JAMA surgery最新文献

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Bioengineered Human Arteries for the Repair of Vascular Injuries. 用于修复血管损伤的生物工程人体动脉。
IF 15.7 1区 医学
JAMA surgery Pub Date : 2024-11-20 DOI: 10.1001/jamasurg.2024.4893
Ernest E Moore, Michael Curi, Nicholas Namias, Rishi Kundi, Ying Wei Lum, Charles J Fox, Ravi R Rajani, Todd E Rasmussen, Oleksandr Sokolov, Laura E Niklason, Zakaria Khondker, Shamik J Parikh
{"title":"Bioengineered Human Arteries for the Repair of Vascular Injuries.","authors":"Ernest E Moore, Michael Curi, Nicholas Namias, Rishi Kundi, Ying Wei Lum, Charles J Fox, Ravi R Rajani, Todd E Rasmussen, Oleksandr Sokolov, Laura E Niklason, Zakaria Khondker, Shamik J Parikh","doi":"10.1001/jamasurg.2024.4893","DOIUrl":"10.1001/jamasurg.2024.4893","url":null,"abstract":"<p><strong>Importance: </strong>Vascular injuries require urgent repair to minimize loss of limb and life. Standard revascularization relies on autologous vein or synthetic grafts, but alternative options are needed when adequate vein is not feasible and when clinical conditions preclude safe use of synthetic materials.</p><p><strong>Objective: </strong>To evaluate the performance of the acellular tissue engineered vessel (ATEV) in the repair of arterial injuries.</p><p><strong>Design, setting, and participants: </strong>Two open-label, single-arm, nonrandomized clinical trials, including 1 prospective civilian study (CLN-PRO-V005 [V005]) and 1 retrospective observational study in a war zone (CLN-PRO-V017 [V017]), were conducted from September 2018 to January 2024 (follow-up ongoing) at 19 level 1 trauma centers in the US and Israel and 5 frontline hospitals in Ukraine. Patients had vascular injury, no autologous vein available for emergent revascularization, and risk factors for wound infection. Data were analyzed from September 2023 to January 2024.</p><p><strong>Intervention: </strong>The ATEV is a bioengineered vascular conduit grown from human vascular cells, available off the shelf, and implantable without immunosuppression.</p><p><strong>Main outcomes and measures: </strong>Primary patency at day 30 was the primary outcome. Secondary outcomes included limb salvage, graft infection, and patient survival. A systematic literature review identified synthetic graft benchmarks in the treatment of arterial trauma for the same end points.</p><p><strong>Results: </strong>The V005 and V017 studies evaluated 69 and 17 patients, respectively, and included 51 in V005 and 16 in V017 with noniatrogenic arterial injuries of the extremities. The majority were male (V005, 38 [74.5%]; V017, 16 [100%]), the mean (SD) ages were similar (V005, 33.5 [13.6] years; V017, 34.2 [9.0] years), and the mean (SD) Injury Severity Scores were similar (V005, 20.8 [10.5]; V017, 20.1 [18.9]). Penetrating injuries dominated (V005, 29 patients [56.9%]; V017, 14 patients [87.5%]). At day 30 for the V005 and V017 trials, respectively, ATEV primary patency was 84.3% (95% CI, 72.0%-91.8%) and 93.8% (95% CI, 71.7%-98.9%); secondary patency was 90.2% (95% CI, 79.0%-95.7%) and 93.8% (95% CI, 71.7%-98.9%); amputation rate was 9.8% (95% CI, 4.3%-21.0%) and 0% (95% CI, 0.0%-19.4%); ATEV infection rate was 2.0% (95% CI, 0.4%-10.3%) and 0% (95% CI, 0.0%-19.4%); and death rate was 5.9% (95% CI, 2.0%-15.9%) and 0% (95% CI, 0.0%-19.4%) (no deaths attributed to the ATEV). Day 30 synthetic graft benchmarks were as follows: secondary patency, 78.9%; amputation, 24.3%; infection, 8.4%; and death, 3.4%.</p><p><strong>Conclusions and relevance: </strong>Results of 2 single-arm trials in civilian and real-world military settings suggest that the ATEV provides benefits in terms of patency, limb salvage, and infection resistance. Comparing ATEV outcomes with synthetic graft benchmarks demonstrates im","PeriodicalId":14690,"journal":{"name":"JAMA surgery","volume":" ","pages":""},"PeriodicalIF":15.7,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11579887/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-Term Outcomes of Early Surgery vs Endoscopy First in Chronic Pancreatitis: Follow-Up Analysis of the ESCAPE Randomized Clinical Trial. 慢性胰腺炎患者早期手术与先行内镜检查的长期疗效对比:ESCAPE随机临床试验的随访分析。
IF 15.7 1区 医学
JAMA surgery Pub Date : 2024-11-20 DOI: 10.1001/jamasurg.2024.5182
Charlotte L van Veldhuisen, Marinus A Kempeneers, Florence E M de Rijk, Stefan A Bouwense, Marco J Bruno, Paul Fockens, Jan W Poley, Usama Ahmed Ali, Thomas L Bollen, Olivier R Busch, Peter van Duijvendijk, Hendrik M van Dullemen, Casper H van Eijck, Harry Van Goor, Muhanned Hadithi, Jan-Willem Haveman, Yolande Keulemans, Vincent B Nieuwenhuijs, Alexander C Poen, Rogier P Voermans, Adriaan C Tan, Willem Thijs, Robert C Verdonk, Ben J Witteman, Jeanin E van Hooft, Hjalmar C van Santvoort, Marcel G Dijkgraaf, Marc G Besselink, Marja A Boermeester, Yama Issa
{"title":"Long-Term Outcomes of Early Surgery vs Endoscopy First in Chronic Pancreatitis: Follow-Up Analysis of the ESCAPE Randomized Clinical Trial.","authors":"Charlotte L van Veldhuisen, Marinus A Kempeneers, Florence E M de Rijk, Stefan A Bouwense, Marco J Bruno, Paul Fockens, Jan W Poley, Usama Ahmed Ali, Thomas L Bollen, Olivier R Busch, Peter van Duijvendijk, Hendrik M van Dullemen, Casper H van Eijck, Harry Van Goor, Muhanned Hadithi, Jan-Willem Haveman, Yolande Keulemans, Vincent B Nieuwenhuijs, Alexander C Poen, Rogier P Voermans, Adriaan C Tan, Willem Thijs, Robert C Verdonk, Ben J Witteman, Jeanin E van Hooft, Hjalmar C van Santvoort, Marcel G Dijkgraaf, Marc G Besselink, Marja A Boermeester, Yama Issa","doi":"10.1001/jamasurg.2024.5182","DOIUrl":"10.1001/jamasurg.2024.5182","url":null,"abstract":"<p><strong>Importance: </strong>Patients with painful chronic pancreatitis and a dilated pancreatic duct can be treated by early surgery or an endoscopy-first approach.</p><p><strong>Objective: </strong>To compare long-term clinical outcomes of early surgery vs an endoscopy-first approach using follow-up data from the ESCAPE randomized clinical trial.</p><p><strong>Design, setting, and participants: </strong>Between April 2011 and September 2018, 88 patients with painful chronic pancreatitis were randomly assigned to early surgery or an endoscopy-first approach in 30 hospitals in the Netherlands collaborating in the Dutch Pancreatitis Study Group as part of the ESCAPE randomized clinical trial. For the present cohort study, long-term clinical data were collected after the initial 18-month follow-up. Follow-up was completed in June 2022, and data analysis was performed in June 2023.</p><p><strong>Exposure: </strong>Patients with chronic pancreatitis were randomly assigned to early surgery or an endoscopy-first approach.</p><p><strong>Main outcomes and measures: </strong>The primary end point was pain, assessed by the Izbicki pain score; secondary end points included patient-reported complete pain relief and satisfaction. Predefined subgroups included patients who progressed from endoscopy to surgery and those with ductal clearance obtained by endoscopy. Analysis was performed according to the intention-to-treat principle.</p><p><strong>Results: </strong>In this cohort study, 86 of 88 overall patients could be evaluated, with a mean (SD) follow-up period of 98 (16) months. Of 88 initial patients, 21 patients (24%) were female, and mean (SD) patient age was 61 (10) years. At the end of long-term follow-up, the mean (SD) Izbicki pain score was significant lower (33 [31] vs 51 [31]) in the early surgery group, as was the rate of patient-reported complete pain relief (14 of 31 patients [45%] vs 6 of 30 patients [20%]), compared to the endoscopy-first group. After the initial 18-month follow-up, 11 of 43 patients in the early surgery group (26%) underwent reinterventions vs 19 of 43 patients in the endoscopy-first group (44%). At the end of follow-up, more patients in the early surgery group were \"very satisfied\" with their treatment (22 of 31 patients [71%] vs 10 of 30 patients [33%]). Patients who progressed from endoscopy to surgery (22 of 43 patients [51%]) had significantly worse mean (SD) Izbicki pain scores (33 [31] vs 52 [24]) compared to the early surgery group and had a lower rate of complete pain relief (55% for early surgery vs 12% for endoscopy first). In the endoscopy-first group, patients with endoscopic ductal clearance had similar mean (SD) Izbicki pain scores as the remaining patients (49 [34] vs 53 [28]).</p><p><strong>Conclusions and relevance: </strong>In this cohort study evaluating long-term outcomes of the ESCAPE randomized clinical trial, after approximately 8 years of follow-up, early surgery was superior to an endoscopy-first ","PeriodicalId":14690,"journal":{"name":"JAMA surgery","volume":" ","pages":""},"PeriodicalIF":15.7,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11579886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sustainability in Surgery-Reinvesting in People Over Things. 外科手术的可持续性--重人轻物。
IF 15.7 1区 医学
JAMA surgery Pub Date : 2024-11-20 DOI: 10.1001/jamasurg.2024.4515
Neelima Tummala, Colleen M Fitzpatrick, Kelly N Wright
{"title":"Sustainability in Surgery-Reinvesting in People Over Things.","authors":"Neelima Tummala, Colleen M Fitzpatrick, Kelly N Wright","doi":"10.1001/jamasurg.2024.4515","DOIUrl":"https://doi.org/10.1001/jamasurg.2024.4515","url":null,"abstract":"","PeriodicalId":14690,"journal":{"name":"JAMA surgery","volume":" ","pages":""},"PeriodicalIF":15.7,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bioengineering on the Front Lines. 前线的生物工程。
IF 15.7 1区 医学
JAMA surgery Pub Date : 2024-11-20 DOI: 10.1001/jamasurg.2024.5137
Britt H Tonnessen, Alan Dardik
{"title":"Bioengineering on the Front Lines.","authors":"Britt H Tonnessen, Alan Dardik","doi":"10.1001/jamasurg.2024.5137","DOIUrl":"https://doi.org/10.1001/jamasurg.2024.5137","url":null,"abstract":"","PeriodicalId":14690,"journal":{"name":"JAMA surgery","volume":" ","pages":""},"PeriodicalIF":15.7,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Quality of Evidence Supporting Clinical Practice Guidelines in General Surgery: A Meta-Analysis. 支持普外科临床实践指南的证据质量:一项 Meta 分析。
IF 15.7 1区 医学
JAMA surgery Pub Date : 2024-11-20 DOI: 10.1001/jamasurg.2024.4751
Ali B Abbasi, Adrian Valderrama, Hannah C Decker, Tasce Bongiovanni, Elizabeth C Wick
{"title":"The Quality of Evidence Supporting Clinical Practice Guidelines in General Surgery: A Meta-Analysis.","authors":"Ali B Abbasi, Adrian Valderrama, Hannah C Decker, Tasce Bongiovanni, Elizabeth C Wick","doi":"10.1001/jamasurg.2024.4751","DOIUrl":"10.1001/jamasurg.2024.4751","url":null,"abstract":"","PeriodicalId":14690,"journal":{"name":"JAMA surgery","volume":" ","pages":""},"PeriodicalIF":15.7,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11579889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgery-First for Painful Chronic Pancreatitis. 疼痛型慢性胰腺炎的首选手术。
IF 15.7 1区 医学
JAMA surgery Pub Date : 2024-11-20 DOI: 10.1001/jamasurg.2024.5181
Ville Sallinen, Arto Kokkola, Pauli Puolakkainen
{"title":"Surgery-First for Painful Chronic Pancreatitis.","authors":"Ville Sallinen, Arto Kokkola, Pauli Puolakkainen","doi":"10.1001/jamasurg.2024.5181","DOIUrl":"https://doi.org/10.1001/jamasurg.2024.5181","url":null,"abstract":"","PeriodicalId":14690,"journal":{"name":"JAMA surgery","volume":" ","pages":""},"PeriodicalIF":15.7,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histotripsy-A Novel and Intriguing Technique of Liver Ablation. 组织切削术--一种新颖而有趣的肝脏消融技术。
IF 15.7 1区 医学
JAMA surgery Pub Date : 2024-11-20 DOI: 10.1001/jamasurg.2024.2339
Colin J Rog, Mohamed Alassas, Evan Ong
{"title":"Histotripsy-A Novel and Intriguing Technique of Liver Ablation.","authors":"Colin J Rog, Mohamed Alassas, Evan Ong","doi":"10.1001/jamasurg.2024.2339","DOIUrl":"https://doi.org/10.1001/jamasurg.2024.2339","url":null,"abstract":"","PeriodicalId":14690,"journal":{"name":"JAMA surgery","volume":" ","pages":""},"PeriodicalIF":15.7,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is It Just Component Separation That Improves Reoperation Rates? 提高再手术率的仅仅是组件分离吗?
IF 15.7 1区 医学
JAMA surgery Pub Date : 2024-11-13 DOI: 10.1001/jamasurg.2024.5068
Wendy A Brown, Yit Leang, Kaleb R Lourensz
{"title":"Is It Just Component Separation That Improves Reoperation Rates?","authors":"Wendy A Brown, Yit Leang, Kaleb R Lourensz","doi":"10.1001/jamasurg.2024.5068","DOIUrl":"https://doi.org/10.1001/jamasurg.2024.5068","url":null,"abstract":"","PeriodicalId":14690,"journal":{"name":"JAMA surgery","volume":" ","pages":""},"PeriodicalIF":15.7,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Travel to High-Volume Centers and Survival After Esophagectomy for Cancer 前往高流量中心就诊与癌症食管切除术后的存活率
IF 16.9 1区 医学
JAMA surgery Pub Date : 2024-11-13 DOI: 10.1001/jamasurg.2024.5009
Sara Sakowitz, Syed Shahyan Bakhtiyar, Saad Mallick, Jane Yanagawa, Peyman Benharash
{"title":"Travel to High-Volume Centers and Survival After Esophagectomy for Cancer","authors":"Sara Sakowitz, Syed Shahyan Bakhtiyar, Saad Mallick, Jane Yanagawa, Peyman Benharash","doi":"10.1001/jamasurg.2024.5009","DOIUrl":"https://doi.org/10.1001/jamasurg.2024.5009","url":null,"abstract":"ImportanceOngoing efforts have encouraged the regionalization of esophageal adenocarcinoma treatment to high-volume centers (HVCs). Yet such centralization has been linked with increased patient travel burden and reduced postoperative continuity of care.ObjectiveTo determine whether traveling to undergo esophagectomy at HVCs is linked with superior overall survival compared with receiving care locally at low-volume centers (LVC).Design, Setting, and ParticipantsThis cohort study considered data for all patients diagnosed with stage I through III esophageal adenocarcinoma in the 2010-2021 National Cancer Database. Patients were stratified based on distance traveled to receive care and the annual esophagectomy volume at the treating hospital: the travel-HVC cohort included patients in the top 25th percentile of travel burden who received care at centers in the top volume quartile, and the local-LVC cohort represented those in the bottom 25th percentile of travel burden who were treated at centers in the lowest volume quartile. Data were analyzed from July 2023 to January 2024.Main Outcomes and MeasuresThe primary end points were overall survival at 1 year and 5 years. Secondary end points included perioperative outcomes and factors linked with traveling to receive care.ResultsOf 17 970 patients, 2342 (13%) comprised the travel-HVC cohort, and 1969 (11%), the local-LVC cohort. The median (IQR) age was 65 (58-71) years; 3748 (87%) were male and 563 (13%) were female. After risk adjustment and with care at local LVCs as the reference, traveling to HVC was associated with superior survival at 1 year (hazard ratio for mortality [HR], 0.69; 95% CI, 0.58-0.83) and 5 years (HR, 0.80; 95% CI, 0.70-0.90). Stratifying by stage, traveling to HVCs was associated with comparable outcomes for stage I disease but reduced mortality for stage III (1-year HR, 0.72; 95% CI, 0.60-0.87; 5-year HR, 0.83; 95% CI, 0.74-0.93). Further, traveling to HVC was associated with greater lymph node harvest (β, 5.08 nodes; 95% CI, 3.78-6.37) and likelihood of margin-negative resection (adjusted odds ratio, 1.83; 95% CI, 1.29-2.60).Conclusions and RelevanceTraveling to HVCs for esophagectomy was associated with improved 1-year and 5-year survival compared with receiving care locally at LVCs, particularly among patients with locoregionally advanced disease. Future studies are needed to ascertain barriers to care and develop novel targeted pathways to ensure equitable access to high-volume facilities and high-quality oncologic care.","PeriodicalId":14690,"journal":{"name":"JAMA surgery","volume":"80 1","pages":""},"PeriodicalIF":16.9,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142601967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Going the Distance-Whether the Outcome Is Worth the Travel. 长途跋涉--结果是否值得旅行。
IF 15.7 1区 医学
JAMA surgery Pub Date : 2024-11-13 DOI: 10.1001/jamasurg.2024.5004
Ngoc-Quynh Chu, Daniela Molena
{"title":"Going the Distance-Whether the Outcome Is Worth the Travel.","authors":"Ngoc-Quynh Chu, Daniela Molena","doi":"10.1001/jamasurg.2024.5004","DOIUrl":"https://doi.org/10.1001/jamasurg.2024.5004","url":null,"abstract":"","PeriodicalId":14690,"journal":{"name":"JAMA surgery","volume":" ","pages":""},"PeriodicalIF":15.7,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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