Nermine Elmaraghy, S. Abbadi, Gehan Elhadidi, Asmaa A. Hashem, A. Yousef
{"title":"Virulence Genes in Pseudomonas Aeruginosa Strains Isolated at Suez Canal University Hospitals with Respect to the Site of Infection and Antimicrobial Resistance","authors":"Nermine Elmaraghy, S. Abbadi, Gehan Elhadidi, Asmaa A. Hashem, A. Yousef","doi":"10.29328/JOURNAL.IJCMBT.1001006","DOIUrl":"https://doi.org/10.29328/JOURNAL.IJCMBT.1001006","url":null,"abstract":"1Associate Professor of Medical Microbiology, Department of Medical Microbiology &Immunology Faculty of Medicine Suez Canal University; Ismailia, Egypt 2Professor of Medical Microbiology, Department of Medical Microbiology & Immunology Faculty of Medicine, Suez University, Suez, Egypt 3Professor of Medical Microbiology, Department of Medical Microbiology & Immunology Faculty of Medicine, Suez Canal University, Ismailia, Egypt 4Lecturer of Medical Microbiology, Department of Medical Microbiology & Immunology Faculty of Medicine, Suez Canal University, Ismailia, Egypt 5Lecturer of Medical Microbiology Department of Medical Microbiology & Immunology Faculty of Medicine, Suez Canal University, Ismailia, Egypt","PeriodicalId":142966,"journal":{"name":"International Journal of Clinical Microbiology and Biochemical Technology","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132940063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Host biomarkers for early diagnosis of infectious diseases: A comprehensive review","authors":"Arindam Chakraborty, S. Monica","doi":"10.29328/JOURNAL.IJCMBT.1001005","DOIUrl":"https://doi.org/10.29328/JOURNAL.IJCMBT.1001005","url":null,"abstract":"Biomarkers have been used in the diagnosis of disease and other conditions for many decades. There are diverse ranges of analytical targets, including metabolites, nucleic acids and proteins were used as a biomarker. Clinical diagnoses already rely heavily on these for patient disease classifi cation, management, and informing treatment and care pathways. For that there is always a need of rapid and point of care test. However, until fairly recently, studies of biomarker effi cacy in a clinical setting were mainly limited to single or dual use, and the landscape was complex, confused, and often inconsistent. Few candidates emerged from this somewhat clouded picture: C-reactive protein, procalcitonin (PCT) for sepsis, ADA for mycobacterium tuberculosis and a Circulating miRNAs serve as molecular markers for diverse physiological and pathological conditions. Review Article","PeriodicalId":142966,"journal":{"name":"International Journal of Clinical Microbiology and Biochemical Technology","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122496519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Trypanosoma dionisii as an experimental model to study anti-Trypanosoma cruzi drugs: A comparative analysis with benznidazole, posaconazole and amiodarone","authors":"Barrias Es, Borges Tr, W. Desouza","doi":"10.29328/JOURNAL.IJCMBT.1001003","DOIUrl":"https://doi.org/10.29328/JOURNAL.IJCMBT.1001003","url":null,"abstract":"Chagas disease is a public health problem in Latin America and its treatment is based on the use of benznidazole or nifurtimox compounds. Both present problems such as resistance, ineffi ciency in chronic infection and cytotoxic effects. New compounds such as posaconazole and amiodarone have been tested against T. cruzi and shown to be effective. In addition, new molecules have been synthesized and tested against T. cruzi. Because this protozoan is highly pathogenic, even with a number of cases of accidental laboratory infections, few laboratories located outside Latin America are authorized to work with its infective developmental stages. On the other hand, Trypanosoma dionisii is a non-pathogenic protozoan phylogenetically related to T. cruzi and that shares similar strategies to complete its life cycle in mammalian cells in vitro. Here, we describe a comparative analysis of the sensitivity of both parasites to benznidazole, posoconazole and amiodarone. We also analyzed the morphological effects of these compounds on both Trypanosoma species using electron microscopy. Our results show that T. dionisii is more sensitive to the compounds tested than T. cruzi. They also support a previous suggestion that it may constitute an excellent model for large scale screening of compounds against T. cruzi. Research Article","PeriodicalId":142966,"journal":{"name":"International Journal of Clinical Microbiology and Biochemical Technology","volume":"96 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134298192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}