Iranian Journal of Neonatology IJN最新文献

Accuracy of Urine Calprotectin in the Diagnosis of Acute Kidney Injury in Neonates: A Cross-Sectional Study 尿钙保护蛋白诊断新生儿急性肾损伤的准确性:一项横断面研究

Iranian Journal of Neonatology IJN Pub Date : 2021-10-31 DOI: 10.22038/IJN.2021.53102.1962

N. Khalesi, S. Mohammadian, N. Hooman, M. Khodadost, L. Allahqoli

{"title":"Accuracy of Urine Calprotectin in the Diagnosis of Acute Kidney Injury in Neonates: A Cross-Sectional Study","authors":"N. Khalesi, S. Mohammadian, N. Hooman, M. Khodadost, L. Allahqoli","doi":"10.22038/IJN.2021.53102.1962","DOIUrl":"https://doi.org/10.22038/IJN.2021.53102.1962","url":null,"abstract":"Background Urine calprotectin significantly elevates in acute kidney injury (AKI) in adult and pediatric patients. The present study aimed to assess the accuracy of urine calprotectin as a diagnostic marker for (AKI) in neonates.Methods This cross-sectional study assessed urine calprotectin in 100 neonates (80 newborns with confirmed AKI and 20 healthy ones). Random urine calprotectin was measured by Enzyme-linked Immunosorbent Assay (ELISA) and then compared between the two groups. We included the neonates who had received at least 48 h of intravenous fluid and met the inclusion and exclusion criteria. Receiver-operating characteristic (ROC) curve was used to set a cut-off point for urine calprotectin for the prediction of AKI. The overall accuracy and Kappa coefficient were used to assess the agreement between the two methods. A p-value less than 0.05 was considered statistically significant.Results Urine calprotectin levels were not significantly higher in neonates with AKI, as compared to those in the healthy ones (146.2 versus 142.4; P=0.1). The results pointed to an optimal cut-off value of 123.5 mg/dl for urine calprotectin with the area under the curve of 0.515 (the sensitivity, specificity, positive predictive value, and negative predictive value were obtained at 77.5%, 40%, 83.7%, and 30.7%, respectively). The overall accuracy and Kappa agreement coefficient were reported as 70% and 0.15, r (P=0.11).Conclusion As evidenced by the results of the resent study, although urine calprotectin level elevates in AKI in neonates, it is not more sensitive than gold standards to predict AKI.","PeriodicalId":14584,"journal":{"name":"Iranian Journal of Neonatology IJN","volume":"50 1","pages":"8-14"},"PeriodicalIF":0.0,"publicationDate":"2021-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85437022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early-Onset Neonatal Sepsis: A Retrospective Study among 1,119 Moroccan Newborns Admitted to the National Reference Center in Neonatology and Nutrition, Rabat, Morocco 早发性新生儿脓毒症:摩洛哥拉巴特新生儿和营养国家参考中心1119名摩洛哥新生儿的回顾性研究

Iranian Journal of Neonatology IJN Pub Date : 2021-10-31 DOI: 10.22038/IJN.2021.54250.1997

Kenza Hattoufi, M. Obtel, H. Aguenaou, A. Kharbach, A. Barkat

{"title":"Early-Onset Neonatal Sepsis: A Retrospective Study among 1,119 Moroccan Newborns Admitted to the National Reference Center in Neonatology and Nutrition, Rabat, Morocco","authors":"Kenza Hattoufi, M. Obtel, H. Aguenaou, A. Kharbach, A. Barkat","doi":"10.22038/IJN.2021.54250.1997","DOIUrl":"https://doi.org/10.22038/IJN.2021.54250.1997","url":null,"abstract":"Background: Early-onset neonatal sepsis remains a common and serious problem for neonates. The clinical manifestations of neonatal sepsis are nonspecific and have varied clinical features. Therefore, their diagnosis is based on a combination of clinical presentation, the use of biological tests, and anamnestic arguments. The purpose of this study was to describe the infection risk factors and clinical, paraclinical and evolutionary characteristics of newborns admitted for suspicion of early-onset neonatal sepsis, and to highlights the importance of C-reactive protein to diagnose neonatal sepsis. \u0000Methods: This retrospective and analytical study was conducted from January 1 to December 31, 2016, at the National Reference Center for Neonatology and Nutrition at Children's Hospital, University Hospital Centre Ibn Sina of Rabat.\u0000Results: During that period, 1199 newborns met the inclusion criteria. At admission, 52% of the cases were under the age of one day. Symptomatic newborns represented 67.4% of the cases. The hospitalized cases with one or more infectious risk factors were represented 80.3% of cases. The C-reactive protein was positive (> 20 mg/L) in 698 (58%) newborns. Univariate analysis showed that C-reactive protein value was significantly associated with age groups (p<0.001), presence of at least one infectious risk factor (p<0.001), and the presence of respiratory (p<0.001), cutaneous (p<0.001), circulatory (p=0.02), and neurological (p=0.008) symptoms. The diagnosis of early-onset neonatal infection with a meningeal, pulmonary, or ocular location was retained in 5, 2, and 0.2% of the cases, respectively. The mortality rate was 7%.\u0000Conclusion: Screening, management, and reduction of early early-onset neonatal infection remain a crucial challenge, which requires coordination between pediatricians and obstetricians to obtain reliable data and identify newborns at risk.","PeriodicalId":14584,"journal":{"name":"Iranian Journal of Neonatology IJN","volume":"24 1","pages":"30-39"},"PeriodicalIF":0.0,"publicationDate":"2021-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75938345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Neuregulin Levels and Neuregulin-1 Polymorphism with Short-term Morbidities in Preterm Neonates 神经调节蛋白水平和神经调节蛋白-1多态性与早产儿短期发病的关系

Iranian Journal of Neonatology IJN Pub Date : 2021-10-31 DOI: 10.22038/IJN.2021.46291.1781

B. Lubis, O. R. Ramayani, R. A. Ganie, G. D. Tjipta, S. H. Effendi

{"title":"Association of Neuregulin Levels and Neuregulin-1 Polymorphism with Short-term Morbidities in Preterm Neonates","authors":"B. Lubis, O. R. Ramayani, R. A. Ganie, G. D. Tjipta, S. H. Effendi","doi":"10.22038/IJN.2021.46291.1781","DOIUrl":"https://doi.org/10.22038/IJN.2021.46291.1781","url":null,"abstract":"Background Premature birth is linked to neonatal morbidity and mortality worldwide. Neuregulin (NRG) is a trophic factor from the growth factor (GF) of a transmembrane polypeptide, encoded by four different genes, including NRG-1 which acts as an endogenous protector in fetal development. Decreased levels of NRG-1 affect several organs. The relationship between NRG-1 polymorphism and the outcome of neonatal development has been widely studied. There are no studies that have assessed NRG-1 levels and NRG-1 rs35753505 C/T polymorphism in preterm neonates, as well as its association with short-term morbidities in Indonesia.Methods This cross-sectional study was conducted on preterm neonates with the gestational age of 32-36 weeks in Medan, North Sumatera, Indonesia, from December 2017 to December 2018. It aimed to evaluate the association of NRG-1 levels and NRG1 polymorphism with short-term morbidities. Samples were obtained from cord blood specimens. Enzyme-linked immunosorbent assay (ELISA) was used to determine NRG-1 levels, and NRG-1 polymorphism was sequenced by polymerase chain reaction (PCR). Observations in preterm neonates were made during the first 72 h to assess short-term morbidities.Results During the study period, 48 cord blood specimens from preterm neonates were found eligible for analysis. Preterm neonates with low NRG-1 levels had a 10-times higher risk of developing short-term morbidities. The presence of CC and CT genotypes increased the risk of developing short-term morbidities 13.33 times (P=0.003) and 6.19 times (P=0.019), respectively. The presence of the C allele in subjects' genotype increased the risk of short-term morbidities 4.04 times (P=0.001), compared to those with T allele.Conclusion As evidenced by the obtained results, preterm neonates with low NRG-1 levels had a higher risk of developing short-term morbidities. Furthermore, there was a significant association between NRG-1 rs35753505 C/T polymorphism and short-term morbidities.","PeriodicalId":14584,"journal":{"name":"Iranian Journal of Neonatology IJN","volume":"112 1","pages":"22-29"},"PeriodicalIF":0.0,"publicationDate":"2021-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80736164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impacts of the COVID-19 pandemic on health of preterm infants in Iran COVID-19大流行对伊朗早产儿健康的影响

Iranian Journal of Neonatology IJN Pub Date : 2021-10-31 DOI: 10.22038/ijn.2021.53317.1989

M. Zarkesh

{"title":"Impacts of the COVID-19 pandemic on health of preterm infants in Iran","authors":"M. Zarkesh","doi":"10.22038/ijn.2021.53317.1989","DOIUrl":"https://doi.org/10.22038/ijn.2021.53317.1989","url":null,"abstract":"Coronavirus disease 2019 (COVID-19) directly increases the risk of preterm delivery. Furthermore, the COVID-19 pandemic may indirectly impact the health status of preterm infants. In the present study we noted several views regarding the negative effects of this viral disease on postnatal health that need much consideration. \u0000Methods: A short communication study was carried out in 2020. Literatures indicating several adverse effects of COVID 19 pandemic on health of preterm neonates were reviewed. \u0000Results: Literature review has revealed that regarding the protecting newborns from infectious risk in the neonatal intensive care units (NICU), several policies have been implemented. Isolation of ill COVID-19 positive mother, mother-infant separation, interruption of skin to skin contact and breastfeeding, restrictions associated with the presence of parents in the NICUs are some of them. Moreover, postponing the follow-up consultations and lack of healthcare services are also other influencing problems. Conclusion: It seems urgent measures must be implemented to protect preterm neonates and their parents against severe consequences. Providing adequate and professional human resources in the NICUs, improvement of virtual communication for parent's involvement in the NICU admission period and postnatal follow-up appointments, promotion of exclusive breastfeeding for subjects without any contraindication, reminding vaccination schedule by calling or texting, reducing the family's financial burden by governmental support, improving mother-infant bonding with respiratory and hand hygiene are a few recommendations that could be beneficial.","PeriodicalId":14584,"journal":{"name":"Iranian Journal of Neonatology IJN","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82454339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early detection of Central Nervous System (CNS) abnormality by Neurosonography in critically ill neonates. 危重新生儿中枢神经系统(CNS)异常的早期超声检测。

Iranian Journal of Neonatology IJN Pub Date : 2021-10-31 DOI: 10.22038/IJN.2021.55001.2020

A. Taksande, R. Rao

{"title":"Early detection of Central Nervous System (CNS) abnormality by Neurosonography in critically ill neonates.","authors":"A. Taksande, R. Rao","doi":"10.22038/IJN.2021.55001.2020","DOIUrl":"https://doi.org/10.22038/IJN.2021.55001.2020","url":null,"abstract":"Background: Neurosonography has commonly used for screening in a tertiary level hospital with a neonatal intensive care unit (NICU), for early detection of Central Nervous System (CNS) defects like intra-ventricular haemorrhage (IVH), hydrocephalus, cerebral edema or any structural anomalies. in the neonates brain. Aim: To study the detection of Central Nervous System (CNS) abnormality by neurosonography in critically ill neonates. Materials and methods: This was a cross sectional study done in NICU, AVBRH, Sawangi Meghe. By taking detailed maternal history and clinical examination, neonate is described as “critically ill”. These neonates subjected to neurosonogram (NUSG) according to the inclusion and exclusion criteria as per the protocols and various anomalies noted. Gestational age, birth weight, clinical examination, investigation, neurosonography finding and outcome were evaluated. Results: Neurosonography performed in 105 critically ill neonates. Out of that, 21 had abnormal neurosonography finding. There was no significant correlation of birth weight and gestational age of high-risk neonate with abnormal neurosonograpy (p=0.538 & p=0.130). The most frequent clinical manifestation was RDS followed by neonatal seizure. The mean HR,RR, SBP,DBP and SpO2 were 140±19.81, 54.08±13.07, 90.96±8.66, 54.13±8.39 and 94.39±6.93 respectively. There was no statistically significant correlation between the vital parameters and the presence of abnormalities on neurosonography. On neurosonography, 20% of neonates had abnormal findings. About 8.57% of these had hydrocephalus, 6.6% Intraventricular haemorrhage, 1.90% has periventricular echogenicity, 0.95% had cerebral oedema, 0.95% had germinal matrix haemorrhage and 1% had brain abscess. Seventy-two neonates (68.57%) participate had positive outcome at the time of NICU discharge and 19(18.10%) were died. Conclusion: Neurosonography is a useful tool in NICU. It is acceptable and reliable modality to screen critically ill neonates and aid in early detection and management of these ill neonates.","PeriodicalId":14584,"journal":{"name":"Iranian Journal of Neonatology IJN","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86314321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

APERT SYNDROM case report APERT综合征病例报告

Iranian Journal of Neonatology IJN Pub Date : 2021-10-31 DOI: 10.22038/IJN.2021.50324.1881

Hosein Mahmoodzade, S. Mafinejad, H. Ehteshammanesh, G. Bayani

引用次数: 0

Caudal regression syndrome: A case report and literature of review 尾侧退化综合征1例报告及文献复习

Iranian Journal of Neonatology IJN Pub Date : 2021-10-31 DOI: 10.22038/IJN.2021.51887.1918

H. Babaei, M. Khosravifar

{"title":"Caudal regression syndrome: A case report and literature of review","authors":"H. Babaei, M. Khosravifar","doi":"10.22038/IJN.2021.51887.1918","DOIUrl":"https://doi.org/10.22038/IJN.2021.51887.1918","url":null,"abstract":"Abstract\u0000Introduction: Lumbosacral agenesis or caudal regression syndrome (CRS) is a rare congenital malformation that is represented with symmetrical sacrococcygeal or lumbosacrococcygeal agenesis with a varied incidence between 1 per 25000 live birth to 2.5 per 100000 live birth. Additionally, manifold abnormalities may associate CRS e.g. spinal cord malformations, cardiac malformations, lipomyelomeningocele, orthopaedic deformities, renal agenesis and neurogenic bladder, tethered-cord, sacral agenesis, and anorectal atresia\u0000Case Presentation: We report a case of a male neonate delivered to a 28-year-old diabetic mother at 38 weeks’ gestation diagnosed with CRS. In this case lumbosacral agenesis, hip dislocation, and club foot deformities along with cardiac abnormalities including, small patent dactus arteriosus (PDA), atrial septal defect (ASD), hypertrophic cardiomyopathy (HCM) without left ventricular outlet obstruction were presented. \u0000Conclusions: Having the 200-fold increased relative risk of developing CRS in infants of diabetic mothers in mind, this case report provides evidence that uncontrolled diabetes might increase the chance of CRS in the infants.","PeriodicalId":14584,"journal":{"name":"Iranian Journal of Neonatology IJN","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81042182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radiofrequency Ablation of Umbilical Cord for Reduction of Twin Reversed Arterial Perfusion Sequence: A Case Series 射频消融脐带减少双动脉灌注序列反转:一个病例系列

Iranian Journal of Neonatology IJN Pub Date : 2021-10-31 DOI: 10.22038/IJN.2021.56074.2048

F. R. Sharbaf, M. Ghaemi, M. Shirazi, Behrokh Sahebdel, M. Haghiri, F. Golshahi

{"title":"Radiofrequency Ablation of Umbilical Cord for Reduction of Twin Reversed Arterial Perfusion Sequence: A Case Series","authors":"F. R. Sharbaf, M. Ghaemi, M. Shirazi, Behrokh Sahebdel, M. Haghiri, F. Golshahi","doi":"10.22038/IJN.2021.56074.2048","DOIUrl":"https://doi.org/10.22038/IJN.2021.56074.2048","url":null,"abstract":"Objective: To evaluate the outcome of radiofrequency ablation of the umbilical cord in the reduction of Twin Reversed Arterial Perfusion (TRAP) sequence or acardiac twin in monochorionic diamniotic pregnancies.\u0000 Material and methods: In this prospective study, 25 cases of monochorionic diamniotic pregnancy with one acardiac twin underwent selected reduction using radiofrequency ablation (RFA) in the second trimester of gestational age, from 2018 to 2019 in a tertiary referral hospital affiliated to Tehran University of Medical Sciences. \u0000Results: The overall survival rate was 84%. The mean±SD of gestational age at the time of the procedure and delivery were 20.0±3.8 and 35w±6.0 days respectively. Nine neonates were admitted to the neonatal intensive care unit (NICU) and 4 miscarriages were recorded in less than 24 weeks. The procedures in all cases were technically successful in achieving selective termination.\u0000Conclusion: Radiofrequency ablation for fetal reduction in acardiac twins in monochorionic pregnancies appears to be a safe and reasonable option.","PeriodicalId":14584,"journal":{"name":"Iranian Journal of Neonatology IJN","volume":"87 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75091143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Clinical profile, mortality and short term outcome in asphyxiated neonates treated with therapeutic hypothermia in limited-resource setting, a cohort study 在资源有限的环境下，治疗性低温治疗窒息新生儿的临床概况、死亡率和短期结果，一项队列研究

Iranian Journal of Neonatology IJN Pub Date : 2021-10-31 DOI: 10.22038/IJN.2021.55472.2034

Nilesh Jain, J. Prajapati, Pramila Ramawat, D. Singh

{"title":"Clinical profile, mortality and short term outcome in asphyxiated neonates treated with therapeutic hypothermia in limited-resource setting, a cohort study","authors":"Nilesh Jain, J. Prajapati, Pramila Ramawat, D. Singh","doi":"10.22038/IJN.2021.55472.2034","DOIUrl":"https://doi.org/10.22038/IJN.2021.55472.2034","url":null,"abstract":"Objective :To evaluate the effectiveness of therapeutic hypothermia(TH) among asphyxiated newborns for reducing mortality, adverse clinical events, and short-term outcomes in comparison to asphyxiated newborns treated with standard therapy.\u0000Material and method: Non-randomised cohort study at the tertiary care center. Study population: Asphyxiated newborns admitted in NICU within 24 hrs of life meeting the lab and/or clinical criteria of Severe Birth Asphyxia. Eligible newborns who received TH were labeled as recipients and newborns who received standard care were labeled as non-recipient.\u0000Results: Out of 176 infants studied, 89 newborns received TH, and 87 newborns received standard care. Recipients of TH had 15.3% lower mortality than non-recipients (P<0.05). The incidence of adverse clinical events was similar among both groups. At discharge 73.2% among recipients vs 56.8% non recipients were neurologically normal( p=0.01). 92.6% among recipients vs 70.1% non recipients were able to breast feed (p<0.05), 30.4% of recipients vs 46.2% non-recipients required anti-epileptics(p<0.05).\u0000Conclusion: TH is effective and feasible with a decrease in the rate of death, better neurological status at discharge, and less need for anti-epileptics without increasing adverse clinical events at limited-resource settings using low-cost devices.","PeriodicalId":14584,"journal":{"name":"Iranian Journal of Neonatology IJN","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86504047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oculo-auriculo-vertebral Spectrum (Goldenhar Syndrome): Presentation of Three Cases 眼-耳-椎谱(Goldenhar综合征):3例报告

Iranian Journal of Neonatology IJN Pub Date : 2021-10-01 DOI: 10.22038/IJN.2021.56277.2054

Samet Benli, A. Çaglar, E. Taşkin, M. Aydin

{"title":"Oculo-auriculo-vertebral Spectrum (Goldenhar Syndrome): Presentation of Three Cases","authors":"Samet Benli, A. Çaglar, E. Taşkin, M. Aydin","doi":"10.22038/IJN.2021.56277.2054","DOIUrl":"https://doi.org/10.22038/IJN.2021.56277.2054","url":null,"abstract":"BackgroundThe oculo-auriculo-vertebral spectrum (OAVS) includes three closely related rare congenital diseases of different severity with an incidence of 1/3500-7000 individuals. The involvement is usually unilateral; however, bilateral involvement may also occur. In addition to craniofacial anomalies, defects in the cardiovascular, genitourinary, vertebral, and central nervous systems can be observed as well. The phenotype of the cases is highly variable. Goldenhar syndrome is the most severe form of this condition.Case reportIn total, three instructive cases of Goldenhar syndrome with different features have been reported in the present case study. The most common ear anomalies among these three cases included external auditory canal atresia, helix deformities, preauricular skin tag and/or ear pitting, microtia, and conductive hearing loss. The second case was presented with hemifacial microsomia on the more severely affected right side, and the third case had bilateral Brushfield spots and a dermolipoma ophthalmological findings.ConclusionBased on the findings of the present study, OAVS should also be considered in the differential diagnosis of the cases with facial and ear anomalies.","PeriodicalId":14584,"journal":{"name":"Iranian Journal of Neonatology IJN","volume":"19 1","pages":"96-100"},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81851846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0