International Journal of Pediatric Endocrinology最新文献_第8页

Growth and descent of the testes in infants with hypogonadotropic hypogonadism receiving subcutaneous gonadotropin infusion. 皮下注射促性腺激素治疗促性腺功能减退症婴儿睾丸的生长和下降。

International Journal of Pediatric Endocrinology Pub Date : 2016-01-01 Epub Date: 2016-07-04 DOI: 10.1186/s13633-016-0031-9

Anne-Sophie Lambert, Pierre Bougneres

{"title":"Growth and descent of the testes in infants with hypogonadotropic hypogonadism receiving subcutaneous gonadotropin infusion.","authors":"Anne-Sophie Lambert, Pierre Bougneres","doi":"10.1186/s13633-016-0031-9","DOIUrl":"https://doi.org/10.1186/s13633-016-0031-9","url":null,"abstract":"Background: One third of infants with congenital hypogonadotropic hypogonadism (CHH) are said to have micropenis and/or bilateral or unilateral cryptorchidism leading many of them to orchiopexy. Our previous study in two patients suggests that prolonged subcutaneous infusion of large doses of gonadotropins might normalize testicular function and growth.Case presentation: To confirm the effects of early and prolonged subcutaneous infusion of large doses of gonadotropins on growth and descent of the testes. Eight boys with CHH, aged 0.25-11 months. Testes were non-palpable in 5 or in high scrotal position in 3. CHH was isolated in 5 infants and part of a syndrome of combined pituitary hormonal deficits in the 3 others. In response to gonadotropin infusion, mean levels of testicular hormones were normalized. Complete testis descent occurred in 6 patients. Partial descent occurred in 2. Testes re-ascended in 1 patient. Testes and penis gained normal dimensions in all cases.Conclusion: Subcutaneous gonadotropin infusion seems able to induce testis descent in a large proportion of infants with CHH. If confirmed, this may allow patients to avoid testes surgery but studies in larger series are needed to evaluate the benefits of this treatment versus traditional orchiopexy.","PeriodicalId":14271,"journal":{"name":"International Journal of Pediatric Endocrinology","volume":"2016 ","pages":"13"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s13633-016-0031-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34637493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 38

Body mass index in girls with idiopathic central precocious puberty during and after treatment with GnRH analogues. 在GnRH类似物治疗期间和之后特发性中枢性性早熟女孩的体重指数。

International Journal of Pediatric Endocrinology Pub Date : 2016-01-01 Epub Date: 2016-08-05 DOI: 10.1186/s13633-016-0033-7

A J Arcari, M G Gryngarten, A V Freire, M G Ballerini, M G Ropelato, I Bergadá, M E Escobar

{"title":"Body mass index in girls with idiopathic central precocious puberty during and after treatment with GnRH analogues.","authors":"A J Arcari, M G Gryngarten, A V Freire, M G Ballerini, M G Ropelato, I Bergadá, M E Escobar","doi":"10.1186/s13633-016-0033-7","DOIUrl":"https://doi.org/10.1186/s13633-016-0033-7","url":null,"abstract":"Background: In girls with Idiopathic Central Precocious Puberty (ICPP) concern has been raised by the potential impact of GnRH-analogues (GnRHa) treatment on body weight. We evaluated the effect of GnRHa on Body Mass Index (BMI) in girls with ICPP according to weight status at diagnosis.Methods: One hundred seventeen ICPP girls were divided according to pretreatment weight status in: normal weight (NW), overweight (OW) and obese (OB). BMI at one and two years of treatment was assessed. BMI-SDS of 60 patients who reached adult height (AH) was compared to that of 33 ICPP untreated girls.Results: NW girls significantly increased their baseline BMI-SDS at 1 and 2 years of treatment. OW girls only had a significant increment at one year of treatment while OB girls showed no BMI-SDS change. Patients evaluated at AH (at least four years after GnRHa withdrawal) showed a significant decrease on BMI compared to baseline and a significantly lower BMI than the untreated group.Conclusion: In ICPP girls the BMI increase under GnRHa was inversely related to the pretreatment weight status. In the long term follow-up, no detrimental effect of GnRHa on body weight was observed. BMI-SDS was lower in treated than in untreated girls.","PeriodicalId":14271,"journal":{"name":"International Journal of Pediatric Endocrinology","volume":"2016 ","pages":"15"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s13633-016-0033-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34630796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Fat free mass index and fat mass index tracing on body composition chart in diabetes adolescent girls 糖尿病少女身体成分图的无脂质量指数和脂肪质量指数追踪

International Journal of Pediatric Endocrinology Pub Date : 2015-04-28 DOI: 10.1186/1687-9856-2015-S1-P20

Sochung Chung, H. Park, B. Kwak, Kyo Sun Kim

引用次数: 1

Growth effect of tki treatment in childhood CML tki治疗对儿童期CML生长的影响

International Journal of Pediatric Endocrinology Pub Date : 2015-04-28 DOI: 10.1186/1687-9856-2015-S1-P32

Y. J. Jeon, In Ah Jung, W. Cho, Jaewook Lee, N. Chung, M. Jung, B. Cho, Byung-Kyu Suh

引用次数: 0

An infant with Cushing syndrome 一个患有库欣综合症的婴儿

International Journal of Pediatric Endocrinology Pub Date : 2015-04-28 DOI: 10.1186/1687-9856-2015-S1-P41

A. Sng, K. Loke, Y. Lim, C. Ho

引用次数: 0

ISPAD and its role in the management of diabetes in the young in the Indian subcontinent and the Far East ISPAD及其在印度次大陆和远东年轻人糖尿病管理中的作用

International Journal of Pediatric Endocrinology Pub Date : 2015-04-28 DOI: 10.1186/1687-9856-2015-S1-O15

S. Greene

引用次数: 0

Novel mutation in the hepatocyte nuclear factor 1B/maturity – onset diabetes of the young type 5 gene – unreported Vietnamese case 新突变的肝细胞核因子1B/成熟型糖尿病的年轻5型基因-未报道的越南病例

International Journal of Pediatric Endocrinology Pub Date : 2015-04-28 DOI: 10.1186/1687-9856-2015-S1-P25

V. C. Dũng, Bùi Phương Thảo, C. T. B. Ngọc, Nguyen Ngoc Khanh, Nguyen Phu Dat, S. Ellard, M. Craig

引用次数: 0

Novel heterozygous deletion in the HNF1β gene - adolescent with antibody negative diabetes, longstanding hyperglycaemia without ketosis, cataracts, small echogenic kidneys with a cortical cyst, pancreatic atrophy, exocrine pancreatic insufficiency and a uterine anomaly 新发现的HNF1β基因杂合缺失——患有抗体阴性糖尿病、长期高血糖但无酮症、白内障、伴有皮质囊肿的小回声肾、胰腺萎缩、外分泌胰腺功能不全和子宫异常的青少年

International Journal of Pediatric Endocrinology Pub Date : 2015-04-28 DOI: 10.1186/1687-9856-2015-S1-P1

L. Conwell, I. McGown

引用次数: 0

Sirolimus therapy following subtotal pancreatectomy in neonatal hyperinsulinemic hypoglycaemia: a case report 西罗莫司治疗次全胰切除术后新生儿高胰岛素性低血糖:1例报告

International Journal of Pediatric Endocrinology Pub Date : 2015-04-28 DOI: 10.1186/1687-9856-2015-S1-P81

M. Abraham, S. Flanagan, V. Shetty, Glynis Price, M. deBock, A. Siafarikas, S. Ellard, S. Resnick, E. Whan, E. Davis, T. Jones, K. Hussain, C. Choong

引用次数: 0

Insulin-like Growth Factor 1 (IGF-1) measurements recorded in the OZGROW database and their relation to growth response in children currently being treated with growth hormone OZGROW数据库中记录的胰岛素样生长因子1 (IGF-1)测量及其与目前接受生长激素治疗的儿童生长反应的关系

International Journal of Pediatric Endocrinology Pub Date : 2015-04-28 DOI: 10.1186/1687-9856-2015-S1-P38

I. Hughes, M. Harris, A. Cotterill

引用次数: 0