JDDG: Journal der Deutschen Dermatologischen Gesellschaft最新文献

{"title":"Kongresskalender 2020","authors":"","doi":"10.1111/ddg.14055","DOIUrl":"https://doi.org/10.1111/ddg.14055","url":null,"abstract":"","PeriodicalId":14702,"journal":{"name":"JDDG: Journal der Deutschen Dermatologischen Gesellschaft","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87573110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unusual flaccid blistering with mucosal involvement upon immune checkpoint inhibition","authors":"D. Niebel, Christine Brägelmann, J. Wenzel, T. Bieber","doi":"10.1111/ddg.13954","DOIUrl":"https://doi.org/10.1111/ddg.13954","url":null,"abstract":"We report the case of a 75-year-old female patient who presented with recent flaccid blistering and intense itching for a week. Concomitantly she also experienced eye redness, for which she applied antibiotic eye drops (gentamicin), and mild oral paresthesia. A preceding common cold had just resolved by the time of presentation. The patient had a medical history of ulcerated melanoma (Breslow's thickness 10 mm) on her upper arm one year before. She was treated according to guidelines with wide excision and sentinel lymph node biopsy. Since then, repeated surgery revealed a total of five metastases in supraclavicular lymph nodes; the stage of disease was IIID (American Joint Committee on Cancer [AJCC 2017]: pT4b pN3c cM0 R0). Molecular pathology analysis of the tumor detected an activating neuroblastoma RAS viral oncogene homolog (NRAS) mutation, but no druggable BRAF gene mutation; the patient therefore received an adjuvant treatment with nivolumab. The first dose was given one month before formation of the skin lesions. Apart from hypertension and hypothyroidism there was no relevant comorbidity.","PeriodicalId":14702,"journal":{"name":"JDDG: Journal der Deutschen Dermatologischen Gesellschaft","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85890787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autorenverzeichnis DDG KOMPAKT 2020","authors":"","doi":"10.1111/ddg.14022","DOIUrl":"https://doi.org/10.1111/ddg.14022","url":null,"abstract":"","PeriodicalId":14702,"journal":{"name":"JDDG: Journal der Deutschen Dermatologischen Gesellschaft","volume":"350 11‐12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91419155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kongresskalender 2020","authors":"","doi":"10.1111/ddg.14034","DOIUrl":"https://doi.org/10.1111/ddg.14034","url":null,"abstract":"","PeriodicalId":14702,"journal":{"name":"JDDG: Journal der Deutschen Dermatologischen Gesellschaft","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88522082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Journal‐Club","authors":"C. Bendick, Robert W. Gruber","doi":"10.1111/ddg.14010_g","DOIUrl":"https://doi.org/10.1111/ddg.14010_g","url":null,"abstract":"","PeriodicalId":14702,"journal":{"name":"JDDG: Journal der Deutschen Dermatologischen Gesellschaft","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73358999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deckblatt+Editoren","authors":"","doi":"10.1111/ddg.14020","DOIUrl":"https://doi.org/10.1111/ddg.14020","url":null,"abstract":"","PeriodicalId":14702,"journal":{"name":"JDDG: Journal der Deutschen Dermatologischen Gesellschaft","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81933649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physicians' level of hindrance by body hair in dermatoscopy and clinical benefit of an automated hair removal algorithm","authors":"C. Fink, L. Uhlmann, Karsten Vogt, R. Schneiderbauer, C. Menzer, F. Toberer, Timo E. Schank, A. Enk, H. Haenssle","doi":"10.1111/ddg.13967","DOIUrl":"https://doi.org/10.1111/ddg.13967","url":null,"abstract":"Dermatoscopy may be hindered by body hair, and the development of an automated hair removal algorithm (AuHRA) might improve the diagnostic accuracy. However, the physicians' exact level of hindrance and the clinical benefit attained by AuHRA has not been assessed. The objectives of this study are to quantify the physicians' level of hindrance by body hair and the level of improvement in the visibility of underlying dermatoscopic patterns after application of AuHRA to digital images of hair‐covered nevi.","PeriodicalId":14702,"journal":{"name":"JDDG: Journal der Deutschen Dermatologischen Gesellschaft","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78544989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spectrum of ichthyoses in an Austrian ichthyosis cohort from 2004 to 2017","authors":"Magdalena Seidl-Philipp, U. Schatz, Irina Gasslitter, V. Moosbrugger-Martinz, S. Blunder, A. Schossig, J. Zschocke, M. Schmuth, R. Gruber","doi":"10.1111/ddg.13968","DOIUrl":"https://doi.org/10.1111/ddg.13968","url":null,"abstract":"Ichthyoses are a heterogeneous disease group, which makes clinical classification challenging. An ichthyosis cohort at a center for genodermatoses is presented in detail.","PeriodicalId":14702,"journal":{"name":"JDDG: Journal der Deutschen Dermatologischen Gesellschaft","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80459278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Journal‐Club","authors":"J. Weiß","doi":"10.1111/ddg.13994_g","DOIUrl":"https://doi.org/10.1111/ddg.13994_g","url":null,"abstract":"","PeriodicalId":14702,"journal":{"name":"JDDG: Journal der Deutschen Dermatologischen Gesellschaft","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87419709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous targeted therapy for metastatic melanoma and hepatitis C","authors":"L. Kofler, C. Berg, K. Kofler, A. Geipel, H. Lipp, Alisa Müller, T. Eigentler, A. Forschner","doi":"10.1111/ddg.13952","DOIUrl":"https://doi.org/10.1111/ddg.13952","url":null,"abstract":"Combined therapy of advanced melanoma with BRAF/MEK inhibitors leads to an improvement of overall survival [1–6]. In 2014, the combined HCV-NS5A/nucleotide polymerase inhibitor Harvoni® was approved for the treatment of chronic hepatitis C and demonstrated to be highly effective in previously untreated patients [7]. However, active hepatitis C was a common exclusion criterion in registration trials for metastasized melanoma and was also valid in the Combi-V and Combi-D trials [8, 9]. We describe a patient with an advanced nodular melanoma (pT3bN3M1b, stage IV) with a proven BRAF-V600E mutation. Clinical and radiological examination revealed the presence of pulmonary metastases as well as unresectable, painful, locoregional metastases. A chronic hepatitis C infection was known for some years but was not treated. Laboratory testing showed 42.400 IU HCV RNA/ml serum using a quantitative PCR (COBAS AmpliPrep/COBAS TaqMan HCV Quantitative Test, version 2.0; Roche Diagnostics Deutschland, Mannheim, Germany) as well as evidence of anti-hepatitis C antibodies. Based upon a recommendation of our interdisciplinary tumor board, targeted hepatitis C-therapy with ledipasvir 90 mg and sofosbuvir 400 mg (Harvoni®) was initiated for twelve consecutive weeks. Simultaneously, we started a combined targeted melanoma treatment with dabrafenib 300 mg (Tafinlar®) and trametinib 2 mg (Mekinist®). The tumor board recommended targeted melanoma therapy due to painful locoregional metastases, since a more rapid treatment could be expected than for checkpoint inhibitors. Initially, trametinib as well as ledipasvir/sofosbuvir were taken at the same time in the morning. At the first follow-up visit, the patient reported nocturnal chills and intermittent diarrhea. We excluded an infectious cause for these symptoms. As ledipasvir/sofosbuvir and trametinib are eliminated by the breast cancer resistant protein (BCRP), which is an efflux transport protein strongly expressed in barrier tissues, a competitive drug interaction may be assumed to underlie these adverse reactions [10]. We could not exclude an interaction via hepatic OATP1B3 uptake, which would result in higher BRAF/MEK-inhibitor plasma-levels [11]. Therefore, an interval of two hours after intake of BRAF/MEK inhibitors was recommended for ledipasvir/sofosbuvir, resulting in complete resolution of the symptoms. No further side effects have been reported by the patient so far. At a follow-up visit three months after completing the treatment with ledipasvir/sofosbuvir, HCV-RNA-PCR remained negative. We observed complete response of the melanoma metastases. The targeted therapy with dabrafenib and trametinib is currently continuing. Various side effects have been described for BRAF/MEK inhibitors, including diarrhea and chills. Therefore, careful clinical examination and a detailed anamnesis is of great importance. Good safety profiles for patients with hepatitis C have already been reported for anti-PD-1 therapy [12, 13]. ","PeriodicalId":14702,"journal":{"name":"JDDG: Journal der Deutschen Dermatologischen Gesellschaft","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83963554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}