IF 3.2 3区生物学

IUBMB Life Pub Date : 2026-05-01 DOI: 10.1002/iub.70107

Jie Zhu, Yuchen Huang, Xiaoqin Wu, Liusuyu Zhu, Jiahao Liu, Jinhuan Wei, Xilin Sha

{"title":"Low SFXN1 Expression Predicts Poor Clinical Outcomes and Promotes Tumor Aggressiveness in Colon Adenocarcinoma.","authors":"Jie Zhu, Yuchen Huang, Xiaoqin Wu, Liusuyu Zhu, Jiahao Liu, Jinhuan Wei, Xilin Sha","doi":"10.1002/iub.70107","DOIUrl":"https://doi.org/10.1002/iub.70107","url":null,"abstract":"Sideroflexin 1 (SFXN1), predominantly localized in the inner mitochondrial membrane, exhibits differential expression across various tumor types. However, its specific role in colon adenocarcinoma (COAD) remains unclear. This study aimed to investigate the diagnostic and prognostic significance of SFXN1 in COAD. The expression and prognostic value of SFXN1 in COAD were evaluated using the Cancer Genome Atlas (TCGA) database. Bioinformatics analyses were conducted to assess the relationships between SFXN1 expression and clinical stage, prognosis, and immune infiltration in COAD. The biological role of SFXN1 in COAD was further validated through in vivo and in vitro experiments. SFXN1 was found to be expressed at low levels in COAD. Reduced SFXN1 expression was significantly associated with poor clinical outcomes in COAD patients. Furthermore, SFXN1 expression correlated with immune infiltration and immune checkpoint regulation in COAD. Functional experiments demonstrated that SFXN1 inhibition enhanced the proliferation, migration, and invasion of COAD cells, whereas SFXN1 overexpression suppressed tumor growth in vivo. Low SFXN1 expression is associated with an unfavorable clinical prognosis in COAD. Targeting SFXN1 may offer a promising avenue for developing personalized and more effective therapeutic strategies for patients with COAD.","PeriodicalId":14728,"journal":{"name":"IUBMB Life","volume":"78 5","pages":"e70107"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147815547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-Cell Dissection of Malignant Cell Heterogeneity Reveals Functional Programs and Clinically Relevant Subtypes in Head and Neck Squamous Cell Carcinoma. 恶性细胞异质性的单细胞解剖揭示头颈部鳞状细胞癌的功能程序和临床相关亚型。

IF 3.2 3区生物学

IUBMB Life Pub Date : 2026-05-01 DOI: 10.1002/iub.70104

Ahmed Osman Mohamed, Yin He, Xiaosheng Wang

{"title":"Single-Cell Dissection of Malignant Cell Heterogeneity Reveals Functional Programs and Clinically Relevant Subtypes in Head and Neck Squamous Cell Carcinoma.","authors":"Ahmed Osman Mohamed, Yin He, Xiaosheng Wang","doi":"10.1002/iub.70104","DOIUrl":"https://doi.org/10.1002/iub.70104","url":null,"abstract":"Head and neck squamous cell carcinoma (HNSCC) is a highly heterogeneous malignancy with poor prognosis and limited predictive biomarkers for therapy response. Characterizing malignant cell heterogeneity may improve prognostic and therapeutic stratification. We integrated single-cell RNA sequencing (scRNA-seq) data from 58 HNSCC patients (181,003 cells) to define malignant cell subpopulations, their differentiation states, developmental trajectories, cell-cell interactions, and spatial localization. Coexpression gene modules and meta-programs were identified using hdWGCNA and NMF. These programs were projected onto bulk RNA-seq datasets to classify HNSCC subtypes and examine associations with clinical outcomes, tumor microenvironment (TME), genomic instability, and predicted response to immune checkpoint inhibitors (ICIs). Twelve malignant clusters were identified with distinct clinical and molecular features. MC-5 exhibited a stem-like phenotype associated with poor prognosis, while MC-7 and MC-11 showed high TME communication and immune engagement. Coexpression analysis revealed 16 modules and eight meta-programs encompassing proliferation, differentiation, stress response, and immune activity. Translation to bulk RNA-seq defined three HNSCC subtypes (MS-1, MS-2, MS-3) with divergent survival, immune infiltration, stromal composition, and genomic features. MS-2, an immune-enriched subtype, demonstrated superior survival, high HPV positivity, and predicted ICI responsiveness. A 25-gene malignant cell score (MCScore) robustly predicted both prognosis and immunotherapy response. This study provides a comprehensive map of malignant cell heterogeneity in HNSCC, identifies key functional expression programs, and defines molecular subtypes with clinical and therapeutic relevance. Malignant cell-specific signatures, such as MCScore, offer promising tools for patient stratification and precision immunotherapy.","PeriodicalId":14728,"journal":{"name":"IUBMB Life","volume":"78 5","pages":"e70104"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147815568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integration of Single-Cell and Spatial Transcriptomics With Experimental Validation Uncovers Macrophage Diversity and Spatial Landscape in Carotid Atherosclerosis. 单细胞和空间转录组学整合与实验验证揭示巨噬细胞多样性和颈动脉粥样硬化的空间景观。

IF 3.2 3区生物学

IUBMB Life Pub Date : 2026-05-01 DOI: 10.1002/iub.70105

Rongxing Qin, Caiqi Li, Hongyu Xu, Xinyu Lai, Li Chen

{"title":"Integration of Single-Cell and Spatial Transcriptomics With Experimental Validation Uncovers Macrophage Diversity and Spatial Landscape in Carotid Atherosclerosis.","authors":"Rongxing Qin, Caiqi Li, Hongyu Xu, Xinyu Lai, Li Chen","doi":"10.1002/iub.70105","DOIUrl":"https://doi.org/10.1002/iub.70105","url":null,"abstract":"The core pathogenesis of carotid atherosclerosis (CAS) lies in the rupture of vulnerable plaques, with macrophages (MC) playing a critical role in plaque progression and destabilization. However, the functional characteristics of MC subpopulations in CAS remain poorly understood. This study systematically investigates the cellular composition of CAS and the regulatory mechanisms of MC by integrating single-cell RNA sequencing (scRNA-seq), in vitro models, and spatial transcriptomics. Differentially expressed genes upregulated in MC were significantly enriched in multiple signaling pathways, including Lipid and Atherosclerosis, Lysosome, and Antigen Processing and Presentation. Gene Set Variation Analysis (GSVA) revealed higher MC scores for Angiogenesis and Lipid Metabolism in the atherosclerotic core (AC). A total of seven distinct MC subtypes were identified. Pseudotime analysis indicated that IGSF21+ MC constitute the initial cell population, while FABP4+ MC represent the terminal cells along the trajectory. An in vitro atherosclerosis model was established to validate the diagnostic value of SPP1, FTH1, and FTL. Spatial transcriptomics further revealed the spatial connection patterns of the SPP1 signaling pathway network across different cell types. This study provides novel molecular insights into the pathogenesis of CAS and lays the groundwork for developing diagnostic biomarkers and therapeutic targets.","PeriodicalId":14728,"journal":{"name":"IUBMB Life","volume":"78 5","pages":"e70105"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipo-Glc-1,6-P2: A Bioprecursor Prodrug for Phosphomannomutase-2 Congenital Disorder of Glycosylation 脂酰葡萄糖-1,6- p2：先天性糖基化失调的生物递归前药。

IF 3.2 3区生物学

IUBMB Life Pub Date : 2026-04-12 DOI: 10.1002/iub.70101

Federica Sodano, Maria Monticelli, Bruno Hay Mele, Barbara Rolando, Loretta Lazzarato, Angela De Simone, Vincenza Andrisano, Debora Paris, Maria Grazia Rimoli, Maria Vittoria Cubellis, Giuseppina Andreotti

{"title":"Lipo-Glc-1,6-P2: A Bioprecursor Prodrug for Phosphomannomutase-2 Congenital Disorder of Glycosylation","authors":"Federica Sodano, Maria Monticelli, Bruno Hay Mele, Barbara Rolando, Loretta Lazzarato, Angela De Simone, Vincenza Andrisano, Debora Paris, Maria Grazia Rimoli, Maria Vittoria Cubellis, Giuseppina Andreotti","doi":"10.1002/iub.70101","DOIUrl":"10.1002/iub.70101","url":null,"abstract":"Phosphomannomutase-2 (PMM2) deficiency leads to the prominent Congenital Disorder of Glycosylation (CDG), a rare disease currently lacking effective treatment options. The complete absence of PMM2 activity is incompatible with life, and all patients carry at least one missense destabilising variant that allows residual enzymatic function. This makes PMM2-CDG amenable to pharmacological chaperone treatment. Glucose-1,6-bisphosphate (Glc-1,6-P2) is PMM2's natural activator and stabiliser, but its clinical application is severely limited due to its unfavourable physicochemical profile. Here, we applied the bioprecursor prodrug strategy to design and synthesise Lipo-Glc-1,6-P2, a novel prodrug with good stability and oral bioavailability. Its advantageous physicochemical profile was confirmed through metabolomics-based studies in fibroblasts derived from PMM2-CDG patient.","PeriodicalId":14728,"journal":{"name":"IUBMB Life","volume":"78 4","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://iubmb.onlinelibrary.wiley.com/doi/epdf/10.1002/iub.70101","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147673623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deciphering the Angiogenic Switch: The Role of miRNAs in Breast Cancer 解读血管生成开关：mirna在乳腺癌中的作用。

IF 3.2 3区生物学

IUBMB Life Pub Date : 2026-04-07 DOI: 10.1002/iub.70102

Heba Ibrahim Abd El-Moaty, Ahmed S. Doghish, Shaza H. Aly, Mai A. Abd-Elmawla, Manar Mohammed El Tabaa, Nehal I. Rizk, Ahmed E. Elesawy, Sherif S. Abdel Mageed, Osama A. Mohammed, Samy Y. Elkhawaga, Hanan A. Rizk, Alaa Ashraf, Rabab S. Hamad, Reda M. Mansour

{"title":"Deciphering the Angiogenic Switch: The Role of miRNAs in Breast Cancer","authors":"Heba Ibrahim Abd El-Moaty, Ahmed S. Doghish, Shaza H. Aly, Mai A. Abd-Elmawla, Manar Mohammed El Tabaa, Nehal I. Rizk, Ahmed E. Elesawy, Sherif S. Abdel Mageed, Osama A. Mohammed, Samy Y. Elkhawaga, Hanan A. Rizk, Alaa Ashraf, Rabab S. Hamad, Reda M. Mansour","doi":"10.1002/iub.70102","DOIUrl":"10.1002/iub.70102","url":null,"abstract":"<div>\u0000 \u0000 Angiogenesis, which is the formation of new blood vessels from existing vasculature, exhibits a pivotal role in breast cancer progression and promotes metastasis. This complex biological process is influenced by the dynamic balance of pro- and anti-angiogenic factors within the tumor microenvironment, such as vascular endothelial growth factor, fibroblast growth factors, and angiopoietins. Targeted therapeutic strategies have been developed to interfere with angiogenic signaling, aiming to normalize or inhibit the tumor vasculature. In recent years, miRNAs have arisen as crucial post-transcriptional regulators of gene expression implicated in angiogenic homeostasis. These microRNAs can function as either promoters or suppressors of angiogenesis by targeting mRNAs that encode angiogenic factors or other signaling molecules. Deregulated expressions of these miRNAs in BC are associated with perturbed angiogenesis, tumor progression, and therapeutic resistance. This review presents a thorough overview of the molecular processes controlling angiogenesis in BC and highlights the emerging roles of angioregulatory miRNAs. The article also discusses the therapeutic potential of targeting miRNAs to modulate tumor angiogenesis, providing novel insights for the development of miRNA-based diagnostics and therapeutics in BC management.\u0000 </div>","PeriodicalId":14728,"journal":{"name":"IUBMB Life","volume":"78 4","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147633561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CYP17A1 Locus: Regulatory Mechanisms and Clinical Associations With Cardiovascular Disease and Metabolic Syndrome CYP17A1位点：与心血管疾病和代谢综合征的调节机制和临床关联

IF 3.2 3区生物学

IUBMB Life Pub Date : 2026-04-03 DOI: 10.1002/iub.70096

Yasmine Chakkor, Redouane Aherrahrou

引用次数: 0

Hypoxia-Inducible Factors as Guardians of Cancer Stem Cell Fate: Implications for Novel Therapies. 缺氧诱导因子作为癌症干细胞命运的守护者：对新疗法的影响。

IF 3.2 3区生物学

IUBMB Life Pub Date : 2026-04-01 DOI: 10.1002/iub.70092

Qamar Abuhassan, Hamzeh J Al-Ameer, Hani Moslem Ahmed, Jasur Rizaev, Azizbek Togaev, Rasim M Salih, Mohaned Adil

{"title":"Hypoxia-Inducible Factors as Guardians of Cancer Stem Cell Fate: Implications for Novel Therapies.","authors":"Qamar Abuhassan, Hamzeh J Al-Ameer, Hani Moslem Ahmed, Jasur Rizaev, Azizbek Togaev, Rasim M Salih, Mohaned Adil","doi":"10.1002/iub.70092","DOIUrl":"10.1002/iub.70092","url":null,"abstract":"Cancer stem cells (CSCs) represent a dynamic, therapy-refractory subpopulation that fuels tumor initiation, metastasis, and relapse through remarkable self-renewal capacity and phenotypic plasticity. Extensive evidence has established that hypoxia-inducible factors (HIFs), especially HIF-1α and HIF-2α, are key regulators of CSC behavior within the hypoxic tumor microenvironment (TME) across diverse malignancies, including breast cancer, glioblastoma, and colorectal carcinoma. Under hypoxic conditions, HIFs stabilization orchestrates stemness maintenance, epithelial-mesenchymal transition (EMT), immune evasion, and metabolic reprogramming. Concurrently, HIF activity upregulates efflux transporters and anti-apoptotic genes, thereby contributing to resistance against chemotherapy and radiotherapy. This review integrates recent advances in HIF-CSC crosstalk, with particular emphasis on interactions with core pluripotency networks (Oct4, Sox2, Nanog), therapy-induced CSC enrichment, and hypoxia-driven immune suppression. We further highlight current limitations and prospects of HIF-targeted strategies, including isoform-specific inhibitors and combination regimens. By addressing existing knowledge gaps, this work provides a comprehensive framework to guide the development of next-generation therapies aimed at durable CSC eradication and improved clinical outcomes in hypoxia-driven cancers.","PeriodicalId":14728,"journal":{"name":"IUBMB Life","volume":"78 4","pages":"e70092"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HIF Signalling Modulates p53/miR-145-5p Axis in Hypoxia-Driven Tumorigenesis of HepG2 Tumourspheres. HIF信号在缺氧驱动的HepG2肿瘤发生中调节p53/miR-145-5p轴

IF 3.2 3区生物学

IUBMB Life Pub Date : 2026-04-01 DOI: 10.1002/iub.70103

Sakunie Sawai, Pooi-Fong Wong, Thamil Selvee Ramasamy

{"title":"HIF Signalling Modulates p53/miR-145-5p Axis in Hypoxia-Driven Tumorigenesis of HepG2 Tumourspheres.","authors":"Sakunie Sawai, Pooi-Fong Wong, Thamil Selvee Ramasamy","doi":"10.1002/iub.70103","DOIUrl":"https://doi.org/10.1002/iub.70103","url":null,"abstract":"Hypoxia is associated with increased tumour aggressiveness and relapses in hepatocellular carcinoma (HCC) through HIF signalling. Tumour suppressor p53, its deacetylase SIRT1 and liver-specific miRNAs are deregulated in hypoxia, further driving HCC tumorigenesis. The role of HIFs-p53-SIRT1-miRNAs in tumorigenesis of HepG2 tumourspheres under hypoxic conditions remains unexplored, hence is the focus of this study. HepG2 tumourspheres cultured under hypoxic and serum-free conditions for 19 days showed reduced proliferation and apoptosis, and increased pro-survival autophagy, CSC features and resistance. HIF-1α and HIF-2α proteins were stabilised in HepG2 tumourspheres cultured in hypoxia for up to 15 days compared to only up to 24 h in monolayer cells. p53 was activated in hypoxia, evidenced by significant increase in Ace-p53 expression and Ace-p53/total-p53 ratio, which were negatively correlated with HIF-1α/HIF-2α throughout hypoxia. Concurrently, nuclear p53 localisation was reduced in hypoxia, suggesting HIFs-suppression of p53 transcriptional activity. SIRT1 however, showed no correlation with p53 acetylation and HIF-1α/HIF-2α, with no notable changes in its nuclear-cytoplasmic localisation. Among the six selected miRNAs, miR-145-5p, -26a-5p and -375-3p were upregulated, miR-22-3p was downregulated, while miR-29c-3p and miR-34a-5p remained unchanged. miR-145-5p showed a negative correlation with p53 expression in hypoxia. Pharmacological inhibition of HIFs resulted in significant upregulation of p53 and miR-375-3p, while SIRT1, miR-145-5p and miR-26a-5p were downregulated. miR-145-5p was negatively correlated with p53 protein when HIFs were stabilised but positively correlated when HIFs were inhibited. This study highlights the role of HIFs/p53/miR-145-5p-associated regulation under hypoxic conditions in HepG2 tumourspheres, providing insights for future therapeutic exploration in HCC.","PeriodicalId":14728,"journal":{"name":"IUBMB Life","volume":"78 4","pages":"e70103"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-Assembled Nanovaccines: A Promising Strategy for Overcoming Influenza Variability and Advancing Universal Vaccine Development. 自组装纳米疫苗：克服流感变异性和推进通用疫苗开发的有希望的策略。

IF 3.2 3区生物学

IUBMB Life Pub Date : 2026-04-01 DOI: 10.1002/iub.70097

Chou-Yi Hsu, Ihab M Abdelrahim, Ahmed Hjazi, Hansraj Choubisa, Mirza R Baig, Haider W Alsarhan, Vimal Arora, Tina Saeed Basunduwah, Pusparaj Samantsinghar, Gunjan Singh

{"title":"Self-Assembled Nanovaccines: A Promising Strategy for Overcoming Influenza Variability and Advancing Universal Vaccine Development.","authors":"Chou-Yi Hsu, Ihab M Abdelrahim, Ahmed Hjazi, Hansraj Choubisa, Mirza R Baig, Haider W Alsarhan, Vimal Arora, Tina Saeed Basunduwah, Pusparaj Samantsinghar, Gunjan Singh","doi":"10.1002/iub.70097","DOIUrl":"https://doi.org/10.1002/iub.70097","url":null,"abstract":"Influenza viruses present an ongoing global health risk because they are always changing, which in turn results in the ineffectiveness of current strain-specific vaccines and leaves the world vulnerable to potential pandemics. The need for a universal influenza vaccine, designed to develop lasting broadly protective immunity against volatile influenza virus strains has led to advances in immunogen design. Nanotechnology, specifically self-assembled nanovaccines, offers a truly revolutionary \"bottom-up\" strategy to address this issue. Nanovaccines that spontaneously self-assemble into easily discernable pathogen-like nanoparticles, including protein cages (e.g., ferritin) and virus-like particles, provide densely displayed conserved influenza epitopes-such as hemagglutinin (HA) stalk, neuraminidase (NA), and M2 ectodomain (M2e)-in a multivalent array, greatly enhancing B-cell activation, initiated by extensive receptor crosslinking, and generating immune responses to a magnitude and breadth that is unattainable with soluble antigens. Moreover, self-assembled nanovaccines, often in adjuvant-free or self-adjuvanting formulations, not only induce durable and broad cross-protective humoral and cellular immunity but also offer protection from numerous heterosubtypic viral challenges. While significant hurdles remain in scaling the process to a manufacturing level and subsequently translating it into the clinic, self-assembling nanovaccines represent a paradigm shift in influenza prevention, providing a rational and promising pathway toward the development of a universal vaccine and a rapid response platform for future pandemics.","PeriodicalId":14728,"journal":{"name":"IUBMB Life","volume":"78 4","pages":"e70097"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147690152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanocurcumin in Oral Disease Therapy: A Review of Innovations and Future Prospects. 纳米姜黄素在口腔疾病治疗中的研究进展与展望

IF 3.2 3区生物学

IUBMB Life Pub Date : 2026-04-01 DOI: 10.1002/iub.70099

Quanbing Wang, Ke Jiang, Xiaofei Lan, Lan Zhang, Yuyan Duan, Jinxing Gao, Hong Chen

{"title":"Nanocurcumin in Oral Disease Therapy: A Review of Innovations and Future Prospects.","authors":"Quanbing Wang, Ke Jiang, Xiaofei Lan, Lan Zhang, Yuyan Duan, Jinxing Gao, Hong Chen","doi":"10.1002/iub.70099","DOIUrl":"https://doi.org/10.1002/iub.70099","url":null,"abstract":"Curcumin exhibits strong anti-inflammatory, antioxidant, and anticancer activities. However, its clinical use is limited due to poor solubility, low gastrointestinal absorption, and rapid systemic metabolism. Nanocurcumin offers enhanced solubility, bioavailability, and targeted delivery through systems such as nanoparticles, liposomes, micelles, and nanoemulsions. In oral health, nanocurcumin has shown significant therapeutic promise. In periodontitis models, it attenuates pro-inflammatory cytokines and oxidative stress markers. In radiation- and chemotherapy-induced oral mucositis, randomized clinical trials report reduced lesion severity and pain scores with nanomicellar curcumin compared to placebo. Studies on oral lichen planus and aphthous ulcers have demonstrated superior symptom control and lesion resolution with nanocurcumin compared to conventional curcumin or corticosteroids. Preclinical data in oral squamous cell carcinoma reveal antiproliferative, pro-apoptotic, and anti-angiogenic effects mediated through the NF-κB, STAT3, and MAPK pathways. This review explores nanoformulation strategies, their physicochemical advantages, and therapeutic outcomes across in vitro, in vivo, and clinical studies. It also addresses translational challenges like stability, cost, and regulatory hurdles and discusses future perspectives including personalized nanomedicine and multifunctional nanocarriers. Nanocurcumin represents a promising advancement in oral therapeutics with potential to bridge current gaps in treatment efficacy and drug delivery.","PeriodicalId":14728,"journal":{"name":"IUBMB Life","volume":"78 4","pages":"e70099"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147698685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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