Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)最新文献_第9页

Amantadine Intoxication Caused by Blood Level Elevation: Two Case Reports in Patients with Mild to Moderate Renal Dysfunction 血药浓度升高引起金刚烷胺中毒:轻中度肾功能不全2例报告

Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) Pub Date : 2021-05-10 DOI: 10.5649/jjphcs.47.264

Y. Fukuda, Yukiko Tanaka, Takako Morita, Ayako Nakanaga, Keiko Michishita, I. Nakakura, F. Kitazawa, Masahiko Tsujikawa

引用次数: 0

Risk Factor of Proteinuria in Patients Receiving Ramucirumab 接受Ramucirumab的患者蛋白尿的危险因素

Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) Pub Date : 2021-05-10 DOI: 10.5649/jjphcs.47.250

Tomoya Tanaka, Yasuko Kurata, Naotake Takase, Mayuko Himoto, Toru Shinmen, Kazuki Dan, M. Kajizono, Yasuyuki Masaoka, Akihiko Nakamoto, H. Nawa, Y. Kitamura, H. Ikesue, Nobuyuki Muroi, T. Sendo, Ikuko Miki

引用次数: 0

Retrospective Study of the Frequency of TMP/SMX Prophylaxis Use and the Incidence of Pneumocystis Pneumonia Following Systemic Corticosteroid Therapy in Intraocular Inflammatory Disease Patients 眼内炎性疾病患者全身性皮质类固醇治疗后预防性使用TMP/SMX的频率和肺囊虫性肺炎发生率的回顾性研究

Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) Pub Date : 2021-05-10 DOI: 10.5649/jjphcs.47.272

Y. Shibata, M. Hagihara, Hideo Kato, N. Asai, Yusuke Koizumi, H. Suematsu, Y. Yamagishi, H. Mikamo

引用次数: 0

Multicenter Joint Retrospective Study on the Onset of Immune-related Adverse Events by TPS in Patients Indicated for Non-small Cell Lung Cancer Pembrolizumab Monotherapy Pembrolizumab单药治疗非小细胞肺癌患者TPS发生免疫相关不良事件的多中心联合回顾性研究

Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) Pub Date : 2021-05-10 DOI: 10.5649/jjphcs.47.239

Koki Mizukami, Y. Sakata, K. Seo, Shinichiro Kitamoto, T. Mura, A. Kikkawa, Koichi Hiraki

引用次数: 0

Development of a Tube Administration Method Based on Tablet Crushing Technology Using a Rotation-Revolution Mixer 基于旋转-旋转混合器压片技术的管状给药方法的开发

Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) Pub Date : 2021-05-10 DOI: 10.5649/jjphcs.47.225

Ryoka Goto, Misa Minami, Itsuki Uno, Mizuki Yamaguchi, K. Inaba, Kousuke Takemoto, Motoki Nakao, N. Hashimoto, N. Nagai

引用次数: 0

Effect of Magnesium Oxide on the Stability of ACE Inhibitors in Simple Suspension Method 氧化镁对简单悬浮法ACE抑制剂稳定性的影响

Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) Pub Date : 2021-04-10 DOI: 10.5649/jjphcs.47.208

Y. Takano, Haruka Kabe, Kenta Mizoi, Keiko Hakoda, T. Mineno, K. Yano, T. Ogihara

{"title":"Effect of Magnesium Oxide on the Stability of ACE Inhibitors in Simple Suspension Method","authors":"Y. Takano, Haruka Kabe, Kenta Mizoi, Keiko Hakoda, T. Mineno, K. Yano, T. Ogihara","doi":"10.5649/jjphcs.47.208","DOIUrl":"https://doi.org/10.5649/jjphcs.47.208","url":null,"abstract":"In the simple suspension method, the intended medicine is suspended in hot water when administered to a patient by tube. Suspension of the laxative, magnesium oxide is reported to hydrolyze ester-type drugs. Because several angiotensin converting enzyme (ACE) inhibitors have ester bonds in their structure, magnesium oxide may cause incompatibility when suspended with an ACE inhibitor. The purpose of this study was to clarify the effect of magnesium oxide on the stability of eight kinds of ACE inhibitors in the simple suspension method. When suspended together with magnesium oxide in hot water (55 ℃ ), temocapril, delapril, captopril, and benazepril showed a significant decrease in concentration compared to when suspended alone. Enalapril, trandolapril, quinapril, and imidapril, however, showed no significant decrease. When temocapril was suspended with magnesium oxide, the concentration of its hydrolysis product temocaprilat was increased in a time-dependent manner. In addition, when temocapril was suspended in a carbonate-sodium bicarbonate buffer (pH 10.6), temocapril degradation was slower than with magnesium oxide, suggesting that the temocapril decomposition is not a simple hydrolysis caused only by pH but one requiring the presence of magnesium oxide as a catalyst. Ester structures in ACE inhibitors are intended to improve gastrointestinal absorption. Therefore, the condition of several ACE inhibitors kept in suspension with magnesium oxide causes degradation of these drugs, inhibiting their absorption and pharmacological effects. It may be necessary for pharmacists to suggest to physicians that their prescrip-tions be changed to non-degradable ACE inhibitors and/or laxatives other than magnesium oxide. liquid chromatography:","PeriodicalId":14574,"journal":{"name":"Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85988893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Case of Bilateral Breast Cancer with Severe Liver Dysfunction Caused by Simultaneous Liver Metastasis in which Chemotherapy could be Continued by Adjusting the Paclitaxel Dose 双侧乳腺癌伴严重肝功能障碍并发肝转移，通过调整紫杉醇剂量可继续化疗1例

Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) Pub Date : 2021-04-10 DOI: 10.5649/jjphcs.47.217

Junya Hashizume, Megumi Matsumoto, H. Yano, R. Otsubo, Ayako Fukushima, Kayoko Sato, Hiroo Nakagawa, H. Harasawa, Tadahiro Nakamura, H. Sasaki, T. Nagayasu, Yukinobu Kodama

引用次数: 0

Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) Pub Date : 2021-04-10 DOI: 10.5649/jjphcs.47.185

Keisuke Matsuura, Kakeru Nambu, Keisuke Ikeda, Y. Hashimoto

{"title":"Similarities of Transport Characteristics of Lipophilic Cations between Porcine Kidney Epithelial LLC-PK₁ Cells and 5-Component Liposomes","authors":"Keisuke Matsuura, Kakeru Nambu, Keisuke Ikeda, Y. Hashimoto","doi":"10.5649/jjphcs.47.185","DOIUrl":"https://doi.org/10.5649/jjphcs.47.185","url":null,"abstract":"In the previous study, we prepared phosphatidylcholine (PC) liposomes and phosphatidylserine (PS)-containing PC/PS liposomes, and investigated the uptake characteristics of lipophilic organic cations. The uptake of bisoprolol into PC/PS liposomes was significantly greater than that into PC liposomes. In the present study, we prepared the 5-component liposomes containing PC, PS, phosphatidylethanolamine, sphingomyelin, and cholesterol, and compared the uptake characteristics of lipophilic organic cations into the liposomes with that into porcine kidney LLC-PK 1 cells. The uptake of flecainide was significantly inhibited by lipophilic diphenhydramine (DPH) both in 5-component liposomes and in LLC-PK 1 cells, but not by hydrophilic tetraethylammonium. The 50 ％ inhibitory concentration (IC 50 value) for the DPH-sensitive uptake of flecainide was 1.08 mM and 657 µ M in the 5-component liposomes and LLC-PK 1 cells, respectively. In addition, the uptake of the various 11 cationic compounds both into the 5-component liposomes and into LLC-PK 1 cells was significantly correlated with their lipophilicity (Log D) values and their polar surface area (Log PSA) values. Collectively, the uptake characteristics of lipophilic cations in the 5-component liposomes was considerably similar to that of the postulated H + /lipophilic cation antiport system in LLC-PK 1 cells.","PeriodicalId":14574,"journal":{"name":"Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78707764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intervention Evaluation for All Injectable Antimicrobial Use Cases Practiced by Full-time Pharmacist in the Antimicrobial Stewardship Team 抗菌药物管理团队专职药剂师实施的所有注射用例的干预评估

Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) Pub Date : 2021-04-10 DOI: 10.5649/jjphcs.47.192

Sachiyo Obana, Akari Yoshida, Ayako Chimori, Takakazu Kuwana, K. Ueno, Hidekatsu Fukuda, Satoshi Takashima, Mitsunari Yamamoto

{"title":"Intervention Evaluation for All Injectable Antimicrobial Use Cases Practiced by Full-time Pharmacist in the Antimicrobial Stewardship Team","authors":"Sachiyo Obana, Akari Yoshida, Ayako Chimori, Takakazu Kuwana, K. Ueno, Hidekatsu Fukuda, Satoshi Takashima, Mitsunari Yamamoto","doi":"10.5649/jjphcs.47.192","DOIUrl":"https://doi.org/10.5649/jjphcs.47.192","url":null,"abstract":"The antimicrobial stewardship team (AST) plays an important role in assisting with the treatment of infectious diseases. In August 2018, we started a program to dedicate a pharmacist to the AST and performed consultations focusing on patients before receiving intravenous antibiotics and all patients receiving intravenous antibiotics. In this study, we inves-tigated the impact of full-time pharmacist interventions on antimicrobial stewardship pre- (August 2017 – July 2018) and post- (August 2018 – July 2019) intervention. The total number of consultations with the full-time pharmacist increased significantly at 71 and 252 consultations pre- and post-intervention, respectively. There was no significant difference in the intervention, and a total of 69 (pass rate 85.5 ％ ) and 230 (83.5 ％ ) prescription improvement proposals were made pre- and post-intervention, respectively ( P = 0.852). There was no difference in 30-day mortality pre- and post-intervention. Additionally, as compared to the period from August 2017 to July 2018, that is, before the intervention, Antimicrobial Use Density (AUD) / Days of Therapy (DOT) for carbapenem antibiotics decreased from 0.73 to 0.58 during the intervention period ( P = 0.004). Based on these results, we suggest that the implementation of aggressive consultations and interventions by the full-time pharmacist is useful for promoting the appropriate treatment.","PeriodicalId":14574,"journal":{"name":"Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73280308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Pharmacist Intervention on the Incidence of Postoperative Nausea and Vomiting and the Anesthesiologist’s Decision on Preventive Measures 药师干预对术后恶心呕吐发生率的影响及麻醉医师对预防措施的决定

Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) Pub Date : 2021-04-10 DOI: 10.5649/jjphcs.47.179

Kenzo Ikari, Shinya Suzuki, H. Seki, Kanako Nomura, Yayoi Sotozono, Ranko Yoshida, Takako Sakaue, Tomokazu Ito, T. Arase, S. Hayashi

{"title":"The Impact of Pharmacist Intervention on the Incidence of Postoperative Nausea and Vomiting and the Anesthesiologist’s Decision on Preventive Measures","authors":"Kenzo Ikari, Shinya Suzuki, H. Seki, Kanako Nomura, Yayoi Sotozono, Ranko Yoshida, Takako Sakaue, Tomokazu Ito, T. Arase, S. Hayashi","doi":"10.5649/jjphcs.47.179","DOIUrl":"https://doi.org/10.5649/jjphcs.47.179","url":null,"abstract":"Postoperative nausea and vomiting (PONV) are common and unpleasant postoperative complications. Although guidelines recommend preventative measures according to PONV risk, anesthesiologists do not always follow the guidelines. In this study, we investigated whether the pharmacists ʼ proposal of a PONV prevention method to anesthesiologists in accordance with the guidelines affected the decision-making of anesthesiologists and subsequent PONV development. Two hundred and five patients who underwent gynecological surgery at Keiyu Hospital were included in this study, and the number of preventative measures selected by an anesthesiologist and frequency of PONV complications before and after the pharmacists ʼ intervention were determined. After the intervention, the number of preventative measures imple-mented by the anesthesiologist increased in the PONV moderate- and high-risk groups ( P < 0.01) and incidence of PONV in patients decreased [odds ratio 0.362 (95 ％ confidence interval 0.174 – 0.726) ( P < 0.01)]. It is the intention of anesthesiologists for pharmacists to evaluate PONV risk and propose preventative measures that comply with guidelines to anesthesiologists. The results of this study show that the proposal of pharmacists on PONV prophylaxis affects anesthesiologists ʼ decision-making and is effective in preventing PONV.","PeriodicalId":14574,"journal":{"name":"Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75199646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0