JAMA cardiology最新文献

{"title":"Intensive Blood Pressure Control in Older Adults-Reply.","authors":"Xiaofan Guo, Guozhe Sun, Yingxian Sun","doi":"10.1001/jamacardio.2024.5444","DOIUrl":"10.1001/jamacardio.2024.5444","url":null,"abstract":"","PeriodicalId":14657,"journal":{"name":"JAMA cardiology","volume":" ","pages":"400-401"},"PeriodicalIF":14.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Error in Abstract and Visual Abstract.","authors":"","doi":"10.1001/jamacardio.2025.0396","DOIUrl":"10.1001/jamacardio.2025.0396","url":null,"abstract":"","PeriodicalId":14657,"journal":{"name":"JAMA cardiology","volume":" ","pages":"402"},"PeriodicalIF":14.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11883581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Donning the Hijab-A Cardiology Fellow's Journey With Advocacy and Inclusion.","authors":"Najah Ali Khan","doi":"10.1001/jamacardio.2024.5667","DOIUrl":"10.1001/jamacardio.2024.5667","url":null,"abstract":"","PeriodicalId":14657,"journal":{"name":"JAMA cardiology","volume":" ","pages":"307-308"},"PeriodicalIF":14.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety, Feasibility, and Diagnostic Yield of Invasive Coronary Function Testing: Netherlands Registry of Invasive Coronary Vasomotor Function Testing.","authors":"Caïa Crooijmans, Tijn P J Jansen, Joan G Meeder, Janneke Woudstra, Martijn Meuwissen, Annemiek M J De Vos, Valeria Paradies, Els G M Olde Bijvank, Patty Winkler, Nicola S Vos, Karin Arkenbout, Pier Woudstra, Martin G Stoel, Tim P Van de Hoef, Stijn C H Van den Oord, Jos W M G Widdershoven, Wouter Remkes, Aysun Cetinyurek-Yavuz, Hester M Den Ruijter, N Charlotte Onland-Moret, Eric Boersma, Marcel A M Beijk, Yolande Appelman, Jan J Piek, Regina E Konst, Angela H E M Maas, Niels Van Royen, Aukelien C Dimitriu-Leen, Suzette E Elias-Smale, Peter Damman","doi":"10.1001/jamacardio.2024.5670","DOIUrl":"10.1001/jamacardio.2024.5670","url":null,"abstract":"<p><strong>Importance: </strong>Patients with angina and no obstructive coronary artery disease frequently have coronary vasomotor dysfunction as underlying pathophysiological mechanism, comprising epicardial spasm, microvascular spasm, and/or microcirculatory dysfunction. These endotypes can be diagnosed by invasive coronary function testing which has previously shown to be safe in tertiary and expert centers.</p><p><strong>Objective: </strong>To determine the prevalence of vasomotor dysfunction in patients with angina and no obstructive coronary artery disease who were clinically referred for a coronary function test (CFT); and assess safety and feasibility of a CFT.</p><p><strong>Design, setting, and participants: </strong>This quality improvement study was performed using the Netherlands Registry of Invasive Coronary Vasomotor Function Testing (NL-CFT), a prospective, observational registry, in 15 participating hospitals (2 tertiary and 13 nontertiary). Patients with angina and no obstructive coronary artery disease who were referred for a clinically indicated CFT between December 2020 and January 2024 were included.</p><p><strong>Main outcomes and measures: </strong>A complete CFT consisted of acetylcholine spasm provocation testing and assessment of microcirculatory function. Prevalence of different endotypes based on test results and overall safety were assessed.</p><p><strong>Results: </strong>Among a total of 1207 patients included, 978 (81%) were female; and the mean (SD) age was 60 (10) years. The prevalence of coronary vasomotor dysfunction was very high (78%). There were 11 (0.9%) major and 10 (0.8%) minor complications reported. Of them, 3 major and all minor were definitely related to the coronary function test. No procedural death, myocardial infarction, or stroke was observed. No differences were found in the occurrence of complications between tertiary and nontertiary centers.</p><p><strong>Conclusions and relevance: </strong>This study found that a CFT was feasible and safe to perform in both tertiary and nontertiary centers with a high diagnostic yield.</p>","PeriodicalId":14657,"journal":{"name":"JAMA cardiology","volume":" ","pages":"384-390"},"PeriodicalIF":14.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11840684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intensive Blood Pressure Control in Older Adults.","authors":"Yuxian Huang, Xiangmin Tan","doi":"10.1001/jamacardio.2024.5447","DOIUrl":"10.1001/jamacardio.2024.5447","url":null,"abstract":"","PeriodicalId":14657,"journal":{"name":"JAMA cardiology","volume":" ","pages":"400"},"PeriodicalIF":14.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"JAMA Cardiology.","authors":"","doi":"10.1001/jamacardio.2024.3417","DOIUrl":"https://doi.org/10.1001/jamacardio.2024.3417","url":null,"abstract":"","PeriodicalId":14657,"journal":{"name":"JAMA cardiology","volume":"10 4","pages":"304"},"PeriodicalIF":14.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Predisposition to Low-Density Lipoprotein Cholesterol and Incident Type 2 Diabetes.","authors":"Akshaya Ravi, Satoshi Koyama, So Mi Jemma Cho, Sara Haidermota, Whitney Hornsby, Patrick T Ellinor, Pradeep Natarajan","doi":"10.1001/jamacardio.2024.5072","DOIUrl":"10.1001/jamacardio.2024.5072","url":null,"abstract":"<p><strong>Importance: </strong>Treatment to lower high levels of low-density lipoprotein cholesterol (LDL-C) reduces incident coronary artery disease (CAD) risk but modestly increases the risk for incident type 2 diabetes (T2D). The extent to which genetic factors across the cholesterol spectrum are associated with incident T2D is not well understood.</p><p><strong>Objective: </strong>To investigate the association of genetic predisposition to increased LDL-C levels with incident T2D risk.</p><p><strong>Design, setting, and participants: </strong>In this large prospective, population-based cohort study, UK Biobank participants who underwent whole-exome sequencing and genome-wide genotyping were included. Participants were separated into 7 groups with familial hypercholesterolemia (FH), predicted loss of function (pLOF) in APOB or PCSK9 variants, and LDL-C polygenic risk score (PRS) quintiles. Data were collected between 2006 and 2010, with a median follow-up of 13.7 (IQR, 12.9-14.5) years. Data were analyzed from March 1 to November 1, 2024.</p><p><strong>Exposures: </strong>LDL-C level, LDL-C PRS, FH, or pLOF variant status.</p><p><strong>Main outcomes and measures: </strong>Cox proportional hazards regression models adjusted for age, sex, genotyping array, lipid-lowering medication use, and the first 10 genetic principal components were fitted to assess the association between LDL-C genetic factors and incident T2D and CAD risks.</p><p><strong>Results: </strong>Among the 361 082 participants, mean (SD) age was 56.8 (8.0) years, 194 751 (53.9%) were female, and mean (SD) baseline LDL-C level was 138.0 (33.6) mg/dL. During the follow-up period, 22 619 (6.3%) participants developed incident T2D and 17 966 (5.0%) developed incident CAD. The hazard ratio for incident T2D was lowest in the FH group (0.65; 95% CI, 0.54-0.77), while the highest risk was in the pLOF group (1.48; 95% CI, 1.18-1.86). The association between LDL-C PRS and incident T2D was 0.72 (95% CI, 0.66-0.79) for very high LDL-C PRS, 0.87 (95% CI, 0.84-0.90) for high LDL-C PRS, 1.13 (95% CI, 1.09-1.17) for low LDL-C PRS, and 1.26 (95% CI, 1.15-1.38) for very low LDL-C PRS. CAD risk increased directly with the LDL-C PRS.</p><p><strong>Conclusions and relevance: </strong>In this cohort study, LDL-C and T2D risks were inversely associated across genetic mechanisms for LDL-C variation. Further elucidation of the mechanisms associating low LDL-C risk with increased risk of T2D is warranted.</p>","PeriodicalId":14657,"journal":{"name":"JAMA cardiology","volume":" ","pages":"379-383"},"PeriodicalIF":14.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Cardiovascular Disease Divide-A Tale of 2 High-Income Nations.","authors":"Sadiya S Khan","doi":"10.1001/jamacardio.2024.5312","DOIUrl":"10.1001/jamacardio.2024.5312","url":null,"abstract":"","PeriodicalId":14657,"journal":{"name":"JAMA cardiology","volume":" ","pages":"358"},"PeriodicalIF":14.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Error in End Matter.","authors":"","doi":"10.1001/jamacardio.2025.0703","DOIUrl":"https://doi.org/10.1001/jamacardio.2025.0703","url":null,"abstract":"","PeriodicalId":14657,"journal":{"name":"JAMA cardiology","volume":"10 4","pages":"402"},"PeriodicalIF":14.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arrhythmic Risk Stratification of Carriers of Filamin C Truncating Variants.","authors":"Marta Gigli, Davide Stolfo, Giulia Barbati, Sharon Graw, Suet Nee Chen, Marco Merlo, Kristen Medo, Caterina Gregorio, Matteo Dal Ferro, Alessia Paldino, Maria Perotto, J Peter van Tintelen, Anneline S J M Te Riele, Annette F Baas, Arthur M Wilde, Ahmad S Amin, Arjan C Houweling, Perry Elliott, Douglas Cannie, Michelle Michels, Stephan A C Schoonvelde, Sanjay Prasad, Paz Upasana Tayal, Momina Yazdani, Deborah Morris-Rosendahl, Pablo Garcia-Pavia, Eva Cabrera-Romero, Barbara Bauce, Kalliopi Pilichou, Diane Fatkin, Renee Johnson, Daniel P Judge, Kimberly L Foil, Stephane Heymans, Job A J Verdonschot, Sophie L V M Stroeks, Neal K Lakdawala, Purohit Anisha, Matthew O'Neill, M Benjamin Shoemaker, Dan M Roden, Hugh Calkins, Cynthia A James, Brittney Murray, Victoria N Parikh, Euan A Ashley, Chloe Reuter, Massimo Imazio, Marco Canepa, Pietro Ameri, Jiangping Song, Gianfranco Sinagra, Matthew R G Taylor, Luisa Mestroni","doi":"10.1001/jamacardio.2024.5543","DOIUrl":"10.1001/jamacardio.2024.5543","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Importance: &lt;/strong&gt;Filamin C truncating variants (FLNCtv) are a rare cause of cardiomyopathy with heterogeneous phenotypic presentations. Despite a high incidence of life-threatening ventricular arrhythmias and sudden cardiac death (SCD), reliable risk predictors to stratify carriers of FLNCtv are lacking.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To determine factors predictive of SCD/major ventricular arrhythmias (MVA) in carriers of FLNCtv.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Design, setting, and participants: &lt;/strong&gt;This was an international, multicenter, retrospective cohort study conducted from February 2023 to June 2024. The Filamin C Registry Consortium included 19 referral centers for genetic cardiomyopathies worldwide. Participants included carriers of pathogenic or likely pathogenic FLNCtv. Phenotype negative was defined as the absence of any pathological findings detected by 12-lead electrocardiogram (ECG), Holter ECG monitoring, echocardiography, or cardiac magnetic resonance.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Exposures: &lt;/strong&gt;Composite of SCD and MVA in carriers of FLNCtv.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Main outcomes and measures: &lt;/strong&gt;The primary outcome was a composite of SCD and MVA, the last including aborted SCD, sustained ventricular tachycardia, and appropriate implantable cardioverter-defibrillator (ICD) interventions.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Among 308 individuals (median [IQR] age, 45 [33-56] years; 160 male [52%]) with FLNCtv, 112 (36%) were probands, and 72 (23%) were phenotype negative. Median (IQR) left ventricular ejection fraction (LVEF) was 51% (38%-59%); 89 participants (34%) had LVEF less than 45%, and 50 (20%) had right ventricular dysfunction. During a median (IQR) follow-up of 34 (8-63) months, 57 individuals (19%) experienced SCD/MVA, with an annual incidence rate of 4 cases per 100 person-years (95% CI, 3-6). Incidence rates were higher in probands vs nonprobands and in phenotype-positive vs phenotype-negative individuals. A predictive model estimating SCD/MVA risk was derived from multivariable analysis, which included older age, male sex, previous syncope, nonsustained ventricular tachycardia, and LVEF with a time-dependent area under the curve (AUC) ranging between 0.76 (95% CI, 0.67-0.86) at 12 months and 0.78 (95% CI, 0.70-0.86) at 72 months. Notably, the association of LVEF with the SCD/MVA risk was not linear, showing significant lower risk for values of LVEF greater than 58%, and no increase for values less than 58%. Internal validation with bootstrapping confirmed good accuracy and calibration of the model. Results were consistent in subgroups analysis (ie, phenotype-positive carriers and phenotype-positive carriers without MVA at onset).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions and relevance: &lt;/strong&gt;Results suggest that the risk of SCD/MVA in phenotype-positive carriers of FLNCtv was high. A 5-variable predictive model derived from this cohort allows risk estimation and could support clinicians in the shared decision for prophylactic ICD implantatio","PeriodicalId":14657,"journal":{"name":"JAMA cardiology","volume":" ","pages":"359-369"},"PeriodicalIF":14.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11822610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}