International Journal of Clinical Microbiology and Biochemical Technology最新文献

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Virulence Genes in Pseudomonas Aeruginosa Strains Isolated at Suez Canal University Hospitals with Respect to the Site of Infection and Antimicrobial Resistance 苏伊士运河大学医院铜绿假单胞菌感染部位及耐药性的毒力基因分析
International Journal of Clinical Microbiology and Biochemical Technology Pub Date : 2019-07-05 DOI: 10.29328/JOURNAL.IJCMBT.1001006
Nermine Elmaraghy, S. Abbadi, Gehan Elhadidi, Asmaa A. Hashem, A. Yousef
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引用次数: 14
Host biomarkers for early diagnosis of infectious diseases: A comprehensive review 宿主生物标志物在传染病早期诊断中的应用综述
International Journal of Clinical Microbiology and Biochemical Technology Pub Date : 2019-06-05 DOI: 10.29328/JOURNAL.IJCMBT.1001005
Arindam Chakraborty, S. Monica
{"title":"Host biomarkers for early diagnosis of infectious diseases: A comprehensive review","authors":"Arindam Chakraborty, S. Monica","doi":"10.29328/JOURNAL.IJCMBT.1001005","DOIUrl":"https://doi.org/10.29328/JOURNAL.IJCMBT.1001005","url":null,"abstract":"Biomarkers have been used in the diagnosis of disease and other conditions for many decades. There are diverse ranges of analytical targets, including metabolites, nucleic acids and proteins were used as a biomarker. Clinical diagnoses already rely heavily on these for patient disease classifi cation, management, and informing treatment and care pathways. For that there is always a need of rapid and point of care test. However, until fairly recently, studies of biomarker effi cacy in a clinical setting were mainly limited to single or dual use, and the landscape was complex, confused, and often inconsistent. Few candidates emerged from this somewhat clouded picture: C-reactive protein, procalcitonin (PCT) for sepsis, ADA for mycobacterium tuberculosis and a Circulating miRNAs serve as molecular markers for diverse physiological and pathological conditions. Review Article","PeriodicalId":142966,"journal":{"name":"International Journal of Clinical Microbiology and Biochemical Technology","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122496519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Trypanosoma dionisii as an experimental model to study anti-Trypanosoma cruzi drugs: A comparative analysis with benznidazole, posaconazole and amiodarone 以酒锥虫为实验模型研究抗克氏锥虫药物:与苯并硝唑、泊沙康唑和胺碘酮的比较分析
International Journal of Clinical Microbiology and Biochemical Technology Pub Date : 2018-10-17 DOI: 10.29328/JOURNAL.IJCMBT.1001003
Barrias Es, Borges Tr, W. Desouza
{"title":"Trypanosoma dionisii as an experimental model to study anti-Trypanosoma cruzi drugs: A comparative analysis with benznidazole, posaconazole and amiodarone","authors":"Barrias Es, Borges Tr, W. Desouza","doi":"10.29328/JOURNAL.IJCMBT.1001003","DOIUrl":"https://doi.org/10.29328/JOURNAL.IJCMBT.1001003","url":null,"abstract":"Chagas disease is a public health problem in Latin America and its treatment is based on the use of benznidazole or nifurtimox compounds. Both present problems such as resistance, ineffi ciency in chronic infection and cytotoxic effects. New compounds such as posaconazole and amiodarone have been tested against T. cruzi and shown to be effective. In addition, new molecules have been synthesized and tested against T. cruzi. Because this protozoan is highly pathogenic, even with a number of cases of accidental laboratory infections, few laboratories located outside Latin America are authorized to work with its infective developmental stages. On the other hand, Trypanosoma dionisii is a non-pathogenic protozoan phylogenetically related to T. cruzi and that shares similar strategies to complete its life cycle in mammalian cells in vitro. Here, we describe a comparative analysis of the sensitivity of both parasites to benznidazole, posoconazole and amiodarone. We also analyzed the morphological effects of these compounds on both Trypanosoma species using electron microscopy. Our results show that T. dionisii is more sensitive to the compounds tested than T. cruzi. They also support a previous suggestion that it may constitute an excellent model for large scale screening of compounds against T. cruzi. Research Article","PeriodicalId":142966,"journal":{"name":"International Journal of Clinical Microbiology and Biochemical Technology","volume":"96 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134298192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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