JACC: Cardiovascular Interventions最新文献

{"title":"Recommended Steps for UNICORN With Balloon-Expandable Valves","authors":"Kwong-Yue Eric Chan MBBS, Chun-Ka Wong MBBS, Tai-Leung Chan MBBS, Gilbert H.L. Tang MD MSc MBA, Simon Cheung-Chi Lam MBBS","doi":"10.1016/j.jcin.2025.05.034","DOIUrl":"https://doi.org/10.1016/j.jcin.2025.05.034","url":null,"abstract":"","PeriodicalId":14666,"journal":{"name":"JACC: Cardiovascular Interventions","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144515235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Outcomes of Real-World Transcatheter Tricuspid Valve Replacement.","authors":"Domenico Angellotti,Isabel Mattig,Daryoush Samim,Björn Goebel,Charlotte Jantsch,Barbara Rubinic,Tobias Ruf,Tobias Geisler,Mirjam Kessler,Matti Adam,Lukas Stolz,Varius Dannenberg,Mohammad Kassar,Konstantinos Stathogiannis,Vincenzo Cesario,Nicolas Dumonteil,Michael Chrissoheris,Konstantinos Spargias,Stephan Baldus,Wolfgang Rottbauer,Muhammed Gerçek,Philippe M Bartko,Harald Lapp,Henryk Dreger,Jörg Hausleiter,Philipp Lurz,Stephan Windecker,Volker Rudolph,Fabien Praz","doi":"10.1016/j.jcin.2025.06.002","DOIUrl":"https://doi.org/10.1016/j.jcin.2025.06.002","url":null,"abstract":"BACKGROUNDTranscatheter tricuspid valve replacement (TTVR) has been recently approved for the treatment of patients with severe tricuspid regurgitation (TR). Real-world evidence regarding the commercial use of TTVR is lacking.OBJECTIVESThe aim of this study was to investigate the real-world safety and efficacy of the EVOQUE TTVR system in patients with severe TR treated at 12 experienced heart valve centers in 5 European countries.METHODSConsecutive patients treated with the EVOQUE system since approval in Europe (October 2023 to February 2025) were included in this retrospective analysis. Clinical outcomes were assessed at 30-day follow-up.RESULTSThe study included 176 patients (mean age 77.8 years, 72.0% women, median TRI-SCORE 5 points [IQR: 2 points]). At a median follow-up time of 30 days (IQR: 2 days), severe or greater TR was reduced to mild or none in 126 of 128 patients (98.4%; P < 0.001). NYHA functional class improved from 20.2% (28 of 138) class I or II at baseline to 79.7% (110 of 138; P) at 1 month (P < 0.001), with signs of improved hepatorenal function (estimated glomerular filtration rate 47.0 ± 19.9 mL/min/1.73 m2 vs 53.7 ± 23.3 mL/min/1.73 m2 [P < 0.001]; bilirubin 14.2 ± 8.8 μmol/L vs 11.0 ± 9.8 μmol/L [P < 0.001]). Massive or torrential TR at baseline was more common among patients who improved compared with those with stable or worsening NYHA functional class (75 of 98 [76.5%] vs 20 of 40 [50.0%]; P = 0.004). Permanent pacemaker implantation was required in 21 of 111 pacemaker-naive patients (18.9%), in particular those with conduction disturbances at baseline (OR: 4.53; 95% CI: 1.73-11.82; P = 0.002). Moderate or severe right ventricular dysfunction was an independent predictor of clinical failure at 1-month follow-up (OR: 3.60; 95% CI: 1.39-9.32, P = 0.008).CONCLUSIONSTR elimination following TTVR in a real-world setting was associated with significant symptom and end-organ functional improvement. Patients with massive or torrential TR were more likely to experience functional improvement. Pre-existing conduction disturbances are associated with increased risk for pacemaker implantation, while baseline right ventricular dysfunction is a strong predictor of adverse clinical outcomes.","PeriodicalId":14666,"journal":{"name":"JACC: Cardiovascular Interventions","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcatheter Edge-to-Edge Repair for Atrial and Ventricular Secondary Mitral Regurgitation: Insights From the REPAIR Study.","authors":"Philipp von Stein,Lukas Stolz,Jean Marc Haurand,Matthias Gröger,Felix Rudolph,Donika Mustafa,Jannik Jobst,Christoph Alexander Mues,Amir Abbas Mahabadi,Isabel A Hoerbrand,Carl Schulz,Atsushi Sugiura,Jennifer von Stein,Christos Iliadis,Philipp Lurz,Muhammed Gerçek,Patrick Horn,Mirjam Kessler,Guido Ascione,Tienush Rassaf,Marcel Weber,Niklas Schofer,Mathias Konstandin,Florian Schindhelm,Helge Möllmann,Bernhard Unsöld,Henning Guthoff,Stephan Baldus,Wolfgang Rottbauer,Volker Rudolph,Juan F Granada,Jörg Hausleiter,Roman Pfister,Victor Mauri,","doi":"10.1016/j.jcin.2025.05.031","DOIUrl":"https://doi.org/10.1016/j.jcin.2025.05.031","url":null,"abstract":"BACKGROUNDSecondary mitral regurgitation (SMR) has 2 phenotypes: atrial (aSMR) and ventricular (vSMR). The role of mitral valve transcatheter edge-to-edge repair (M-TEER) in aSMR remains less defined, with limited evidence on the PASCAL implant (Edwards Lifesciences).OBJECTIVESThe authors sought to evaluate and compare outcomes of SMR phenotypes undergoing M-TEER.METHODSREPAIR (REgistry of PAscal for mItral Regurgitation) is an investigator-initiated, multicenter registry of patients undergoing M-TEER. aSMR was defined by left atrial dilation with preserved left ventricular size and ejection fraction. Outcomes included MR ≤1+ at discharge, technical success, NYHA functional class improvement, and 1-year survival.RESULTSAmong 915 patients (166 [18%] aSMR, 749 [82%] vSMR), the median follow-up was 491 days (Q1-Q3: 360-833 days). MR ≤1+ was achieved in 77.2% vs 71.4% (P = 0.162), with technical success in 97.0% vs 98.3% (P = 0.446). NYHA functional class improved in both phenotypes (P < 0.001), with 61.2% vs 61.3% in functional class ≤II at follow-up (P > 0.999). One-year survival was 88.4% (95% CI: 82.8%-94.4%) vs 86.0% (95% CI: 83.1%-89.0%; P = 0.346). In aSMR patients, 1-year survival was significantly lower in patients with baseline tricuspid regurgitation (TR) grade ≥moderate compared with those with <moderate TR (84.3% [95% CI: 77.0%-92.3%] vs 100.0% [95% CI: 100.0%-100.0%]; P = 0.041). In vSMR patients, survival was similar between ≥moderate and <moderate baseline TR (83.9% [95% CI: 79.8%-88.2%] vs 89.3% [95% CI: 85.0%-93.8%]; P = 0.051).CONCLUSIONSM-TEER effectively reduces MR to ≤1+ and improves symptoms in both aSMR and vSMR. Particularly in aSMR, ≥moderate baseline TR is linked to worse outcomes, warranting consideration as an additional treatment target.","PeriodicalId":14666,"journal":{"name":"JACC: Cardiovascular Interventions","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simplified and Improved Commissural Alignment Technique With the Supra-Annular, Self-Expanding Evolut FX System.","authors":"Chieh Yang Christopher Koo,George Petrossian,Newell Robinson,William Chung,Matthew Henry,Andrew Berke,Kristin Pasquarello,Ziad Ali,Omar Khalique,Jaffar M Khan","doi":"10.1016/j.jcin.2025.06.003","DOIUrl":"https://doi.org/10.1016/j.jcin.2025.06.003","url":null,"abstract":"","PeriodicalId":14666,"journal":{"name":"JACC: Cardiovascular Interventions","volume":"102 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From TAVR to TTVR: Echoes of Progress and Caution.","authors":"Mohamad Alkhouli,Kuan-Chih Huang","doi":"10.1016/j.jcin.2025.06.001","DOIUrl":"https://doi.org/10.1016/j.jcin.2025.06.001","url":null,"abstract":"","PeriodicalId":14666,"journal":{"name":"JACC: Cardiovascular Interventions","volume":"639 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Value of Microvascular Function in Takotsubo Syndrome: a Pooled Analysis of Individual Patient Data.","authors":"Rob Eerdekens,Mohamed El Farissi,Giovanni Luigi De Maria,Aviel Shetrit,Robert Sykes,Christina Ekenbäck,Jonas Persson,Jonas Spaak,Liam S Couch,Fernando Alfonso,Fernando Rivero,Nieves Gonzalo,Javier Escaned,Iván J Núñez Gil,Oscar Vedia Cruz,Reut Amar Shamir,Ophir Freund,Marc Vanderheyden,Marta Belmonte,Emanuele Barbato,Pim A L Tonino,Adrian Banning,Ole Geir Solberg,Colin Berry,William F Fearon,Frederik M Zimmermann","doi":"10.1016/j.jcin.2025.05.028","DOIUrl":"https://doi.org/10.1016/j.jcin.2025.05.028","url":null,"abstract":"BACKGROUNDCoronary microvascular dysfunction appears to play a major role in the pathogenesis of Takotsubo Syndrome (TTS). However, the prognostic value of microvascular function measured in the acute phase of TTS is unclear.METHODSIn a collaborative, pooled analysis of individual patient data from nine prospective TTS cohorts, invasive assessment of coronary microvascular function was performed, including the index of microcirculatory resistance (IMR), coronary flow reserve (CFR), and microvascular resistance reserve (MRR). The primary endpoint was all-cause mortality. Secondary endpoints included major adverse cardiac and cerebrovascular events (MACCE) defined as the composite of all-cause death, recurrence of TTS, stroke, transient ischemic attack, or myocardial infarction.RESULTSOne hundred and sixty six patients with TTS were included, in whom 130 (78%) had the typical (apical) TTS variant and 36 (22%) an atypical variant. During a median follow-up of 20.6 [4.3 - 60.0] months, all-cause mortality occurred in 17 patients (10.2%) and MACCE in 29 patients (17.5%). IMR, CFR, and MRR were associated with all-cause mortality. After adjustment for baseline differences, IMR was the only independent predictor of both all-cause mortality (aHR 3.9; 95% CI: 1.39-10.88, P = 0.010; c-statistic 0.817 (95% CI: 0.711-0.923)) and MACCE (aHR 2.6; 95% CI: 1.17-5.67; P = 0.018; c-statistic 0.719 (95% CI: 0.612-0.826)).CONCLUSIONSIn this pooled analysis of individual patient data from nine prospective TTS cohorts, microvascular dysfunction measured in the acute phase, was associated with all-cause mortality. In particular, an elevated microvascular resistance, as assessed by IMR, was the only independent predictor of both mortality and MACCE.","PeriodicalId":14666,"journal":{"name":"JACC: Cardiovascular Interventions","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"800.21 Aortic Valve Replacement: Do Hospital Location and Size Matter?","authors":"C. Umeh, R. Gupta, G. Kaur, R. Dhawan, B. Eghreriniovo, J. Obi, S. Maguwudze, P. Mahdavian, S. Kumar, M. Zainea, J. Mohan","doi":"10.1016/j.jcin.2024.01.246","DOIUrl":"https://doi.org/10.1016/j.jcin.2024.01.246","url":null,"abstract":"","PeriodicalId":14666,"journal":{"name":"JACC: Cardiovascular Interventions","volume":"141 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140464230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"400.25 Comparing the Clinical Outcomes of Fractional Flow Reserve and Intravascular Ultrasonography in Guiding Percutaneous Coronary Intervention","authors":"A. M. Balakrishna, A. Aboeata, A. Jhand","doi":"10.1016/j.jcin.2024.01.192","DOIUrl":"https://doi.org/10.1016/j.jcin.2024.01.192","url":null,"abstract":"","PeriodicalId":14666,"journal":{"name":"JACC: Cardiovascular Interventions","volume":"308 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140466417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"800.6 Impact of Hospital Procedural Volume on the Outcomes of Transcatheter End-to-End Mitral Valve Repair in Clinical Trials Non-Eligible Patients","authors":"A. Maraey, H. Elsharnoby, N. Bardia, M. Mahmoud, N. Chaaban, A. Elzanaty, M. Patel, A. Fares, O. Sajdeya, M. Khalil","doi":"10.1016/j.jcin.2024.01.266","DOIUrl":"https://doi.org/10.1016/j.jcin.2024.01.266","url":null,"abstract":"","PeriodicalId":14666,"journal":{"name":"JACC: Cardiovascular Interventions","volume":"54 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140464368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"700.06 Comprehensive Radiation Shield Minimizes Operator Radiation Exposure and Obviates Need for Lead Aprons in Coronary and Structural Intervention","authors":"D. Rizik","doi":"10.1016/j.jcin.2024.01.224","DOIUrl":"https://doi.org/10.1016/j.jcin.2024.01.224","url":null,"abstract":"","PeriodicalId":14666,"journal":{"name":"JACC: Cardiovascular Interventions","volume":"39 26","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140464899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}