enrollment for cohort 1 will continue until May 2026. All data collection is expected to be completed by June 2027. Data analyses are estimated to take approximately 6 months. The project is scheduled to conclude in December 2027.</p><p><strong>Conclusions: </strong>The CLUMP project is set t","PeriodicalId":14755,"journal":{"name":"JMIR Research Protocols","volume":"14 ","pages":"e74408"},"PeriodicalIF":1.5,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
App-Based Smoking Urge Reduction Intervention for Young Adults: Protocol Combining a Microrandomized Trial and Conventional Between-Subject Randomized Trial. 基于app的年轻人吸烟冲动减少干预:结合微随机试验和常规受试者间随机试验的方案。
IF 1.5
JMIR Research Protocols Pub Date : 2025-09-23 DOI: 10.2196/74388
Johannes Thrul, Janardan Devkota, Joseph J C Waring, Michael R Desjardins, Josef Hamoud, Jasmin Han, Felix Naughton, Vadim Zipunnikov, Tamar Mendelson, Carl Latkin, David Epstein, Meghan Moran
{"title":"App-Based Smoking Urge Reduction Intervention for Young Adults: Protocol Combining a Microrandomized Trial and Conventional Between-Subject Randomized Trial.","authors":"Johannes Thrul, Janardan Devkota, Joseph J C Waring, Michael R Desjardins, Josef Hamoud, Jasmin Han, Felix Naughton, Vadim Zipunnikov, Tamar Mendelson, Carl Latkin, David Epstein, Meghan Moran","doi":"10.2196/74388","DOIUrl":"10.2196/74388","url":null,"abstract":"<p><strong>Background: </strong>Tobacco smoking is the leading preventable cause of morbidity and mortality in the United States, and young adults have high smoking rates. Although most young adult smokers are interested in quitting, they underutilize professional cessation support. Smartphones have wide reach and integration into young adults' lives, and these devices offer great opportunities to deliver cessation interventions by delivering messages suggesting coping strategies \"in the moment\" when smokers need cessation support.</p><p><strong>Objective: </strong>The overall goal of this trial is to evaluate the efficacy of cognitive behavioral therapy (CBT) and mindfulness or acceptance and commitment therapy (ACT) messages for young adults targeted at specific high-risk situations for smoking.</p><p><strong>Methods: </strong>We will conduct a microrandomized trial (MRT; within-subject randomization) to test the efficacy of CBT and mindfulness or ACT compared with control messages for reducing smoking urge up to 15 minutes after message delivery, nested in a conventional between-subject randomized controlled trial (RCT). A conventional between-subject control group of participants who will complete ecological momentary assessment (EMA) only without intervention messages will allow us to test if messages reduce cigarettes per day at the end of treatment, 3-month follow-up, and 6-month follow-up. Among MRT intervention group participants, we will explore how message efficacy may be moderated by substance co-use (cannabis, alcohol, other drugs) and exposure to specific settings (home, work, bars).</p><p><strong>Results: </strong>As of June 2025, we had enrolled 58 participants of the target sample of 160, with 52% (30/58) assigned to the MRT group and 48% (28/58) assigned to the EMA-only control.</p><p><strong>Conclusions: </strong>Smoking onset is now more common among young adults than adolescents, and early cessation substantially reduces morbidity and mortality from smoking, making age-appropriate, tailored, and scalable interventions for this high-priority population even more important. Results of this trial will provide evidence on the efficacy of tailored intervention messages to help young adult smokers cope with smoking urges as an integral part of smartphone interventions. Findings will inform the field about key principles, strategies, and efficacy of situational tailoring of app-based tobacco use urge reduction messages.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov NCT05836103; https://clinicaltrials.gov/study/NCT05836103.</p><p><strong>International registered report identifier (irrid): </strong>DERR1-10.2196/74388.</p>","PeriodicalId":14755,"journal":{"name":"JMIR Research Protocols","volume":"14 ","pages":"e74388"},"PeriodicalIF":1.5,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness of Tocotrienol-Rich Fraction in Older Adults: Protocol for a Randomized, Double-Blind, Placebo-Controlled Trial. 富生育三烯醇馏分在老年人中的有效性:一项随机、双盲、安慰剂对照试验的方案。
IF 1.5
JMIR Research Protocols Pub Date : 2025-09-23 DOI: 10.2196/73039
Nor Amira Nabila Amir Razak, Jo Aan Goon, Wan Zurinah Wan Ngah, Suzana Makpol, Mohd Hanafi Ahmad Damanhuri, Nor Faeizah Ibrahim, Nur Fathiah Abdul Sani, Nuraqila Mohd Murshid, Anis Faqihah Mohd Azizan, Kok Yong Chin, Amilia Aminuddin, Mohd Heikal Mohd Yunus, Munirah Md Mansor, Juvenia Rui En Neo, Wei Ney Yap, Hsieu Yen Loong, Yee Wei Ung
{"title":"Effectiveness of Tocotrienol-Rich Fraction in Older Adults: Protocol for a Randomized, Double-Blind, Placebo-Controlled Trial.","authors":"Nor Amira Nabila Amir Razak, Jo Aan Goon, Wan Zurinah Wan Ngah, Suzana Makpol, Mohd Hanafi Ahmad Damanhuri, Nor Faeizah Ibrahim, Nur Fathiah Abdul Sani, Nuraqila Mohd Murshid, Anis Faqihah Mohd Azizan, Kok Yong Chin, Amilia Aminuddin, Mohd Heikal Mohd Yunus, Munirah Md Mansor, Juvenia Rui En Neo, Wei Ney Yap, Hsieu Yen Loong, Yee Wei Ung","doi":"10.2196/73039","DOIUrl":"10.2196/73039","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Tocotrienol, a naturally occurring form of vitamin E, has been extensively studied for its potent antioxidant, anti-inflammatory, and immune-stimulating properties. However, the clinical impact of tocotrienol supplementation on older adults' overall health and well-being remains relatively unexplored. This research aims to investigate the efficacy of tocotrienol-rich fraction (TRF) on various health parameters associated with general well-being in individuals aged between 50 years and 75 years.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;It is hypothesized that TRF supplementation may exhibit positive outcomes on blood biochemistry and several physiological aspects, including lowered levels of oxidative stress and inflammation biomarkers; improvement in vascular age; and enhancement of skin condition, bone mineral density, and cognitive function.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This randomized, double-blind, placebo-controlled trial was designed to investigate the effectiveness of TRF supplementation on overall health in healthy older adults. The study aims to assess the impact of a daily dosage of 200 mg of TRF over a period of 6 months. A total of 220 participants is enrolled in the study, with one-half receiving the placebo and the other one-half receiving TRF supplementation. The study comprises 3 time points: baseline, 3 months, and 6 months. At each time point, various measurements are taken to evaluate different aspects of health. The primary outcome measurements include blood biochemistry assessments, such as liver function tests, renal profile, lipid profile, and full blood count. Oxidative stress markers, including malondialdehyde, advanced glycation end products, protein carbonyl, and isoprostane, are also evaluated. Immune response markers such as interleukin-6 and tumor necrosis factor-α are assessed. Satiety regulation is examined through measurements of leptin and ghrelin. Body composition and skin health parameters, including wrinkling, pigmentation, elasticity, hydration, and sebum secretion, are evaluated. Additionally, arterial stiffness is assessed using arteriography at baseline and 6 months. For secondary outcome measures, bone mineral density is measured using dual x-ray absorptiometry, and cognitive function is assessed using the Montreal Cognitive Assessment, Rey Auditory Verbal Learning Test, and digital span test. Both bone mineral density and cognitive function are also measured at baseline and 6 months.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The study is progressing as planned, with 209 participants recruited as of April 2025. The research was funded in 2019, and data collection started in December 2020. Preliminary data analysis has been completed for the first 120 participants, and final results are expected upon completion of data collection and unblinding in 2026.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;By comprehensively evaluating these health aspects, this study seeks to provide valuable insights int","PeriodicalId":14755,"journal":{"name":"JMIR Research Protocols","volume":"14 ","pages":"e73039"},"PeriodicalIF":1.5,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Rationale for the Use of Acupuncture to Stabilize Blood Pressure Fluctuations During Total Laparoscopic Hysterectomy: Protocol for a Pilot Parallel-Group Randomized Clinical Trial. 修正:在全腹腔镜子宫切除术中使用针灸稳定血压波动的基本原理:一项平行组随机临床试验方案。
IF 1.5
JMIR Research Protocols Pub Date : 2025-09-23 DOI: 10.2196/82570
Jee Young Lee, Ju-Won Roh, Kyung-Hee Han, Min-Jeong Kim, Young Jeong Na, Bo Seong Yun, Joohyun Lee
{"title":"Correction: Rationale for the Use of Acupuncture to Stabilize Blood Pressure Fluctuations During Total Laparoscopic Hysterectomy: Protocol for a Pilot Parallel-Group Randomized Clinical Trial.","authors":"Jee Young Lee, Ju-Won Roh, Kyung-Hee Han, Min-Jeong Kim, Young Jeong Na, Bo Seong Yun, Joohyun Lee","doi":"10.2196/82570","DOIUrl":"10.2196/82570","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.2196/77009.].</p>","PeriodicalId":14755,"journal":{"name":"JMIR Research Protocols","volume":"14 ","pages":"e82570"},"PeriodicalIF":1.5,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aiding Chronic Obstructive Pulmonary Disease and Congestive Heart Failure Ultrasound-Guided Management Through Enhanced Point-of-Care Ultrasound (ACCUMEN-POCUS): Protocol for a Randomized Controlled Trial. 通过增强的护理点超声辅助慢性阻塞性肺疾病和充血性心力衰竭:一项随机对照试验方案。
IF 1.5
JMIR Research Protocols Pub Date : 2025-09-23 DOI: 10.2196/76186
Michelle Nora Grinman, Peter Nakhla, Steve Reid, Dennis Moon, Negar Dehghan Noudeh, Oladoyin Olaosebikan, Amanda Chung Yan Ip, Salomé Saunders, Ryan Kozicky, John Conly, Andrew Wallace Kirkpatrick, Jeff Round, Irene Wai Yan Ma, Suean Pascoe, Ghazwan Altabbaa
{"title":"Aiding Chronic Obstructive Pulmonary Disease and Congestive Heart Failure Ultrasound-Guided Management Through Enhanced Point-of-Care Ultrasound (ACCUMEN-POCUS): Protocol for a Randomized Controlled Trial.","authors":"Michelle Nora Grinman, Peter Nakhla, Steve Reid, Dennis Moon, Negar Dehghan Noudeh, Oladoyin Olaosebikan, Amanda Chung Yan Ip, Salomé Saunders, Ryan Kozicky, John Conly, Andrew Wallace Kirkpatrick, Jeff Round, Irene Wai Yan Ma, Suean Pascoe, Ghazwan Altabbaa","doi":"10.2196/76186","DOIUrl":"10.2196/76186","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Hospital at home (HAH) programs offer acute care at home as a substitute for inpatient hospitalization, reducing health care costs while maintaining safety and care quality. Despite point-of-care ultrasound (POCUS) having been validated in inpatient and emergency settings, its role in HAH care remains underexplored. Common conditions treated in medical HAH programs, such as acute exacerbation of chronic obstructive pulmonary disease (AE-COPD), acute decompensated heart failure (ADHF), and pneumonia, are highly amenable to POCUS integration into clinical decision-making and have been proven to improve health care use outcomes. The portability of POCUS makes it ideal for use in HAH; however, its feasibility remains to be proven given the need for health care provider training and use in online settings.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;This study evaluates the feasibility and clinical utility of remotely interpreted lung and inferior vena cava (IVC) POCUS acquired by community paramedics to support real-time clinical decision-making for HAH patients with AE-COPD, ADHF, and pneumonia in Calgary, Alberta.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This randomized controlled trial compares usual HAH care (control) to lung and IVC POCUS-enhanced HAH care (intervention). Handheld POCUS devices captured images that were securely shared using a cloud-based application. This enabled real-time image sharing among the clinical team, facilitating immediate decision-making by remote physicians. A mixed methods approach will evaluate clinical outcomes, patient experiences, health care use, and health care provider perceptions of POCUS integration. The primary outcome is defined as the length of stay for the index HAH admission. Quantitative analysis will assess clinical efficacy and health care resource use, while qualitative methods, such as interviews and surveys, will capture patient and health care provider experiences.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Study funding began in April 2022, and data collection commenced in December 2023. Patient recruitment was finalized on December 31, 2024. This study included a 3-month follow-up for significant outcomes and will include a 1-year follow-up for long-term health care use, including admissions to long-term care. In total, 20 patients were enrolled (intervention group: n=10, 50%; control group: n=10, 50%). Initial results highlighted the feasibility and potential benefits of remotely acquired POCUS imaging in HAH. Full data analysis is in progress.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;This study is the first randomized controlled trial to investigate remotely acquired POCUS by nonphysician practitioners for real-time lung and IVC remote decision-making in HAH care. Findings will provide insights into whether serial lung and IVC POCUS assessments improve ADHF, AE-COPD, and pneumonia outcomes in the HAH setting, enhancing understanding of the value of POCUS integration from a health care provide","PeriodicalId":14755,"journal":{"name":"JMIR Research Protocols","volume":"14 ","pages":"e76186"},"PeriodicalIF":1.5,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cultural Adaptation of Together+, a Status-Neutral mHealth Intervention to Improve HIV Prevention and Care for Adolescent and Young Men Who Have Sex With Men in Vietnam: Protocol for a Co-Design Study. Together+的文化适应,一种中立状态的移动健康干预措施,以改善越南青少年和年轻男男性行为者的艾滋病毒预防和护理:一项共同设计研究的协议。
IF 1.5
JMIR Research Protocols Pub Date : 2025-09-23 DOI: 10.2196/73895
Minh X Nguyen, William C Miller, Le Minh Giang, Patrick S Sullivan
{"title":"Cultural Adaptation of Together+, a Status-Neutral mHealth Intervention to Improve HIV Prevention and Care for Adolescent and Young Men Who Have Sex With Men in Vietnam: Protocol for a Co-Design Study.","authors":"Minh X Nguyen, William C Miller, Le Minh Giang, Patrick S Sullivan","doi":"10.2196/73895","DOIUrl":"10.2196/73895","url":null,"abstract":"<p><strong>Background: </strong>Adolescent and young men who have sex with men (AYMSM) are experiencing an ongoing epidemic in Vietnam. HIV testing and preexposure prophylaxis uptake among AYMSM remain low in Vietnam, especially compared to older men. AYMSM living with HIV are also less likely to initiate HIV care. M-Cubed is a status-neutral mobile intervention developed in the United States focusing on HIV prevention and care among men who have sex with men. The app has the potential to significantly contribute to improving the HIV prevention and care continuum for AYMSM.</p><p><strong>Objective: </strong>We propose to adapt the M-Cubed app for AYMSM in Vietnam to create Together+, a status-neutral app that promotes HIV testing, preexposure prophylaxis use, and HIV care.</p><p><strong>Methods: </strong>Adaptation will focus on ensuring that the content, features, and design of the app are culturally relevant to AYMSM in Vietnam. The adaptation process will comprise five phases: (1) adaptation and creation of videos and messages in Vietnamese, (2) in-depth interviews to further inform app adaptation, (3) app prototype development, (4) app theater testing, and (5) beta testing of the adapted app. AYMSM aged between 15 and 19 years and health care staff in Hanoi, Vietnam, will be recruited for in-depth interviews in phase 1 and focus group discussions in phase 4. Qualitative data will be analyzed thematically, and results will be generated after reviewing memos, code reports, and the matrix. To evaluate the feasibility and usability of the Together+ app, we will provide access to 30 AYMSM and encourage them to use the app for 30 days. We will assess observed use and collect quantitative and qualitative data from test users. After 30 days, we will evaluate the usability and feasibility of the Together+ app through in-app analytics as well as online quantitative surveys and individual exit interviews with participants.</p><p><strong>Results: </strong>As of September 2025, we are in the process of adapting the set of 15 videos for Vietnamese AYMSM (phase 1) and analyzing qualitative data from in-depth interviews (phase 2). Data collection for the pilot phase will be completed by August 2026.</p><p><strong>Conclusions: </strong>Adaptations of proven effective interventions are a promising and efficient way to develop interventions for new service populations but require formal adaptation and evaluation in the new service population. Once culturally adapted for AYMSM in Vietnam, the Together+ app has the potential to significantly contribute to improving the HIV prevention and care continuum for this population. The findings of the adaptation process will document the level of usability and feasibility of the Together+ app and shed light on the perceptions of AYMSM and other stakeholders in Vietnam regarding status-neutral mobile health interventions.</p><p><strong>International registered report identifier (irrid): </strong>PRR1-10.2196/73895.</p>","PeriodicalId":14755,"journal":{"name":"JMIR Research Protocols","volume":"14 ","pages":"e73895"},"PeriodicalIF":1.5,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perceptions of Occupational Risk and Adherence to Tuberculosis Prevention Among Health Care Workers: Protocol for a Scoping Review. 卫生保健工作者对职业风险和结核病预防依从性的认识:范围审查方案。
IF 1.5
JMIR Research Protocols Pub Date : 2025-09-22 DOI: 10.2196/64037
Agus Fitriangga, Alex Alex, Eka Ardiani Putri
{"title":"Perceptions of Occupational Risk and Adherence to Tuberculosis Prevention Among Health Care Workers: Protocol for a Scoping Review.","authors":"Agus Fitriangga, Alex Alex, Eka Ardiani Putri","doi":"10.2196/64037","DOIUrl":"10.2196/64037","url":null,"abstract":"<p><strong>Background: </strong>Tuberculosis (TB) is a major public health problem around the world. Health care workers (HCWs) are at a much higher risk of contracting TB because they are often working around sick people in clinical settings. Even though HCWs play a key role in controlling TB, we still do not fully understand how they see this risk and how it affects their willingness to follow preventive measures.</p><p><strong>Objective: </strong>This study aims to examine the existing body of knowledge on HCWs' perceived risks of TB and how these perceptions impact their adherence to TB prevention measures. The results of this scoping review will identify gaps in the current literature that should inform policy and practice and guide future research studies to optimize TB prevention among HCWs.</p><p><strong>Methods: </strong>This scoping review will be conducted following the framework proposed by Arksey and O'Malley, incorporating the recent advancements. This approach involves 6 key stages: identifying the research question; identifying relevant studies; selecting studies; charting the data; collating, summarizing, and reporting the results; and consulting with stakeholders.</p><p><strong>Results: </strong>As of June 2024, 1345 records were identified (1234 from databases and 111 from other sources), and 667 duplicates were removed. The remaining 678 records were screened by title and abstract, with 216 progressing to full-text review. After applying the eligibility criteria, 42 studies were included in the final analysis. Screening and full-text assessments were conducted between September and October 2024. Data extraction and thematic analysis were performed in winter 2024. The final data synthesis stage is expected to be completed by 2025.</p><p><strong>Conclusions: </strong>HCWs' perceptions of risk have a considerable effect on how well they follow TB prevention measures such as using personal protective equipment and undergoing health screenings. Lack of resources, lack of training, and the stigma around TB are some of the main barriers to TB prevention adherence. The thematic analysis showed that adherence levels were different depending on the support offered by the institution and the TB knowledge level and perception of each HCW. Although TB treatment has become more effective, nosocomial infections are still a big concern, especially in low- and middle-income countries like Indonesia, where HCWs are more likely to have latent TB infections. This review shows how important it is for HCWs to understand how TB prevention behaviors work. To improve HCW adherence, the gaps in institutional support, stigma, and training must be filled. Future interventions should be based on the specific problems found in low- and middle-income countries. This will make health care safer for everyone around the world.</p><p><strong>International registered report identifier (irrid): </strong>DERR1-10.2196/64037.</p>","PeriodicalId":14755,"journal":{"name":"JMIR Research Protocols","volume":"14 ","pages":"e64037"},"PeriodicalIF":1.5,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12501531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Examining the Effect of Virtual Reality-Based Fast-Food Marketing on Eating-Related Outcomes in Young Adults: Protocol for a Randomized Controlled Trial. 研究基于虚拟现实的快餐营销对年轻人饮食相关结果的影响:一项随机对照试验方案。
IF 1.5
JMIR Research Protocols Pub Date : 2025-09-22 DOI: 10.2196/69096
Omni Cassidy, Emma Boyland, Susan Persky, Andrea B Troxel, Brian Elbel
{"title":"Examining the Effect of Virtual Reality-Based Fast-Food Marketing on Eating-Related Outcomes in Young Adults: Protocol for a Randomized Controlled Trial.","authors":"Omni Cassidy, Emma Boyland, Susan Persky, Andrea B Troxel, Brian Elbel","doi":"10.2196/69096","DOIUrl":"10.2196/69096","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Black communities, compared to White communities, are disproportionately targeted with more unhealthy food advertisements on television and social media. Exposure to unhealthy food and beverage marketing is associated with appetitive sensations, purchase intention, and intake behaviors, which may contribute to poor overall diet quality and worsening nutritional disparities in Black communities. Despite the negative effects, food and beverage companies are expanding their reach and harnessing advanced technology to create immersive experiences using virtual reality (VR). Black young adults may be uniquely vulnerable.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;We aim to explore the effect of a VR-based fast-food marketing experience (compared with a VR-based nonfood control) on purchase intention, arousal, and hunger in a sample of Black and White young adults.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;We will recruit 200 Black and White young adults (aged 18-24 years) from the New York City metropolitan area for a 1-time, 2-hour laboratory-based study. After screening and obtaining informed consent, eligible participants will be randomized to 1 of 2 VR conditions: a VR-based fast-food marketing experience (Wendyverse; experimental) or a VR-based nonfood control (Nikeland). In the Wendyverse, users can order from the restaurant operated by Wendy's, play games, meet others who may be visiting the Wendyverse, and access codes that can be used to obtain free food at physical restaurants. The control condition will be the Nikeland app, where participants can play sports, try on apparel, and engage with celebrity athletes. Study personnel will provide a 5-minute training session to participants before beginning the experiment to ensure that they feel comfortable in the VR environment. Participants will otherwise engage with the VR app independently. The primary outcomes will be fast-food purchase intention, assessed via a self-report questionnaire; arousal, assessed via electrodermal activity or skin conductance; and hunger, assessed via salivary reactivity. We will also conduct secondary analyses to examine interactions by race, ethnicity, and food or nutrition insecurity as a proxy for socioeconomic status. Analyses of covariance and multiple linear regressions will be conducted to examine the effects of VR-based fast-food marketing exposure on the relevant outcomes (compared to the control).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;This study was funded by the National Institute on Minority Health and Health Disparities in September 2024. Recruitment is expected to begin in September 2025. We expect to complete data collection by October 2026 and begin data cleaning and analysis in November 2026.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;On the basis of previous research and data, we anticipate that young adults randomized to view VR-based food and beverage marketing will self-report higher purchase intention and demonstrate stronger arousal and hunger","PeriodicalId":14755,"journal":{"name":"JMIR Research Protocols","volume":"14 ","pages":"e69096"},"PeriodicalIF":1.5,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12501532/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Potential of the World Health Organization's Skin NTDs App to Support and Improve the Detection of Skin-Related Neglected Tropical Diseases: Protocol for a Performance Evaluation and Feasibility Study in Senegal. 世界卫生组织皮肤被忽视热带病应用程序支持和改进皮肤相关被忽视热带病检测的潜力:塞内加尔绩效评估和可行性研究方案。
IF 1.5
JMIR Research Protocols Pub Date : 2025-09-19 DOI: 10.2196/69420
Dior Sall, Dominik Jockers, Pauline Dioussé, Jonas Wachinger, Gilbert Batista, Jose Antonio Ruiz Postigo, Laurene Petitfour, Charlotte Robert, Bachir Mansour Diallo, Fulgence Abdou Faye, Yacine Dieng, Maresa Neuerer, Agbogbenkou Tevi Dela-Dem Lawson, Felicitas Schwermann, Carme Carrion, Louis Hyacinthe Zoubi, Papa Mamadou Diagne, Christa Kasang, Fatou Ndiaye Oumar Sy, Mahamath Cisse, Till Bärnighausen, Madoky Diop
{"title":"Potential of the World Health Organization's Skin NTDs App to Support and Improve the Detection of Skin-Related Neglected Tropical Diseases: Protocol for a Performance Evaluation and Feasibility Study in Senegal.","authors":"Dior Sall, Dominik Jockers, Pauline Dioussé, Jonas Wachinger, Gilbert Batista, Jose Antonio Ruiz Postigo, Laurene Petitfour, Charlotte Robert, Bachir Mansour Diallo, Fulgence Abdou Faye, Yacine Dieng, Maresa Neuerer, Agbogbenkou Tevi Dela-Dem Lawson, Felicitas Schwermann, Carme Carrion, Louis Hyacinthe Zoubi, Papa Mamadou Diagne, Christa Kasang, Fatou Ndiaye Oumar Sy, Mahamath Cisse, Till Bärnighausen, Madoky Diop","doi":"10.2196/69420","DOIUrl":"10.2196/69420","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;The World Health Organization (WHO) roadmap aims to control, eliminate, or eradicate neglected tropical diseases (NTDs) by promoting innovation in prevention, diagnosis, and treatment. In this context, mobile health (mHealth) tools could play an important role in improving health care across the globe, including for skin-related NTDs. One such tool is the WHO Skin NTDs App (currently available in its beta version), which utilizes artificial intelligence (AI) algorithms to classify skin lesion images and offers diagnostic suggestions and management information to bolster early detection at primary care levels. However, to harness the full potential of this and similar mHealth tools, additional insights into their diagnostic performance and potential implementation avenues in settings with limited access to trained dermatologists are essential.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;The objective of our mixed methods study is to test the functionality, operability, and potential of the AI-supported diagnostic component of the WHO Skin NTDs App (beta version) to support the detection of skin NTDs and common skin conditions in Senegal.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;We are conducting a diagnostic accuracy study combined with a qualitative preimplementation usability exploration. For the quantitative component, we will collect and analyze approximately 800 skin lesion images from patients presenting to the dermatology unit at the Thiès regional hospital in Senegal. Each lesion will be independently assessed by the AI-based WHO Skin NTDs App and by a dermatologist who will provide a diagnosis serving as the reference standard. Performance metrics, including accuracy, sensitivity, specificity, precision, F&lt;sub&gt;1&lt;/sub&gt;-score, and area under the receiver operating characteristic curve, will be calculated for each diagnostic category to evaluate the app's ability to detect skin-related NTDs. In parallel, we will conduct semistructured in-depth interviews with a purposive sample of 70-80 stakeholders, including policymakers, health care workers, community leaders, dermatologists, and members of leprosy-affected communities. Interviews will explore perceptions of the app's usability, acceptability, and potential barriers and facilitators to its adoption within Senegal's health system. Thematic analysis will be used to interpret qualitative data. Findings will help inform the design of an app-based intervention to be piloted in future community-level studies.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;We expect the results to provide detailed insights into the feasibility and potential of the WHO Skin NTDs App to support and improve the detection of skin NTDs and common skin conditions at the community level in Senegal. We started data collection in August 2024, with the first results expected to be available in 2025.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Our study will assess the performance and potential use of the WHO Skin NTDs App to detect","PeriodicalId":14755,"journal":{"name":"JMIR Research Protocols","volume":"14 ","pages":"e69420"},"PeriodicalIF":1.5,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12495362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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