Iranian journal of kidney diseases最新文献

{"title":"Quercetin Ameliorates Renal Fibrosis via SIRT5 in Diabetic Nephropathy.","authors":"Guangyu Ma, Zhi Xu, Yishu Zhang, Bingzheng Dong, Yunye Zhang, Xing Cheng, Jingqiu Cheng, Wei Sun, Jianyun Wang","doi":"10.61186/","DOIUrl":"10.61186/","url":null,"abstract":"<p><strong>Objectives: </strong>Renal fibrosis represents the principal pathological characteristic of diabetic nephropathy (DN). Quercetin, a well-known flavonoid with diverse pharmacological effects, has been studied for its link to preventing DN. Previous studies indicated that SIRT5 might have significant implications in fibrotic diseases. This study investigated whether the protective effects of quercetin on DN was related to SIRT5.</p><p><strong>Methods: </strong>Three doses of quercetin (30 mg/kg, 60 mg/kg, and 120 mg/kg) were orally administered to streptozotocin-induced diabetic rats over a period of four months. Colorimetric methods were used to measure blood urea nitrogen (BUN), serum creatinine (SCr) and urine creatinine (UCr). Enzyme-linked immunosorbent assay (ELISA) was used to quantify the level of urine microalbumin (Ualb). The ratio of urine microalbumin to urine creatinine (Ualb/UCr) was calculated. Periodic acid-Schiff (PAS) stain and Masson's trichrome stain were used to observe glycogen deposition and collagen accumulation in the renal cortex, respectively. Western blot, ELISA, and immunohistochemical stain were performed to quantify the levels of SIRT5 protein in kidneys of rats.</p><p><strong>Results: </strong>Diabetic rats exhibited increased levels of SCr, BUN, and Ualb/UCr, accompanied by significant glycogen deposition and collagen accumulation in renal cortex. These changes were associated with an increased level of SIRT5 protein. Following treatment of DN rats with varying doses of quercetin, all kidney function and pathology indices showed varying degrees of reversal, accompanied by a reduction in SIRT5 protein levels.</p><p><strong>Conclusion: </strong>Quercetin ameliorated renal fibrosis in DN rats via the inhibition of SIRT5, suggesting a novel mechanism of quercetin in the treatment of DN.</p>","PeriodicalId":14610,"journal":{"name":"Iranian journal of kidney diseases","volume":"19 3","pages":"149-155"},"PeriodicalIF":0.9,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148156550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Efficacy of High-flux Hemodialysis for Treating Uremia and its Effect on Microinflammation and Nutritional Status.","authors":"Fei Guo, Jiakang Sun, Deheng Wan, Yan Wang","doi":"10.61186/","DOIUrl":"10.61186/","url":null,"abstract":"<p><strong>Introduction: </strong>The objective of this study was to evaluate the clinical efficacy of high-flux hemodialysis for treating uremia and its effect on microinflammation and nutritional status.</p><p><strong>Methods: </strong>This was a case-control study. One hundred and twenty patients under chronic hemodialysis in Qinhuangdao Haigang Hospital from June 2021 to June 2023 were randomly divided into experiment group and control groups, with 60 patients in each group. Patients in the experiment group received high-flux hemodialysis (HFHD), while those in the control group underwent conventional hemodialysis. The differences between the two groups regarding clinical efficacy, inflammatory factors including  IL-6, CRP and TNF-a, and macromolecular toxins including β2-microglobulin, parathyroid hormone, and cysteine protease inhibitor were compared. The levels of nutritional indices including serum transferrin, albumin, and hemoglobin were compared between the two groups after 6 months of therapy. All patients were followed- up for 1.5 to 2 years, and the incidence of their cardiovascular and cerebrovascular events after treatment was analyzed.</p><p><strong>Results: </strong>The response rate (markedly effective + effective)/total number of cases × 100%.) was 93% in the experiment vs. 80% in the control group (P = .03). After treatment, IL-6, CRP, TNF-a,  β2-microglobulin, parathyroid hormone, and cysteine protease inhibitor significantly reduced and serum transferrin, albumin and hemoglobin significantly improved in the experiment vs. control group (P = .00). At the end of the follow-up period the incidence of cardiovascular and cerebrovascular diseases was 7% in the experiment group, which was markedly lower than that of 22% in the control group (P = .02).</p><p><strong>Conclusion: </strong>High-flux hemodialysis is a safe and effective treatment for uremia with remarkable clinical efficacy, offering various benefits such as significant reduction of inflammatory biomarkers and macromolecular toxins, improvement of patients' nutritional status, and reduction of the incidence of cardiovascular and cerebrovascular diseases.</p>","PeriodicalId":14610,"journal":{"name":"Iranian journal of kidney diseases","volume":"19 3","pages":"165-171"},"PeriodicalIF":0.9,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148156565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Spatiotemporal Analysis of Hemodialysis Incidence Rate and Impact of the COVID-19 Pandemic on the End-Stage Kidney Disease Trend.","authors":"Naeimehossadat Asmarian, Shahrokh Ezzatzadegan Jahromi, Mahsa Banifatemi, Farnaz Niroomand, Mahsa Torabi Jahromi, Maryam Kamranpoor Jahromi, Zahra Shayan","doi":"10.52547/yqv30x70","DOIUrl":"10.52547/yqv30x70","url":null,"abstract":"<p><strong>Introduction: </strong>Limited research has been conducted on the spatial trend of end-stage kidney disease (ESKD), particularly hemodialysis (HD), in developing countries. This is problematic considering the growing demand for dialysis services in these regions. To bridge this research gap, this study evaluates the spatial trend of chronic dialysis incidence rates over a significant period (2007 to early 2021) in a large population, while also investigating the influence of the COVID-19 pandemic on this trend.</p><p><strong>Methods: </strong>We used data from the Shiraz University of Medical Sciences Specific Diseases Affairs database (2007-2021) on 8,368 dialysis patients. A Bayesian spatiotemporal model analyzed the data to estimate ESKD trends and relative risks with hemodialysis in 29 counties.</p><p><strong>Results: </strong>Among the patients receiving maintenance dialysis for end-stage kidney disease (ESKD), 3,348(40%) were female and 5,020(60%) were male. The average age was 57.58 ± 17, with a median age of 56 (2-98) years. The standardized incidence rate in 2007 was 0.78, while in 2020-21, it increased to 0.86. The estimated mean relative risk was 1.20, ranging from 0.43 to 4.35. We observed a consistent fixed trend with a coefficient of 0.99. During the COVID-19 pandemic and outside of it, we noticed an increased spatiotemporal interaction in the central and northern regions of the province, despite the temporal trend remaining relatively stable.</p><p><strong>Conclusion: </strong>Our study reveals previously unexplored geographic disparities in ESKD incidence within Fars province from 2007 to 2021. The notable increase in dialysis cases in the central and northern regions emphasizes the urgency of addressing this public health concern.</p>","PeriodicalId":14610,"journal":{"name":"Iranian journal of kidney diseases","volume":"19 3","pages":"172-180"},"PeriodicalIF":0.9,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148156490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlations between Serum Magnesium and PTH Levels and Vascular Calcification in Patients Undergoing Hemodialysis and Study of Associated Factors.","authors":"Xiaofang Wu, Qun Ding","doi":"10.61186/","DOIUrl":"10.61186/","url":null,"abstract":"<p><strong>Introduction: </strong>This study is an attempt to investigate the correlations between serum magnesium (Mg) and parathyroid hormone (PTH) levels and abdominal aortic calcification (AAC) score.</p><p><strong>Methods: </strong>This retrospective analysis was conducted on the clinical records of 101 cases undergoing maintenance hemodialysis at Liyang People's Hospital (China) between May 2021 and May 2023. The clinical features of the calcified and non-calcified groups were compared. Cardiovascular calcification was defined as intima-media thickness (IMT ) ≥1.2 mm or local thickness≥0.5 mm. Logistic regression analysis was carried out for identifying independent influencing factors of calcification. Furthermore, the correlations between these influencing factors and AAC were analysed.</p><p><strong>Results: </strong>Calcification was diagnosed in 76 patients (75.2%). In comparison to the non-calcified group, the calcified group showed markedly elevated age, dialysis duration, and phosphorus levels of (P), alkaline phosphatase (AKP), parathyroid hormone (PTH), ferritin (FER), and low-density lipoprotein (LDL). (P < .05). Conversely, the calcified group had significantly lower body mass index (BMI) and magnesium (Mg) levels compared to the non-calcified group (P < .05). Logistic regression analysis identified age (P = .006), dialysis duration (P = .002), PTH (P = .016), and Mg (P < .001) as independent influencing factors of calcification. Furthermore, age, dialysis duration, and PTH were positively bound up with AAC score (P < .05), while Mg was negatively bound up with it (P < .001).</p><p><strong>Conclusion: </strong>Mg may be a protective factor to inhibit vascular calcification. Age, dialysis duration and PTH affect the calcification process through various mechanisms.</p>","PeriodicalId":14610,"journal":{"name":"Iranian journal of kidney diseases","volume":"19 3","pages":"156-164"},"PeriodicalIF":0.9,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148156498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What Nephrologists Should Know About Infection Prevention Measures Before and During Eculizumab Administration in Children?","authors":"Shirin Sayyahfar","doi":"10.61186/","DOIUrl":"10.61186/","url":null,"abstract":"<p><p>Eculizumab is a recombinant humanized monoclonal antibody that acts as a terminal complement inhibitor. It works by binding to complement protein 5 and inhibiting its cleavage, thereby preventing the production of the complement terminal complex known as C5b-9. Eculizumab has been prescribed by physicians in Iran in both the adult and pediatric fields for the treatment of various diseases. Patients who receive this product are at an increased risk of life-threatening infections, with meningococcal disease being one of the most prevalent threats. Therefore, children receiving eculizumab, should receive meningococcal vaccine. Furthermore, the most effective method to prevent infection in these patients is a combination of vaccination and prophylactic antibiotic usage. Antibiotic prophylaxis should be initiated immediately after the initiation of eculizumab and continued for four weeks after discontinuation of the drug.  This review aims to address physicians' questions particularly pediatric nephrologists regarding any necessary changes in routine vaccinations for children receiving eculizumab. Additionally, the article discusses infections that may occur more frequently in this population and emphasizes the importance of vaccination and preventive measures. The review also aims to introduce the most up- to- date recommendations for infection prevention before and during eculizumab treatment.</p>","PeriodicalId":14610,"journal":{"name":"Iranian journal of kidney diseases","volume":"19 3","pages":"135-140"},"PeriodicalIF":0.9,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148156517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subgroup Analyses in the Treatment of Diabetic Nephropathy: A Meta-Analysis.","authors":"Yunhua Peng, Xi Chen, Qiying Yang, Mohammad Rava, MeiXue Ji","doi":"10.52547/8m2eex75","DOIUrl":"10.52547/8m2eex75","url":null,"abstract":"<p><strong>Introduction: </strong>This meta-analysis synthesizes and evaluates treatments for diabetic nephropathy, focusing on subgroup analyses to understand efficacy variations across diverse patient demographics and disease characteristics, thereby advancing personalized healthcare in diabetic kidney disease.</p><p><strong>Methods: </strong>Adhering to PRISMA guidelines, a thorough literature search across PubMed, NCBI, and Web of Science initially identified 904 studies spanning from 2015 to 2023. A meticulous screening process, involving the review of titles and abstracts and the application of stringent inclusion and exclusion criteria, refined the selection to six studies. These studies were selected for their comprehensive focus on diabetic nephropathy, availability of odds ratio data, and detailed subgroup analyses. Statistical synthesis was conducted using a random-effects model, and heterogeneity was assessed using the I² statistic.</p><p><strong>Results: </strong>Analysis of the selected studies revealed significant heterogeneity in treatment effectiveness related to patient demographics, nephropathy stages, genotypes, and other disease-specific characteristics. The overall estimated odds ratio (OR) for treatment efficacy was 2.7 (95% CI: 1.8-3.6), indicating a moderate effect size. This variation highlighted the complex interplay of genetic, environmental, and lifestyle factors in nephropathy treatment outcomes. The study also delved into the mechanistic aspects of treatment interactions with diverse nephropathy subtypes, thereby offering a deeper understanding of the efficacy of treatments within specific patient categories.</p><p><strong>Conclusions: </strong>The study underscores the critical need for personalized treatment strategies in diabetic nephropathy, providing valuable insights for healthcare professionals. It advocates for tailoring treatments to individual patient profiles to optimize outcomes, enhancing patient care quality. These findings reinforce the value of subgroup-based approaches and support evidence-based, patient-centric management in diabetic kidney disease.</p>","PeriodicalId":14610,"journal":{"name":"Iranian journal of kidney diseases","volume":"19 3","pages":"141-148"},"PeriodicalIF":0.9,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148156563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Angiotensin Converting Enzyme Gene Deletion/Deletion Genotype with Risk of Autosomal Dominant Polycystic Kidney Disease: A Single-center Study from Iranian Azeri Turkish Population.","authors":"Zahra Nasiri, Matin Mobaraki, Khadijeh Makhdoomi, Ali Taghizadeh Afshari, Morteza Bagheri","doi":"10.61186/","DOIUrl":"10.61186/","url":null,"abstract":"<p><strong>Introduction: </strong>Autosomal Dominant Polycystic kidney disease (ADPKD) is defined as one of the most common genetic disorders and the cause of kidney failure or end-stage kidney disease (ESKD). Several studies have shown that renin-angiotensin system has an important role in pathogenesis of ADPKD. The aim of this study was to examine the association between the angiotensin converting enzyme (ACE) gene Deletion/Deletion (D/D) polymorphism and risk of ADPKD among Iranian patients from west Azerbaijan province of Iran.</p><p><strong>Methods: </strong>This case-control study was conducted on 40 patients and 72 controls. Genetic polymorphism of the ACE gene was determined using polymerase chain reaction (PCR) and electrophoresis.</p><p><strong>Result: </strong>The frequency (frequency%) of ACE gene I/I, I/D, D/D genotypes were 5 (12.5%), 12 (30%), 23 (57.5%) in cases and 16 (22.22%), 30 (41.67%), 26 (36.11%) in controls, respectively. The frequency (frequency%) of ACE gene I and D alleles were 22 (27.5%) and 58 (72.5%) in cases and, 62 (43.06%) and 82 (56.94%) in controls, respectively. Statistical analysis indicated that there were significant differences among the cases and controls regarding ACE gene D/D genotypes (P = .028). The ACE gene D/D genotype was associated with increased ADPKD susceptibility with an OR of 2.39, (95%) CI =  (1.09-5.28), and P = .028. But in the case of ACE gene, I/I and I/D genotypes, there were no statistically significant differences between cases and controls (P > .05). Considering allelic comparison, the ACE gene D allele was associated with ADPKD susceptibility with an OR of 1.99, (95%) CI =  (1.1-3.6), and P = .021.</p><p><strong>Conclusion: </strong>Our findings suggest that ACE gene D/D genotype was associated with ADPKD.</p>","PeriodicalId":14610,"journal":{"name":"Iranian journal of kidney diseases","volume":"19 2","pages":"84-88"},"PeriodicalIF":0.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144158912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Prediction Model of Early Diabetic Nephropathy Based on Conventional Ultrasound Parameters and Hematological Indices and Its Application.","authors":"Yong Cheng, Xiao Yan Li, Ying Fu Ye","doi":"10.52547/bvgedh79","DOIUrl":"10.52547/bvgedh79","url":null,"abstract":"<p><strong>Introduction: </strong>Diabetic nephropathy (DN) is a chronic microvascular complication of diabetes mellitus, leading to end-stage kidney disease and increased mortality. Early detection and treatment are essential to prevent DN. This study aims to develop a diagnostic prediction model for early DN.  Methods. This retrospective analysis study was conducted on 205 patients with type 2 diabetes mellitus (T2DM) treated between September 2019 and September 2022. Patients with stage A1 albumin-to-creatinine ratio (ACR) (< 30 mg/g) were categorized as the simple diabetes mellitus group (n = 134), and those with ACR 30-300 mg/g at stage A2 were classified as the early diabetic nephropathy group (n = 71). Relevant ultrasound parameters and hematological indices were selected through univariate and multivariate screenings. A nomogram model was constructed based on the results of multi-factor screening. Internal validation was performed by using Bootstrap methods with 1000 repetitions, receiver operating characteristic (ROC) curve analysis evaluated model differentiation, calibration curves verified model consistency, and decision curve analysis assessed clinical utility.  Results. Multivariate logistic regression identified renal artery resistance index (RI), renal cortex shear wave velocity (SWV), Cystatin C (CysC), Retinol-binding protein (RBP), and Glycated Hemoglobin (HbA1C) as significant factors for early DN (all P < .05). The nomogram model showed good differentiation and consistency and has high clinical value and practicality in predicting DN.</p><p><strong>Conclusion: </strong>The prediction model for early DN, based on conventional ultrasound parameters and hematological indices, demonstrates good prediction efficiency and clinical practicability.</p>","PeriodicalId":14610,"journal":{"name":"Iranian journal of kidney diseases","volume":"19 2","pages":"89-96"},"PeriodicalIF":0.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144158909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The lncRNA OIP5-AS1/miR-181a-5p Axis Promotes TGF-β1-induced Fibrosis in HK2 Cells.","authors":"Xiaoyan Li, Hongxia Peng, Qing Feng, Shumei Zhong, Yi Li, Yingling Zheng, Guang Yang","doi":"10.52547/7wk1jf85","DOIUrl":"10.52547/7wk1jf85","url":null,"abstract":"<p><strong>Introduction: </strong>Th is study was conducted to explore the role of OIP5-AS1 in a fibrosis cell model through its interaction with miR-181a-5p.</p><p><strong>Methods: </strong>An in-vitro fibrosis model was established by inducing human renal tubular epithelial cells (HK2) with TGF-β1. The expression levels of OIP5-AS1 and miR-181a-5p in the control (Normal) and model (TGF-β1) groups were measured using Quantitative Real-time Polymerase Chain Reaction (qPCR).. qPCR and  Western Blot  (WB) were used to detect the expression of genes and proteins related to fibrosis and EMT in the two groups of cells. Subsequently, The effect of OIP5-AS1 on TGF-β1-induced fibrosis in HK2 cells was investigated by assessing cell proliferation using the CCK-8 assay and analyzing the expression of fibrosis- and EMT-related proteins through WB.. The targeting relationship between OIP5-AS1 and miR-181a-5p, as well as the influence of OIP5-AS1 on miR-181a-5p expression, was investigated using a dual-luciferase reporter assay. Subsequently, the impact of miR-181a-5p upregulation on the proliferation of TGF-β1-induced HK2 cells was examined through a CCK-8 assay.</p><p><strong>Results: </strong>The study found that TGF-β1 treatment upregulated OIP5-AS1, α-SMA, Col-IV, and FN in HK2 cells while downregulating miR-181a-5p and E-cadherin. OIP5-AS1 downregulation promoted cell proliferation and inhibited fibrosis-related proteins. MiR-181a-5p was identified as a direct target of OIP5-AS1, and its upregulation enhanced cell proliferation. Conclusion . The suppression of OIP5-AS1 attenuates TGF-β1-induced fibrosis in HK2 cells through the regulation of miR-181a-5p.</p>","PeriodicalId":14610,"journal":{"name":"Iranian journal of kidney diseases","volume":"19 2","pages":"97-105"},"PeriodicalIF":0.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Serum Phosphate Levels in Critically Ill Patients with Acute Kidney Injury Undergoing Continuous Renal Replacement Therapy Using Different Dialysates.","authors":"Moo Jun Kim, Hae Ri Kim, Young Rok Ham, Jae Wan Jeon","doi":"10.61186/","DOIUrl":"10.61186/","url":null,"abstract":"<p><strong>Introduction: </strong>Continuous renal replacement therapy (CRRT) is a recommended dialysis modality for hemodynamically unstable and critically ill patients with kidney failure. This study aimed to evaluate the effect of variations in serum phosphate levels based on the dialysate used during CRRT and to determine the impact of prognosis and mortality of patients with using dialysate solutions with diverse electrolyte compositions.</p><p><strong>Methods: </strong>We retrospectively analyzed 117 patients' records, treated with intensive CRRT, comprising 70 patients treated with Phoxilium®, and 47 patients treated with MultiBic®.</p><p><strong>Results: </strong>After 72 hours of CRRT, the Phoxilium and non-Phoxilium groups exhibited significantly different serum calcium, bicarbonate, and phosphate levels, as determined by an independent-samples t-test. (P < .05). The Kaplan-Meier analysis revealed no significant difference in survival rates between the two groups, demonstrating that the variation in serum phosphate level after 72h of CRRT did not significantly influence survival outcomes. (P = .581). The difference in serum phosphate levels after 72h of CRRT might affect respiratory muscles; however, although cumulative survival exhibited a stepwise decrease with longer mechanical ventilation duration, the two groups did not show significant difference in survival (P = .819). The incidence of hypophosphatemia was significantly lower in the group where CRRT was performed with Phoxilium dialysate containing phosphate compared to the group where CRRT was performed with non-Phoxilium dialysate, and severe hypophosphatemia did not occur. There were no significant associations between hypophosphatemia, mortality, and duration of mechanical ventilation.</p><p><strong>Conclusion: </strong>Selecting Phoxilium as a dialysate for CRRT should be considered to correct severe hypophosphatemia, prevent complications, and improve prognosis.</p>","PeriodicalId":14610,"journal":{"name":"Iranian journal of kidney diseases","volume":"19 2","pages":"106-117"},"PeriodicalIF":0.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144158914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}