Issues and Development in Health Research Vol. 4最新文献_第2页

Recent study on Laboratory Development Cellular Immune Features and Immune Interference of Prototype Eschericia Coli and Pseudomonas Aeruginosa Combined Bacterins in a Lapin Model Lapin模型中大肠杆菌与铜绿假单胞菌复合菌原型的实验室发育、细胞免疫特性及免疫干扰研究进展

Issues and Development in Health Research Vol. 4 Pub Date : 2021-08-21 DOI: 10.9734/bpi/idhr/v4/4165f

I. Shnawa, Ferial J. Abd, Assel H. Neama

{"title":"Recent study on Laboratory Development Cellular Immune Features and Immune Interference of Prototype Eschericia Coli and Pseudomonas Aeruginosa Combined Bacterins in a Lapin Model","authors":"I. Shnawa, Ferial J. Abd, Assel H. Neama","doi":"10.9734/bpi/idhr/v4/4165f","DOIUrl":"https://doi.org/10.9734/bpi/idhr/v4/4165f","url":null,"abstract":"Bacterial vaccines, the bacterins are of both prophylactic and therapeutic potential s .Autogenous bacterins ,however, are of profound importance in certain clinical settings like complicated urinary tract infections. The aim of the present work was at development, cellular immune features and immune interference of combined E.coli and P,aeruginosa in rabbits. Single E.coli and single P. aeruginosa as well as balanced [1xE-1xP,2xE-2x P strength], and unbalanced [1xE-2xP, 2xE-1xP strength] heat killed bacterin combinations were prepared, developed and evaluated on laboratory scale. The developmental features were found; pure, safe, antigenic and immunogenic. These combined bacterins induced an increase in mitotic index of bone marrow cells, significant leukocyte inhibitory factors, increased spleen body index. Balanced one x and two x combined bacterins induced higher IL10 mean values than normal. 2x strength bacterin combinations initiate higher IL2 concentration mean values than single bacterin and control. Both of the unbalanced bacterin combinations were rising up the TNF alpha concentration means than that of single bacterin and control. In practical sense, the immune interference in rabbits primed with the study bacterin combination lead to, either of three results as; one damp the other, one enhance the other and one doesn’t affect the other. The immune interference appeared in the form of; one enhance the other like that of IL2 and IL10 cytokine responses. The present findings are being novel in cases of Pseudomonas lung and urinary tract infections as potential experimental therapeutic bacterin. As well as they may be of help in cases of cancer immunotherapy in man and laboratory animals.","PeriodicalId":14517,"journal":{"name":"Issues and Development in Health Research Vol. 4","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81762705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determining the Impact of the Interactions of CYP2B6*6 and CYP2A6 Polymorphisms on the Treatment of Nicotine Dependence 确定CYP2B6*6和CYP2A6多态性相互作用对尼古丁依赖治疗的影响

Issues and Development in Health Research Vol. 4 Pub Date : 2021-08-21 DOI: 10.9734/bpi/idhr/v4/3964f

Yawo M Akrodou

{"title":"Determining the Impact of the Interactions of CYP2B6*6 and CYP2A6 Polymorphisms on the Treatment of Nicotine Dependence","authors":"Yawo M Akrodou","doi":"10.9734/bpi/idhr/v4/3964f","DOIUrl":"https://doi.org/10.9734/bpi/idhr/v4/3964f","url":null,"abstract":"Introduction: Nicotine metabolising enzymes CYP2B6 and CYP2A6 are implicated in the treatment of nicotine addiction.Even though evidence suggests they may interact to influence nicotine dependence treatment outcomes in terms of nicotine dependence and withdrawal syndromes, as well as therapy types (placebo, bupropion, and NRT), the importance of their interaction in nicotine cessation has yet to be fully substantiated and clarified. \u0000Methods: A total of 1862 people were analysed, including Caucasians and African Americans. The Fagerstrom Test for Nicotine Dependency (FTND) and Wisconsin Inventory of Smoking Dependence Motives (WISDM) measures were used to assess nicotine dependence and withdrawal syndrome, respectively. Participants were needed to smoke at least ten cigarettes per day and to use one of three types of therapy (placebo, NRT, or bupropion) for two weeks before reporting their quitting status six months later. Participants were also screened for SNPs CYP2A6*1A (rs1137115), *1H (rs616636070),*4A (rs28399434), *9A (rs28399443),*12A (rs28399442), and CYP2B6*6(rs3745274) for nicotine genotype analysis. \u0000Results: The chi-squared test revealed that gene variations were consistently distributed in the population withp-values > 0.05. According to logistic regression analysis, CYP2A6*4A was most significantly associated with the odds ratio (OR) of quitting smoking in each treatment group with nicotine dependence syndrome (OR=1.61, 95% CI 1.31-1.96), and *4A in individuals with nicotine withdrawal syndrome (OR=1.70, 95% CI 1.15-1.95). In the bupropion group, the ANOVA test revealed a significant main interaction effect between CYP2B6*6, *1A, *4A, and *12A gene variants. \u0000Conclusion: CYP2A6 and CYP2B6*6 may interact to improve the chances of nicotine addiction treatment success.","PeriodicalId":14517,"journal":{"name":"Issues and Development in Health Research Vol. 4","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82974390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mid-Arm Circumference and Triceps Skin-Fold Thickness in Rural School Children: A Cross Sectional Study 农村学龄儿童中臂围与三头肌皮肤褶厚的横断面研究

Issues and Development in Health Research Vol. 4 Pub Date : 2021-01-01 DOI: 10.9734/bpi/idhr/v4/4454f

S. Kolekar, S. Sawant

引用次数: 1

Etiological Evaluation of Pancytopenia in a Tertiary Care Hospital: A Prospective Study 三级医院全血细胞减少症的病因学评价:一项前瞻性研究

Issues and Development in Health Research Vol. 4 Pub Date : 2016-11-07 DOI: 10.9734/bpi/idhr/v4/4150f

A. Dasgupta, S. Padma, K. Sajitha, Jayaprakash Shetty

{"title":"Etiological Evaluation of Pancytopenia in a Tertiary Care Hospital: A Prospective Study","authors":"A. Dasgupta, S. Padma, K. Sajitha, Jayaprakash Shetty","doi":"10.9734/bpi/idhr/v4/4150f","DOIUrl":"https://doi.org/10.9734/bpi/idhr/v4/4150f","url":null,"abstract":"Background : Pancytopenia is not a disease by itself, however it is a common hematological problem characterized by simultaneous presence of anemia, leucopenia and thrombocytopenia. The disease pattern associated with pancytopenia varies with geographic location, age group, nutritional status, drug intake and prevalence of infective disorder. This prospective study was to investigate and identify different causes of pancytopenia with frequency, to ascertain percentage of occurrence of pancytopenia, to determine its incidence in relation to sex and age, and to compare findings with those of other similar studies. Methods: 80 patients diagnosed with pancytopenia were clinically evaluated, with complete blood count, peripheral smears, and bone marrow aspiration-biopsy whenever possible in Justice K. S. Hegde Hospital attached to Nitte University, Deralakatte, Mangalore, from June 2012 to June 2014. Results: Among the 80 cases analyzed, most of the cases were seen in the age group of 41-50 years, with male predominance. Hypersplenism (28.75%), malaria (16.25%) and megaloblastic anemia (13.75%) were the three commonest causes in our hospital. In 13 cases of malaria, Plasmodium vivax (8 cases) was most commonly noted. Conclusion: The present study concludes that varied causes of pancytopenia can be attributed to the geographic area, nutritional and drug intakes, personal habits, infective causes, stringency of diagnostic criteria, and differences in methodology used. Hence, a detailed clinical history and meticulous examination along with hematological investigations provide invaluable information in the complete workup of patients with pancytopenia for understanding the disease processes, planning further investigations and management, and ascertain the cause.","PeriodicalId":14517,"journal":{"name":"Issues and Development in Health Research Vol. 4","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88654960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4