Cell Interaction - Molecular and Immunological Basis for Disease Management最新文献

Immunological Basis for the Development of Allergic Diseases-Prevalence, Diagnosis and Treatment Strategies 过敏性疾病发展的免疫学基础——患病率、诊断和治疗策略

Cell Interaction - Molecular and Immunological Basis for Disease Management Pub Date : 2021-01-25 DOI: 10.5772/INTECHOPEN.95804

S. N. Pramod

{"title":"Immunological Basis for the Development of Allergic Diseases-Prevalence, Diagnosis and Treatment Strategies","authors":"S. N. Pramod","doi":"10.5772/INTECHOPEN.95804","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.95804","url":null,"abstract":"Allergy is an immune disorder due to over responsiveness of immune system to a relatively normal and harmless antigen; derived from environmental and dietary substances commonly referred as allergens. Allergy is an IgE mediated type I hypersensitivity which is characterized by the degranulation of specialized white blood cells known as mast cells and basophils. Majority of characterized allergens are proteinaceous in nature and induce Th2 response. Specific Th2 cytokines elicit the induction of allergen specific IgE antibodies in sensitive individuals. The IgE binds to Fc epsilon receptor on basophil/mast cells and on exposure, allergens cross links the IgE and induce release of hypersensitivity mediators that result in allergic symptoms. The symptoms varies from mild allergies like hay fever, itchiness, rashes, rhinatisis, conjunctivitis to a severe condition such as Asthma and some time life threatening anaphylaxis. At present a various blood based test exist to diagnose allergies which include skin prick, patch test and Specific IgE tests. The best treatment available is to avoid exposure to allergens alternatively use of anti-histamines, steroids or other symptom reducing medications are in practice. Immunotherapy to desensitize the response to allergen and targeted therapy are promising for allergy in future.","PeriodicalId":147231,"journal":{"name":"Cell Interaction - Molecular and Immunological Basis for Disease Management","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129126167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Innovative In Vitro Models for the Study of Lung Diseases 肺部疾病研究的创新体外模型

Cell Interaction - Molecular and Immunological Basis for Disease Management Pub Date : 2020-12-17 DOI: 10.5772/intechopen.95300

Vittorio Picchio, V. Cammisotto, Francesca Pagano, R. Carnevale, I. Chimenti

引用次数: 0

Immune System Modulations in Cancer Treatment: Nanoparticles in Immunotherapy 癌症治疗中的免疫系统调节:免疫治疗中的纳米颗粒

Cell Interaction - Molecular and Immunological Basis for Disease Management Pub Date : 2020-11-18 DOI: 10.5772/intechopen.94560

K. Kızılbey, N. Türkoğlu, F. Kırmızıtaş

{"title":"Immune System Modulations in Cancer Treatment: Nanoparticles in Immunotherapy","authors":"K. Kızılbey, N. Türkoğlu, F. Kırmızıtaş","doi":"10.5772/intechopen.94560","DOIUrl":"https://doi.org/10.5772/intechopen.94560","url":null,"abstract":"Cancer immunotherapy is based on the idea of overcoming the main problems in the traditional cancer treatments and enhancing the patient’s long-term survival and quality of life. Immunotherapy methods aimed to influence the immune system, to detect and eradicate the tumors site and predict the potential results. Nowadays, nanomaterials-based immunotherapy approaches are gaining interest due to numerous advantages like their ability to target cells and tissues directly and reduce the off-target toxicity. Therefore, topics about immune system components, nanomaterials, their usage in immunotherapy and the benefits they provide will be discussed in this presented book chapter. Immunotherapy can be divided into two groups mainly; active and passive immunotherapy including their subtitles such as immune checkpoint inhibitors, adoptive immunotherapy, CAR-T therapies, vaccines, and monoclonal antibodies. Main classification and the methods will be evaluated. Furthermore, state-of-art nanocarriers based immunotherapy methods will be mentioned in detail. The terms of size, charge, material type and surface modifications of the nanoparticles will be reviewed to understand the interference of immune system and nanoparticles and their advantages/disadvantages in immunotherapy systems.","PeriodicalId":147231,"journal":{"name":"Cell Interaction - Molecular and Immunological Basis for Disease Management","volume":"82 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128164562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Organoids Models for the Study of Cell-Cell Interactions 细胞-细胞相互作用研究的类器官模型

Cell Interaction - Molecular and Immunological Basis for Disease Management Pub Date : 2020-11-16 DOI: 10.5772/INTECHOPEN.94562

Margarita Jiménez-Palomares, Alba Cristobal, Maxime Ruiz

引用次数: 0

Role of Toll-Like Receptor (TLR)-Signaling in Cancer Progression and Treatment toll样受体(TLR)信号在癌症进展和治疗中的作用

Cell Interaction - Molecular and Immunological Basis for Disease Management Pub Date : 2020-11-03 DOI: 10.5772/intechopen.94423

S. Prasad, Rahul Kumar

引用次数: 3