Izvestiya of Saratov University. New Series. Series: Chemistry. Biology. Ecology最新文献

{"title":"The spatial distribution of corvid nests in the urbanized environmental components (using the example of the Kirovsky district of Saratov)","authors":"Yulia I. Kuliseva, Evgeniy Yu. Mel’nikov","doi":"10.18500/1816-9775-2023-23-2-227-235","DOIUrl":"https://doi.org/10.18500/1816-9775-2023-23-2-227-235","url":null,"abstract":"This study is dedicated to the nest placement peculiarities of four species of the Corvidae family: the Jackdaw, Rook, Hooded Crow, and Eurasian Magpie – in the urbanized environmental components on the territory of the Kirovsky district of Saratov. The following methods were used in the work: route and areal accounting, cartographic modelling, plotting isolines based on cartographic data, assessing the reliability of differences in the number of corvid nests using Pearson’s chi-squared test, determining the rate of urbanization of various areas of the model area based on the method used by E. L. Lykov, assessing the dependence of the number of nests on the rate of the territory urbanization using Spearman’s correlation coefficient. The distribution of 652 nests according to the biotopes was analyzed, the assessment of the corvid nesting density in various urban environmental habitats was carried out. The nest placement density reaches its maximum in the areas with abundant green places, a large number of nesting sites, both of natural and anthropogenic origin and low rate of human disturbance, being in the areas with low-rise buildings, in the forest belts, in the natural park “ Kumysnaya polyana”and in the old Voskresenskoe cemetery. The Jackdaw and the Rook are the most selective for breeding sites species, their nests being located in human buildings and on closely placed tall trees. The Hooded Crow nests most evenly and successfully occupied the habitats of Saratov. The Magpie’s nesting areas are more associated to large groups of woody vegetation, the highest density of its nest placement was observed in the natural and natural-anthropogenic components of the urban environment. The negative relation between the quantity of nests of the two species – the Hooded Crow and the Magpie – and the rate of the territory urbanization was revealed. The nesting of the Jackdaw and the Rook are affected mostly not by the urbanization rate, but the availability of breeding sites.","PeriodicalId":14627,"journal":{"name":"Izvestiya of Saratov University. New Series. Series: Chemistry. Biology. Ecology","volume":"190 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73861640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cycvalone in the synthesis of nitrogen-, oxygen-containing heterocycles","authors":"D. A. Rogov, A. P. Krivenko","doi":"10.18500/1816-9775-2023-23-2-159-165","DOIUrl":"https://doi.org/10.18500/1816-9775-2023-23-2-159-165","url":null,"abstract":"Cycvalone is an analogue of curcumin (EE conformation), exhibits a wide range of biological activity (antioxidant, hepatoprotective, membrane stabilizing, anti-ulcer) and is used in medical practice as a choleretic. Numerous methods of producing cycvalone are known, including industrial ones, but its reactions have been studied much less. Some reactions of cycvalone with N, C-nucleophiles (hydrazines, malononitrile) have been carried out. Reactions with getarylamines that could lead to the synthesis of compounds including pharmacophore fragments remained completely unexplored. We have used cycvalone as a substrate for the synthesis of nitrogen-, oxygen-containing heterosystems of a number of chromenopyrimidine, aminochromencarbonitrile, indazole, triazoloquinazoline. The structure of the obtained new substances has been established by spectral methods (IR, NMR). Schemes of formation of reaction products have been proposed.","PeriodicalId":14627,"journal":{"name":"Izvestiya of Saratov University. New Series. Series: Chemistry. Biology. Ecology","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75200439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colormetric system for monitoring the growth of microalgae Dunaliella salina under laboratory conditions","authors":"A. Galitskaya, Aram A. Akopian, L. Dykman, V. Bogatyrev","doi":"10.18500/1816-9775-2023-23-1-104-109","DOIUrl":"https://doi.org/10.18500/1816-9775-2023-23-1-104-109","url":null,"abstract":"The brackish microalgae Dunaliella salina, being an extremophilic halophyte, is a promising object for biotechnological production. The aim of this work is to develop a methodology for non-destructive control of the development of a microalgae culture under conditions of balanced growth during periodic cultivation on plates. Before the start of the experiment, the microalgae culture was synchronized. The quantitative content of chlorophylls a and b, as well as carotenoids, was determined spectrophotometrically in alcohol extracts. During cultivation, time-lapse images were recorded on a smartphone camera. The basis of the colorimetric evaluation is the analysis of the time series of images in the RGB color model. It is shown that the ratio of colors correlates to a high degree with the content of the determined main plant pigments – chlorophylls and carotenoids, and with the data of spectrophotometric measurements of live suspensions. The changes in the blue channel are the most pronounced, the least being in the green channel. The logarithm of color intensity is linearly dependent on the degree of dilution of the culture. The developed method for real-time monitoring of the development dynamics of the D. salina microalgae culture makes it possible to build growth curves and solve multiparametric problems to optimize the cultivation of microalgae, including when working with large arrays of samples.","PeriodicalId":14627,"journal":{"name":"Izvestiya of Saratov University. New Series. Series: Chemistry. Biology. Ecology","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81578228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thin layer chromatography of some statins in aqueous organic mobile phases modified with buffer solutions","authors":"","doi":"10.18500/1816-9775-2023-23-1-28-38","DOIUrl":"https://doi.org/10.18500/1816-9775-2023-23-1-28-38","url":null,"abstract":"The influence of a number of factors on the chromatographic properties of statins (atorvastatin, rosuvastatin, simvastatin) in normal-phase and reverse-phase chromatography modes has been studied by the method of the thin-layer chromatography (TLC) in order to select the most effective analytical systems for the total and separate determination of statins in pharmaceuticals. The study has been performed by ascending TLC on commercial plates with polar, weakly polar, and nonpolar phases. Efficiency and selectivity of chromatographic separation of statins have been established: the nature of the stationary phase (SF), the nature of the mobile phase (MF), the nature and concentration of the organic solvent of the mobile phase, the ionic strength of the solution. It has been revealed that the most effective SF are the reverse-phase plates RP-18, on which statins are separated with a high value of the number of theoretical plates (N) and the lowest value of the height of the equivalent theoretical plate (H). From organic solvents, the aprotic solvent acetonitrile turned out to be effective, which in the MF of the acetonitrile –water composition (70:30) gives the best results of chromatographic separation of statins. It has been found that with an increase in the ionic strength of the solution in the range of 0.1–1.5 mol (KCl), the mobility of statins changes slightly, which is accompanied by a significant blurring of chromatographic zones and deterioration of statin separation, and therefore no strong electrolyte was introduced in further studies. Binary mixtures of atorvastatin and simvastatin have been separated under selected optimal conditions. It has been found that the greatest selectivity of separation is observed in the MF acetonitrile – phosphate buffer (70:30) at pH 3. Quantitative determination of atorvastatin in «Atorvastatin-OBL», «Liprimar» and «Tulip» drugs has been carried out to optimize the chromatography conditions. The correctness and reliability of the determination has been established using the standard drug atorvastatin, Sr did not exceed 0.01–0.02.","PeriodicalId":14627,"journal":{"name":"Izvestiya of Saratov University. New Series. Series: Chemistry. Biology. Ecology","volume":"290 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77503184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular mechanisms of the opening of the blood-brain barrier in rodents by means of sound","authors":"E. Sarantseva, T. Iskra, O. Semyachkina-Glushkovskaya","doi":"10.18500/1816-9775-2023-23-1-94-103","DOIUrl":"https://doi.org/10.18500/1816-9775-2023-23-1-94-103","url":null,"abstract":"In this study, in experiments on 35 healthy male mice of the C57BL/6 line weighing 25±3 g, it was shown that loud sound/music for 2 hours causes a temporary increase in the permeability of the blood-brain barrier (BBB) in rodents. To investigate changes in the permeability of the blood-brain barrier, the molecular mechanisms responsible for its discovery were investigated using laser speckle-contrast imaging of regional cerebral blood flow (rCBF), immunohistochemical analysis and biochemical analysis of adrenaline in blood plasma. With a sound-dependent increase in the permeability of the blood-brain barrier, there was a decrease in signal intensity from CLND-5, Occ, JAM and an increase in the signal from ZO-1. However, after 4 hours, the signal intensity from the studied proteins was restored, which may be due to their internalization. The results of the study of the effects of music and sound on of BBB in the intact brain require a revision of traditional knowledge about the barrier functions of the brain and open up new opportunities for non-invasive drug delivery strategies. They also may offer some insight into the etiology of brain disorders that follow inadvertent or deliberate exposure to very loud sounds, i.e. battle or rock concerts.","PeriodicalId":14627,"journal":{"name":"Izvestiya of Saratov University. New Series. Series: Chemistry. Biology. Ecology","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80751131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"4-Ethoxymethylene-2-phenyl-5(4H)-oxazolone in reactions with various heterocyclic amines","authors":"Anna V. Miroshnikova, Aleksandra S. Tikhomolova, Natalya O. Vasilkova, A. Egorova","doi":"10.18500/1816-9775-2023-23-1-11-17","DOIUrl":"https://doi.org/10.18500/1816-9775-2023-23-1-11-17","url":null,"abstract":"The analysis of the literature data has showed that there is no information on the behavior in 5(4H)-oxazolones with amines under the conditions of a sealed vessel reactor, which makes it possible to obtain heterocyclic systems with different amines. We have developed and presented an easy, fast, reliable and innovative method for the preparation of a new series of compounds with synthetic and biological potential, based on the interaction of 4-ethoxymethylene-2-phenyl-5(4H)-oxazolone and heterocyclic amines with different ring sizes and sets heteroatoms using a sealed vessel reactor. Based on the results obtained, it has been found that the transformation proceeds by the mechanism of nucleophilic addition of Michael. The scheme of the conducted interaction has been discussed. Initially, the amino group of the amine used is attacked at the exocyclic C=C bond of the initial substrate, ethoxymethylenexazolone, proceeding with the elimination of a well-leaving ethoxy group in the form of an ethanol molecule, which leads to the final 4-hetarylaminomethylidene derivatives of oxazol-5(4H)-one. In the course of the work, it has been found that the use of a sealed vessel reactor makes it possible to reduce the time of transformations, to achieve an increase in selectivity and yields of target products compared to the usual type of activation of the reaction mixture, such as boiling in ethanol. It has been shown that not only the type of activation, but also the nature of the solvent used affects the rate of the reaction. It has been found that under these conditions the transfor mation proceeds with the preservation of the oxazol-5(4Н)-one ring. Control over the course of reactions, determination of individuality and identification of the obtained compounds have been carried out by TLC, elemental analysis, IR-, NMR spectroscopy.","PeriodicalId":14627,"journal":{"name":"Izvestiya of Saratov University. New Series. Series: Chemistry. Biology. Ecology","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81118636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Free-radical graft copolymerization acrylamide, 2-sodium 2-acrylamido-2-methylpropane sulfonic onto chitosan","authors":"Arthur S. Obshitser, T. Bayburdov, S. L. Shmakov","doi":"10.18500/1816-9775-2023-23-1-18-27","DOIUrl":"https://doi.org/10.18500/1816-9775-2023-23-1-18-27","url":null,"abstract":"The method presents obtaining hydrosoluble graft copolymer of complicated structure based on сhitosan, acrylamide (AM), sodium 2-acrylamido-2-methylpropane sulfonic (АМPS-Na) in order to obtain flocсulant which is resistant to salt of transition metals and heat temperature, and in order to use it as a reagent for oil production processes. The obvious advantages of this copolymer can be attributed to its biodegradation due to inclusion of a biopolymer into the composition of the copolymer, which is important for the preservation of ecology, and efficiency of its synthetic analogues. The graft copolymerization acrylamide and sodium 2-acrylamido-2-methylpropane sulfonic onto active sites of chitosan has been performed under condition of high concentration monomers in nitrogen atmosphere using combined initiator system of complex composition under the following order monomers [АА]>[АМПС-Na]. Kinetic study of graft copolymerization has been carried out using thermometry methods. Attempts have been made to describe mathematically the reaction of graft monomers АM and АМPS-Na onto chitosan. The IR spectra analysis of copolymers has been carried out. The study of reaction rate and molecular characteristics of synthesized copolymers has been conducted under changing concentration of chitosan, monomers, ratio components of the initiator system and reaction temperature during synthesis. It has been determined that the averaged energy activation of copolymerization reaction was in the range of reaction temperature 10–25°С. Molecular composition and proposed structure of the grafted copolymers have been determined by the results of viscosity and sedimentation analysis. The results of this study allow to obtain grafted copolymers with specified properties and structure to use them in such areas as sewage and industrial water treatment and mineral industry.","PeriodicalId":14627,"journal":{"name":"Izvestiya of Saratov University. New Series. Series: Chemistry. Biology. Ecology","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88997846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acid extraction of radionuclides from soil samples using autoclave decomposition","authors":"S. Salmenbayev, Ardak M. Miratova, R. Kenzhebaev","doi":"10.18500/1816-9775-2023-23-1-62-69","DOIUrl":"https://doi.org/10.18500/1816-9775-2023-23-1-62-69","url":null,"abstract":"The specifics of the nuclear tests carried out on the territory of the former Semipalatinsk test site (STS) led to the emergence of various sites that differ in levels of radioactive contamination and radionuclide composition. This also led to a significant difference in the solubility of radioactive particles. Traditionally, the “Experimental Field” testing ground was characterized by the presence of sparingly soluble, vitrified particles, which was determined by the features inherent in ground tests of nuclear weapons, namely, the interaction of the high-temperature explosion region with soil particles. The presence of such sparingly soluble particles in the soil cover makes it impossible to use 6–8 М HCl and 7–8 М HNO 3 solutions which are most often used radiochemical analysis to determine the content of 90Sr and 239+240Pu. This paper considers methods for the acid extraction of anthropogenic radionuclides from soils of the STS using autoclaving. The aim of the research is to develop a method for the acid extraction of anthropogenic radionuclides from enlarged soil samples using autoclave decomposition. A blank soil sample was used to determine the optimal autoclave decomposition parameters; to test the acid extraction method, a soil sample was taken from the territory of the “experimental field” testing ground. The radionuclide 137Cs has been used as the most optimal indicator of acid extraction due to its strong fixation on clay and mineral soil particles and ease of detection by the gamma radiation. Autoclave decomposition has been carried out by dissolving the studied samples in a mixture of mineral acids (HCl, HNO3, HF, H2SO4). The specific activity of radionuclide has been determined on a BE3830 gamma spectrometer with a high-purity germanium detector (Canberra, USA), the amount of undecomposed soil residue has been determined gravimetrically (PA214C analytical balance, Ohaus, USA). The data obtained indicate that the most complete extraction of 137Cs occurs when using concentrated HF solutions (individually or in a mixture with other mineral acids). The degree of extraction of 137Cs varied from 85 to 100%. The worst results have been shown by the use of a mixture of acids 3HCl:HNO 3. In this case the degree of extraction of 137Cs did not exceed 20%. The efficiency of decomposition of soil samples weighing 10 g with a concentrated solution of HF at a temperature of 120 to 160 ºC was ≥95%.","PeriodicalId":14627,"journal":{"name":"Izvestiya of Saratov University. New Series. Series: Chemistry. Biology. Ecology","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86140622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation of new substituted imidazolone derivatives based on 1-(2-oxo-2-phenylethylidene)pyrrolo[3,2,1-ij]quinolin-2-ones","authors":"A. A. Skoptsova, N. Novichikhina, A. S. Shestakov, Khidmet S. Shikhaliev","doi":"10.18500/1816-9775-2023-23-1-4-10","DOIUrl":"https://doi.org/10.18500/1816-9775-2023-23-1-4-10","url":null,"abstract":"This work demonstrates the possibility of obtaining new biologically active molecules containing a privileged imidazolone fragment by the Brønsted acid-catalyzed reaction of 1,3-dimethylurea with 1-(2-oxo-2-phenylethylidene)pyrrolo[3,2,1-ij]quinolin-2-ones. The presence of an active oxoylidene system in ones makes it possible to introduce these compounds into cyclization reactions with various binucleophilic agents. The choice of such an N,N-binucleophile as 1,3-dimethylurea allowed us to obtain a number of new 1-(oxoimidazolyl)pyrrolo[3,2,1-ij]quinolin- 2-ones in a process carried out at reflux in acetonitrile and a tenfold excess of 1,3-dimethylurea via p-toluenesulfonic acid catalysis. It has been found that 1-(oxoimidazolyl)pyrrolo[3,2,1-ij]quinolin-2-ones in solution undergo keto-enol tautomerism. This is evidenced by the duplication of characteristic proton signals and the presence of the hydroxyl group proton signal in the region of 4.95 ppm in the 1H NMR spectrum of the obtained compounds. Also, based on the experimental data, we have presented a possible reaction mechanism. It is assumed that the reaction proceeds through consistent intermolecular addition of 1,3-dimethylurea to 1-phenacylidenepyrrolo[3,2,1-ij]quinolin-2-ones with intramolecular cyclization, followed by elimination of a water molecule.","PeriodicalId":14627,"journal":{"name":"Izvestiya of Saratov University. New Series. Series: Chemistry. Biology. Ecology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90193406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of atmospheric air pollution by physical and chemical characteristics of snowmelt","authors":"E. O. Markova, Yuliya P. Koryakina, Margarita A. Titova, Daria А. Baranova-Fedorova","doi":"10.18500/1816-9775-2023-23-1-51-61","DOIUrl":"https://doi.org/10.18500/1816-9775-2023-23-1-51-61","url":null,"abstract":"The state of the environment in cities is determined by the degree of pollution of individual components of the environment. Geochemical anomalies in urban agglomerations are often formed in pollution depositing media such as soil, snow cover, bottom sediments. The purpose of the study is environmental monitoring of anthropogenic impact in different areas of Smolensk and Vyazma according to the physical and chemical characteristics of melted snow. Snow was chosen as the object of the study, because it accumulates many substances entering the atmosphere, and subsequently can become a source of secondary pollution of the soil cover, underground and surface waters. The study determined organoleptic parameters (smell, color, turbidity, the presence of sediment in melt water), chemical parameters (the number of suspended particles, pH, total rigidity and mineralization, the amount of organic substances).The presence of chloride ions (Cl-), sulfate ions (SO42-), nitrate ions (NO3-), nitrite ions (NO2-), bicarbonate ions (HCO3-) and ions of some heavy metals (Pb2+, Cu2+, Fe3+) have been determined. Bioindication of the studied samples on watercress has been carried out in parallel. A low level of air pollution in Smolensk and Vyazma has been established. The greatest contribution to the formation of the level of pollution in the cold period of the year is made by suspended substances, iron and manganese compounds in concentrations exceeding the maximum permissible concentration. The concentration of impurities depends on the distance from large industrial objects, automobile and railway objects, sanitary and technical condition and cleaning regime of the territory. The courtyard territories of Smolensk and Vyazma are the cleanest. The largest part of snow pollution is provided by the thermoelectric power stations and transport. Samples taken near car parks, railway tracks and near the thermoelectric power stations were the most unfavorable.","PeriodicalId":14627,"journal":{"name":"Izvestiya of Saratov University. New Series. Series: Chemistry. Biology. Ecology","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90652853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}