International journal of scientific research最新文献

{"title":"STUDY OF PLATELET INDICES AS PROGNOSTIC MARKERS IN COVID-19","authors":"Nayana L, Rajesh H Chandan, P. Kalagi, N. S. Kamkeri, Purushotham Reddy","doi":"10.36106/ijsr/8100894","DOIUrl":"https://doi.org/10.36106/ijsr/8100894","url":null,"abstract":"Background: Platelet distribution width and mean platelet volume are markers of platelet activation. Platelets are not only involved in hemostasis\u0000and coagulation, but play a signicant role in innate immunity and inammatory response. Excess production of cytokines and acute phase\u0000reactants affect megakaryopoiesis resulting in the release of immature platelets from the bone marrow altering platelet indices. In this study we\u0000aimed to investigate the relationship of platelet indices in RTPCR proven COVID-19 patients and non COVID patients. Methods: An\u0000observational comparative two group cohort clinical study was conducted on 200 COVID-19 patients and 100 normal individuals. The platelet\u0000indices like Platelet count, Mean platelet volume (MPV), Platelet distribution width (PDW), Platelet large cell ratio (P-LCR) and Plateletcrit (PCT)\u0000were compared among two groups. Results: Platelet count in COVID-19 patients were low (p<0.001) compared to controls. P-LCR was also\u0000signicantly decreased in COVID-19 patients in comparison to non-COVID individuals. MPV, PDW and PCT were high in COVID 19 patients in\u0000comparison to controls, but was not signicantly raised in a large number of cases. Conclusion: Platelet indices like platelet count, MPV, PDW, PLCR and PCTare simple, cost effective and easily available laboratory parameters from routinely used automated hematology analyzers which are\u0000signicantly altered in COVID-19 infection and thereby can be used as biomarkers in COVID-19.","PeriodicalId":14358,"journal":{"name":"International journal of scientific research","volume":"32 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141057893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AN OBSERVATIONAL STUDY ON SURGICAL CHARACTERISTICS, MANAGEMENT MODALITIES AND SHORT-TERM TREATMENT OUTCOMES OF DIABETIC FOOT ULCERS AT A TERTIARY HOSPITAL","authors":"Arunava Jana, Diptangshu Das, Manojit Barman, Lita Bag","doi":"10.36106/ijsr/7605172","DOIUrl":"https://doi.org/10.36106/ijsr/7605172","url":null,"abstract":"Background: Diabetic foot ulcers (DFUs) are serious consequence of poorly controlled diabetes. DFUs are a therapeutic challenge in developing\u0000countries. This observational study aimed to analyse surgical characteristics, management modalities and short-term treatment outcomes of DFUs.\u0000Methods: This study was conducted on 155 patients. Data covering detailed history, management modalities and short-term outcomes were\u0000collected through an interviewer-administered structured questionnaire. Results: Mean age of patients is 58.32 ± 14.24 years, comprising 57.4%\u0000males. 54.8% patients belong in upper-lower class. 51.6% had diabetes for 5-10 years, 54.8% with very poor HbA1C > 10%. Ulcers involving the\u0000toes 34.8% and 82.6% ulcers were > 3 cm². Severe DFUs (Wagner grade 3-5) were seen in 75.4% of patients. Main intervention was surgical\u0000debridement. 37.4% suffered from SSI; revision amputation was done in 11.6% patients. Mean length of hospital stay 19 ± 12.1 days and mortality\u0000rate was 1.33%. Conclusion: Majority of patients had advanced DFUs. Larger prospective study should be done for proper management.\u0000Screening and proper evaluation can reduce complications.","PeriodicalId":14358,"journal":{"name":"International journal of scientific research","volume":"39 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141046232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASSESSMENT OF THE PHYSICAL AND MENTAL WELL-BEING AMONG INDIAN SURGEONS: A CROSS-SECTIONAL STUDY","authors":"Prakruti Gabhawalla, Aditi Advilkar, Shalaka Indap, Rajeev Joshi","doi":"10.36106/ijsr/0701113","DOIUrl":"https://doi.org/10.36106/ijsr/0701113","url":null,"abstract":"Current literature on physical and mental health of a surgeon in India is scarce. We conducted a questionnaire-based cross-sectional, descriptive\u0000study across surgical trainees and consultants and studied multiple aspects of the surgeons' physical and mental well-being. 75.72% (262/346) of\u0000surgeons reported experiencing work-related musculoskeletal disorders of varying degrees as a direct result of their work. Moreover, out of 346\u0000surgeons, 66% (228 surgeons) reported that they feel emotionally exhausted after work, several times a month or every day. 33% (114 surgeons)\u0000admitted to having no feelings or an impersonal response towards patients and 50% (173 surgeons) had a low sense of personal accomplishments.\u0000It is suggested that surgeons become aware of their state of well-being, given the inevitability of physical and mental fatigue in a surgical career, and\u0000take measures to improvise their quality of life.","PeriodicalId":14358,"journal":{"name":"International journal of scientific research","volume":"27 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CAUSES OF BLINDNESS IN PATIENTS WHO CAME FOR BLINDNESS CERTIFICATE IN TERTIARY EYECARE INSTITUTE OF OPHTHALMOLOGY IN WESTERN INDIA DURING THE YEAR 2019-2021","authors":"Rutvi Parmar, Kamini Prajapati, Abhishek Chauhan","doi":"10.36106/ijsr/4902104","DOIUrl":"https://doi.org/10.36106/ijsr/4902104","url":null,"abstract":"Purpose: To analyse applications of blindness certicate to nd out causes of blindness in tertiary eyecare Institute of Ophthalmology in western\u0000India. Methods: Data was collected from patients coming to tertiary eyecare Institute of Ophthalmology in western india during the course of 2\u0000years from 2019 to 2021. Patients were explained about the procedure and written consent was taken. After thorough examination, nal diagnosis\u0000was made.. In this study patients with blindness impairment > 40% who were entitled to government benets were taken. All patients were\u0000analysed and categorised according to age group and aetiology. The visual impairment percentage was given to them by using disability percentage\u0000and denition proposed by International Classification of Disease 11 (ICD 11, 2018) Results: and then compared with other studies. 200 patients\u0000who came for blindness certicate at our institute were included in our study. Out of this, 29% belonged to 46-60 year age group. 136 patients (68%)\u0000were found to be 100% visually disabled and eligible for all benets and concessions. Retinal diseases were the commonest cause for visual\u0000disability in the age group between 46-75 years (23%). Retinal diseases were the commonest cause fo Conclusion: r visual disability in elders. In\u0000age group 0-15 year, retinal diseases and retinitis pigmentosa were the main reasons for visual disability. These type of studies help in population\u0000based surveys to plan, implement and supervise eye care health services.","PeriodicalId":14358,"journal":{"name":"International journal of scientific research","volume":"27 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141024934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the Interplay: Warfarin and Metronidazole Drug Interaction Dynamics","authors":"P. C. Sandhya, M Bhavana Reddy, V. Padma, S.V. Sathyapriya, Sujana Reddy, I. M, Sharath Chandra Reddy Turpu, V. Veera Vignesh","doi":"10.36106/ijsr/4703389","DOIUrl":"https://doi.org/10.36106/ijsr/4703389","url":null,"abstract":"A 65 year old male patient was admitted in our hospital with complaints of breathlessness on exertion, haematemesis, history of malaena. Patient\u0000had history of loose stools 10 days back and was on tab metronidazole 400mg tid for 5 days. On general examination, there was pallor and\u0000laboratory investigations showed PT ( test ) more than 100, peripheral smear showed normocytic normochromic RBCs admixed with microcytic\u0000and macrocytic RBCs with anisopoikilocytosis showing occasional tear drop cells. Patient was on Tab Acitrom 2mg 0-0-2. Tab acitrom was\u0000stopped and patient was given Vit K, Fresh frozen plasma and Packed red blood cells transfusion. Patient's Haemoglobin started improving and PT\u0000came within normal limits. Patient improved symptomatically","PeriodicalId":14358,"journal":{"name":"International journal of scientific research","volume":"50 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141049191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RENAL PAPILLARY ADENOMA : AN INCIDENTAL FINDING ON AUTOPSY","authors":"Sumiti Gupta, Nishtha Gupta, Priyanka Rawat, Nilay Nishith","doi":"10.36106/ijsr/3202560","DOIUrl":"https://doi.org/10.36106/ijsr/3202560","url":null,"abstract":"The incidence of benign renal tumours is less, especially when compared to renal cell carcinomas, as most are detected incidentally or at autopsy.1\u0000Reported in 7% of kidneys resected for other tumors, they are more frequent in resected kidneys accompanying RCC, papillary type compared with\u0000other subtypes.2 Present in 7 - 40% of autopsy studies, frequency increases with age.2 We present a case of 30 year old deceased male whose viscera\u0000including brain, heart, lungs, liver, spleen and kidney were received in the Department of Pathology, PGIMS, Rohtak, Haryana for\u0000histopathological examination. The histopathological examination of the kidney showed Renal papillary Adenoma.","PeriodicalId":14358,"journal":{"name":"International journal of scientific research","volume":"41 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141053524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PROGRESSION AND PERSPECTIVE, A 20-YEAR RETROSPECTIVE ON SYSTEMATIC LUPUS ERYTHEMATOSUS THERAPEUTICS: A NARRATIVE REVIEW","authors":"Nixat Patel, Tirth Hinsu, Shivangi Sharma, Meetkumar Pipaliy, Dhruvin Patel, Jahanvi Kasodariya, Jetal Joshi, Yugam Rajeshkumar Oza","doi":"10.36106/ijsr/2608816","DOIUrl":"https://doi.org/10.36106/ijsr/2608816","url":null,"abstract":"This study aims to examine efcacy and safety of current regimen in comparison to novel therapeutic regimens with treat-to-target strategies and\u0000agents consisting of non-steroidal immunosuppressants, biologics, and nonpharmacologic treatment options. This study also highlights future\u0000treatment options under investigation, aiming to identify potential avenues for improved patient care and disease control. Novel therapies have\u0000shown greater improvements in treatment of SLE which would cause decrease in use of steroids and more patient specic targeted therapies. This\u0000will help in identifying any knowledge gaps and propose future research directions to address the same and contribute to the enhancement of patient\u0000outcomes and quality of life by providing insights into optimal approaches to SLE management.","PeriodicalId":14358,"journal":{"name":"International journal of scientific research","volume":"17 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141142908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BLUNT CHEST TRAUMA CAUSING DELAYED ATRIAL FIBRILLATION.","authors":"Takshak Shanka, Poonam Arora, Parvathy Sasidharan, B. Bhardwaj, Sreejith Jayachandran, Aishwarya Nair","doi":"10.36106/ijsr/7204513","DOIUrl":"https://doi.org/10.36106/ijsr/7204513","url":null,"abstract":"Blunt Cardiac Injuries are injuries acquired due to blunt trauma to the heart. Minor ECG or cardiac enzyme abnormalities and arrhythmias are a\u0000subset of BCI, referred to as cardiac contusions. BCI is associated with signicant morbidity and mortality, and due to the absence of a denitive\u0000diagnostic test, is difcult to diagnose. Delayed presentation of arrhythmias beyond the initial 48 hours of trauma is rare.We present a case of an\u0000elderly female, who presented with atrial brillation ten days after sustaining a blunt chest trauma. She was managed in accordance with the AHA\u0000ACLS guidelines, but ultimately succumbed within an hour of Emergency stay. Elderly patients may require prolonged monitoring after blunt\u0000chest trauma.","PeriodicalId":14358,"journal":{"name":"International journal of scientific research","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141024351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NOVEL METHOD OF “SANTOSH-PGI STAPLER-NEPHRECTOMY WITH TRANEXAMIC ACID & NORADRENALINE” IN RENAL CELL CARCINOMA WITH SUPRADIAPHRAGMATIC INFERIOR VENA CAVA TUMOUR THROMBUS FOR DECREASING OPERATIVE TIMES & BLOOD LOSS","authors":"Santosh Kumar, Rohit Sanjay Deshpande, Shanky Singh, Sivakumar S","doi":"10.36106/ijsr/6802659","DOIUrl":"https://doi.org/10.36106/ijsr/6802659","url":null,"abstract":"Radical resection of renal cell carcinoma with renal vein & supradiaphragmatic inferior vena cava thrombosis, is often associated with signicant\u0000amount of blood loss during the surgery, owing to the dense peri-renal reactive adhesions, altered hilar anatomy & parasitic/collateral vessels from\u0000the surface of kidney to colon and retrohepatic area & retroperitoneum. It is standard practice to proceed with nephrectomy initially, followed by\u0000retrieval of the thrombus; however, the opposite can also be performed. Invariably, surgery in these cases is associated with signicant blood loss,\u0000mainly due to the extensive network of peri-nephric collateral vessels. Hence, adequate preoperative patient preparedness is the norm. In this case\u0000series, we aim to highlight a novel method of decreasing the intra-operative time & blood loss associated with nephrectomy, during radical\u0000resection of renal tumours associated with tumour thrombus which eventually led to decreased intra-operative blood loss and operative times.","PeriodicalId":14358,"journal":{"name":"International journal of scientific research","volume":"10 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141037793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A STUDY TO EVALUATE THE PERIOPERATIVE RESPIRATORY MECHANICS IN PATIENTS UNDERGOING LAPROSCOPIC ABDOMINAL SURGERIES USING FORCED OSCILLATION TECHNIQUE","authors":"M. M. N., Mohan J, Arun B J, Pooja Kr, Mahnaaz Sultana","doi":"10.36106/ijsr/1508427","DOIUrl":"https://doi.org/10.36106/ijsr/1508427","url":null,"abstract":"Need For Study Perioperative prediction of respiratory complications is important in patients undergoing laparoscopic surgeries under general\u0000anesthesia,. Spirometry- most frequently used method for perioperative evaluation of respiratory function, but it is effort dependent. Forced\u0000oscillation technique(FOT) overcomes this problem as it is a simple, effortless and non-invasive means of assessing the respiratory mechanics, The\u0000technique involves external application of pressure wave to the respiratory system while the patient is breathing normally at tidal volume followed\u0000by measurement of airow. It is capable of detecting respiratory changes due to endotracheal intubation, duration of general anesthesia and carbon\u0000dioxide insufation both in airway (blocks, narrowing, spasms) as well as parenchyma (consolidation, atelectasis or collapse) In our study, we\u0000intend to analyze these changes in patients undergoing laparoscopic abdominal surgeries under general anesthesia which may help in early\u0000detection and in turn guide to decerese the incidence of respiratory complications.\u0000Aim&objective1) To evaluate the changes in respiratory resistance and reactance in patients undergoing laparoscopic abdominal surgeries using Forced\u0000Oscillation Technique before and after surgery.\u00002) To evaluate the clinical prole of patients with signicant changes.\u0000Materials And Methods- This is a ongoing prospective-observational study started in November 2022 at hospitals attached to Bangalore Medical\u0000College and Research institute (BMCRI). After obtaining ethical committee clearence, an informed written consent was taken from 12 patients\u0000were enrolled into the study. FOT test was performed 24hours before and 24 hours after surgery and results were tabulated using SPSS version 27\u0000and calculated with student t- test. Results:- Out of 12 cases, respiratory reactance at 5 Hz (R5) and respiratory resistance of R5-20 (small airway)\u0000changed signicantly in 4 patients (36%) who underwent surgery for more than 2 hours duration. Respiratory reactance (X5) changed signicantly\u0000in 6 (50%) patients who underwent laparoscopic surgery for more than 2 hours. The study is currently ongoing and the nal results will be displayed\u0000on the day of presentation. Conclusion:- The forced oscillation technique is a clinical tool that can be used to predict respiratory mechanics before\u0000and after surgery. However, it remains to be seen that, it plays a role in predicting clinical outcomes in terns of reducing postoperative morbidity","PeriodicalId":14358,"journal":{"name":"International journal of scientific research","volume":"82 S366","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141133648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}