International Conferences on Biological Information and Biomedical Engineering最新文献_第2页

Bioinformatics and Biotechnology Research Issues 生物信息学和生物技术研究问题

International Conferences on Biological Information and Biomedical Engineering Pub Date : 2003-03-10 DOI: 10.1109/BIBE.2003.10001

N. Bourbakis

引用次数: 0

Medical Applications of Radiation Micro-Force (Invited Presentation) 辐射微力的医学应用(特邀报告)

International Conferences on Biological Information and Biomedical Engineering Pub Date : 2001-03-04 DOI: 10.1109/BIBE.2001.974438

M. Fatemi, J. Greenleaf

引用次数: 3

SVM-based miRNA: MiRNA∗ duplex prediction 基于支持向量机的miRNA: miRNA *双工预测

International Conferences on Biological Information and Biomedical Engineering Pub Date : 1900-01-01 DOI: 10.1109/BIBE.2012.6399670

Nestoras Karathanasis, I. Tsamardinos, A. Armen, Panayiota Poirazi

{"title":"SVM-based miRNA: MiRNA∗ duplex prediction","authors":"Nestoras Karathanasis, I. Tsamardinos, A. Armen, Panayiota Poirazi","doi":"10.1109/BIBE.2012.6399670","DOIUrl":"https://doi.org/10.1109/BIBE.2012.6399670","url":null,"abstract":"We address the problem of predicting the miRNA: miRNA* duplex stemming from a microRNA (miRNA) hairpin precursor and we present a SVM-based methodology to address it. Predicting the miRNA: miRNA* duplex is a first step towards identifying the mature miRNA, suggesting possible miRNA targets and ultimately, reducing experimentation effort, time, and cost. We measure the error in terms of the absolute difference of the true and predicted location of all of the four ends of the duplex and/or of each end separately. Our mean absolute error over all ends is 1.61 ± 2.24 nts as measured on a hold-out set of 220 miRNA hairpin precursor sequences. In addition, our tool precisely predicts (with 0 nt deviation) the starting position for 57% and 52% of the miRNAs in the 5' and 3' strands of the same dataset, significantly outperforming the state-of-the-art tool MaturePred which achieves 18% and 12%, respectively, on the same task. Overall, our method accurately identifies not only the starting nucleotide of novel miRNA: miRNA* duplexes - and thus individual miRNAs- but also their length, while outperforming the current state-of-the-art tool.","PeriodicalId":147263,"journal":{"name":"International Conferences on Biological Information and Biomedical Engineering","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116657901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

RiboSW

International Conferences on Biological Information and Biomedical Engineering Pub Date : 1900-01-01 DOI: 10.1109/BIBE.2009.12

Tzu-Hao Chang, Li-Ching Wu, Chi-Ta Yeh, Cheng-Wei Chang, Baw-Jhiune Liu, Hsien-Da Huang, Jorng-Tzong Horng

{"title":"RiboSW","authors":"Tzu-Hao Chang, Li-Ching Wu, Chi-Ta Yeh, Cheng-Wei Chang, Baw-Jhiune Liu, Hsien-Da Huang, Jorng-Tzong Horng","doi":"10.1109/BIBE.2009.12","DOIUrl":"https://doi.org/10.1109/BIBE.2009.12","url":null,"abstract":"Riboswitches are cis-acting genetic regulatory elements within a specific mRNA, and can regulate both transcription and translation by interacting with their corresponding metabolites. Recently, more and more riboswitches were identified and investigated about their roles in regulatory functions in different species. Both of the sequence contexts and structural conformations are important characteristics of riboswitches. None of previous developed tools, such Covariance Models (CMs), Riboswitch finder, and RibEx, provides a web server for efficiently searching homologous instances to known riboswitches and considers two crucial characteristics of each riboswitch, such as structural conformations and sequence contexts of functional regions. Therefore, we developed a systematic method to identify twelve kinds of riboswitches. The method is implemented and provided as a web server, RiboSW, to efficiently and conveniently identify riboswitches within messenger RNA sequences. RiboSW is now available on the web at http://bioinfo.csie.ncu.edu.tw/RiboSW/. The predictive accuracy of the proposed method is comparable with other previous tools. The efficiency of the proposed method for identifying riboswitches was improved in order to achieve a reasonable computational time required for the prediction. That makes it possible to have an accurate and convenient web server for biologists to obtain their analyzing results in a given mRNA sequence.","PeriodicalId":147263,"journal":{"name":"International Conferences on Biological Information and Biomedical Engineering","volume":"242 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114004575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

"Quo vadis cardiovascular informatics?"

International Conferences on Biological Information and Biomedical Engineering Pub Date : 1900-01-01 DOI: 10.1109/bibe.2008.4696644

I. Kakadiaris

引用次数: 0