International Journal of Pharmaceutical Sciences and Nanotechnology最新文献

{"title":"Black Fungus: Pandemic Devastating India?","authors":"Biswajeet Acharya, P. K. Sahu, G. Pattnaik, A. Behera, Santosh Kumar Ranajit, Dinesh Kumar Sharma, A. Meher","doi":"10.37285/ijpsn.2022.15.2.9","DOIUrl":"https://doi.org/10.37285/ijpsn.2022.15.2.9","url":null,"abstract":"Black fungus is the latest threat to the patients who just recovered from the covid-19. Black fungus is a type of mucormycosis infection, predominantly seen in patients with co-morbidities, mainly diabetes, cancer, immunocompromised infections, and organ transplant. Rising black fungus cases are not only a major aesthetic problem disrupting the medical and socioeconomic system, but it also senses another upcoming pandemic in India. Black fungus has a clinical appearance that is indistinguishable from other common illnesses at first, and it is invariably deadly unless diagnosed early or untreated vigorously. Rapid and precise diagnostic procedures, as well as the availability of less toxic, more effective antifungal drugs like posaconazole and isavuconazole, should be pursued as targets for improved black fungus care. The liposomal Amphotericin B had brought new rays of hope for treating black fungus by providing better efficacy amongst people. Since there is a dearth of literature regarding the management of black fungus patients, the article focused on the incidences, prevalence, diagnosis, and treatment protocol, to gain insight into the extent of this epidemic in India in 2021.","PeriodicalId":14382,"journal":{"name":"International Journal of Pharmaceutical Sciences and Nanotechnology","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74563108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Characterization of topical microemulsion as novel drug delivery system for Dapsone","authors":"Anjali Bedse, Ajinath Nikam, Aditi Kulkarni, V. Potnis, S. Dhamane","doi":"10.37285/ijpsn.2022.15.1.8","DOIUrl":"https://doi.org/10.37285/ijpsn.2022.15.1.8","url":null,"abstract":"Dapsone is a Biopharmaceutical Classification System class II drug with anti inflammatory, immunosuppressive, antibacterial, and antibiotic properties and is  used as an antileprotic. The purpose of the present study was to investigate the  potential of a microemulsion formulation for topical delivery of dapsone to enhance  permeation and to avoid systemic side effects. When administered orally, dapsone  undergoes hepatic metabolism. Its hepatic metabolite, dapsone hydroxylamine,  shows systemic side effects such as hemolytic anaemia peripheral neuropathy,  nausea, and headache. A novel drug delivery system in the form of a microemulsion  was developed for dapsone. This is the first attempt that dapsone has been  combined with chaulmoogra oil in a topical microemulsion. The primary drugs used  for the treatment of leprosy are found in chaulmoogra seeds. Considering its good  solubilizing capacity and its use in the treatment of leprosy, chaulmoogra oil was  chosen as the oil phase. Based on emulsification ability, Cremophor RH40 and PEG  400 were selected as surfactant and co-surfactant, respectively. A pseudo-ternary  phase diagram was constructed to identify the microemulsion region. Smix  (Cremophor RH40: PEG-400 in the ratio of 1:2) was most effective in imparting  stability to the formulation. The selected formulation exhibited appropriate  diffusion behavior (in vitro). The developed dapsone containing microemulsion  formulation exhibited the optimal homogeneity, clarity, pH, type of microemulsion,  viscosity, percent drug content, and percent transmittance to qualify as a topical  drug delivery system for local treatment of leprosy.  ","PeriodicalId":14382,"journal":{"name":"International Journal of Pharmaceutical Sciences and Nanotechnology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86052819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guidelines for Nano pharmaceutical products for regulatory approval","authors":"Bikash Medhi Bikash Medhi","doi":"10.37285/ijpsn.2022.15.1.1","DOIUrl":"https://doi.org/10.37285/ijpsn.2022.15.1.1","url":null,"abstract":"Introduction \u0000The word 'nano' refers to a Greek prefix that means  'dwarf' or very little,' and represents a thousand  millionth of a meter (10-9) in length. Nanoscience and  nanotechnology are the study and application of  nanoscale range materials. Initially, the term  Nanotechnology was used by N. Taniguchi in 1974 at an  international conference on industrial production in  Tokyo to characterize the super-thin processing of  materials with nanometre accuracy and the fabrication of  nano-sized systems (Bayda S. et al., 2020). The usage of  nanomaterials has enhanced the application of  nanomedicine in various therapeutics area with  challenges and limitations over the last ten years.  Alteration of the physiochemical, biological, mechanical  & other properties of the materials made the  nanomaterials and it can be utilized in different useful  activities such as drug development, drug target.  Nanotechnology utilized novel nanomaterials to make  useful products. This technology has been used to  overcome the limitations & challenges in different drug  therapies. (Harea JI et al., 2017).   \u0000The combination of nanotechnology with  pharmaceuticals and biomedicals is termed nano  pharmaceutical. Nanopharmaceuticals is a new  technology in current practice. As a result, there are no  widely agreed nanopharmaceuticals guidelines. The  general idea of regulatory requirements for Active  Pharmaceutical Ingredients (API), as stated in the  CDSCO's New Drugs and Clinical Trial Rules 2019, was  mandatory in drug development pathways. These criteria  are also in line with the International Council for  Harmonization (ICH) recommendations and  international standards that other countries using such  items follow. New Drugs and Clinical Trials Rules, 2019  should be followed in different drug development. (Harea  JI et al., 2017).   \u0000 Globally, there are important guidelines developed by  the United States Food & Drugs Administration  (USFDA), International Council for Harmonization  (ICH), or Organization for Economic Co-operation and  Development (OECD). (Harea JI et al., 2017).   \u0000 Current regulatory approaches by US Food & Drug  Administration (FDA), established the nanotechnology  task force in August 2006. This regulatory approach  encourages the development of nanoproducts. FDA has  issued the guidelines in 2007 to the industry to address  the benefits & risks of Drugs, medical devices, and other  nanoproducts. FDA is also working with other U.S.  government agencies to focus on the safety & efficacy of  nanoproducts and U.S. initiates the National  Nanotechnology Initiative (NNI) which is a federal  research & development program to coordinate the effort  of all government agencies involved in nanotechnology.  The main goal of the NNI is to maintain the class of  research & development program, encourage inducing  the new technologies in the product, developing the supporting infrastructure & tools needed for  nanotechnology (Ventola et al., 2012). ","PeriodicalId":14382,"journal":{"name":"International Journal of Pharmaceutical Sciences and Nanotechnology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87756474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review on nano-emulsion based gel formulations: emulgel, technology and recent advances","authors":"Prashant Gupta, D. Patel","doi":"10.37285/ijpsn.2022.15.1.3","DOIUrl":"https://doi.org/10.37285/ijpsn.2022.15.1.3","url":null,"abstract":"Dermatological products are being used for treating skin infections and pain  /inflammation related disease from ancient times. The topical drug delivery  provides many advantages over the other routes of drug administration. Apart from  conventional dosage forms like creams, powders, lotions, gels, ointments,  researchers are exploring new modifications in the dosage form for improved drug  penetrations and enhanced pharmacodynamic activity of poorly absorbed drugs  from the skin. Existing topical formulations are associated with the problems like  stability, stickiness, irritation, lower spreadability, limited drug permeability and  absorption. Formulation of Nano-emulsion based gels (Emulgel) is proved to be  prominent approach for overcoming the barriers associated with the conventional  dosage forms. Emulgels are prepared by screening oils, surfactant and co-surfactant  on the basis of drug solubility. Nano-Emulsion is prepared using suitable techniques  and then embedded into the gel matrix for skin application. Drug present in the oil  portion in the micelles form (less than 500nm globule size) provides more area for  absorption thereby more penetration and therapeutic activity. Emulgel processes  desirable properties like greaseless, spreadability, emollient, non-staining, good  consistency and improved organoleptic characteristics. Permeations enhancers are  also explored for enhancing the penetration of drug incorporated in the Emulgel. ","PeriodicalId":14382,"journal":{"name":"International Journal of Pharmaceutical Sciences and Nanotechnology","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76034421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of artificial intelligence in the pharmaceutical industry on working culture: Review","authors":"D. Devendra, Dr.Akash Singh Panwar Akash, Dr.Megha Verma, Pradeepgolani, Sanjay A Nagdev","doi":"10.37285/ijpsn.2022.15.1.5","DOIUrl":"https://doi.org/10.37285/ijpsn.2022.15.1.5","url":null,"abstract":"The pharmaceutical and healthcare industries have benefited greatly from artificial  intelligence in recent years. A wide range of pharmaceutical fields, such as this novel  approach, showed potential in drug discovery, continuous manufacturing (CM),  dosage form design, and quality control. This article focuses on the use of artificial  intelligence in the pharmaceutical sector. Before all else, the film sheds light on how  AI will be implemented into health care, as well as its potential benefits. To  conclude, there are several hurdles to overcome in the project implementation. At  present, it's no secret that artificial intelligence (AI) and genetic algorithms (ANNs)  are becoming increasingly popular in the pharmaceutical industry. In the  pharmaceutical industry, artificial intelligence (AI) has shown promise, and it can be  used in combination with robotics. Physical robots could revolutionize the  healthcare industry. To keep their minds sharp and alert, it's used as a social  interaction guide with elderly patients. In the pharmaceutical industry, artificial  intelligence (AI) will help reduce costs and time.  ","PeriodicalId":14382,"journal":{"name":"International Journal of Pharmaceutical Sciences and Nanotechnology","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87988353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poly-Herbal Formulations: Current Status and Future Perspectives for Treatment of Various Complications","authors":"K. V. Madhav, Aksa Maheen, Kiranmai Mandhava","doi":"10.37285/ijpsn.2021.14.6.1","DOIUrl":"https://doi.org/10.37285/ijpsn.2021.14.6.1","url":null,"abstract":"In customary medication, the greater part of infections has been treated by reveling of plant or plant items. As indicated by the Ayurveda individual herbs are deficient to accomplish an ideal restorative impact. To conquer this issue numerous spice structure in certain proportion is utilized that will give a superior restorative impact in better manner with decreased harmfulness. To grow such mediation, current examination will address about polyherbal formulation uses and its outline in treatment of different diseases and ailments. Home grown medications have existed worldwide since long time ago, therefore they bear history, and they were utilized in Chinese, Egyptian and Indian medications for different treatment. This review primarily centers around significance of polyherbal and its clinical importance. ","PeriodicalId":14382,"journal":{"name":"International Journal of Pharmaceutical Sciences and Nanotechnology","volume":"84 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75908593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antitumor Efficacy of Silver Nanoparticles Biosynthe-sized from Marine Red Seaweed Halymenia porphyroides Boergesen on Dalton’s Lymphoma Ascites in Mice","authors":"V. Manam, S. Murugesan","doi":"10.37285/ijpsn.2021.14.6.5","DOIUrl":"https://doi.org/10.37285/ijpsn.2021.14.6.5","url":null,"abstract":"The biosynthesized silver nanoparticles from marine red seaweed Halymenia porphyroides against Dalton’s lymphoma ascites (DLA)-induced tumor inoculation was studied for antitumor activity. The biosynthesized silver nanoparticles from marine red seaweed Halymenia porphyroides were given orally to Swiss albino mice (50 mg/kg/day) for 14 days showed a significant reduction in body weight, packed cell volume, andviable tumor cell count when compared to the mice of the DLA control group.The haematological parameters of the treatment group with biosynthesized silver nanoparticles also exhibited increased haemoglobin, RBCs, Platelets, and decreased WBCs compared to the DLA control group of mice. Similarly, the biochemical parameters like total cholesterol, aspartate amino-transferase (AST), alanine aminotransferase (ALT), triglycerides (TL), and alkaline phosphatase (ALP) of the treatment control group with biosynthesized silver nanoparticles reversed the parameters to normal levels compared to the DLA control group of mice. The antitumor efficacy of the biosynthesized silver nanoparticles from Halymenia porphyroides was confirmed based on the haematological, biochemical, life span, packed cell volume, cell count, and histopathological analysis. ","PeriodicalId":14382,"journal":{"name":"International Journal of Pharmaceutical Sciences and Nanotechnology","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73565179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoliposomal Topical Formulation for Increasing Safety and Combating Microbial Drug Resistance in Leprosy","authors":"Deep Patel, Deepa H. Patel, D. Talele","doi":"10.37285/ijpsn.2021.14.6.7","DOIUrl":"https://doi.org/10.37285/ijpsn.2021.14.6.7","url":null,"abstract":"Nanoliposomes were prepared using solvent injection method and topical spray using simple dispersion method. The particle size and % Entrapment Efficiency were found 18.01 ± 0.21 nm and 87.71 ± 0.12% respectively. TEM studies showed that the particles were in spherical shape. Drying time, volume per spray, area of film and dose uniformity were found to be 280 ± 0.002 sec, 0.16± 0.021 ml, 155.57 ± 0.012 cm2 and 0.15± 0.0012 ml respectively which showed good spraying conditions on the affected area. Stability study shows that dapsone and chaulmoogra oil loaded nanoliposomal topical spray was stable at accelerated condition up to 1 month. The present investigation provides a safe approach by improving the outer membrane permeability to combat microbial drug resistance and increasing safety in leprosy treatment. ","PeriodicalId":14382,"journal":{"name":"International Journal of Pharmaceutical Sciences and Nanotechnology","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81434534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and Evaluation of Efavirenz Loaded Solid Lipid Nanoparticle for Boosting Oral Bioavailability","authors":"Harshita Gupta, Ashish K. Srivastava","doi":"10.37285/ijpsn.2021.14.6.8","DOIUrl":"https://doi.org/10.37285/ijpsn.2021.14.6.8","url":null,"abstract":"Present work illustrates that efavirenz-loaded solid lipid nanoparticles were prepared with the objective of increasing bioavailability and protection of drugs due to biocompatible lipidic content. Efavirenz is generally used for the treatment of HIV. Selection of the suitable lipid phase, surfactant, and cosurfactant was done by individual screening method with the construction of pseudo-ternary phase study. The formulations were prepared by the microemulsion method followed by the lyophilization technique. EFV-SLN has shown a mean particle size of 55.73 ± 3.9 nm having a PDI of 0.153 ± 0.451. Zeta potential was found to be -9.98mV and the formulation was found stable. In vivo pharmaco-kinetic studies exhibited 5.41-fold enhancement in peak plasma concentration (","PeriodicalId":14382,"journal":{"name":"International Journal of Pharmaceutical Sciences and Nanotechnology","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83191763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Silico Studies of Bioactive Compounds from Hibiscus rosa-sinensis Against HER2 and ESR1 for Breast Cancer Treatment","authors":"K. Agrawal, Y. Murti, Jyoti, N. Agrawal, Tripanshu Gupta","doi":"10.37285/ijpsn.2021.14.6.3","DOIUrl":"https://doi.org/10.37285/ijpsn.2021.14.6.3","url":null,"abstract":"The most common type of cancer and the second biggest cause of death is breast cancer. The disease is the leading cause of death in women aged 45 to 55. It's a multi-stage disease in which viruses have a role in one stage. Breast cancer is an illness that affects the sufferer, their family, and the entire community all over the world. Breast cancer has no established cause, however specific risk factors have been found. Age, race, gender, and family history are all fixed and immutable characteristics. Other elements, such as social and familial support, can help to mitigate the harmful effects.The aim of the present study was to investigate the bioactive ligand for the breast cancer treatment against the HER2 and ESR1 proteins by molecular docking studies. HER2 is an oncogene and membrane tyrosine kinase that is overexpressed and gene amplified in about 20% of breast tumours. When active, it sends proliferative and anti-apoptotic signals to the cell. It is the most important factor in the genesis and progression of breast cancer tumours. To carry out this work protein structures were download from the PDB database and ligands three dimensional structures were downloaded from the PubChem database. The docking was performed by using the iGEMDOCK software suit. The binding energies of bioactive molecules from Hibiscus rosa-sinensis were found to be Rutin (-139.779, -102.743), Quercetin (-106.5, -99.7807), Kaempferol (-105.824, -92.5271), Myricetin         (-111.913, -99.603) and Methotrexate (-140.69, -130.165) against HER2 and ESR1 proteins respectively. Lowest energy of Rutin compared to Methotrexate showed highest binding among the other bioactive molecules.The binding energies of the molecules are the sum of hydrogen bond, vanderwaal’s and electrostatic energies that inversely linked to protein-ligand interaction. From the result of the current study we can conclude that among the four bioactive molecule rutin has lowest binding energy so it could be used as an inhibitor of HER2 and ESR1 protein for the treatment of breast carcinoma in future. ","PeriodicalId":14382,"journal":{"name":"International Journal of Pharmaceutical Sciences and Nanotechnology","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78068550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}